TY - JOUR AU - Yuste, Rafael AU - Hawrylycz, Michael AU - Aalling, Nadia AU - Aguilar-Valles, Argel AU - Arendt, Detlev AU - Arnedillo, Ruben Armananzas AU - Ascoli, Giorgio A. AU - Bielza, Concha AU - Bokharaie, Vahid AU - Bergmann, Tobias Borgtoft AU - Bystron, Irina AU - Capogna, Marco AU - Chang, Yoonjeung AU - Clemens, Ann AU - de Kock, Christiaan P. J. AU - DeFelipe, Javier AU - Dos Santos, Sandra Esmeralda AU - Dunville, Keagan AU - Feldmeyer, Dirk AU - Fiáth, Richárd AU - Fishell, Gordon James AU - Foggetti, Angelica AU - Gao, Xuefan AU - Ghaderi, Parviz AU - Goriounova, Natalia A. AU - Güntürkün, Onur AU - Hagihara, Kenta AU - Hall, Vanessa Jane AU - Helmstaedter, Moritz AU - Herculano, Suzana AU - Hilscher, Markus M. AU - Hirase, Hajime AU - Hjerling-Leffler, Jens AU - Hodge, Rebecca AU - Huang, Josh AU - Huda, Rafiq AU - Khodosevich, Konstantin AU - Kiehn, Ole AU - Koch, Henner AU - Kuebler, Eric S. AU - Kühnemund, Malte AU - Larrañaga, Pedro AU - Lelieveldt, Boudewijn AU - Louth, Emma Louise AU - Lui, Jan H. AU - Mansvelder, Huibert D. AU - Marin, Oscar AU - Martinez-Trujillo, Julio AU - Moradi Chameh, Homeira AU - Nath, Alok AU - Nedergaard, Maiken AU - Němec, Pavel AU - Ofer, Netanel AU - Pfisterer, Ulrich Gottfried AU - Pontes, Samuel AU - Redmond, William AU - Rossier, Jean AU - Sanes, Joshua R. AU - Scheuermann, Richard AU - Serrano-Saiz, Esther AU - Steiger, Jochen F. AU - Somogyi, Peter AU - Tamás, Gábor AU - Tolias, Andreas Savas AU - Tosches, Maria Antonietta AU - García, Miguel Turrero AU - Vieira, Hermany Munguba AU - Wozny, Christian AU - Wuttke, Thomas V. AU - Yong, Liu AU - Yuan, Juan AU - Zeng, Hongkui AU - Lein, Ed TI - A community-based transcriptomics classification and nomenclature of neocortical cell types JF - NATURE NEUROSCIENCE J2 - NAT NEUROSCI VL - 23 PY - 2020 SP - 1456 EP - 1468 PG - 13 SN - 1097-6256 DO - 10.1038/s41593-020-0685-8 UR - https://m2.mtmt.hu/api/publication/31409669 ID - 31409669 LA - English DB - MTMT ER - TY - JOUR AU - Kandrács, Ágnes AU - Hofer, Katharina AU - Tóth, Kinga AU - Tóth, Estilla Zsófia AU - Entz, László AU - Bagó, Attila György AU - Erőss, Loránd AU - Jordán, Zsófia AU - Nagy, Gábor AU - Fabó, Dániel AU - Ulbert, István AU - Wittner, Lucia TI - Presence of synchrony-generating hubs in the human epileptic neocortex JF - JOURNAL OF PHYSIOLOGY-LONDON J2 - J PHYSIOL-LONDON VL - 597 PY - 2019 IS - 23 SP - 5639 EP - 5670 PG - 32 SN - 0022-3751 DO - 10.1113/JP278499 UR - https://m2.mtmt.hu/api/publication/30795909 ID - 30795909 N1 - Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, Hungary National Institute of Clinical Neuroscience, Budapest, Hungary Cited By :1 Export Date: 12 March 2020 CODEN: JPHYA Correspondence Address: Wittner, L.; Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of SciencesHungary; email: wittner.lucia@ttk.mta.hu Funding details: K119443, PD121123 Funding details: European Social Fund, ESF, EFOP‐3.6.3‐VEKOP‐ 16‐2017‐00002 Funding details: Magyar Tudományos Akadémia, MTA Funding details: KTIA_NAP_13‐1‐2013‐0001, DF, KTIA_13_NAP‐A‐IV/1‐4,6, 2017‐1.2.1‐NKP‐2017‐00002, KTIA‐NAP17‐3‐2017‐0001 Funding text 1: This study was supported by the Postdoctoral fellowship of the Hungarian Academy of Sciences (to K. T.), by the Hungarian Brain Research Program, KTIA_13_NAP‐A‐IV/1‐4,6, KTIA 13 NAP‐A‐I/1 and 2017‐1.2.1‐NKP‐2017‐00002 (to IU) and KTIA_NAP_13‐1‐2013‐0001, KTIA‐NAP17‐3‐2017‐0001 (to DF), by the Hungarian National Research Fund OTKA K119443 (to LW) and PD121123 (to KT) grants, and by the European Social Fund EFOP‐3.6.3‐VEKOP‐ 16‐2017‐00002 (to ÁK). Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, Hungary National Institute of Clinical Neuroscience, Budapest, Hungary Cited By :1 Export Date: 24 April 2020 CODEN: JPHYA Correspondence Address: Wittner, L.; Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of SciencesHungary; email: wittner.lucia@ttk.mta.hu Funding details: K119443, PD121123 Funding details: European Social Fund, ESF, EFOP‐3.6.3‐VEKOP‐ 16‐2017‐00002 Funding details: Magyar Tudományos Akadémia, MTA Funding details: KTIA_NAP_13‐1‐2013‐0001, DF, KTIA_13_NAP‐A‐IV/1‐4,6, 2017‐1.2.1‐NKP‐2017‐00002, KTIA‐NAP17‐3‐2017‐0001 Funding text 1: This study was supported by the Postdoctoral fellowship of the Hungarian Academy of Sciences (to K. T.), by the Hungarian Brain Research Program, KTIA_13_NAP‐A‐IV/1‐4,6, KTIA 13 NAP‐A‐I/1 and 2017‐1.2.1‐NKP‐2017‐00002 (to IU) and KTIA_NAP_13‐1‐2013‐0001, KTIA‐NAP17‐3‐2017‐0001 (to DF), by the Hungarian National Research Fund OTKA K119443 (to LW) and PD121123 (to KT) grants, and by the European Social Fund EFOP‐3.6.3‐VEKOP‐ 16‐2017‐00002 (to ÁK). Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, Hungary National Institute of Clinical Neuroscience, Budapest, Hungary Cited By :1 Export Date: 25 May 2020 CODEN: JPHYA Correspondence Address: Wittner, L.; Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of SciencesHungary; email: wittner.lucia@ttk.mta.hu Funding details: K119443, PD121123 Funding details: European Social Fund, ESF, EFOP‐3.6.3‐VEKOP‐ 16‐2017‐00002 Funding details: Magyar Tudományos Akadémia, MTA Funding details: KTIA_NAP_13‐1‐2013‐0001, DF, KTIA_13_NAP‐A‐IV/1‐4,6, 2017‐1.2.1‐NKP‐2017‐00002, KTIA‐NAP17‐3‐2017‐0001 Funding text 1: This study was supported by the Postdoctoral fellowship of the Hungarian Academy of Sciences (to K. T.), by the Hungarian Brain Research Program, KTIA_13_NAP‐A‐IV/1‐4,6, KTIA 13 NAP‐A‐I/1 and 2017‐1.2.1‐NKP‐2017‐00002 (to IU) and KTIA_NAP_13‐1‐2013‐0001, KTIA‐NAP17‐3‐2017‐0001 (to DF), by the Hungarian National Research Fund OTKA K119443 (to LW) and PD121123 (to KT) grants, and by the European Social Fund EFOP‐3.6.3‐VEKOP‐ 16‐2017‐00002 (to ÁK). Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, Hungary National Institute of Clinical Neuroscience, Budapest, Hungary Cited By :1 Export Date: 28 May 2020 CODEN: JPHYA Correspondence Address: Wittner, L.; Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of SciencesHungary; email: wittner.lucia@ttk.mta.hu Funding details: K119443, PD121123 Funding details: European Social Fund, ESF, EFOP‐3.6.3‐VEKOP‐ 16‐2017‐00002 Funding details: Magyar Tudományos Akadémia, MTA Funding details: KTIA_NAP_13‐1‐2013‐0001, DF, KTIA_13_NAP‐A‐IV/1‐4,6, 2017‐1.2.1‐NKP‐2017‐00002, KTIA‐NAP17‐3‐2017‐0001 Funding text 1: This study was supported by the Postdoctoral fellowship of the Hungarian Academy of Sciences (to K. T.), by the Hungarian Brain Research Program, KTIA_13_NAP‐A‐IV/1‐4,6, KTIA 13 NAP‐A‐I/1 and 2017‐1.2.1‐NKP‐2017‐00002 (to IU) and KTIA_NAP_13‐1‐2013‐0001, KTIA‐NAP17‐3‐2017‐0001 (to DF), by the Hungarian National Research Fund OTKA K119443 (to LW) and PD121123 (to KT) grants, and by the European Social Fund EFOP‐3.6.3‐VEKOP‐ 16‐2017‐00002 (to ÁK). LA - English DB - MTMT ER - TY - JOUR AU - Boldog, Eszter AU - Bakken, TE AU - Hodge, RD AU - Novotny, M AU - Aevermann, BD AU - Baka, Judith AU - Bordé, Sándor AU - Close, JL AU - Diez-Fuertes, F AU - Ding, SL AU - Faragó, Nóra AU - Kocsis, Ágnes Katalin AU - Kovács, Balázs AU - Maltzer, Z AU - McCorrison, JM AU - Miller, JA AU - Molnár, Gábor AU - Oláh, Gáspár AU - Ozsvár, Attila AU - Rózsa, Márton AU - Shehata, SI AU - Smith, KA AU - Sunkin, SM AU - Tran, DN AU - Venepally, P AU - Wall, A AU - Puskás, László AU - Barzó, Pál AU - Steemers, FJ AU - Schork, NJ AU - Scheuermann, RH AU - Lasken, RS AU - Lein, ES AU - Tamás, Gábor TI - Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type JF - NATURE NEUROSCIENCE J2 - NAT NEUROSCI VL - 21 PY - 2018 IS - 9 SP - 1185 EP - 1195 PG - 11 SN - 1097-6256 DO - 10.1038/s41593-018-0205-2 UR - https://m2.mtmt.hu/api/publication/3408147 ID - 3408147 N1 - MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of Szeged, Szeged, Hungary Allen Institute for Brain Science, Seattle, WA, United States J. Craig Venter Institute, La Jolla, CA, United States Department of Neurosurgery, University of Szeged, Szeged, Hungary Laboratory of Functional Genomics, Department of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary Illumina, Inc., San Diego, CA, United States Department of Pathology, University of California, San Diego, CA, United States Cited By :20 Export Date: 30 July 2019 CODEN: NANEF Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of SzegedHungary; email: gtamas@bio.u-szeged.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; glutamate decarboxylase, 9024-58-2; parvalbumin, 56094-12-3, 83667-75-8; somatostatin, 38916-34-6, 51110-01-1; RNA, 63231-63-0; RNA Funding details: GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155 Funding details: National Institute of Mental Health Funding text 1: The authors thank the Allen Institute for Brain Science founders, Paul G. Allen and Jody Allen, for their vision, encouragement, and support. The authors thank L. Christiansen and F. Zhang from Illumina, Inc. for their assistance with RNA sequencing. This work was supported by the ERC Interimpact project (G.T.), the National Institute of Mental Health (USA) RFA MH 17 210 (E.S.L., G.T.), the Hungarian Academy of Sciences (G.T.), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), and by the National Brain Research Program, Hungary (G.T.). MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of Szeged, Szeged, Hungary Allen Institute for Brain Science, Seattle, WA, United States J. Craig Venter Institute, La Jolla, CA, United States Department of Neurosurgery, University of Szeged, Szeged, Hungary Laboratory of Functional Genomics, Department of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary Illumina, Inc., San Diego, CA, United States Department of Pathology, University of California, San Diego, CA, United States Cited By :20 Export Date: 1 August 2019 CODEN: NANEF Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of SzegedHungary; email: gtamas@bio.u-szeged.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; glutamate decarboxylase, 9024-58-2; parvalbumin, 56094-12-3, 83667-75-8; somatostatin, 38916-34-6, 51110-01-1; RNA, 63231-63-0; RNA Funding details: GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155 Funding details: National Institute of Mental Health Funding text 1: The authors thank the Allen Institute for Brain Science founders, Paul G. Allen and Jody Allen, for their vision, encouragement, and support. The authors thank L. Christiansen and F. Zhang from Illumina, Inc. for their assistance with RNA sequencing. This work was supported by the ERC Interimpact project (G.T.), the National Institute of Mental Health (USA) RFA MH 17 210 (E.S.L., G.T.), the Hungarian Academy of Sciences (G.T.), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), and by the National Brain Research Program, Hungary (G.T.). MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of Szeged, Szeged, Hungary Allen Institute for Brain Science, Seattle, WA, United States J. Craig Venter Institute, La Jolla, CA, United States Department of Neurosurgery, University of Szeged, Szeged, Hungary Laboratory of Functional Genomics, Department of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary Illumina, Inc., San Diego, CA, United States Department of Pathology, University of California, San Diego, CA, United States Cited By :21 Export Date: 17 August 2019 CODEN: NANEF Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of SzegedHungary; email: gtamas@bio.u-szeged.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; glutamate decarboxylase, 9024-58-2; parvalbumin, 56094-12-3, 83667-75-8; somatostatin, 38916-34-6, 51110-01-1; RNA, 63231-63-0; RNA Funding details: GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155 Funding details: National Institute of Mental Health Funding text 1: The authors thank the Allen Institute for Brain Science founders, Paul G. Allen and Jody Allen, for their vision, encouragement, and support. The authors thank L. Christiansen and F. Zhang from Illumina, Inc. for their assistance with RNA sequencing. This work was supported by the ERC Interimpact project (G.T.), the National Institute of Mental Health (USA) RFA MH 17 210 (E.S.L., G.T.), the Hungarian Academy of Sciences (G.T.), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), and by the National Brain Research Program, Hungary (G.T.). MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of Szeged, Szeged, Hungary Allen Institute for Brain Science, Seattle, WA, United States J. Craig Venter Institute, La Jolla, CA, United States Department of Neurosurgery, University of Szeged, Szeged, Hungary Laboratory of Functional Genomics, Department of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary Illumina, Inc., San Diego, CA, United States Department of Pathology, University of California, San Diego, CA, United States Cited By :22 Export Date: 24 August 2019 CODEN: NANEF Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of SzegedHungary; email: gtamas@bio.u-szeged.