TY - JOUR AU - Bikov, András AU - Szabó, Helga AU - Piroska, Márton AU - Kunos, László AU - Szily, Marcell AU - Ligeti, Balázs AU - Makra, Nóra AU - Szabó, Dóra AU - Tárnoki, Dávid László AU - Tárnoki, Ádám Domonkos TI - Gut Microbiome in Patients with Obstructive Sleep Apnoea JF - APPLIED SCIENCES-BASEL J2 - APPL SCI-BASEL VL - 12 PY - 2022 IS - 4 PG - 12 SN - 2076-3417 DO - 10.3390/app12042007 UR - https://m2.mtmt.hu/api/publication/32687570 ID - 32687570 N1 - North West Lung Centre, Wythenshawe Hospital, Manchester University Foundation Trust, Manchester, M23 9LT, United Kingdom Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester, M13 9NT, United Kingdom Department of Pulmonology, Semmelweis University, Budapest, 1085, Hungary Medical Imaging Centre, Semmelweis University, Budapest, 1085, Hungary Central Radiological Diagnostic Department, Medical Centre Hungarian Defence Forces, Budapest, 1134, Hungary Institute of Medical Microbiology, Semmelweis University, Budapest, 1085, Hungary Faculty of Information Technology and Bionics, Pazmany Peter Catholic University, Budapest, 1085, Hungary Cited By :3 Export Date: 20 July 2023 Correspondence Address: Tarnoki, A.D.; Medical Imaging Centre, Hungary; email: tarnoki2@gmail.com LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Helga AU - Hernyes, Anita AU - Piroska, Márton AU - Ligeti, Balázs AU - Fussy, Peter AU - Zöldi, Luca AU - Galyasz, Szonja AU - Makra, Nóra AU - Szabó, Dóra AU - Tárnoki, Ádám Domonkos AU - Tárnoki, Dávid László TI - Association between Gut Microbial Diversity and Carotid Intima-Media Thickness JF - MEDICINA-LITHUANIA J2 - MED LITH VL - 57 PY - 2021 IS - 3 PG - 11 SN - 1010-660X DO - 10.3390/medicina57030195 UR - https://m2.mtmt.hu/api/publication/31974190 ID - 31974190 N1 - Medical Imaging Centre, Semmelweis University, Budapest, 1082, Hungary Central Radiological Diagnostic Department, Medical Centre Hungarian Defence Forces, Budapest, 1134, Hungary Institute of Medical Microbiology, Semmelweis University, Budapest, 1089, Hungary Faculty of Information Technology and Bionics, Pazmany Peter Catholic University, Budapest, 1088, Hungary Faculty of Medicine, Semmelweis University, Budapest, 1085, Hungary Cited By :15 Export Date: 23 January 2024 Correspondence Address: Szabo, H.; Medical Imaging Centre, Hungary; email: szabo.helga@semmelweis-univ.hu Correspondence Address: Szabo, H.; Central Radiological Diagnostic Department, Hungary; email: szabo.helga@semmelweis-univ.hu Chemicals/CAS: RNA, Ribosomal, 16S LA - English DB - MTMT ER - TY - JOUR AU - Mansour, Bassel AU - Monyók, Ádám AU - Makra, Nóra AU - Gajdács, Márió AU - Vadnay, István AU - Ligeti, Balázs AU - Juhász, János AU - Szabó, Dóra AU - Ostorházi, Eszter TI - Bladder cancer-related microbiota. examining differences in urine and tissue samples TS - examining differences in urine and tissue samples JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 10 PY - 2020 IS - 1 PG - 10 SN - 2045-2322 DO - 10.1038/s41598-020-67443-2 UR - https://m2.mtmt.hu/api/publication/31374214 ID - 31374214 LA - English DB - MTMT ER - TY - JOUR AU - Szily, Marcell AU - Tárnoki, Ádám Domonkos AU - Tárnoki, Dávid László AU - Kovacs, Daniel T AU - Forgó, Bianka AU - Lee, Jooyeon AU - Kim, Eunae AU - Sung, Joohon AU - Kunos, László AU - Mészáros, Martina AU - Müller, Veronika AU - Bikov, András TI - Genetic influences on the onset of obstructive sleep apnoea and daytime sleepiness. a twin study TS - a twin study JF - RESPIRATORY RESEARCH J2 - RESP RES VL - 20 PY - 2019 IS - 1 PG - 6 SN - 1465-9921 DO - 10.1186/s12931-019-1095-x UR - https://m2.mtmt.hu/api/publication/30724108 ID - 30724108 N1 - Department of Radiology, Semmelweis University, 78/A Ulloi street, Budapest, 1082, Hungary Complex Disease and Genome Epidemiology Branch, Department of Public Health Science, School of Public Health, Seoul National University, Seoul, South Korea Department