https://m2.mtmt.hu/ hun 2026-04-21 03:00 true true 1 1 1 1 100 1 1 DESC publishedYear false ASC firstAuthor true ASC title true JournalArticle 31775906 VALIDATED true 0 false 2025-12-30T11:11:18.268+0000 2025-01-20T09:24:00.085+0000 2020-12-14T08:55:51.996+0000 true 10072696 Havas Petra /api/admin/10072696 Admin true 2025-01-20T09:24:00.096+0000 2025-01-20T09:24:00.096+0000 2023-08-03T10:12:25.355+0000 true 10082735 Tóth-Lipták Péter /api/admin/10082735 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Cibula, D Completion of radical hysterectomy does not improve survival of patients with cervical cancer and intraoperatively detected lymph node involvement ABRAX international retrospective cohort study true true /api/journal/1486 REVIEWED true false 1486 false 1486 true 0959-8049 1879-0852 Journal FOREIGN 143 88 100 88 13 2021 The management of cervical cancer patients with intraoperative detection of lymph node involvement remains controversial. Since all these patients are referred for (chemo)radiation after the surgery, the key decision is whether radical hysterectomy should be completed as originally planned, taking into account an additional morbidity associated with extensive surgical dissection prior to adjuvant treatment. The ABRAX study investigated whether completing a radical uterine procedure is associated with an improved oncological outcome of such patients.We performed retrospective analyses of 515 cervical cancer patients (51 institutions, 19 countries) who were referred for primary curative surgery between 2005 and 2015 (stage IA-IIB, common tumour types) in whom lymph node involvement was detected intraoperatively. Patients were stratified according to whether the planned uterine surgery was completed (COMPL group, N = 361) or abandoned (ABAND group, N = 154) to compare progression-free survival. Definitive chemoradiation was given to 92.9% patients in the ABAND group and adjuvant (chemo)radiation or chemotherapy to 91.4% of patients in the COMPL group.The risks of recurrence (hazard ratio [HR] 1.154, 95% confidence intervals [CI] 0.799-1.666, P = 0.45), pelvic recurrence (HR 0.836, 95% CI 0.458-1.523, P = 0.56), or death (HR 1.064, 95% CI 0.690-1.641, P = 0.78) were not significantly different between the two groups. No subgroup showed a survival benefit from completing radical hysterectomy. Disease-free survival reached 74% (381/515), with a median follow-up of 58 months. Prognostic factors were balanced between the two groups. FIGO stage and number of pelvic lymph nodes involved were significant prognostic factors in the whole study cohort.We showed that the completion of radical hysterectomy does not improve survival in patients with intraoperatively detected lymph node involvement, regardless of tumour size or histological type. If lymph node involvement is confirmed intraoperatively, abandoning uterine radical procedure should be considered, and the patient should be referred for definitive chemoradiation.NCT04037124. true 2020 true true true false true false NONE 2025-12-30 false 59 0 59 42 2 58 56 55 48 59 59 42 42 42 17 0 59 42 59 42 0 0 0 D1 false false false false 2021-03-14T08:56:08.601+0000 Országos Onkológiai Intézet 1 12 1 26 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 94808654 /api/authorship/94808654 1 0.038 true false true Cibula D true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94808655 /api/authorship/94808655 2 0.03846154 false false false Dostalek L true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94808656 /api/authorship/94808656 3 0.03846154 false false false Hillemanns P true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true 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false false Jaeger A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94808663 /api/authorship/94808663 10 0.03846154 false false false Capilna M E true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94808664 /api/authorship/94808664 11 0.03846154 false false false Weinberger V true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94808665 /api/authorship/94808665 12 0.03846154 false false false Klat J true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94808666 /api/authorship/94808666 13 0.03846154 false false false Schmidt R L true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94808667 /api/authorship/94808667 14 0.03846154 false false false Lopez A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 94808668 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sjr true true ClassificationExternal 1306 /api/classificationexternal/1306 true 1306 true D1 DIRECT true true /api/publication/31775906 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" >Cibula D ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Dostalek L </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hillemanns P </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Scambia G </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jarkovsky J </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Persson J </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Raspagliesi F </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10067878"><a href="/gui2/?type=authors&mode=browse&sel=10067878" target="_blank">Novak Z (<span class="authorship-author-name">Novák Zoltán</span> <span class="authorAux-mtmt"> Szülész-nőgyógyász és nőgyógyászati daganatsebész</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jaeger A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Capilna M E </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Weinberger V </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Klat J </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schmidt R L </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lopez A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Scibilia G </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pareja R </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kucukmetin A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kreitner L </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >El-Balat A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pereira G J R </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Laufhütte S </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Isla-Ortiz D </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Toptas T </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gil-Ibanez B </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Vergote I </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Runnenbaum I </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31775906" target="_blank">Completion of radical hysterectomy does not improve survival of patients with cervical cancer and intraoperatively detected lymph node involvement : ABRAX international retrospective cohort study.</a></div> <div> <span class="journal-title">EUROPEAN JOURNAL OF CANCER</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0959-8049">0959-8049</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1879-0852">1879-0852</a>)</span>: <span class="journal-volume">143</span> <span class="page"> pp 88-100 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.ejca.2020.10.037" target="_blank" href="https://doi.org/10.1016/j.ejca.2020.10.037"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000604902700014" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000604902700014"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85097244416" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85097244416"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33290995" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33290995&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 59</span> | Független: 42 | Függő: 17 | Nem jelölt: 0 | WoS jelölt: 55 | Scopus jelölt:&nbsp;48 | WoS/Scopus jelölt:&nbsp;59 | DOI jelölt:&nbsp;56 </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31775906</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2025.01.20. 10:24 Pirmann Tamás (OOI addmin5, admin) </div> </div></div>