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; glutamate decarboxylase, 9024-58-2; parvalbumin, 56094-12-3, 83667-75-8; somatostatin, 38916-34-6, 51110-01-1; RNA, 63231-63-0; RNA Funding details: GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155 Funding details: National Institute of Mental Health Funding text 1: The authors thank the Allen Institute for Brain Science founders, Paul G. Allen and Jody Allen, for their vision, encouragement, and support. The authors thank L. Christiansen and F. Zhang from Illumina, Inc. for their assistance with RNA sequencing. This work was supported by the ERC Interimpact project (G.T.), the National Institute of Mental Health (USA) RFA MH 17 210 (E.S.L., G.T.), the Hungarian Academy of Sciences (G.T.), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), and by the National Brain Research Program, Hungary (G.T.). MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of Szeged, Szeged, Hungary Allen Institute for Brain Science, Seattle, WA, United States J. Craig Venter Institute, La Jolla, CA, United States Department of Neurosurgery, University of Szeged, Szeged, Hungary Laboratory of Functional Genomics, Department of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary Illumina, Inc., San Diego, CA, United States Department of Pathology, University of California, San Diego, CA, United States Cited By :22 Export Date: 28 August 2019 CODEN: NANEF Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of SzegedHungary; email: gtamas@bio.u-szeged.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; glutamate decarboxylase, 9024-58-2; parvalbumin, 56094-12-3, 83667-75-8; somatostatin, 38916-34-6, 51110-01-1; RNA, 63231-63-0; RNA Funding details: GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155 Funding details: National Institute of Mental Health Funding text 1: The authors thank the Allen Institute for Brain Science founders, Paul G. Allen and Jody Allen, for their vision, encouragement, and support. The authors thank L. Christiansen and F. Zhang from Illumina, Inc. for their assistance with RNA sequencing. This work was supported by the ERC Interimpact project (G.T.), the National Institute of Mental Health (USA) RFA MH 17 210 (E.S.L., G.T.), the Hungarian Academy of Sciences (G.T.), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), and by the National Brain Research Program, Hungary (G.T.). MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of Szeged, Szeged, Hungary Allen Institute for Brain Science, Seattle, WA, United States J. Craig Venter Institute, La Jolla, CA, United States Department of Neurosurgery, University of Szeged, Szeged, Hungary Laboratory of Functional Genomics, Department of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary Illumina, Inc., San Diego, CA, United States Department of Pathology, University of California, San Diego, CA, United States Cited By :36 Export Date: 12 March 2020 CODEN: NANEF Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of SzegedHungary; email: gtamas@bio.u-szeged.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; glutamate decarboxylase, 9024-58-2; parvalbumin, 56094-12-3, 83667-75-8; somatostatin, 38916-34-6, 51110-01-1; RNA, 63231-63-0; RNA Funding details: GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155 Funding details: National Institute of Mental Health, NIMH Funding details: European Research Council, ERC Funding details: Magyar Tudományos Akadémia, MTA Funding text 1: The authors thank the Allen Institute for Brain Science founders, Paul G. Allen and Jody Allen, for their vision, encouragement, and support. The authors thank L. Christiansen and F. Zhang from Illumina, Inc. for their assistance with RNA sequencing. This work was supported by the ERC Interimpact project (G.T.), the National Institute of Mental Health (USA) RFA MH 17 210 (E.S.L., G.T.), the Hungarian Academy of Sciences (G.T.), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), and by the National Brain Research Program, Hungary (G.T.). MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of Szeged, Szeged, Hungary Allen Institute for Brain Science, Seattle, WA, United States J. Craig Venter Institute, La Jolla, CA, United States Department of Neurosurgery, University of Szeged, Szeged, Hungary Laboratory of Functional Genomics, Department of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary Illumina, Inc., San Diego, CA, United States Department of Pathology, University of California, San Diego, CA, United States Cited By :39 Export Date: 15 April 2020 CODEN: NANEF Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of SzegedHungary; email: gtamas@bio.u-szeged.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; glutamate decarboxylase, 9024-58-2; parvalbumin, 56094-12-3, 83667-75-8; somatostatin, 38916-34-6, 51110-01-1; RNA, 63231-63-0; RNA Funding details: GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155 Funding details: National Institute of Mental Health, NIMH Funding details: European Research Council, ERC Funding details: Magyar Tudományos Akadémia, MTA Funding text 1: The authors thank the Allen Institute for Brain Science founders, Paul G. Allen and Jody Allen, for their vision, encouragement, and support. The authors thank L. Christiansen and F. Zhang from Illumina, Inc. for their assistance with RNA sequencing. This work was supported by the ERC Interimpact project (G.T.), the National Institute of Mental Health (USA) RFA MH 17 210 (E.S.L., G.T.), the Hungarian Academy of Sciences (G.T.), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), and by the National Brain Research Program, Hungary (G.T.). MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of Szeged, Szeged, Hungary Allen Institute for Brain Science, Seattle, WA, United States J. Craig Venter Institute, La Jolla, CA, United States Department of Neurosurgery, University of Szeged, Szeged, Hungary Laboratory of Functional Genomics, Department of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary Illumina, Inc., San Diego, CA, United States Department of Pathology, University of California, San Diego, CA, United States Cited By :39 Export Date: 24 April 2020 CODEN: NANEF Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of SzegedHungary; email: gtamas@bio.u-szeged.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; glutamate decarboxylase, 9024-58-2; parvalbumin, 56094-12-3, 83667-75-8; somatostatin, 38916-34-6, 51110-01-1; RNA, 63231-63-0; RNA Funding details: GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155 Funding details: National Institute of Mental Health, NIMH Funding details: European Research Council, ERC Funding details: Magyar Tudományos Akadémia, MTA Funding text 1: The authors thank the Allen Institute for Brain Science founders, Paul G. Allen and Jody Allen, for their vision, encouragement, and support. The authors thank L. Christiansen and F. Zhang from Illumina, Inc. for their assistance with RNA sequencing. This work was supported by the ERC Interimpact project (G.T.), the National Institute of Mental Health (USA) RFA MH 17 210 (E.S.L., G.T.), the Hungarian Academy of Sciences (G.T.), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), and by the National Brain Research Program, Hungary (G.T.). MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of Szeged, Szeged, Hungary Allen Institute for Brain Science, Seattle, WA, United States J. Craig Venter Institute, La Jolla, CA, United States Department of Neurosurgery, University of Szeged, Szeged, Hungary Laboratory of Functional Genomics, Department of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary Illumina, Inc., San Diego, CA, United States Department of Pathology, University of California, San Diego, CA, United States Cited By :40 Export Date: 18 May 2020 CODEN: NANEF Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of SzegedHungary; email: gtamas@bio.u-szeged.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; glutamate decarboxylase, 9024-58-2; parvalbumin, 56094-12-3, 83667-75-8; somatostatin, 38916-34-6, 51110-01-1; RNA, 63231-63-0; RNA Funding details: GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155 Funding details: National Institute of Mental Health, NIMH Funding details: European Research Council, ERC Funding details: Magyar Tudományos Akadémia, MTA Funding text 1: The authors thank the Allen Institute for Brain Science founders, Paul G. Allen and Jody Allen, for their vision, encouragement, and support. The authors thank L. Christiansen and F. Zhang from Illumina, Inc. for their assistance with RNA sequencing. This work was supported by the ERC Interimpact project (G.T.), the National Institute of Mental Health (USA) RFA MH 17 210 (E.S.L., G.T.), the Hungarian Academy of Sciences (G.T.), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), and by the National Brain Research Program, Hungary (G.T.). MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of Szeged, Szeged, Hungary Allen Institute for Brain Science, Seattle, WA, United States J. Craig Venter Institute, La Jolla, CA, United States Department of Neurosurgery, University of Szeged, Szeged, Hungary Laboratory of Functional Genomics, Department of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary Illumina, Inc., San Diego, CA, United States Department of Pathology, University of California, San Diego, CA, United States Cited By :41 Export Date: 20 May 2020 CODEN: NANEF Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of SzegedHungary; email: gtamas@bio.u-szeged.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; glutamate decarboxylase, 9024-58-2; parvalbumin, 56094-12-3, 83667-75-8; somatostatin, 38916-34-6, 51110-01-1; RNA, 63231-63-0; RNA Funding details: GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155 Funding details: National Institute of Mental Health, NIMH Funding details: European Research Council, ERC Funding details: Magyar Tudományos Akadémia, MTA Funding text 1: The authors thank the Allen Institute for Brain Science founders, Paul G. Allen and Jody Allen, for their vision, encouragement, and support. The authors thank L. Christiansen and F. Zhang from Illumina, Inc. for their assistance with RNA sequencing. This work was supported by the ERC Interimpact project (G.T.), the National Institute of Mental Health (USA) RFA MH 17 210 (E.S.L., G.T.), the Hungarian Academy of Sciences (G.T.), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), and by the National Brain Research Program, Hungary (G.T.). MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of Szeged, Szeged, Hungary Allen Institute for Brain Science, Seattle, WA, United States J. Craig Venter Institute, La Jolla, CA, United States Department of Neurosurgery, University of Szeged, Szeged, Hungary Laboratory of Functional Genomics, Department of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary Illumina, Inc., San Diego, CA, United States Department of Pathology, University of California, San Diego, CA, United States Cited By :41 Export Date: 26 May 2020 CODEN: NANEF Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of SzegedHungary; email: gtamas@bio.u-szeged.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; glutamate decarboxylase, 9024-58-2; parvalbumin, 56094-12-3, 83667-75-8; somatostatin, 38916-34-6, 51110-01-1; RNA, 63231-63-0; RNA Funding details: GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155 Funding details: National Institute of Mental Health, NIMH Funding details: European Research Council, ERC Funding details: Magyar Tudományos Akadémia, MTA Funding text 1: The authors thank the Allen Institute for Brain Science founders, Paul G. Allen and Jody Allen, for their vision, encouragement, and support. The authors thank L. Christiansen and F. Zhang from Illumina, Inc. for their assistance with RNA sequencing. This work was supported by the ERC Interimpact project (G.T.), the National Institute of Mental Health (USA) RFA MH 17 210 (E.S.L., G.T.), the Hungarian Academy of Sciences (G.T.), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), and by the National Brain Research Program, Hungary (G.T.). MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of Szeged, Szeged, Hungary Allen Institute for Brain Science, Seattle, WA, United States J. Craig Venter Institute, La Jolla, CA, United States Department of Neurosurgery, University of Szeged, Szeged, Hungary Laboratory of Functional Genomics, Department of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary Illumina, Inc., San Diego, CA, United States Department of Pathology, University of California, San Diego, CA, United States Cited By :60 Export Date: 28 December 2020 CODEN: NANEF Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of SzegedHungary; email: gtamas@bio.u-szeged.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; glutamate decarboxylase, 9024-58-2; parvalbumin, 56094-12-3, 83667-75-8; somatostatin, 38916-34-6, 51110-01-1; RNA, 63231-63-0; RNA Funding details: National Research, Development and Innovation Office, GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155 Funding details: National Institute of Mental Health, NIMH Funding details: European Research Council, ERC Funding details: Magyar Tudományos Akadémia, MTA Funding text 1: The authors thank the Allen Institute for Brain Science founders, Paul G. Allen and Jody Allen, for their vision, encouragement, and support. The authors thank L. Christiansen and F. Zhang from Illumina, Inc. for their assistance with RNA sequencing. This work was supported by the ERC Interimpact project (G.T.), the National Institute of Mental Health (USA) RFA MH 17 210 (E.S.L., G.T.), the Hungarian Academy of Sciences (G.T.), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), and by the National Brain Research Program, Hungary (G.T.). MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of Szeged, Szeged, Hungary Allen Institute for Brain Science, Seattle, WA, United States J. Craig Venter Institute, La Jolla, CA, United States Department of Neurosurgery, University of Szeged, Szeged, Hungary Laboratory of Functional Genomics, Department of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary Illumina, Inc., San Diego, CA, United States Department of Pathology, University of California, San Diego, CA, United States Cited By :68 Export Date: 18 March 2021 CODEN: NANEF Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits, Hungary; email: gtamas@bio.u-szeged.