TY  - JOUR
AU  - Ferenczy, György
AU  - Keserű, György Miklós
TI  - On the enthalpic preference of fragment binding
JF  - MEDCHEMCOMM
J2  - MEDCHEMCOMM
VL  - 7
PY  - 2016
IS  - 2
SP  - 332
EP  - 337
PG  - 6
SN  - 2040-2503
DO  - 10.1039/C5MD00542F
UR  - https://m2.mtmt.hu/api/publication/3023251
ID  - 3023251
N1  - WoS:hiba:000370693900015 2019-03-02 21:55 DOI azonosító nem egyezik
AB  - Detailed thermodynamic analysis of fragment binding revealed that unlike drug-like compounds, fragments bind with significant enthalpic preference. This observation is in line with the size dependency of binding enthalpy contributions and is also supported by a large body of experimental data from direct binding thermodynamic measurements. The enthalpy-driven binding of fragments represents a thermodynamic rationale for fragment-based drug discovery programs and suggests guidelines for fragment-based optimization programs.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Jakó, Tamás
AU  - Szabó, Eszter
AU  - Tábi, Tamás
AU  - Zachar, Gergely
AU  - Csillag, András
AU  - Szökő, Éva
TI  - Chiral analysis of amino acid neurotransmitters and neuromodulators in mouse brain by CE-LIF.
JF  - ELECTROPHORESIS
J2  - ELECTROPHORESIS
VL  - 35
PY  - 2014
IS  - 19
SP  - 2870
EP  - 2876
PG  - 7
SN  - 0173-0835
DO  - 10.1002/elps.201400224
UR  - https://m2.mtmt.hu/api/publication/2713158
ID  - 2713158
N1  - Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary            
            Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, Hungary            
            Cited By :32            
            Export Date: 25 July 2024            
            CODEN: ELCTD            
            Correspondence Address: Szöko, E.; Department of Pharmacodynamics, Hungary
AB  - Chiral CE method has been developed for quantitative determination of d-amino acid modulators of NMDA glutamate receptor; d-serine and d-aspartate along with l-glutamate and l-aspartate in biological samples. These ligands are suggested to be involved in regulation of NMDA receptor related brain functions, such as neurogenesis, neuronal plasticity, and memory formation. For sensitive determination of the amino acids LIF detection was chosen, and a fluorogenic reagent, 7-fluoro-4-nitro-2,1,3-benzoxadiazole was used for derivatization. An amino-modified beta-CD, 6-monodeoxy-6-mono(3-hydroxy)propylamino-beta-CD (HPA-beta-CD) was applied as chiral selector. Determinations were accomplished in a polyacrylamide coated capillary and reverse polarity was used for the analysis of the negatively charged analytes. The method was optimized and validated; 6 mM HPA-beta-CD in 50 mM HEPES buffer, pH 7 was appropriate to achieve baseline separation of the analytes. The limit of quantification with acceptable accuracy is 0.05 muM for both d-amino acids. The method was used for the determination of d-aspartate and d-serine content in various brain regions of adult mice.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Völgyi, Gergely
AU  - Ruiz, R
AU  - Box, K
AU  - Comer, J
AU  - Bosch, E
AU  - Takácsné Novák, Krisztina
TI  - Potentiometric and spectrophotometric pKa determination of water-insoluble compounds: Validation study in a new cosolvent system
JF  - ANALYTICA CHIMICA ACTA
J2  - ANAL CHIM ACTA
VL  - 583
PY  - 2007
IS  - 2
SP  - 418
EP  - 428
PG  - 11
SN  - 0003-2670
DO  - 10.1016/j.aca.2006.10.015
UR  - https://m2.mtmt.hu/api/publication/1490577
ID  - 1490577
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Tam, K Y
AU  - Takácsné Novák, Krisztina
TI  - Multi-wavelength spectrophotometric determination of acid dissociation constants: A validation study
JF  - ANALYTICA CHIMICA ACTA
J2  - ANAL CHIM ACTA
VL  - 434
PY  - 2001
IS  - 1
SP  - 157
EP  - 167
PG  - 11
SN  - 0003-2670
DO  - 10.1016/S0003-2670(01)00810-8
UR  - https://m2.mtmt.hu/api/publication/1490592
ID  - 1490592
LA  - English
DB  - MTMT
ER  -