https://m2.mtmt.hu/ hun 2026-03-14 13:49 true true 1 2 2 1 100 1 2 DESC publishedYear false ASC firstAuthor true ASC title true JournalArticle 2186144 VALIDATED true 0 2014-12-24T11:23:33.000+0000 false 2186144 2026-03-10T13:39:50.367+0000 2020-01-24T09:34:13.478+0000 2013-01-28T15:21:52.000+0000 true 10025100 Bödör Csaba /api/author/10025100 Author true 10025100 2020-06-08T10:56:56.496+0000 2020-06-08T10:56:56.496+0000 2013-12-10T10:26:40.000+0000 true 10022176 Laczik Cecilia /api/admin/10022176 Admin true 10022176 2020-01-24T09:34:13.495+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Iyengar, S P110alpha mediated constitutive PI3K signaling limits the efficacy of p110delta-selective inhibition in mantle cell lymphoma, particularly with multiple relapse. true true /api/journal/767 REVIEWED true false 767 false 767 true 0006-4971 1528-0020 Journal FOREIGN 121 12 2274 2284 2274 11 2013 Phosphoinositide-3 kinase (PI3K) pathway activation contributes to mantle cell lymphoma (MCL) pathogenesis but early phase studies of the PI3K p110delta inhibitor GS-1101 have reported inferior responses in MCL compared to other non-Hodgkin lymphomas. As the relative importance of the class IA PI3K isoforms p110alpha, p110beta and p110delta in MCL is not clear, we studied expression of these isoforms and assessed their contribution to PI3K signaling in this disease. We found that while p110delta was highly expressed in MCL, p110alpha showed wide variation and expression increased significantly with relapse. Loss of PTEN expression was found in 16% (22/138) of cases, while PIK3CA and PIK3R1 mutations were absent. Although p110delta inhibition was sufficient to block BCR-mediated PI3K activation, combined p110alpha and p110delta inhibition was necessary to abolish constitutive PI3K activation. In addition, GDC-0941, a predominantly p110alpha/delta inhibitor was significantly more active compared to GS-1101, against MCL cell lines and primary samples. We found that a high PIK3CA/PIK3CD ratio identified a subset of primary MCLs resistant to GS-1101 and this ratio increased significantly with relapse. These findings support the use of dual p110alpha/p110delta inhibitors in MCL and suggest a role for p110alpha in disease progression. 2013 (Bödör Csaba (Hematopatológia); 2013.01.28. 16:21:45) true true true false false NONE 2026-03-10 false 123 0 118 117 1 118 111 116 112 123 118 122 117 122 1 0 123 122 118 117 0 0 0 D1 false false false false 2013-12-10T10:26:40.000+0000 2013-01-28T15:22:59.000+0000 1 7 0 11 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 3634160 /api/authorship/3634160 1 0.09090909 true false Iyengar S true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 16819823 true PersonAuthorship 3634161 /api/authorship/3634161 2 0.09090909 false false Clear A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 16819822 true PersonAuthorship 3634162 /api/authorship/3634162 3 0.09090909 false false Author 10025100 /api/author/10025100 Bödör Csaba true 10025100 true Bodor C true false false 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B (<span class="authorship-author-name">Tóth Balázs</span> <span class="authorAux-mtmt"> Gabonafélék stresszgenetikája</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002559"><a href="/gui2/?type=authors&mode=browse&sel=10002559" target="_blank">Balla T (<span class="authorship-author-name">Balla Tamás</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Weiss WA </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Williams RL </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Shokat KM </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;1184642" target="_blank">A pharmacological map of the PI3-K family defines a role for p110 alpha in insulin signaling</a></div> <div> <span class="journal-title">CELL</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0092-8674">0092-8674</a> <a target="_blank" 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1184642</span> | Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS</span> </div> <div class="lastModified">Utolsó módosítás: 2021.01.19. 08:50 Ferbert Barbara (SE_KK_Admin5_FB - INAKTÍV, admin) </div> <div class="lockedBy">Központi kezelésű 2023.04.13. 20:32 Lévayné Deseő Katalin (MTMT Központi admin) </div> </div></div>