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; glutamate decarboxylase, 9024-58-2; parvalbumin, 56094-12-3, 83667-75-8; somatostatin, 38916-34-6, 51110-01-1; RNA, 63231-63-0; RNA Funding details: National Institute of Mental Health, NIMH Funding details: European Research Council, ERC Funding details: Magyar Tudományos Akadémia, MTA Funding details: National Research, Development and Innovation Office, GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155 Funding text 1: The authors thank the Allen Institute for Brain Science founders, Paul G. Allen and Jody Allen, for their vision, encouragement, and support. The authors thank L. Christiansen and F. Zhang from Illumina, Inc. for their assistance with RNA sequencing. This work was supported by the ERC Interimpact project (G.T.), the National Institute of Mental Health (USA) RFA MH 17 210 (E.S.L., G.T.), the Hungarian Academy of Sciences (G.T.), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), and by the National Brain Research Program, Hungary (G.T.). MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of Szeged, Szeged, Hungary Allen Institute for Brain Science, Seattle, WA, United States J. Craig Venter Institute, La Jolla, CA, United States Department of Neurosurgery, University of Szeged, Szeged, Hungary Laboratory of Functional Genomics, Department of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary Illumina, Inc., San Diego, CA, United States Department of Pathology, University of California, San Diego, CA, United States Cited By :69 Export Date: 19 March 2021 CODEN: NANEF Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits, Hungary; email: gtamas@bio.u-szeged.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; glutamate decarboxylase, 9024-58-2; parvalbumin, 56094-12-3, 83667-75-8; somatostatin, 38916-34-6, 51110-01-1; RNA, 63231-63-0; RNA Funding details: National Institute of Mental Health, NIMH Funding details: European Research Council, ERC Funding details: Magyar Tudományos Akadémia, MTA Funding details: National Research, Development and Innovation Office, GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155 Funding text 1: The authors thank the Allen Institute for Brain Science founders, Paul G. Allen and Jody Allen, for their vision, encouragement, and support. The authors thank L. Christiansen and F. Zhang from Illumina, Inc. for their assistance with RNA sequencing. This work was supported by the ERC Interimpact project (G.T.), the National Institute of Mental Health (USA) RFA MH 17 210 (E.S.L., G.T.), the Hungarian Academy of Sciences (G.T.), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), and by the National Brain Research Program, Hungary (G.T.). MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of Szeged, Szeged, Hungary Allen Institute for Brain Science, Seattle, WA, United States J. Craig Venter Institute, La Jolla, CA, United States Department of Neurosurgery, University of Szeged, Szeged, Hungary Laboratory of Functional Genomics, Department of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary Illumina, Inc., San Diego, CA, United States Department of Pathology, University of California, San Diego, CA, United States Cited By :69 Export Date: 24 March 2021 CODEN: NANEF Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits, Hungary; email: gtamas@bio.u-szeged.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; glutamate decarboxylase, 9024-58-2; parvalbumin, 56094-12-3, 83667-75-8; somatostatin, 38916-34-6, 51110-01-1; RNA, 63231-63-0; RNA Funding details: National Institute of Mental Health, NIMH Funding details: European Research Council, ERC Funding details: Magyar Tudományos Akadémia, MTA Funding details: National Research, Development and Innovation Office, GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155 Funding text 1: The authors thank the Allen Institute for Brain Science founders, Paul G. Allen and Jody Allen, for their vision, encouragement, and support. The authors thank L. Christiansen and F. Zhang from Illumina, Inc. for their assistance with RNA sequencing. This work was supported by the ERC Interimpact project (G.T.), the National Institute of Mental Health (USA) RFA MH 17 210 (E.S.L., G.T.), the Hungarian Academy of Sciences (G.T.), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), and by the National Brain Research Program, Hungary (G.T.). MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of Szeged, Szeged, Hungary Allen Institute for Brain Science, Seattle, WA, United States J. Craig Venter Institute, La Jolla, CA, United States Department of Neurosurgery, University of Szeged, Szeged, Hungary Laboratory of Functional Genomics, Department of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary Illumina, Inc., San Diego, CA, United States Department of Pathology, University of California, San Diego, CA, United States Cited By :69 Export Date: 31 March 2021 CODEN: NANEF Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits, Hungary; email: gtamas@bio.u-szeged.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; glutamate decarboxylase, 9024-58-2; parvalbumin, 56094-12-3, 83667-75-8; somatostatin, 38916-34-6, 51110-01-1; RNA, 63231-63-0; RNA Funding details: National Institute of Mental Health, NIMH Funding details: European Research Council, ERC Funding details: Magyar Tudományos Akadémia, MTA Funding details: National Research, Development and Innovation Office, GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155 Funding text 1: The authors thank the Allen Institute for Brain Science founders, Paul G. Allen and Jody Allen, for their vision, encouragement, and support. The authors thank L. Christiansen and F. Zhang from Illumina, Inc. for their assistance with RNA sequencing. This work was supported by the ERC Interimpact project (G.T.), the National Institute of Mental Health (USA) RFA MH 17 210 (E.S.L., G.T.), the Hungarian Academy of Sciences (G.T.), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), and by the National Brain Research Program, Hungary (G.T.). MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of Szeged, Szeged, Hungary Allen Institute for Brain Science, Seattle, WA, United States J. Craig Venter Institute, La Jolla, CA, United States Department of Neurosurgery, University of Szeged, Szeged, Hungary Laboratory of Functional Genomics, Department of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary Illumina, Inc., San Diego, CA, United States Department of Pathology, University of California, San Diego, CA, United States Cited By :69 Export Date: 6 April 2021 CODEN: NANEF Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits, Hungary; email: gtamas@bio.u-szeged.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; glutamate decarboxylase, 9024-58-2; parvalbumin, 56094-12-3, 83667-75-8; somatostatin, 38916-34-6, 51110-01-1; RNA, 63231-63-0; RNA Funding details: National Institute of Mental Health, NIMH Funding details: European Research Council, ERC Funding details: Magyar Tudományos Akadémia, MTA Funding details: National Research, Development and Innovation Office, GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155 Funding text 1: The authors thank the Allen Institute for Brain Science founders, Paul G. Allen and Jody Allen, for their vision, encouragement, and support. The authors thank L. Christiansen and F. Zhang from Illumina, Inc. for their assistance with RNA sequencing. This work was supported by the ERC Interimpact project (G.T.), the National Institute of Mental Health (USA) RFA MH 17 210 (E.S.L., G.T.), the Hungarian Academy of Sciences (G.T.), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), and by the National Brain Research Program, Hungary (G.T.). MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of Szeged, Szeged, Hungary Allen Institute for Brain Science, Seattle, WA, United States J. Craig Venter Institute, La Jolla, CA, United States Department of Neurosurgery, University of Szeged, Szeged, Hungary Laboratory of Functional Genomics, Department of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary Illumina, Inc., San Diego, CA, United States Department of Pathology, University of California, San Diego, CA, United States Cited By :69 Export Date: 7 April 2021 CODEN: NANEF Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits, Hungary; email: gtamas@bio.u-szeged.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; glutamate decarboxylase, 9024-58-2; parvalbumin, 56094-12-3, 83667-75-8; somatostatin, 38916-34-6, 51110-01-1; RNA, 63231-63-0; RNA Funding details: National Institute of Mental Health, NIMH Funding details: European Research Council, ERC Funding details: Magyar Tudományos Akadémia, MTA Funding details: National Research, Development and Innovation Office, GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155 Funding text 1: The authors thank the Allen Institute for Brain Science founders, Paul G. Allen and Jody Allen, for their vision, encouragement, and support. The authors thank L. Christiansen and F. Zhang from Illumina, Inc. for their assistance with RNA sequencing. This work was supported by the ERC Interimpact project (G.T.), the National Institute of Mental Health (USA) RFA MH 17 210 (E.S.L., G.T.), the Hungarian Academy of Sciences (G.T.), the National Research, Development and Innovation Office of Hungary (GINOP-2.3.2-15-2016-00018, VKSZ-14-1-2015-0155), and by the National Brain Research Program, Hungary (G.T.). MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of Szeged, Szeged, Hungary Allen Institute for Brain Science, Seattle, WA, United States J. Craig Ven AB - We describe convergent evidence from transcriptomics, morphology, and physiology for a specialized GABAergic neuron subtype in human cortex. Using unbiased single-nucleus RNA sequencing, we identify ten GABAergic interneuron subtypes with combinatorial gene signatures in human cortical layer 1 and characterize a group of human interneurons with anatomical features never described in rodents, having large 'rosehip'-like axonal boutons and compact arborization. These rosehip cells show an immunohistochemical profile (GAD1(+)CCK(+), CNR1(-)SST(-)CALB2(-)PVALB(-)) matching a single transcriptomically defined cell type whose specific molecular marker signature is not seen in mouse cortex. Rosehip cells in layer 1 make homotypic gap junctions, predominantly target apical dendritic shafts of layer 3 pyramidal neurons, and inhibit backpropagating pyramidal action potentials in microdomains of the dendritic tuft. These cells are therefore positioned for potent local control of distal dendritic computation in cortical pyramidal neurons. LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Kinga AU - Hofer, Katharina AU - Kandrács, Ágnes AU - Entz, László AU - Bagó, Attila György AU - Erőss, Loránd AU - Jordán, Zsófia AU - Nagy, Gábor AU - Solyom, A AU - Fabó, Dániel AU - Ulbert, István AU - Wittner, Lucia TI - Hyperexcitability of the network contributes to synchronization processes in the human epileptic neocortex. JF - JOURNAL OF PHYSIOLOGY-LONDON J2 - J PHYSIOL-LONDON VL - 596 PY - 2018 IS - 2 SP - 317 EP - 342 PG - 26 SN - 0022-3751 DO - 10.1113/JP275413 UR - https://m2.mtmt.hu/api/publication/3298716 ID - 3298716 N1 - Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, 1117, Hungary Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, 1083, Hungary Department of Information Technology, Pázmány Péter Catholic University, Budapest, 1083, Hungary National Institute of Clinical Neuroscience, Budapest, 1145, Hungary Cited By :22 Export Date: 9 February 2024 CODEN: JPHYA Correspondence Address: Wittner, L.; Institute of Cognitive Neuroscience and Psychology, Hungary; email: wittner.lucia@ttk.mta.hu Funding details: KTIA 13 NAP-A-I/1, KTIA 13 NAP-A-IV/1-4,6, KTIA NAP 13-1-2013-0001 Funding details: Hungarian Scientific Research Fund, OTKA, K119443, PD121123 Funding details: Magyar Tudományos Akadémia, MTA Funding details: Nemzeti Kutatási és Technológiai Hivatal, NKTH, KTIA_13_NAP-A-IV/1-4 Funding details: Seventh Framework Programme, FP7, 600925 Funding text 1: This study was supported by a Postdoctoral Fellowship of the Hungarian Academy of Sciences (to K.T.); by the Hungarian Brain Research Program – Grants No. KTIA 13 NAP-A-IV/1-4,6 and KTIA 13 NAP-A-I/1 (to I.U.) and KTIA NAP 13-1-2013-0001 (to D.F.); by the EU FP7 Grant No. 600925 NeuroSeeker; and by Hungarian National Research Fund grants OTKA K119443 (to L.W.) and PD121123 (to K.T.). AB - Interictal activity is a hallmark in epilepsy diagnostics and is linked to neuronal hypersynchrony. Little is known about perturbations in human epileptic neocortical microcircuits, and their role in generating pathological synchronies. To explore hyperexcitability of the human epileptic network, and its contribution to convulsive activity, we investigated an in vitro model of synchronous burst activity spontaneously occurring in postoperative tissue slices derived from patients with or without preoperative clinical and electrographic manifestations of epileptic activity. Human neocortical slices generated two types of synchronies. Interictal-like discharges (classified as epileptiform events) emerged only in epileptic samples, and were hypersynchronous bursts characterized by considerably elevated levels of excitation. Synchronous population activity was initiated both in epileptic and non-epileptic tissue, with a significantly lower degree of excitability and synchrony, and could not be linked to epilepsy. However, in pharmacoresistant epileptic tissue, higher percentage of slices exhibited population activity, with higher local field potential gradient amplitudes. More intracellularly recorded neurons received depolarizing synaptic potentials, discharging more reliably during the events. Light and electron microscopic examinations showed slightly lower neuron densities, and higher densities of excitatory synapses in the human epileptic neocortex. Our data suggest that human neocortical microcircuits retain their functionality and plasticity in vitro, and can generate two significantly different synchronies. We propose that population bursts might not be pathological events while interictal-like discharges may reflect the epileptogenicity of the human cortex. Our results show that hyperexcitability characterizes the human epileptic neocortical network, and that it is closely related to the emergence of synchronies. This article is protected by copyright. