@article{MTMT:3152197,
	title = {Identifying miRNA regulatory mechanisms in preeclampsia by systems biology approaches},
	url = {https://m2.mtmt.hu/api/publication/3152197},
	author = {Biró, Orsolya and Nagy, Bálint and Rigó, János},
	doi = {10.1080/10641955.2016.1239736},
	journal-iso = {HYPERT PREGN},
	journal = {HYPERTENSION IN PREGNANCY},
	volume = {36},
	unique-id = {3152197},
	issn = {1064-1955},
	abstract = {BACKGROUND: Preeclampsia (PE) is the major cause of maternal and fetal morbidity and mortality, affecting 3-8% of all pregnancies around the globe. miRNAs are small, noncoding RNA molecules, which negatively regulate gene expression. Abnormally expressed miRNAs contribute to pregnancy complications such as PE. The aim of our study was to find possible regulatory mechanisms by system biology approaches, which are connected to the pathogenesis of PE. METHODS: We integrated publicly available miRNA and gene expression profiles and created a network from the significant miRNA-mRNA pairs with the help of MAGIA and Cytoscape softwares. Two subnetworks were expanded by adding protein-protein interactions. Differentially expressed miRNAs were identified for the evaluation of their regulatory effect. We analyzed the miRNAs and their targets using different bioinformatics tools and through literature research. RESULTS: Altogether, 52,603 miRNA-mRNA interactions were generated by the MAGIA web tool. The top 250 interactions were visualized and pairs with q < 0.0001 were analyzed, which included 85 nodes and 80 edges signalizing the connections between 52 regulated genes and 33 miRNAs. A total of 11 of the regulated genes are PE related and 9 of them were targeted by multiple miRNAs. A total of 8 miRNAs were associated with PE before, and 13 miRNAs regulated more than 1 mRNA. Hsa-mir-210 was the highest degree node in the network and its role in PE is well established. CONCLUSIONS: We identified several miRNA-mRNA regulatory mechanisms which may contribute to the pathogenesis of PE. Further investigations are needed to validate these miRNA-mRNA interactions and to enlighten the possibilities of developing potential therapeutic targets.},
	year = {2017},
	eissn = {1525-6065},
	pages = {90-99},
	orcid-numbers = {Biró, Orsolya/0000-0002-4300-3602; Nagy, Bálint/0000-0002-0295-185X; Rigó, János/0000-0003-2762-6516}
}

@article{MTMT:3087644,
	title = {Születéskori testtömeg-, testhossz- és BMI-standardok a 2000–2012. évi országos élveszületési adatok alapján, Magyarországon},
	url = {https://m2.mtmt.hu/api/publication/3087644},
	author = {Joubert, Kálmán and Zsákai, Annamária and Berkő, Péter},
	journal-iso = {DEMOGRÁFIA},
	journal = {DEMOGRÁFIA},
	volume = {58},
	unique-id = {3087644},
	issn = {0011-8249},
	year = {2015},
	eissn = {2498-6496},
	pages = {173-196},
	orcid-numbers = {Zsákai, Annamária/0000-0001-8880-2056}
}

@article{MTMT:2930099,
	title = {Biological properties of extracellular vesicles and their physiological functions},
	url = {https://m2.mtmt.hu/api/publication/2930099},
	author = {Yanez-Mo, M and Siljander, PR and Andreu, Z and Zavec, AB and Borras, FE and Buzás, Edit Irén and Buzás, Krisztina and Casal, E and Cappello, F and Carvalho, J and Colas, E and Cordeiro-da Silva, A and Fais, S and Falcon-Perez, JM and Ghobrial, IM and Giebel, B and Gimona, M and Graner, M and Gursel, I and Gursel, M and Heegaard, NH and Hendrix, A and Kierulf, P and Kokubun, K and Kosanovic, M and Kralj-Iglic, V and Kramer-Albers, EM and Laitinen, S and Lasser, C and Lener, T and Ligeti, Erzsébet and Line, A and Lipps, G and Llorente, A and Lotvall, J and Mancek-Keber, M and Marcilla, A and Mittelbrunn, M and Nazarenko, I and Nolte-'t, Hoen EN and Nyman, TA and O'Driscoll, L and Olivan, M and Oliveira, C and Pállinger, Éva and Del Portillo, HA and Reventos, J and Rigau, M and Rohde, E and Sammar, M and Sanchez-Madrid, F and Santarem, N and Schallmoser, K and Ostenfeld, MS and Stoorvogel, W and Stukelj, R and Van, der Grein SG and Vasconcelos, MH and Wauben, MH and De Wever, O},
	doi = {10.3402/jev.v4.27066},
	journal-iso = {J EXTRACELLULAR VESICL},
	journal = {JOURNAL OF EXTRACELLULAR VESICLES},
	volume = {4},
	unique-id = {2930099},
	abstract = {In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells. While intensive investigation has targeted the role of EVs in different pathological processes, for example, in cancer and autoimmune diseases, the EV-mediated maintenance of homeostasis and the regulation of physiological functions have remained less explored. Here, we provide a comprehensive overview of the current understanding of the physiological roles of EVs, which has been written by crowd-sourcing, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia. This review is intended to be of relevance to both researchers already working on EV biology and to newcomers who will encounter this universal cell biological system. Therefore, here we address the molecular contents and functions of EVs in various tissues and body fluids from cell systems to organs. We also review the physiological mechanisms of EVs in bacteria, lower eukaryotes and plants to highlight the functional uniformity of this emerging communication system.},
	year = {2015},
	eissn = {2001-3078},
	orcid-numbers = {Buzás, Edit Irén/0000-0002-3744-206X; Buzás, Krisztina/0000-0001-8933-2033; Ligeti, Erzsébet/0000-0001-6374-729X; Pállinger, Éva/0000-0002-5789-0951}
}