of Pulmonology, Semmelweis University, Budapest, Hungary Cited By :21 Export Date: 23 January 2024 CODEN: RREEB Correspondence Address: Tarnoki, A.D.; Department of Radiology, 78/A Ulloi street, Hungary; email: tarnoki2@gmail.com AB - Obstructive sleep apnoea (OSA) is one of the major sources of the excessive daily sleepiness, cognitive dysfunction, and it increases cardiovascular morbidity and mortality. Previous studies suggested a possible genetic influence, based on questionnaires but no objective genetic study was conducted to understand the exact variance underpinned by genetic factors.Seventy-one Hungarian twin pairs involved from the Hungarian Twin Registry (48 monozygotic, MZ and 23 dizygotic, DZ pairs, mean age 51 ± 15 years) underwent overnight polysomnography (Somnoscreen Plus Tele PSG, Somnomedics GMBH, Germany). Apnoea hypopnea index (AHI), respiratory disturbance index (RDI) and oxygen desaturation index (ODI) were registered. Daytime sleepiness was measured with the Epworth Sleepiness Scale (ESS). Bivariate heritability analysis was applied.The prevalence of OSA was 41% in our study population. The heritability of the AHI, ODI and RDI ranged between 69% and 83%, while the OSA, defined by an AHI ≥5/h, was itself 73% heritable. The unshared environmental component explained the rest of the variance between 17% and 31%. Daytime sleepiness was mostly determined by the environment, and the variance was influenced in 34% by the additive genetic factors. These associations were present after additional adjustment for body mass index.OSA and the indices of OSA severity are heritable, while daytime sleepiness is mostly influenced by environmental factors. Further studies should elucidate whether close relatives of patients with OSA may benefit from early family risk based screening. LA - English DB - MTMT ER - TY - JOUR AU - Tárnoki, Ádám Domonkos AU - Tárnoki, Dávid László AU - Forgó, Bianka AU - Szabó, Helga AU - Melicher, Dóra AU - Metneki, Julia AU - Littvay, Levente TI - The Hungarian Twin Registry Update: Turning From a Voluntary to a Population-Based Registry JF - TWIN RESEARCH AND HUMAN GENETICS J2 - TWIN RES HUM GENET VL - 22 PY - 2019 IS - 6 SP - 561 EP - 566 PG - 6 SN - 1832-4274 DO - 10.1017/thg.2019.100 UR - https://m2.mtmt.hu/api/publication/31122140 ID - 31122140 N1 - Department of Medical Imaging, Semmelweis University, Budapest, Hungary Hungarian Twin Registry Foundation, Budapest, Hungary Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary MTA-SE Immune-Proteogenomics Extracellular Vesicle Research Group, Budapest, Hungary Department of Political Science, Central European University, Budapest, Hungary Cited By :22 Export Date: 5 February 2025 Correspondence Address: Tarnoki, A.D.; Department of Medical Imaging, Hungary; email: tarnoki2@gmail.com LA - English DB - MTMT ER - TY - JOUR AU - Littvay, Levente AU - Metneki, J AU - Tárnoki, Ádám Domonkos AU - Tárnoki, Dávid László TI - The Hungarian Twin Registry JF - TWIN RESEARCH AND HUMAN GENETICS J2 - TWIN RES HUM GENET VL - 16 PY - 2013 IS - 1 SP - 185 EP - 189 PG - 5 SN - 1832-4274 DO - 10.1017/thg.2012.76 UR - https://m2.mtmt.hu/api/publication/2101783 ID - 2101783 N1 - Epub: 2012 Oct 19:1-5. AB - The first Hungarian Twin Registry was established in Budapest in 1970 through the mandatory reporting of multiple-births. In the 1980s a second, volunteer adult registry was also founded. Unfortunately, both registries ceased to exist in the 1990s. Efforts started in 2006 to revive a Hungarian twin registry. The team spearheading this effort reports here on this progress. Currently, the voluntary Hungarian Twin Registry consists of 310 adult twin pairs and multiplets. Current research focuses on cardiovascular and respiratory health and yielded multiple awards and publications. Efforts are on the way to expand into social, psychological, and obesity studies. LA - English DB - MTMT ER -