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Wittner, Lucia AU - Maglóczky, Zsófia TI - Synaptic Reorganization of the Perisomatic Inhibitory Network in Hippocampi of Temporal Lobe Epileptic Patients JF - BIOMED RESEARCH INTERNATIONAL J2 - BIOMED RES INT VL - 2017 PY - 2017 PG - 13 SN - 2314-6133 DO - 10.1155/2017/7154295 UR - https://m2.mtmt.hu/api/publication/3167675 ID - 3167675 N1 - N1 Funding details: K119443, OTKA, Országos Tudományos Kutatási Alapprogramok N1 Funding details: NN 102802, OTKA, Országos Tudományos Kutatási Alapprogramok N1 Funding text: Acknowledgments The excellent technical assistance of Mrs. Katalin Lengyel, Mr. Gyózó Goda, andMrs. Szépné Emóke Simon is acknowledged. This study was supported by the OTKA, Hungary (NN 102802 and K119443), and theHungarian Brain Research Program Grant KTIA-13-NAP-A-IV/1-4,6. Cited By :6 Export Date: 7 September 2021 Correspondence Address: Maglóczky, Z.; Institute of Experimental Medicine, Hungary; email: magloczky.zsofia@koki.mta.hu Chemicals/CAS: carisoprodol, 78-44-4; cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8; Cholecystokinin; CNR1 protein, human; Parvalbumins; Receptor, Cannabinoid, CB1; Receptors, GABA Funding details: Hungarian Scientific Research Fund, OTKA, K119443, KTIA-13-NAP-A-IV/1-4,6, NN 102802 Funding text 1: Acknowledgments The excellent technical assistance of Mrs. Katalin Lengyel, Mr. Gy?z? Goda, andMrs. Sz?pn? Em?ke Simon is acknowledged. This study was supported by the OTKA, Hungary (NN 102802 and K119443), and theHungarian Brain Research Program Grant KTIA-13-NAP-A-IV/1-4,6. LA - English DB - MTMT ER - TY - JOUR AU - Kohus, Zsolt AU - Káli, Szabolcs AU - Rovira Esteban, Laura AU - Schlingloff, Dániel AU - Papp, Orsolya AU - Freund, Tamás AU - Hájos, Norbert AU - Gulyás, Attila TI - Properties and dynamics of inhibitory synaptic communication within the CA3 microcircuits of pyramidal cells and interneurons expressing parvalbumin or cholecystokinin JF - JOURNAL OF PHYSIOLOGY-LONDON J2 - J PHYSIOL-LONDON VL - 594 PY - 2016 IS - 13 SP - 3745 EP - 3774 PG - 30 SN - 0022-3751 DO - 10.1113/JP272231 UR - https://m2.mtmt.hu/api/publication/3078169 ID - 3078169 N1 - Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary János Szentágothai, PhD Program of Semmelweis University, Budapest, Hungary Péter Pázmány Catholic University, Faculty of Information Technology, Budapest, Hungary Cited By :31 Export Date: 19 May 2022 CODEN: JPHYA Correspondence Address: Gulyás, A.I.; Institute of Experimental Medicine, Hungary; email: gulyas@koki.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8 Funding details: Horizon 2020 Framework Programme, H2020, 720270 AB - Different hippocampal activity patterns are determined primarily by the interaction of excitatory cells and different types of interneurons. To understand the mechanisms underlying the generation of different network dynamics the properties of synaptic transmission need to be uncovered. Perisomatic inhibition has been shown to be critical for the generation of sharp wave-ripples, gamma oscillations as well as pathological epileptic activities. Therefore, we decided to quantitatively and systematically characterize the temporal properties of the synaptic transmission between perisomatic inhibitory neurons and pyramidal cells in the CA3 area of mouse hippocampal slices, using action potential patterns recorded during physiological and pathological network states. PV+ and CCK+ interneurons had distinct intrinsic physiological features. Interneurons of the same type formed reciprocally connected subnetworks, while the connectivity between interneuron classes was sparse. The characteristics of unitary interactions depended on the identity of both synaptic partners, while the short-term plasticity of synaptic transmission depended mainly on the presynaptic cell type. PV+ interneurons showed frequency-dependent depression, while more complex dynamics characterized the output of CCK+ interneurons. We quantitatively captured the dynamics of transmission at these different types of connection with simple mathematical models, and described in detail the response to physiological and pathological discharge patterns. Our data suggest that the temporal propeties of PV+ interneuron transmission may contribute to sharp wave-ripple generation. These findings support the view that intrinsic and synaptic features of PV+ cells make them ideally suited for the generation of physiological network oscillations, while CCK+ cells implement more subtle, graded control in the hippocampus. This article is protected by copyright. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Szegedi, Viktor AU - Paizs, Melinda AU - Csákvári, Eszter AU - Molnár, Gábor AU - Barzó, Pál AU - Tamás, Gábor AU - Lamsa, Karri TI - Plasticity in Single Axon Glutamatergic Connection to GABAergic Interneurons Regulates Complex Events in the Human Neocortex JF - PLOS BIOLOGY J2 - PLOS BIOL VL - 14 PY - 2016 IS - 11 PG - 21 SN - 1544-9173 DO - 10.1371/journal.pbio.2000237 UR - https://m2.mtmt.hu/api/publication/3137400 ID - 3137400 AB - In the human neocortex, single excitatory pyramidal cells can elicit very large glutamatergic EPSPs (VLEs) in inhibitory GABAergic interneurons capable of triggering their firing with short (3-5 ms) delay. Similar strong excitatory connections between two individual neurons have not been found in nonhuman cortices, suggesting that these synapses are specific to human interneurons. The VLEs are crucial for generating neocortical complex events, observed as single pyramidal cell spike-evoked discharge of cell assemblies in the frontal and temporal cortices. However, long-term plasticity of the VLE connections and how the plasticity modulates neocortical complex events has not been studied. Using triple and dual whole-cell recordings from synaptically connected human neocortical layers 2-3 neurons, we show that VLEs in fast-spiking GABAergic interneurons exhibit robust activity-induced long-term depression (LTD). The LTD by single pyramidal cell 40 Hz spike bursts is specific to connections with VLEs, requires group I metabotropic glutamate receptors, and has a presynaptic mechanism. The LTD of VLE connections alters suprathreshold activation of interneurons in the complex events suppressing the discharge of fast-spiking GABAergic cells. The VLEs triggering the complex events may contribute to cognitive processes in the human neocortex, and their long-term plasticity can alter the discharging cortical cell assemblies by learning. LA - English DB - MTMT ER - TY - JOUR AU - Gulyás, Attila AU - Freund, Tamás TI - Generation of physiological and pathological high frequency oscillations: the role of perisomatic inhibition in sharp-wave ripple and interictal spike generation. JF - CURRENT OPINION IN NEUROBIOLOGY J2 - CURR OPIN NEUROBIOL VL - 31 PY - 2015 SP - 26 EP - 32 PG - 7 SN - 0959-4388 DO - 10.1016/j.conb.2014.07.020 UR - https://m2.mtmt.hu/api/publication/2719984 ID - 2719984 N1 - Funding details: 604102 Funding details: NNF 85659, K83251 Funding details: European Research Council, ERC-2011-ADG-294313 Funding details: Hungarian Scientific Research Fund Funding text 1: The authors work was supported by the Hungarian Scientific Research Fund ( OTKA K83251 , NNF 85659 ), European Research Council ( ERC-2011-ADG-294313 ; SERRACO) and the EU FP grant no. 604102 (Human Brain Cited By :29 Export Date: 20 March 2021 CODEN: COPUE Correspondence Address: Gulyás, A.I.; Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43, H-1083 Budapest, Hungary; email: gulyas@koki.hu Chemicals/CAS: parvalbumin, 56094-12-3, 83667-75-8; Parvalbumins Funding details: 604102 Funding details: Seventh Framework Programme, FP7, 294313 Funding details: European Research Council, ERC Funding details: Hungarian Scientific Research Fund, OTKA, K83251, NNF 85659 Funding text 1: The authors work was supported by the Hungarian Scientific Research Fund ( OTKA K83251 , NNF 85659 ), European Research Council ( ERC-2011-ADG-294313 ; SERRACO) and the EU FP grant no. 604102 (Human Brain Project). Cited By :29 Export Date: 31 March 2021 CODEN: COPUE Correspondence Address: Gulyás, A.I.; Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43, H-1083 Budapest, Hungary; email: gulyas@koki.hu Chemicals/CAS: parvalbumin, 56094-12-3, 83667-75-8; Parvalbumins Funding details: 604102 Funding details: Seventh Framework Programme, FP7, 294313 Funding details: European Research Council, ERC Funding details: Hungarian Scientific Research Fund, OTKA, K83251, NNF 85659 Funding text 1: The authors work was supported by the Hungarian Scientific Research Fund ( OTKA K83251 , NNF 85659 ), European Research Council ( ERC-2011-ADG-294313 ; SERRACO) and the EU FP grant no. 604102 (Human Brain Project). Cited By :30 Export Date: 6 April 2021 CODEN: COPUE Correspondence Address: Gulyás, A.I.; Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43, H-1083 Budapest, Hungary; email: gulyas@koki.hu Chemicals/CAS: parvalbumin, 56094-12-3, 83667-75-8; Parvalbumins Funding details: 604102 Funding details: Seventh Framework Programme, FP7, 294313 Funding details: European Research Council, ERC Funding details: Hungarian Scientific Research Fund, OTKA, K83251, NNF 85659 Funding text 1: The authors work was supported by the Hungarian Scientific Research Fund ( OTKA K83251 , NNF 85659 ), European Research Council ( ERC-2011-ADG-294313 ; SERRACO) and the EU FP grant no. 604102 (Human Brain Project). Cited By :30 Export Date: 7 April 2021 CODEN: COPUE Correspondence Address: Gulyás, A.I.; Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43, H-1083 Budapest, Hungary; email: gulyas@koki.hu Chemicals/CAS: parvalbumin, 56094-12-3, 83667-75-8; Parvalbumins Funding details: 604102 Funding details: Seventh Framework Programme, FP7, 294313 Funding details: European Research Council, ERC Funding details: Hungarian Scientific Research Fund, OTKA, K83251, NNF 85659 Funding text 1: The authors work was supported by the Hungarian Scientific Research Fund ( OTKA K83251 , NNF 85659 ), European Research Council ( ERC-2011-ADG-294313 ; SERRACO) and the EU FP grant no. 604102 (Human Brain Project). Cited By :30 Export Date: 13 April 2021 CODEN: COPUE Correspondence Address: Gulyás, A.I.; Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43, H-1083 Budapest, Hungary; email: gulyas@koki.hu Chemicals/CAS: parvalbumin, 56094-12-3, 83667-75-8; Parvalbumins Funding details: 604102 Funding details: Seventh Framework Programme, FP7, 294313 Funding details: European Research Council, ERC Funding details: Hungarian Scientific Research Fund, OTKA, K83251, NNF 85659 Funding text 1: The authors work was supported by the Hungarian Scientific Research Fund ( OTKA K83251 , NNF 85659 ), European Research Council ( ERC-2011-ADG-294313 ; SERRACO) and the EU FP grant no. 604102 (Human Brain Project). AB - Sharp-wave-ripple complexes (SWRs) and interictal-spikes are physiological and pathological forms of irregularly occurring transient high activity events in the hippocampal EEG. They share similar features and carry high-frequency oscillations with different spectral features. Recent results reveal similarities and differences in the generation of the two types of transients, and argue that parvalbumin containing basket cells (PVBCs) are crucial in synchronizing neuronal activity in both cases. SWRs are generated in the reciprocally connected network of inhibitory PVBCs, while in the pathological case, synchronous failure of perisomatic inhibition triggers massive pyramidal cell burst firing. While physiological ripple oscillation is primarily the result of phasic perisomatic inhibitory currents, pathological high-frequency ripples are population spikes of partially synchronous, massively bursting, uninhibited pyramidal cells. LA - English DB - MTMT ER - TY - JOUR AU - Hofer, Katharina AU - Kandrács, Ágnes AU - Ulbert, István AU - Pál, Ildikó AU - Szabó, Csilla AU - Héja, László AU - Wittner, Lucia TI - The hippocampal CA3 region can generate two distinct types of sharp wave-ripple complexes, in vitro. JF - HIPPOCAMPUS J2 - HIPPOCAMPUS VL - 25 PY - 2015 IS - 2 SP - 169 EP - 186 PG - 18 SN - 1050-9631 DO - 10.1002/hipo.22361 UR - https://m2.mtmt.hu/api/publication/2743439 ID - 2743439 N1 - Department of Comparative Psychophysiology, Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary Department of Information