TY - JOUR AU - Czeibert, Kálmán AU - Baksa, Gábor AU - Grimm, András AU - Nagy, Szilvia Anett AU - Kubinyi, Enikő AU - Petneházy, Örs TI - MRI, CT and high resolution macro-anatomical images with cryosectioning of a Beagle brain. Creating the base of a multimodal imaging atlas TS - Creating the base of a multimodal imaging atlas JF - PLOS ONE J2 - PLOS ONE VL - 14 PY - 2019 IS - 3 PG - 25 SN - 1932-6203 DO - 10.1371/journal.pone.0213458 UR - https://m2.mtmt.hu/api/publication/30556417 ID - 30556417 N1 - Department of Ethology, Institute of Biology, Eötvös Loránd University, Budapest, Hungary Department of Anatomy, Histology and Embryology, Semmelweis University of Medical Sciences, Budapest, Hungary Department of Otorhinolaryngology and Head and Neck Surgery, Semmelweis University of Medical Sciences, Budapest, Hungary MTA-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary Neurobiology of Stress Research Group, Szentágothai Research Center, University of Pécs, Pécs, Hungary Department of Neurosurgery, Medical School, University of Pécs, Pécs, Hungary Pécs Diagnostic Centre, Pécs, Hungary University of Kaposvár, Kaposvár, Hungary Export Date: 25 June 2025; Cited By: 20; Correspondence Address: K. Czeibert; Department of Ethology, Institute of Biology, Eötvös Loránd University, Budapest, Hungary; email: czeibert.kalman@ttk.elte.hu; CODEN: POLNC AB - Most common methods that directly show macro- or microscopic anatomy of the brain usually require the removal of the organ from the neurocranium. However, the brain can be revealed in situ by using proper sectioning techniques. Our aim was to both improve the cryosectioning method, test its limits and create a high-resolution macro-anatomical image series of a Beagle brain, which at the time of the study did not exist. A two-year-old female Beagle has been scanned with CT and MRI ante and post mortem, then the arteries of the head were filled with red resin. After freezing to -80°C, a neurocranium block was created and was embedded into a water-gelatin mix. Using a special milling device and a DSLR camera, 1112 consecutive RGB-color cryosections were made with a 100 μm layer thickness and captured in high resolution (300 dpi, 24-bit color, and pixel size was 19.5 x 19.5 μm). Image post-processing was done with Adobe Photoshop CS3 and Thermo Scientific Amira 6.0 softwares, and as a result of the proper alignment and coregistration, visualization and comparing was possible with all the applied imaging modalities (CT, MRI, cryosectioning) in any arbitrary plane. Surface models from the arteries, veins, brain and skull were also generated after segmentation in the same coordinate system, giving a unique opportunity for comparing the two-dimensional and three-dimensional anatomy. This is the first study which focuses directly to this high-definition multimodal visualization of the canine brain, and it provides the most accurate results compared to previous cryosectioning studies, as using an improved method, higher image quality, more detailed image, proper color fidelity and lower artefact formation were achieved. Based on the methodology we described, it can serve as a base for future multimodal (CT, MR, augmented- or virtual reality) imaging atlases for medical, educational and scientific purposes. LA - English DB - MTMT ER - TY - JOUR AU - Bálint, Péter Vince AU - Terslev, Lene AU - Aegerter, Philippe AU - Bruyn, George Arthur Willem AU - Chary-Valckenaere, Isabelle AU - Gandjbakhch, Frederique AU - Iagnocco, Annamaria AU - Jousse-Joulin, Sandrine AU - Moller, Ingrid AU - Naredo, Esperanza AU - Schmidt, Wolfgang A. AU - Wakefield, Richard J. AU - D'Agostino, Maria-Antonietta TI - Reliability of a consensus-based ultrasound