@article{MTMT:30556417, title = {MRI, CT and high resolution macro-anatomical images with cryosectioning of a Beagle brain. Creating the base of a multimodal imaging atlas}, url = {https://m2.mtmt.hu/api/publication/30556417}, author = {Czeibert, Kálmán and Baksa, Gábor and Grimm, András and Nagy, Szilvia Anett and Kubinyi, Enikő and Petneházy, Örs}, doi = {10.1371/journal.pone.0213458}, journal-iso = {PLOS ONE}, journal = {PLOS ONE}, volume = {14}, unique-id = {30556417}, abstract = {Most common methods that directly show macro- or microscopic anatomy of the brain usually require the removal of the organ from the neurocranium. However, the brain can be revealed in situ by using proper sectioning techniques. Our aim was to both improve the cryosectioning method, test its limits and create a high-resolution macro-anatomical image series of a Beagle brain, which at the time of the study did not exist. A two-year-old female Beagle has been scanned with CT and MRI ante and post mortem, then the arteries of the head were filled with red resin. After freezing to -80°C, a neurocranium block was created and was embedded into a water-gelatin mix. Using a special milling device and a DSLR camera, 1112 consecutive RGB-color cryosections were made with a 100 μm layer thickness and captured in high resolution (300 dpi, 24-bit color, and pixel size was 19.5 x 19.5 μm). Image post-processing was done with Adobe Photoshop CS3 and Thermo Scientific Amira 6.0 softwares, and as a result of the proper alignment and coregistration, visualization and comparing was possible with all the applied imaging modalities (CT, MRI, cryosectioning) in any arbitrary plane. Surface models from the arteries, veins, brain and skull were also generated after segmentation in the same coordinate system, giving a unique opportunity for comparing the two-dimensional and three-dimensional anatomy. This is the first study which focuses directly to this high-definition multimodal visualization of the canine brain, and it provides the most accurate results compared to previous cryosectioning studies, as using an improved method, higher image quality, more detailed image, proper color fidelity and lower artefact formation were achieved. Based on the methodology we described, it can serve as a base for future multimodal (CT, MR, augmented- or virtual reality) imaging atlases for medical, educational and scientific purposes.}, year = {2019}, eissn = {1932-6203}, orcid-numbers = {Czeibert, Kálmán/0000-0001-9425-0892; Grimm, András/0000-0002-8369-3396; Nagy, Szilvia Anett/0000-0001-6483-9209; Kubinyi, Enikő/0000-0002-4468-9845; Petneházy, Örs/0000-0001-9698-5753} } @article{MTMT:30569681, title = {Reliability of a consensus-based ultrasound definition and scoring for enthesitis in spondyloarthritis and psoriatic arthritis: an OMERACT US initiative}, url = {https://m2.mtmt.hu/api/publication/30569681}, author = {Bálint, Péter Vince and Terslev, Lene and Aegerter, Philippe and Bruyn, George Arthur Willem and Chary-Valckenaere, Isabelle and Gandjbakhch, Frederique and Iagnocco, Annamaria and Jousse-Joulin, Sandrine and Moller, Ingrid and Naredo, Esperanza and Schmidt, Wolfgang A. and Wakefield, Richard J. and D'Agostino, Maria-Antonietta}, doi = {10.1136/annrheumdis-2018-213609}, journal-iso = {ANN RHEUM DIS}, journal = {ANNALS OF THE RHEUMATIC DISEASES}, volume = {77}, unique-id = {30569681}, issn = {0003-4967}, abstract = {Objectives To evaluate the reliability of consensus-based ultrasound (US) definitions of elementary components of enthesitis in spondyloarthritis (SpA) and psoriatic arthritis (PsA) and to evaluate which of them had the highest contribution to defining and scoring enthesitis.}, year = {2018}, eissn = {1468-2060}, pages = {1730-1735}, orcid-numbers = {Naredo, Esperanza/0000-0003-0017-0096} } @article{MTMT:30608843, title = {Scoring ultrasound synovitis in rheumatoid arthritis: a EULAR-OMERACT ultrasound taskforce-Part 1: definition and development of a standardised, consensus-based scoring system}, url = {https://m2.mtmt.hu/api/publication/30608843}, author = {D'Agostino, Maria-Antonietta and Terslev, Lene and Aegerter, Philippe and Backhaus, Marina and Bálint, Péter Vince and Bruyn, George A. and Filippucci, Emilio and Grassi, Walter and Iagnocco, Annamaria and Jousse-Joulin, Sandrine and Kane, David and Naredo, Esperanza and Schmidt, Wolfgang and Szkudlarek, Marcin and Conaghan, Philip G. and Wakefield, Richard J.}, doi = {10.1136/rmdopen-2016-000428}, journal-iso = {RMD OPEN}, journal = {RMD OPEN}, volume = {3}, unique-id = {30608843}, issn = {2056-5933}, abstract = {Objectives To develop a consensus-based ultrasound (US) definition and quantification system for synovitis in rheumatoid arthritis (RA).}, year = {2017}, eissn = {2056-5933}, orcid-numbers = {Naredo, Esperanza/0000-0003-0017-0096} } @article{MTMT:2769538, title = {Power and color Doppler settings for inflammatory flow. impact on scoring of disease activity in patients with rheumatoid arthritis}, url = {https://m2.mtmt.hu/api/publication/2769538}, author = {Torp-Pedersen, SR and Christensen, R and Szkudlarek, M and Ellegaard, K and D'Agostino, MA and Iagnocco, A and Naredo, E and Bálint, Péter Vince and Wakefield, RJ and Torp-Pedersen, A and Terslev, L}, doi = {10.1002/art.38940}, journal-iso = {ARTHRITIS RHEUMATOL}, journal = {ARTHRITIS & RHEUMATOLOGY}, volume = {67}, unique-id = {2769538}, issn = {2326-5191}, abstract = {Objectives: To determine how settings for power and color Doppler sensitivity varies on different high and intermediate range ultrasound (US) machines and to evaluate the impact of these changes on Doppler scoring of inflammatory joints Methods: Six different types of ultrasound machine were used. On each machine, the factory setting (FS) for superficial musculoskeletal scanning was used unchanged for both color and power Doppler modalities. The settings were then adjusted for increased Doppler sensitivity - study settings (SS). Eleven RA patients with wrist involvement were scanned on the 6 machines each with 4 settings generating 264 Doppler images for scoring and color quantification. Doppler sensitivity was measured with a quantitative assessment of Doppler activity - color fraction (CF) - higher CF indicated higher sensitivity. Results: Power Doppler was more sensitive on half of the machines whereas color Doppler was more sensitive on the other half with both FS and SS. There was an average increase in Doppler sensitivity despite modality of 78% when SS were applied. Over the 6 machines, 2 Doppler modalities, and 2 settings, 7 patients varied between grades 0 and 3 with the other 4 patients between grades 0 and 2. Conclusion: The effect of using different machines, Doppler modalities, and settings has a considerable influence on the quantification of inflammation in RA patients and this must be taken into account in multi-centre studies. (c) 2014 American College of Rheumatology.}, year = {2015}, eissn = {2326-5205}, pages = {386-395} }