Technology and Bionics, Péter Pázmány Catholic University, Budapest, Hungary Department of Functional Neurosurgery, National Institute of Clinical Neurosciences, Budapest, Hungary Cited By :8 Export Date: 14 August 2019 CODEN: HIPPE Correspondence Address: Wittner, L.; Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Hungary Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; gamma-Aminobutyric Acid; Glutamic Acid Department of Comparative Psychophysiology, Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary Department of Information Technology and Bionics, Péter Pázmány Catholic University, Budapest, Hungary Department of Functional Neurosurgery, National Institute of Clinical Neurosciences, Budapest, Hungary Cited By :8 Export Date: 17 August 2019 CODEN: HIPPE Correspondence Address: Wittner, L.; Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Hungary Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; gamma-Aminobutyric Acid; Glutamic Acid Department of Comparative Psychophysiology, Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary Department of Information Technology and Bionics, Péter Pázmány Catholic University, Budapest, Hungary Department of Functional Neurosurgery, National Institute of Clinical Neurosciences, Budapest, Hungary Cited By :8 Export Date: 18 August 2019 CODEN: HIPPE Correspondence Address: Wittner, L.; Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Hungary Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; gamma-Aminobutyric Acid; Glutamic Acid Department of Comparative Psychophysiology, Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary Department of Information Technology and Bionics, Péter Pázmány Catholic University, Budapest, Hungary Department of Functional Neurosurgery, National Institute of Clinical Neurosciences, Budapest, Hungary Cited By :8 Export Date: 12 March 2020 CODEN: HIPPE Correspondence Address: Wittner, L.; Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Hungary Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; gamma-Aminobutyric Acid; Glutamic Acid Department of Comparative Psychophysiology, Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary Department of Information Technology and Bionics, Péter Pázmány Catholic University, Budapest, Hungary Department of Functional Neurosurgery, National Institute of Clinical Neurosciences, Budapest, Hungary Cited By :8 Export Date: 24 April 2020 CODEN: HIPPE Correspondence Address: Wittner, L.; Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Hungary Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; gamma-Aminobutyric Acid; Glutamic Acid Department of Comparative Psychophysiology, Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary Department of Information Technology and Bionics, Péter Pázmány Catholic University, Budapest, Hungary Department of Functional Neurosurgery, National Institute of Clinical Neurosciences, Budapest, Hungary Cited By :8 Export Date: 15 May 2020 CODEN: HIPPE Correspondence Address: Wittner, L.; Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Hungary Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; gamma-Aminobutyric Acid; Glutamic Acid Department of Comparative Psychophysiology, Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary Department of Information Technology and Bionics, Péter Pázmány Catholic University, Budapest, Hungary Department of Functional Neurosurgery, National Institute of Clinical Neurosciences, Budapest, Hungary Cited By :8 Export Date: 18 May 2020 CODEN: HIPPE Correspondence Address: Wittner, L.; Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Hungary Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; gamma-Aminobutyric Acid; Glutamic Acid Department of Comparative Psychophysiology, Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary Department of Information Technology and Bionics, Péter Pázmány Catholic University, Budapest, Hungary Department of Functional Neurosurgery, National Institute of Clinical Neurosciences, Budapest, Hungary Cited By :8 Export Date: 25 May 2020 CODEN: HIPPE Correspondence Address: Wittner, L.; Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Hungary Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; gamma-Aminobutyric Acid; Glutamic Acid Department of Comparative Psychophysiology, Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary Department of Information Technology and Bionics, Péter Pázmány Catholic University, Budapest, Hungary Department of Functional Neurosurgery, National Institute of Clinical Neurosciences, Budapest, Hungary Cited By :8 Export Date: 28 May 2020 CODEN: HIPPE Correspondence Address: Wittner, L.; Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Hungary Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; gamma-Aminobutyric Acid; Glutamic Acid Department of Comparative Psychophysiology, Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary Department of Information Technology and Bionics, Péter Pázmány Catholic University, Budapest, Hungary Department of Functional Neurosurgery, National Institute of Clinical Neurosciences, Budapest, Hungary Cited By :12 Export Date: 7 September 2021 CODEN: HIPPE Correspondence Address: Wittner, L.; Institute of Cognitive Neuroscience and Psychology, Magyar Tudósok körútja 2, Hungary Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; gamma-Aminobutyric Acid; Glutamic Acid Funding details: Hungarian Scientific Research Fund, OTKA, 81357 AB - Hippocampal sharp wave-ripples (SPW-Rs) occur during slow wave sleep and behavioral immobility and are thought to play an important role in memory formation. We investigated the cellular and network properties of SPW-Rs with simultaneous laminar multielectrode and intracellular recordings in a rat hippocampal slice model, using physiological bathing medium. Spontaneous SPW-Rs were generated in the dentate gyrus (DG), CA3 and CA1 regions. These events were characterized by a local field potential gradient (LFPg) transient, increased fast oscillatory activity and increased multiple unit activity (MUA). Two types of SPW-Rs were distinguished in the CA3 region based on their different LFPg and current source density (CSD) pattern. Type 1 (T1) displayed negative LFPg transient in the pyramidal cell layer, and the associated CSD sink was confined to the proximal dendrites. Type 2 (T2) SPW-Rs were characterized by positive LFPg transient in the cell layer, and showed CSD sinks involving both the apical and basal dendrites. In both types, consistent with the somatic CSD source, only a small subset of CA3 pyramidal cells fired, most pyramidal cells were hyperpolarized, while most interneurons increased firing rate before the LFPg peak. Different neuronal populations, with different proportions of pyramidal cells and distinct subsets of interneurons were activated during T1 and T2 SPW-Rs. Activation of specific inhibitory cell subsets - with the possible leading role of perisomatic interneurons - seems to be crucial to synchronize distinct ensembles of CA3 pyramidal cells finally resulting in the expression of different SPW-R activities. This suggests that the hippocampus can generate dynamic changes in its activity stemming from the same excitatory and inhibitory circuits, and so, might provide the cellular and network basis for an input-specific and activity-dependent information transmission. (c) 2014 Wiley Periodicals, Inc. LA - English DB - MTMT ER - TY - JOUR AU - Karlócai, Rita AU - Kohus, Zsolt AU - Káli, Szabolcs AU - Ulbert, István AU - Szabó, Gábor AU - Máté, Zoltán AU - Freund, Tamás AU - Gulyás, Attila TI - Physiological sharp wave-ripples and interictal events in vitro: what's the difference? JF - BRAIN J2 - BRAIN VL - 137 PY - 2014 IS - 2 (Feb) SP - 463 EP - 485 PG - 23 SN - 0006-8950 DO - 10.1093/brain/awt348 UR - https://m2.mtmt.hu/api/publication/2498752 ID - 2498752 N1 - Laboratory of Cerebral Cortex, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Janos Szentagothai PhD Program of Semmelweis University, Budapest, Hungary Institute of Psychology, Hungarian Academy of Sciences, Budapest, Hungary Faculty of Information Technology, Péter Pázmány Catholic University, Budapest, Hungary Laboratory of Molecular Biology and Genetics, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Cited By :44 Export Date: 31 March 2021 CODEN: BRAIA Correspondence Address: Gulyás, A.I.; Institute of Experimental Medicine, Szigony utca 43, H-1083 Budapest, Hungary; email: gulyas@koki.hu Chemicals/CAS: 3 amino 2 (3 carboxypropyl) 6 (4 methoxyphenyl)pyridazinium bromide, 104104-50-9; magnesium, 7439-95-4; parvalbumin, 56094-12-3, 83667-75-8; potassium, 7440-09-7 Funding details: Seventh Framework Programme, FP7, 294313 Funding details: European Research Council, ERC Funding details: Hungarian Scientific Research Fund, OTKA, K83251, OTKA 81357 Funding text 1: This work was supported by:, Hungarian Scientific Research Fund (OTKA K83251 and OTKA 81357), European Research Council Advanced grant for T.F.F. (ERC-2011-ADG-294313) (SERRACO), National Office for Research and Technology NKTH-ANR, Neurogen and Multisca, European Union Seventh Framework Program (NeuroSeker) and TÁMOP-4.2.1.B-11/2/KMR-2011-0002 Laboratory of Cerebral Cortex, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Janos Szentagothai PhD Program of Semmelweis University, Budapest, Hungary Institute of Psychology, Hungarian Academy of Sciences, Budapest, Hungary Faculty of Information Technology, Péter Pázmány Catholic University, Budapest, Hungary Laboratory of Molecular Biology and Genetics, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Cited By :44 Export Date: 6 April 2021 CODEN: BRAIA Correspondence Address: Gulyás, A.I.; Institute of Experimental Medicine, Szigony utca 43, H-1083 Budapest, Hungary; email: gulyas@koki.hu Chemicals/CAS: 3 amino 2 (3 carboxypropyl) 6 (4 methoxyphenyl)pyridazinium bromide, 104104-50-9; magnesium, 7439-95-4; parvalbumin, 56094-12-3, 83667-75-8; potassium, 7440-09-7 Funding details: Seventh Framework Programme, FP7, 294313 Funding details: European Research Council, ERC Funding details: Hungarian Scientific Research Fund, OTKA, K83251, OTKA 81357 Funding text 1: This work was supported by:, Hungarian Scientific Research Fund (OTKA K83251 and OTKA 81357), European Research Council Advanced grant for T.F.F. (ERC-2011-ADG-294313) (SERRACO), National Office for Research and Technology NKTH-ANR, Neurogen and Multisca, European Union Seventh Framework Program (NeuroSeker) and TÁMOP-4.2.1.B-11/2/KMR-2011-0002 Laboratory of Cerebral Cortex, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Janos Szentagothai PhD Program of Semmelweis University, Budapest, Hungary Institute of Psychology, Hungarian Academy of Sciences, Budapest, Hungary Faculty of Information Technology, Péter Pázmány Catholic University, Budapest, Hungary Laboratory of Molecular Biology and Genetics, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Cited By :44 Export Date: 13 April 2021 CODEN: BRAIA Correspondence Address: Gulyás, A.I.; Institute of Experimental Medicine, Szigony utca 43, H-1083 Budapest, Hungary; email: gulyas@koki.hu Chemicals/CAS: 3 amino 2 (3 carboxypropyl) 6 (4 methoxyphenyl)pyridazinium bromide, 104104-50-9; magnesium, 7439-95-4; parvalbumin, 56094-12-3, 83667-75-8; potassium, 7440-09-7 Funding details: Seventh Framework Programme, FP7, 294313 Funding details: European Research Council, ERC Funding details: Hungarian Scientific Research Fund, OTKA, K83251, OTKA 81357 Funding text 1: This work was supported by:, Hungarian Scientific Research Fund (OTKA K83251 and OTKA 81357), European Research Council Advanced grant for T.F.F. (ERC-2011-ADG-294313) (SERRACO), National Office for Research and Technology NKTH-ANR, Neurogen and Multisca, European Union Seventh Framework Program (NeuroSeker) and TÁMOP-4.2.1.B-11/2/KMR-2011-0002 AB - Sharp wave-ripples and interictal events are physiological and pathological forms of transient high activity in the hippocampus with similar features. Sharp wave-ripples have been shown to be essential in memory consolidation, whereas epileptiform (interictal) events are thought to be damaging. It is essential to grasp the difference between physiological sharp wave-ripples and pathological interictal events to understand the failure of control mechanisms in the latter case. We investigated the dynamics of activity generated intrinsically in the Cornu Ammonis region 3 of the mouse hippocampus in vitro, using four different types of intervention to induce epileptiform activity. As a result, sharp wave-ripples spontaneously occurring in Cornu Ammonis region 3 disappeared, and following an asynchronous transitory phase, activity reorganized into a new form of pathological synchrony. During epileptiform events, all neurons increased their firing rate compared to sharp wave-ripples. Different cell types showed complementary firing: parvalbumin-positive basket cells and some axo-axonic cells stopped firing as a result of a depolarization block at the climax of the events in high potassium, 4-aminopyridine and zero magnesium models, but not in the gabazine model. In contrast, pyramidal cells began firing maximally at this stage. To understand the underlying mechanism we measured changes of intrinsic neuronal and transmission parameters in the high potassium model. We found that the cellular excitability increased and excitatory transmission was enhanced, whereas inhibitory transmission was compromised. We observed a strong short-term depression in parvalbumin-positive basket cell to