definition and scoring for enthesitis in spondyloarthritis and psoriatic arthritis: an OMERACT US initiative JF - ANNALS OF THE RHEUMATIC DISEASES J2 - ANN RHEUM DIS VL - 77 PY - 2018 IS - 12 SP - 1730 EP - 1735 PG - 6 SN - 0003-4967 DO - 10.1136/annrheumdis-2018-213609 UR - https://m2.mtmt.hu/api/publication/30569681 ID - 30569681 AB - Objectives To evaluate the reliability of consensus-based ultrasound (US) definitions of elementary components of enthesitis in spondyloarthritis (SpA) and psoriatic arthritis (PsA) and to evaluate which of them had the highest contribution to defining and scoring enthesitis. LA - English DB - MTMT ER - TY - JOUR AU - D'Agostino, Maria-Antonietta AU - Terslev, Lene AU - Aegerter, Philippe AU - Backhaus, Marina AU - Bálint, Péter Vince AU - Bruyn, George A. AU - Filippucci, Emilio AU - Grassi, Walter AU - Iagnocco, Annamaria AU - Jousse-Joulin, Sandrine AU - Kane, David AU - Naredo, Esperanza AU - Schmidt, Wolfgang AU - Szkudlarek, Marcin AU - Conaghan, Philip G. AU - Wakefield, Richard J. TI - Scoring ultrasound synovitis in rheumatoid arthritis: a EULAR-OMERACT ultrasound taskforce-Part 1: definition and development of a standardised, consensus-based scoring system JF - RMD OPEN J2 - RMD OPEN VL - 3 PY - 2017 IS - 1 PG - 9 SN - 2056-5933 DO - 10.1136/rmdopen-2016-000428 UR - https://m2.mtmt.hu/api/publication/30608843 ID - 30608843 AB - Objectives To develop a consensus-based ultrasound (US) definition and quantification system for synovitis in rheumatoid arthritis (RA). LA - English DB - MTMT ER - TY - JOUR AU - Torp-Pedersen, SR AU - Christensen, R AU - Szkudlarek, M AU - Ellegaard, K AU - D'Agostino, MA AU - Iagnocco, A AU - Naredo, E AU - Bálint, Péter Vince AU - Wakefield, RJ AU - Torp-Pedersen, A AU - Terslev, L TI - Power and color Doppler settings for inflammatory flow. impact on scoring of disease activity in patients with rheumatoid arthritis TS - impact on scoring of disease activity in patients with rheumatoid arthritis JF - ARTHRITIS & RHEUMATOLOGY J2 - ARTHRITIS RHEUMATOL VL - 67 PY - 2015 IS - 2 SP - 386 EP - 395 PG - 10 SN - 2326-5191 DO - 10.1002/art.38940 UR - https://m2.mtmt.hu/api/publication/2769538 ID - 2769538 AB - Objectives: To determine how settings for power and color Doppler sensitivity varies on different high and intermediate range ultrasound (US) machines and to evaluate the impact of these changes on Doppler scoring of inflammatory joints Methods: Six different types of ultrasound machine were used. On each machine, the factory setting (FS) for superficial musculoskeletal scanning was used unchanged for both color and power Doppler modalities. The settings were then adjusted for increased Doppler sensitivity - study settings (SS). Eleven RA patients with wrist involvement were scanned on the 6 machines each with 4 settings generating 264 Doppler images for scoring and color quantification. Doppler sensitivity was measured with a quantitative assessment of Doppler activity - color fraction (CF) - higher CF indicated higher sensitivity. Results: Power Doppler was more sensitive on half of the machines whereas color Doppler was more sensitive on the other half with both FS and SS. There was an average increase in Doppler sensitivity despite modality of 78% when SS were applied. Over the 6 machines, 2 Doppler modalities, and 2 settings, 7 patients varied between grades 0 and 3 with the other 4 patients between grades 0 and 2. Conclusion: The effect of using different machines, Doppler modalities, and settings has a considerable influence on the quantification of inflammation in RA patients and this must be taken into account in multi-centre studies. (c) 2014 American College of Rheumatology. LA - English DB - MTMT ER -