@article{MTMT:32487457, title = {Stability Evaluation of Different Oblique Lumbar Interbody Fusion Constructs in Normal and Osteoporotic Condition – A Finite Element Based Study}, url = {https://m2.mtmt.hu/api/publication/32487457}, author = {Bereczki, Ferenc and Turbucz, Máté and Kiss, Rita and Éltes, Péter Endre and Lazáry, Áron}, doi = {10.3389/fbioe.2021.749914}, journal-iso = {FRONT BIOENG BIOTECHNOL}, journal = {FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY}, volume = {9}, unique-id = {32487457}, issn = {2296-4185}, year = {2021}, eissn = {2296-4185}, orcid-numbers = {Bereczki, Ferenc/0000-0002-7929-6259; Turbucz, Máté/0000-0003-0042-5140; Kiss, Rita/0000-0003-3607-8435; Éltes, Péter Endre/0000-0002-4377-8635} } @article{MTMT:31900458, title = {Development of a Computer-Aided Design and Finite Element Analysis Combined Method for Affordable Spine Surgical Navigation With 3D-Printed Customized Template}, url = {https://m2.mtmt.hu/api/publication/31900458}, author = {Éltes, Péter Endre and Bartos, Márton and Hajnal, Benjámin and Pokorni, Ágoston Jakab and Kiss, László and Lacroix, D. and Varga, P.P. and Lazáry, Áron}, doi = {10.3389/fsurg.2020.583386}, journal-iso = {FRONT SURG}, journal = {FRONTIERS IN SURGERY}, volume = {7}, unique-id = {31900458}, issn = {2296-875X}, abstract = {Introduction: Revision surgery of a previous lumbosacral non-union is highly challenging, especially in case of complications, such as a broken screw at the first sacral level (S1). Here, we propose the implementation of a new method based on the CT scan of a clinical case using 3D reconstruction, combined with finite element analysis (FEA), computer-assisted design (CAD), and 3D-printing technology to provide accurate surgical navigation to aid the surgeon in performing the optimal surgical technique by inserting a pedicle screw at the S1 level. Materials and Methods: A step-by-step approach was developed and performed as follows: (1) Quantitative CT based patient-specific FE model of the sacrum was created. (2) The CAD model of the pedicle screw was inserted into the sacrum model in a bicortical convergent and a monocortical divergent position, by overcoming the geometrical difficulty caused by the broken screw. (3) Static FEAs (Abaqus, Dassault Systemes) were performed using 500 N tensile load applied to the screw head. (4) A template with two screw guiding structures for the sacrum was designed and manufactured using CAD design and 3D-printing technologies, and investment casting. (5) The proposed surgical technique was performed on the patient-specific physical model created with the FDM printing technology. The patient-specific model was CT scanned and a comparison with the virtual plan was performed to evaluate the template accuracy Results: FEA results proved that the modified bicortical convergent insertion is stiffer (6,617.23 N/mm) compared to monocortical divergent placement (2,989.07 N/mm). The final template was created via investment casting from cobalt-chrome. The template design concept was shown to be accurate (grade A, Gertzbein-Robbins scale) based on the comparison of the simulated surgery using the patient-specific physical model and the 3D virtual surgical plan. Conclusion: Compared to the conventional surgical navigation techniques, the presented method allows the consideration of the patient-specific biomechanical parameters; is more affordable, and the intraoperative X-ray exposure can be reduced. This new patient- and condition-specific approach may be widely used in revision spine surgeries or in challenging primary cases after its further clinical validation. © Copyright © 2021 Eltes, Bartos, Hajnal, Pokorni, Kiss, Lacroix, Varga and Lazary.}, keywords = {NAVIGATION; computed tomography; spine surgery; Finite element simulation; 3D printing; surgical guidance/navigation}, year = {2021}, eissn = {2296-875X}, orcid-numbers = {Éltes, Péter Endre/0000-0002-4377-8635; Bartos, Márton/0000-0001-8768-1387; Hajnal, Benjámin/0000-0001-9217-6406; Pokorni, Ágoston Jakab/0000-0002-4018-118X; Kiss, László/0000-0001-8255-3052} } @article{MTMT:31036369, title = {Biomechanical assessment of vertebrae with lytic metastases with subject-specific finite element models}, url = {https://m2.mtmt.hu/api/publication/31036369}, author = {Costa, MC and Éltes, Péter Endre and Lazáry, Áron and Varga, PP and Viceconti, Marco and Dall’Ara, E}, doi = {10.1016/j.jmbbm.2019.06.027}, journal-iso = {J MECH BEHAV BIOMED}, journal = {JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS}, volume = {98}, unique-id = {31036369}, issn = {1751-6161}, year = {2019}, eissn = {1878-0180}, pages = {268-290}, orcid-numbers = {Éltes, Péter Endre/0000-0002-4377-8635} } @article{MTMT:31138120, title = {Comparison of patient-specific computational models vs. clinical follow-up, for adjacent segment disc degeneration and bone remodelling after spinal fusion}, url = {https://m2.mtmt.hu/api/publication/31138120}, author = {Rijsbergen, Marc van and van Rietbergen, Bert and Barthelemy, Veronique and Éltes, Péter Endre and Lazáry, Áron and Lacroix, Damien and Noailly, Jérôme and Ho Ba Tho, Marie-Christine and Wilson, Wouter and Ito, Keita}, doi = {10.1371/journal.pone.0200899}, journal-iso = {PLOS ONE}, journal = {PLOS ONE}, volume = {13}, unique-id = {31138120}, abstract = {Spinal fusion is a standard surgical treatment for patients suffering from low back pain attributed to disc degeneration. However, results are somewhat variable and unpredictable. With fusion the kinematic behaviour of the spine is altered. Fusion and/or stabilizing implants carrying considerable load and prevent rotation of the fused segments. Associated with these changes, a risk for accelerated disc degeneration at the adjacent levels to fusion has been demonstrated. However, there is yet no method to predict the effect of fusion surgery on the adjacent tissue levels, i.e. bone and disc. The aim of this study was to develop a coupled and patient-specific mechanoregulated model to predict disc generation and changes in bone density after spinal fusion and to validate the results relative to patient follow-up data. To do so, a multiscale disc mechanoregulation adaptation framework was developed and coupled with a previously developed bone remodelling algorithm. This made it possible to determine extra cellular matrix changes in the intervertebral disc and bone density changes simultaneously based on changes in loading due to fusion surgery. It was shown that for 10 cases the predicted change in bone density and degeneration grade conforms reasonable well to clinical follow-up data. This approach helps us to understand the effect of surgical intervention on the adjacent tissue remodelling. Thereby, providing the first insight for a spine surgeon as to which patient could potentially be treated successfully by spinal fusion and in which patient has a high risk for adjacent tissue changes.}, year = {2018}, eissn = {1932-6203}, orcid-numbers = {Éltes, Péter Endre/0000-0002-4377-8635} }