pyramidal cell transmission. Thus, the collapse of pyramidal cell perisomatic inhibition appears to be a crucial factor in the emergence of epileptiform events. LA - English DB - MTMT ER - TY - JOUR AU - Kerekes, Bálint Péter AU - Tóth, Kinga AU - Kaszás, Attila AU - Chiovini, Balázs AU - Szadai, Zoltán AU - Szalay, Gergely AU - Pálfi, Dénes AU - Bagó, Attila György AU - Spitzer, Klaudia AU - Rózsa J., Balázs AU - Ulbert, István AU - Wittner, Lucia TI - Combined two-photon imaging, electrophysiological, and anatomical investigation of the human neocortex in vitro JF - NEUROPHOTONICS J2 - NEUROPHOTONICS VL - 1 PY - 2014 IS - 1 PG - 10 SN - 2329-423X DO - 10.1117/1.NPh.1.1.011013 UR - https://m2.mtmt.hu/api/publication/2736807 ID - 2736807 N1 - Pázmány Péter Catholic University, Faculty of Information Technology and Bionics, Práter utca 50/a, Budapest, H-1083, Hungary Research Centre for Natural Sciences, Hungarian Academy of Sciences, Institute of Cognitive Neuroscience and Psychology, Budapest, Hungary Two-Photon Imaging Center, Hungarian Academy of Sciences, Institute of Experimental Medicine, Budapest, Hungary National Institute of Clinical Neuroscience, Department of Neurooncology, Budapest, Hungary Cited By :10 Export Date: 18 October 2022 Correspondence Address: Ulbert, I.; Pázmány Péter Catholic University, Práter utca 50/a, Hungary Chemicals/CAS: calcium ion, 14127-61-8 Funding details: PD91151 LA - English DB - MTMT ER - TY - JOUR AU - Schlingloff, Dániel AU - Káli, Szabolcs AU - Freund, Tamás AU - Hájos, Norbert AU - Gulyás, Attila TI - Mechanisms of sharp wave initiation and ripple generation. JF - JOURNAL OF NEUROSCIENCE J2 - J NEUROSCI VL - 34 PY - 2014 IS - 34 SP - 11385 EP - 11398 PG - 14 SN - 0270-6474 DO - 10.1523/JNEUROSCI.0867-14.2014 UR - https://m2.mtmt.hu/api/publication/2721604 ID - 2721604 N1 - Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary Pázmány Péter Catholic University, H-1083 Budapest, Hungary Semmelweis University, H-1085 Budapest, Hungary Cited By :143 Export Date: 8 June 2023 CODEN: JNRSD Correspondence Address: Gulyás, A. I.; Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony utca 43, H-1083 Budapest, Hungary; email: gulyas@koki.hu Chemicals/CAS: 3 amino 2 (3 carboxypropyl) 6 (4 methoxyphenyl)pyridazinium bromide, 104104-50-9; 6 nitro 7 sulfamoylbenzo[f]quinoxaline 2,3 dione, 118876-58-7; parvalbumin, 56094-12-3, 83667-75-8; rhodopsin, 60383-01-9, 9009-81-8; tetrodotoxin, 4368-28-9, 4664-41-9; Agatoxins; Anesthetics, Local; Ank3 protein, mouse; Ankyrins; Calcium Channel Blockers; channelrhodopsin 2, mouse; Parvalbumins; Rhodopsin; Tetrodotoxin Funding details: Seventh Framework Programme, FP7, 294313 AB - Replay of neuronal activity during hippocampal sharp wave-ripples (SWRs) is essential in memory formation. To understand the mechanisms underlying the initiation of irregularly occurring SWRs and the generation of periodic ripples, we selectively manipulated different components of the CA3 network in mouse hippocampal slices. We recorded EPSCs and IPSCs to examine the buildup of neuronal activity preceding SWRs and analyzed the distribution of time intervals between subsequent SWR events. Our results suggest that SWRs are initiated through a combined refractory and stochastic mechanism. SWRs initiate when firing in a set of spontaneously active pyramidal cells triggers a gradual, exponential buildup of activity in the recurrent CA3 network. We showed that this tonic excitatory envelope drives reciprocally connected parvalbumin-positive basket cells, which start ripple-frequency spiking that is phase-locked through reciprocal inhibition. The synchronized GABAA receptor-mediated currents give rise to a major component of the ripple-frequency oscillation in the local field potential and organize the phase-locked spiking of pyramidal cells. Optogenetic stimulation of parvalbumin-positive cells evoked full SWRs and EPSC sequences in pyramidal cells. Even with excitation blocked, tonic driving of parvalbumin-positive cells evoked ripple oscillations. Conversely, optogenetic silencing of parvalbumin-positive cells interrupted the SWRs or inhibited their occurrence. Local drug applications and modeling experiments confirmed that the activity of parvalbumin-positive perisomatic inhibitory neurons is both necessary and sufficient for ripple-frequency current and rhythm generation. These interneurons are thus essential in organizing pyramidal cell activity not only during gamma oscillation, but, in a different configuration, during SWRs. LA - English DB - MTMT ER - TY - JOUR AU - Hájos, Norbert AU - Karlócai, Rita AU - Németh, Beáta AU - Ulbert, István AU - Monyer, H AU - Szabó, Gábor AU - Erdélyi, Ferenc AU - Freund, Tamás AU - Gulyás, Attila TI - Input-Output Features of Anatomically Identified CA3 Neurons during Hippocampal Sharp Wave/Ripple Oscillation In Vitro. JF - JOURNAL OF NEUROSCIENCE J2 - J NEUROSCI VL - 33 PY - 2013 IS - 28 SP - 11677 EP - 11691 PG - 15 SN - 0270-6474 DO - 10.1523/JNEUROSCI.5729-12.2013 UR - https://m2.mtmt.hu/api/publication/2368471 ID - 2368471 N1 - Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary, Germany Péter Pázmány Catholic University, H-1088, Budapest, Hungary, Germany Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, H-1025, Budapest, Hungary, Germany Department of Clinical Neurobiology, University Hospital of Neurology, 69120 Heidelberg, Germany Cited By :55 Export Date: 17 August 2019 CODEN: JNRSD Correspondence Address: Hájos, N.; Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary, Germany; email: hajos@koki.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8 Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary, Germany Péter Pázmány Catholic University, H-1088, Budapest, Hungary, Germany Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, H-1025, Budapest, Hungary, Germany Department of Clinical Neurobiology, University Hospital of Neurology, 69120 Heidelberg, Germany Cited By :55 Export Date: 23 August 2019 CODEN: JNRSD Correspondence Address: Hájos, N.; Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary, Germany; email: hajos@koki.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8 Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary, Germany Péter Pázmány Catholic University, H-1088, Budapest, Hungary, Germany Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, H-1025, Budapest, Hungary, Germany Department of Clinical Neurobiology, University Hospital of Neurology, 69120 Heidelberg, Germany Cited By :55 Export Date: 24 February 2020 CODEN: JNRSD Correspondence Address: Hájos, N.; Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary, Germany; email: hajos@koki.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8 Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary, Germany Péter Pázmány Catholic University, H-1088, Budapest, Hungary, Germany Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, H-1025, Budapest, Hungary, Germany Department of Clinical Neurobiology, University Hospital of Neurology, 69120 Heidelberg, Germany Cited By :55 Export Date: 12 March 2020 CODEN: JNRSD Correspondence Address: Hájos, N.; Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary, Germany; email: hajos@koki.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8 Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary, Germany Péter Pázmány Catholic University, H-1088, Budapest, Hungary, Germany Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, H-1025, Budapest, Hungary, Germany Department of Clinical Neurobiology, University Hospital of Neurology, 69120 Heidelberg, Germany Cited By :56 Export Date: 24 April 2020 CODEN: JNRSD Correspondence Address: Hájos, N.; Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary, Germany; email: hajos@koki.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8 Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary, Germany Péter Pázmány Catholic University, H-1088, Budapest, Hungary, Germany Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, H-1025, Budapest, Hungary, Germany Department of Clinical Neurobiology, University Hospital of Neurology, 69120 Heidelberg, Germany Cited By :56 Export Date: 18 May 2020 CODEN: JNRSD Correspondence Address: Hájos, N.; Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary, Germany; email: hajos@koki.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8 Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary, Germany Péter Pázmány Catholic University, H-1088, Budapest, Hungary, Germany Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, H-1025, Budapest, Hungary, Germany Department of Clinical Neurobiology, University Hospital of Neurology, 69120 Heidelberg, Germany Cited By :56 Export Date: 20 May 2020 CODEN: JNRSD Correspondence Address: Hájos, N.; Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary, Germany; email: hajos@koki.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8 Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary, Germany Péter Pázmány Catholic University, H-1088, Budapest, Hungary, Germany Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, H-1025, Budapest, Hungary, Germany Department of Clinical Neurobiology, University Hospital of Neurology, 69120 Heidelberg, Germany Cited By :60 Export Date: 20 March 2021 CODEN: JNRSD Correspondence Address: Hájos, N.; Institute of Experimental Medicine, , H-1083 Budapest, Hungary, Germany; email: hajos@koki.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8 Funding details: Seventh Framework Programme, FP7, 294313 Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary, Germany Péter Pázmány Catholic University, H-1088, Budapest, Hungary, Germany Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, H-1025, Budapest, Hungary, Germany Department of Clinical Neurobiology, University Hospital of Neurology, 69120 Heidelberg, Germany Cited By :61 Export Date: 31 March 2021 CODEN: JNRSD Correspondence Address: Hájos, N.; Institute of Experimental Medicine, , H-1083 Budapest, Hungary, Germany; email: hajos@koki.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8 Funding details: Seventh Framework Programme, FP7, 294313 Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary, Germany Péter Pázmány Catholic University, H-1088, Budapest, Hungary, Germany Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, H-1025, Budapest, Hungary, Germany Department of Clinical Neurobiology, University Hospital of Neurology, 69120 Heidelberg, Germany Cited By :61 Export Date: 1 April 2021 CODEN: JNRSD Correspondence Address: Hájos, N.; Institute of Experimental Medicine, , H-1083 Budapest, Hungary, Germany; email: hajos@koki.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8 Funding details: Seventh Framework Programme, FP7, 294313 AB - Hippocampal sharp waves and the associated ripple oscillations (SWRs) are implicated in memory processes. These network events emerge intrinsically in the CA3 network. To understand cellular interactions that generate SWRs, we detected first spiking activity followed by recording of synaptic currents in distinct types of anatomically identified CA3 neurons during SWRs that occurred spontaneously in mouse hippocampal slices. We observed that the vast majority of interneurons fired during SWRs, whereas only a small portion of pyramidal cells was found to spike. There were substantial differences in the firing behavior among interneuron groups; parvalbumin-expressing basket cells were one of the most active GABAergic cells during SWRs, whereas ivy cells were silent. Analysis of the synaptic currents during SWRs uncovered that the dominant synaptic input to the pyramidal cell was inhibitory, whereas spiking interneurons received larger synaptic excitation than inhibition. The discharge of all interneurons was primarily determined by the magnitude and the timing of synaptic excitation. Strikingly, we observed that the temporal structure of synaptic excitation and inhibition during SWRs significantly differed between parvalbumin-containing basket cells, axoaxonic cells, and type 1 cannabinoid receptor (CB1)-expressing basket cells, which might explain their distinct recruitment to these synchronous events. Our data support the hypothesis that the active current sources restricted to the stratum pyramidale during SWRs originate from the synaptic output of parvalbumin-expressing basket cells. Thus, in addition to gamma oscillation, these GABAergic cells play a central role in SWR generation. LA - English DB - MTMT ER - TY - JOUR AU - Máté, Zoltán AU - Poles, Marietta Zita AU - Szabó, Gábor AU - Bagyánszki, Mária AU - Talapka, Petra AU - Fekete, Éva AU - Bódi, Nikolett TI - Spatiotemporal expression pattern of DsRedT3/CCK gene construct during postnatal development of myenteric plexus in transgenic mice JF - CELL AND TISSUE RESEARCH J2 - CELL TISSUE RES VL - 352 PY - 2013 IS - 2 SP - 199 EP - 206 PG - 8 SN - 0302-766X DO - 10.1007/s00441-013-1552-7 UR - https://m2.mtmt.hu/api/publication/2167719 ID - 2167719 N1 - Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Szeged 6726, Hungary Institute of Experimental Medicine, Hungarian Academy of Sciences Budapest, Szigony u. 43, Budapest 1083, Hungary Cited By :18 Export Date: 3 August 2023 CODEN: CTSRC Correspondence Address: Bódi, N.; Department of Physiology, Anatomy and Neuroscience, Közép fasor 52, Szeged 6726, Hungary; email: bodiniki85@gmail.com Chemicals/CAS: 5 hydroxytryptophan, 4350-09-8, 56-69-9; cholecystokinin, 9011-97-6, 93443-27-7; red fluorescent protein, 251925-26-5; 5-Hydroxytryptophan, C1LJO185Q9; Cholecystokinin, 9011-97-6; Fluorescent Dyes; Luminescent Proteins; Recombinant Fusion Proteins; red fluorescent protein AB - Cholecystokinin (CCK) is an early marker of both neuronal and endocrine cell lineages in the developing gastrointestinal tract. To determine the quantitative properties and the spatial distribution of the CCK-expressing myenteric neurones in early postnatal life, a transgenic mouse strain with a CCK promoter-driven red fluorescent protein (DsRedT3/CCK) was established. The cell-specific expression of DsRedT3/CCK was validated by in situ hybridization with a CCK antisense riboprobe and by in situ hybridization coupled with immunohistochemistry involving a monoclonal antibody to CCK. A gradual increase in the DsRedT3/CCK-expressing enteric neurones with clear regional differences was documented from birth until the suckling to weaning transition, in parallel with the period of rapid intestinal growth and functional maturation. To evaluate the proportion of myenteric neurones in which DsRedT3/CCK transgene expression was colocalized with the enteric neuronal marker peripherin, immunofluorescence techniques were applied. All DsRedT3/CCK neurones were peripherin-immunoreactive and the proportion of DsRedT3/CCK-expressing myenteric neurones in the duodenum was the highest after the third week of life, when the number of peripherin-immunoreactive myenteric neurones in this region had decreased. Nearly all of the DsRedT3/CCK-expressing neurones also expressed 5-hydroxytryptophan (5-HT). Thus, by utilizing a new transgenic mouse strain, we have demonstrated a small number of CCK-expressing myenteric neurones with a developmentally regulated spatiotemporal distribution. The coexistence of CCK and 5-HT in the majority of these neurones suggests their possible regulatory role in feeding at the suckling to weaning transition. LA - English DB - MTMT ER - TY - JOUR AU - Holderith, Noémi AU - Lőrincz, Andrea AU - Katona, Gergely AU - Rózsa J., Balázs AU - Kulik, A AU - Watanabe, M AU - Nusser, Zoltán TI - Release probability of hippocampal glutamatergic terminals scales with the size of the active zone JF - NATURE NEUROSCIENCE J2 - NAT NEUROSCI VL - 15 PY - 2012 IS - 7 SP - 988 EP - 997 PG - 10 SN - 1097-6256 DO - 10.1038/nn.3137 UR - https://m2.mtmt.hu/api/publication/2015276 ID - 2015276 N1 - Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Two-Photon Imaging Center, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Institute of Anatomy and Cell Biology, Department of Neuroanatomy, University of Freiburg, Freiburg, Germany Centre for Biological Signaling Studies, University of Freiburg, Freiburg, Germany Department of Anatomy, Hokkaido University School of Medicine, Sapporo, Japan Cited By :288 Export Date: 12 June 2023 CODEN: NANEF Correspondence Address: Nusser, Z.; Laboratory of Cellular Neurophysiology, , Budapest, Hungary; email: nusser@koki.hu Chemicals/CAS: glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; Calcium Channels, N-Type; voltage-dependent calcium channel (P-Q type) Funding details: 1.1.1-08/1-2008-0085 Funding details: Wellcome Trust, WT, 083484/Z/07/Z, 090197/Z/09/Z, 094513/Z/10/Z Funding details: Seventh Framework Programme, FP7, 293681 Funding details: European Research Council, ERC Funding details: Deutsche Forschungsgemeinschaft, DFG, SFB 780 Funding details: Magyar Tudományos Akadémia, MTA Funding text 1: N.H. and A.L. are funded by Janos Bolyai Scholarships of the Hungarian Academy of Sciences. Z.N. is supported by Wellcome Trust Equipment (083484/Z/07/Z) and Project Grants (090197/Z/09/Z; 094513/Z/10/Z), a European Research Council Advanced Grant, and a Hungarian National Office for Research and Technology-French National Research Agency TéT Fund (NKTH-Neurogen). B.R. was supported by a GOP grant (1.1.1-08/1-2008-0085). A.K. is supported by a Deutsche Forschungsgemeinschaft (SFB 780) grant. We thank N. Suzuki (Mie University, Japan) for providing Cav2.1−/− mice, A. Unger for helping with the Cav2.1−/− replica labeling, E. Dobai and D. Ronaszéki for technical assistance, M. Sümegi for his help with the modeling, members of Synaptic Systems GmbH for providing the rabbit anti-Cav2.1 antibody, E. Neher and M. Eyre for their comments on the manuscript, and H. Koester for helpful discussions. AB - Cortical synapses have structural, molecular and functional heterogeneity; our knowledge regarding the relationship between their ultrastructural and functional parameters is still fragmented. Here we asked how the neurotransmitter release probability and presynaptic [Ca(2+)] transients relate to the ultrastructure of rat hippocampal glutamatergic axon terminals. Two-photon Ca(2+) imaging-derived optical quantal analysis and correlated electron microscopic reconstructions revealed a tight correlation between the release probability and the active-zone area. Peak amplitude of [Ca(2+)] transients in single boutons also positively correlated with the active-zone area. Freeze- fracture immunogold labeling revealed that the voltage-gated calcium channel subunit Cav2.1 and the presynaptic protein Rim1/2 are confined to the active zone and their numbers scale linearly with the active-zone area. Gold particles labeling Cav2.1 were nonrandomly distributed in the active zones. Our results demonstrate that the numbers of several active-zone proteins, including presynaptic calcium channels, as well as the number of docked vesicles and the release probability, scale linearly with the active-zone area. LA - English DB - MTMT ER - TY - JOUR AU - Maglóczky, Zsófia AU - Tóth, Kinga AU - Karlócai, Rita AU - Nagy, Sára AU - Erőss, Loránd AU - Czirják, Sándor AU - Vajda, János AU - Rasonyi, G AU - Kelemen, Anna AU - Juhos, V AU - Halász, Péter AU - Mackie, K AU - Freund, Tamás TI - Dynamic changes of CB1-receptor expression in hippocampi of epileptic mice and humans JF - EPILEPSIA J2 - EPILEPSIA VL - 51 PY - 2010 IS - Suppl 3 SP - 115 EP - 120 PG - 6 SN - 0013-9580 DO - 10.1111/j.1528-1167.2010.02624.x UR - https://m2.mtmt.hu/api/publication/1373326 ID - 1373326 N1 - Hungarian Academic Science, Institute of Experimental Medicine, Szigony u. 43, 1083 Budapest, Hungary National Institute of Neurosurgery, Budapest, Hungary Department of Neurology, Szent István Hospital, Budapest, Hungary Department of Information Technology, Pázmány Péter Catholic University, Budapest, Hungary Gill Center, Department of Physiological and Brain Sciences, Indiana University, Bloomington, IN, United States Cited By :64 Export Date: 11 December 2024 CODEN: EPILA Correspondence Address: Maglóczky, Z.; Hungarian Academic Science, Szigony u. 43, 1083 Budapest, Hungary; email: zmagloczky@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; pilocarpine, 148-72-1, 54-71-7, 92-13-7; Convulsants; Pilocarpine, 92-13-7; Receptor, Cannabinoid, CB1; Receptors, GABA Funding details: National Institute on Drug Abuse, NIDA, R01DA011322 AB - The endocannabinoid system plays a central role in retrograde synaptic communication, and controls both glutamatergic and gamma-aminobutyric acid (GABA)ergic transmission via type 1 cannabinoid (CB1) receptor. Both in sclerotic human hippocampi and in the chronic phase of pilocarpine-induced epilepsy in mice with sclerosis, CB1-receptor-positive interneuron somata were preserved both in the dentate gyrus and in the CA1 area, and the density of CB1-immunostained fibers increased considerably in the dentate molecular layer. This suggests that, although CB1 receptors are known to be reduced in density on glutamatergic axons, the CB1-receptor-expressing GABAergic axons sprout, or there is an increase of CB1-receptor levels on these fibers. The changes of CB1 immunostaining in association with the GABAergic inhibitory system appear to correlate with the severity of pyramidal cell loss in the CA1 subfield. These results confirm the involvement of the endocannabinoid system associated with GABAergic transmission in human temporal lobe epilepsy (TLE), as well as in the chronic phase of the pilocarpine model in mice. Pharmacotherapy aimed at the modulation of endocannabinoid-mediated retrograde synaptic signaling should take into account the opposite change in CB1-receptor expression observed on glutamatergic versus GABAergic axon terminals. LA - English DB - MTMT ER - TY - JOUR AU - Maglóczky, Zsófia TI - Sprouting in human temporal lobe epilepsy: excitatory pathways and axons of interneurons JF - EPILEPSY RESEARCH J2 - EPILEPSY RES VL - 89 PY - 2010 IS - 1 SP - 52 EP - 59 PG - 8 SN - 0920-1211 DO - 10.1016/j.eplepsyres.2010.01.002 UR - https://m2.mtmt.hu/api/publication/109830 ID - 109830 N1 - PubMed ID: 20149961 Chemicals/CAS: parvalbumin, 56094-12-3, 83667-75-8; Calcium-Binding Protein, Vitamin D-Dependent; Parvalbumins; calbindin Cited By :41 Export Date: 21 August 2019 CODEN: EPIRE Correspondence Address: Maglóczky, Z.; Inst. Exp. Med., Hungarian Acad. Sci., Szigony 43, H-1083 Budapest, Hungary; email: zmagloczky@koki.hu Chemicals/CAS: parvalbumin, 56094-12-3, 83667-75-8; Calcium-Binding Protein, Vitamin D-Dependent; Parvalbumins; calbindin Cited By :41 Export Date: 23 August 2019 CODEN: EPIRE Correspondence Address: Maglóczky, Z.; Inst. Exp. Med., Hungarian Acad. Sci., Szigony 43, H-1083 Budapest, Hungary; email: zmagloczky@koki.hu Chemicals/CAS: parvalbumin, 56094-12-3, 83667-75-8; Calcium-Binding Protein, Vitamin D-Dependent; Parvalbumins; calbindin Cited By :41 Export Date: 24 August 2019 CODEN: EPIRE Correspondence Address: Maglóczky, Z.; Inst. Exp. Med., Hungarian Acad. Sci., Szigony 43, H-1083 Budapest, Hungary; email: zmagloczky@koki.hu Chemicals/CAS: parvalbumin, 56094-12-3, 83667-75-8; Calcium-Binding Protein, Vitamin D-Dependent; Parvalbumins; calbindin Cited By :42 Export Date: 24 February 2020 CODEN: EPIRE Correspondence Address: Maglóczky, Z.; Inst. Exp. Med., Hungarian Acad. Sci., Szigony 43, H-1083 Budapest, Hungary; email: zmagloczky@koki.hu Chemicals/CAS: parvalbumin, 56094-12-3, 83667-75-8; Calcium-Binding Protein, Vitamin D-Dependent; Parvalbumins; calbindin Funding text 1: The author thanks Tamás Freund for his constant support and discussions. The author is grateful to her immediate colleagues, L. Wittner, K. Tóth and Zs. Borhegyi for their fundamental contributions to the projects. The author is grateful to the neurologists and neurosurgeons, P. Halász, D. Fabó, Gy. Rásonyi, V. Juhos, J. Jerney, M. Kassay, A. Altmann, L. Erőss, J. Vajda and S. Czirják for their help and discussions. The author thanks Drs. M. Palkovits, P. Sótonyi and Zs. Borostyánkői/Semmelweis University, Budapest/for providing control human tissue. The excellent technical assistance of Ms. E. Simon, K. Lengyel, K. Iványi and Mr. Gy. Goda is also acknowledged. This study was supported by the grant EPICURE FP6 EC LSH-CT-2006-037315. Cited By :42 Export Date: 12 March 2020 CODEN: EPIRE Correspondence Address: Maglóczky, Z.; Inst. Exp. Med., Hungarian Acad. Sci., Szigony 43, H-1083 Budapest, Hungary; email: zmagloczky@koki.hu Chemicals/CAS: parvalbumin, 56094-12-3, 83667-75-8; Calcium-Binding Protein, Vitamin D-Dependent; Parvalbumins; calbindin Funding text 1: The author thanks Tamás Freund for his constant support and discussions. The author is grateful to her immediate colleagues, L. Wittner, K. Tóth and Zs. Borhegyi for their fundamental contributions to the projects. The author is grateful to the neurologists and neurosurgeons, P. Halász, D. Fabó, Gy. Rásonyi, V. Juhos, J. Jerney, M. Kassay, A. Altmann, L. Erőss, J. Vajda and S. Czirják for their help and discussions. The author thanks Drs. M. Palkovits, P. Sótonyi and Zs. Borostyánkői/Semmelweis University, Budapest/for providing control human tissue. The excellent technical assistance of Ms. E. Simon, K. Lengyel, K. Iványi and Mr. Gy. Goda is also acknowledged. This study was supported by the grant EPICURE FP6 EC LSH-CT-2006-037315. Cited By :43 Export Date: 24 April 2020 CODEN: EPIRE Correspondence Address: Maglóczky, Z.; Inst. Exp. Med., Hungarian Acad. Sci., Szigony 43, H-1083 Budapest, Hungary; email: zmagloczky@koki.hu Chemicals/CAS: parvalbumin, 56094-12-3, 83667-75-8; Calcium-Binding Protein, Vitamin D-Dependent; Parvalbumins; calbindin Funding text 1: The author thanks Tamás Freund for his constant support and discussions. The author is grateful to her immediate colleagues, L. Wittner, K. Tóth and Zs. Borhegyi for their fundamental contributions to the projects. The author is grateful to the neurologists and neurosurgeons, P. Halász, D. Fabó, Gy. Rásonyi, V. Juhos, J. Jerney, M. Kassay, A. Altmann, L. Erőss, J. Vajda and S. Czirják for their help and discussions. The author thanks Drs. M. Palkovits, P. Sótonyi and Zs. Borostyánkői/Semmelweis University, Budapest/for providing control human tissue. The excellent technical assistance of Ms. E. Simon, K. Lengyel, K. Iványi and Mr. Gy. Goda is also acknowledged. This study was supported by the grant EPICURE FP6 EC LSH-CT-2006-037315. Cited By :43 Export Date: 28 May 2020 CODEN: EPIRE Correspondence Address: Maglóczky, Z.; Inst. Exp. Med., Hungarian Acad. Sci., Szigony 43, H-1083 Budapest, Hungary; email: zmagloczky@koki.hu Chemicals/CAS: parvalbumin, 56094-12-3, 83667-75-8; Calcium-Binding Protein, Vitamin D-Dependent; Parvalbumins; calbindin Funding text 1: The author thanks Tamás Freund for his constant support and discussions. The author is grateful to her immediate colleagues, L. Wittner, K. Tóth and Zs. Borhegyi for their fundamental contributions to the projects. The author is grateful to the neurologists and neurosurgeons, P. Halász, D. Fabó, Gy. Rásonyi, V. Juhos, J. Jerney, M. Kassay, A. Altmann, L. Erőss, J. Vajda and S. Czirják for their help and discussions. The author thanks Drs. M. Palkovits, P. Sótonyi and Zs. Borostyánkői/Semmelweis University, Budapest/for providing control human tissue. The excellent technical assistance of Ms. E. Simon, K. Lengyel, K. Iványi and Mr. Gy. Goda is also acknowledged. This study was supported by the grant EPICURE FP6 EC LSH-CT-2006-037315. Cited By :46 Export Date: 31 March 2021 CODEN: EPIRE Correspondence Address: Maglóczky, Z.; Inst. Exp. Med., Szigony 43, H-1083 Budapest, Hungary; email: zmagloczky@koki.hu Chemicals/CAS: parvalbumin, 56094-12-3, 83667-75-8; Calcium-Binding Protein, Vitamin D-Dependent; Parvalbumins; calbindin Cited By :46 Export Date: 1 April 2021 CODEN: EPIRE Correspondence Address: Maglóczky, Z.; Inst. Exp. Med., Szigony 43, H-1083 Budapest, Hungary; email: zmagloczky@koki.hu Chemicals/CAS: parvalbumin, 56094-12-3, 83667-75-8; Calcium-Binding Protein, Vitamin D-Dependent; Parvalbumins; calbindin Cited By :46 Export Date: 6 April 2021 CODEN: EPIRE Correspondence Address: Maglóczky, Z.; Inst. Exp. Med., Szigony 43, H-1083 Budapest, Hungary; email: zmagloczky@koki.hu Chemicals/CAS: parvalbumin, 56094-12-3, 83667-75-8; Calcium-Binding Protein, Vitamin D-Dependent; Parvalbumins; calbindin Cited By :46 Export Date: 14 April 2021 CODEN: EPIRE Correspondence Address: Maglóczky, Z.; Inst. Exp. Med., Szigony 43, H-1083 Budapest, Hungary; email: zmagloczky@koki.hu Chemicals/CAS: parvalbumin, 56094-12-3, 83667-75-8; Calcium-Binding Protein, Vitamin D-Dependent; Parvalbumins; calbindin LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Gergely AU - Holderith, Noémi AU - Gulyás, Attila AU - Freund, Tamás AU - Hájos, Norbert TI - Distinct synaptic properties of perisomatic inhibitory cell types and their different modulation by cholinergic receptor activation in the CA3 region of the mouse hippocampus. JF - EUROPEAN JOURNAL OF NEUROSCIENCE J2 - EUR J NEUROSCI VL - 31 PY - 2010 IS - 12 SP - 2234 EP - 2246 PG - 13 SN - 0953-816X DO - 10.1111/j.1460-9568.2010.07292.x UR - https://m2.mtmt.hu/api/publication/1373328 ID - 1373328 N1 - Laboratory of Network Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Cited By :51 Export Date: 21 August 2019 CODEN: EJONE Correspondence Address: Hájos, N.; Laboratory of Network Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary; email: hajos@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; carbachol, 462-58-8, 51-83-2; Carbachol, 51-83-2; Cholinergic Agonists; Receptors, Cholinergic; gamma-Aminobutyric Acid, 56-12-2 Laboratory of Network Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Cited By :52 Export Date: 14 November 2019 CODEN: EJONE Correspondence Address: Hájos, N.; Laboratory of Network Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary; email: hajos@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; carbachol, 462-58-8, 51-83-2; Carbachol, 51-83-2; Cholinergic Agonists; Receptors, Cholinergic; gamma-Aminobutyric Acid, 56-12-2 Laboratory of Network Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Cited By :53 Export Date: 12 March 2020 CODEN: EJONE Correspondence Address: Hájos, N.; Laboratory of Network Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary; email: hajos@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; carbachol, 462-58-8, 51-83-2; Carbachol, 51-83-2; Cholinergic Agonists; Receptors, Cholinergic; gamma-Aminobutyric Acid, 56-12-2 Laboratory of Network Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Cited By :54 Export Date: 24 April 2020 CODEN: EJONE Correspondence Address: Hájos, N.; Laboratory of Network Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary; email: hajos@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; carbachol, 462-58-8, 51-83-2; Carbachol, 51-83-2; Cholinergic Agonists; Receptors, Cholinergic; gamma-Aminobutyric Acid, 56-12-2 Laboratory of Network Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Cited By :54 Export Date: 20 May 2020 CODEN: EJONE Correspondence Address: Hájos, N.; Laboratory of Network Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary; email: hajos@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; carbachol, 462-58-8, 51-83-2; Carbachol, 51-83-2; Cholinergic Agonists; Receptors, Cholinergic; gamma-Aminobutyric Acid, 56-12-2 Laboratory of Network Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Cited By :54 Export Date: 24 May 2020 CODEN: EJONE Correspondence Address: Hájos, N.; Laboratory of Network Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary; email: hajos@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; carbachol, 462-58-8, 51-83-2; Carbachol, 51-83-2; Cholinergic Agonists; Receptors, Cholinergic; gamma-Aminobutyric Acid, 56-12-2 Laboratory of Network Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Cited By :54 Export Date: 25 May 2020 CODEN: EJONE Correspondence Address: Hájos, N.; Laboratory of Network Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary; email: hajos@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; carbachol, 462-58-8, 51-83-2; Carbachol, 51-83-2; Cholinergic Agonists; Receptors, Cholinergic; gamma-Aminobutyric Acid, 56-12-2 Laboratory of Network Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Cited By :54 Export Date: 30 May 2020 CODEN: EJONE Correspondence Address: Hájos, N.; Laboratory of Network Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary; email: hajos@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; carbachol, 462-58-8, 51-83-2; Carbachol, 51-83-2; Cholinergic Agonists; Receptors, Cholinergic; gamma-Aminobutyric Acid, 56-12-2 Laboratory of Network Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Cited By :57 Export Date: 30 December 2020 CODEN: EJONE Correspondence Address: Hájos, N.; Laboratory of Network Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary; email: hajos@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; carbachol, 462-58-8, 51-83-2; Carbachol, 51-83-2; Cholinergic Agonists; Receptors, Cholinergic; gamma-Aminobutyric Acid, 56-12-2 Laboratory of Network Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Cited By :57 Export Date: 1 January 2021 CODEN: EJONE Correspondence Address: Hájos, N.; Laboratory of Network Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary; email: hajos@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; carbachol, 462-58-8, 51-83-2; Carbachol, 51-83-2; Cholinergic Agonists; Receptors, Cholinergic; gamma-Aminobutyric Acid, 56-12-2 Laboratory of Network Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Cited By :57 Export Date: 19 March 2021 CODEN: EJONE Correspondence Address: Hájos, N.; Laboratory of Network Neurophysiology, , H-1083 Budapest, Hungary; email: hajos@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; carbachol, 462-58-8, 51-83-2; Carbachol, 51-83-2; Cholinergic Agonists; Receptors, Cholinergic; gamma-Aminobutyric Acid, 56-12-2 Laboratory of Network Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Cited By :57 Export Date: 23 March 2021 CODEN: EJONE Correspondence Address: Hájos, N.; Laboratory of Network Neurophysiology, , H-1083 Budapest, Hungary; email: hajos@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; carbachol, 462-58-8, 51-83-2; Carbachol, 51-83-2; Cholinergic Agonists; Receptors, Cholinergic; gamma-Aminobutyric Acid, 56-12-2 Laboratory of Network Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Cited By :58 Export Date: 31 March 2021 CODEN: EJONE Correspondence Address: Hájos, N.; Laboratory of Network Neurophysiology, , H-1083 Budapest, Hungary; email: hajos@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; carbachol, 462-58-8, 51-83-2; Carbachol, 51-83-2; Cholinergic Agonists; Receptors, Cholinergic; gamma-Aminobutyric Acid, 56-12-2 Laboratory of Network Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Cited By :58 Export Date: 1 April 2021 CODEN: EJONE Correspondence Address: Hájos, N.; Laboratory of Network Neurophysiology, , H-1083 Budapest, Hungary; email: hajos@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; carbachol, 462-58-8, 51-83-2; Carbachol, 51-83-2; Cholinergic Agonists; Receptors, Cholinergic; gamma-Aminobutyric Acid, 56-12-2 Laboratory of Network Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Cited By :58 Export Date: 6 April 2021 CODEN: EJONE Correspondence Address: Hájos, N.; Laboratory of Network Neurophysiology, , H-1083 Budapest, Hungary; email: hajos@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; carbachol, 462-58-8, 51-83-2; Carbachol, 51-83-2; Cholinergic Agonists; Receptors, Cholinergic; gamma-Aminobutyric Acid, 56-12-2 Laboratory of Network Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Cited By :58 Export Date: 7 April 2021 CODEN: EJONE Correspondence Address: Hájos, N.; Laboratory of Network Neurophysiology, , H-1083 Budapest, Hungary; email: hajos@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; carbachol, 462-58-8, 51-83-2; Carbachol, 51-83-2; Cholinergic Agonists; Receptors, Cholinergic; gamma-Aminobutyric Acid, 56-12-2 AB - Perisomatic inhibition originates from three types of GABAergic interneurons in cortical structures, including parvalbumin-containing fast-spiking basket cells (FSBCs) and axo-axonic cells (AACs), as well as cholecystokinin-expressing regular-spiking basket cells (RSBCs). These interneurons may have significant impact in various cognitive processes, and are subjects of cholinergic modulation. However, it is largely unknown how cholinergic receptor activation modulates the function of perisomatic inhibitory cells. Therefore, we performed paired recordings from anatomically identified perisomatic interneurons and pyramidal cells in the CA3 region of the mouse hippocampus. We determined the basic properties of unitary inhibitory postsynaptic currents (uIPSCs) and found that they differed among cell types, e.g. GABA released from axon endings of AACs evoked uIPSCs with the largest amplitude and with the longest decay measured at room temperature. RSBCs could also release GABA asynchronously, the magnitude of the release increasing with the discharge frequency of the presynaptic interneuron. Cholinergic receptor activation by carbachol significantly decreased the uIPSC amplitude in all three types of cell pairs, but to different extents. M2-type muscarinic receptors were responsible for the reduction in uIPSC amplitudes in FSBC- and AAC-pyramidal cell pairs, while an antagonist of CB(1) cannabinoid receptors recovered the suppression in RSBC-pyramidal cell pairs. In addition, carbachol suppressed or even eliminated the short-term depression of uIPSCs in FSBC- and AAC-pyramidal cell pairs in a frequency-dependent manner. These findings suggest that not only are the basic synaptic properties of perisomatic inhibitory cells distinct, but acetylcholine can differentially control the impact of perisomatic inhibition from different sources. LA - English DB - MTMT ER - TY - JOUR AU - Wittner, Lucia AU - Huberfeld, G AU - Clémenceau, S AU - Erőss, Loránd AU - Dezamis, E AU - Entz, László AU - Ulbert, István AU - Baulac, M AU - Freund, Tamás AU - Maglóczky, Zsófia AU - Miles, R TI - The epileptic human hippocampal cornu ammonis 2 region generates spontaneous interictal-like activity in vitro JF - BRAIN J2 - BRAIN VL - 132 PY - 2009 IS - 11 SP - 3032 EP - 3046 PG - 15 SN - 0006-8950 DO - 10.1093/brain/awp238 UR - https://m2.mtmt.hu/api/publication/208029 ID - 208029 N1 - Megjegyzés-24981302 Megjegyzés-10019648 FU: INSERM ; Bolyai Janos Research Fellowship ; French and Hungarian : governments [NKTH-Fr38/2006]; ANR; OTKA49122, ETT135/2006 [OTKA49122, : ETT135/2006]; European Union [EC LSH-CT-2006-037315, EU IP IST-027017] FX: INSERM (Poste vert to L. W.); the Bolyai Janos Research Fellowship (to : L. W.); French and Hungarian governments (NKTH-Fr38/2006, ANR; : OTKA49122, ETT135/2006); and the European Union (FP7 EPICURE FP6 EC : LSH-CT-2006-037315, NeuroProbes EU IP IST-027017). PN: Part 11 Megjegyzés-10023086 FU: INSERM ; Bolyai Janos Research Fellowship ; French and Hungarian : governments [NKTH-Fr38/2006]; ANR; OTKA49122, ETT135/2006 [OTKA49122, : ETT135/2006]; European Union [EC LSH-CT-2006-037315, EU IP IST-027017] FX: INSERM (Poste vert to L. W.); the Bolyai Janos Research Fellowship (to : L. W.); French and Hungarian governments (NKTH-Fr38/2006, ANR; : OTKA49122, ETT135/2006); and the European Union (FP7 EPICURE FP6 EC : LSH-CT-2006-037315, NeuroProbes EU IP IST-027017). PN: Part 11 Megjegyzés-10069981 FU: INSERM ; Bolyai Janos Research Fellowship ; French and Hungarian : governments [NKTH-Fr38/2006]; ANR; OTKA49122, ETT135/2006 [OTKA49122, : ETT135/2006]; European Union [EC LSH-CT-2006-037315, EU IP IST-027017] FX: INSERM (Poste vert to L. W.); the Bolyai Janos Research Fellowship (to : L. W.); French and Hungarian governments (NKTH-Fr38/2006, ANR; : OTKA49122, ETT135/2006); and the European Union (FP7 EPICURE FP6 EC : LSH-CT-2006-037315, NeuroProbes EU IP IST-027017). PN: Part 11 Megjegyzés-21346272 PN: Part 11 Megjegyzés-10014367 FU: INSERM ; Bolyai Janos Research Fellowship ; French and Hungarian : governments [NKTH-Fr38/2006]; ANR; OTKA49122, ETT135/2006 [OTKA49122, : ETT135/2006]; European Union [EC LSH-CT-2006-037315, EU IP IST-027017] FX: INSERM (Poste vert to L. W.); the Bolyai Janos Research Fellowship (to : L. W.); French and Hungarian governments (NKTH-Fr38/2006, ANR; : OTKA49122, ETT135/2006); and the European Union (FP7 EPICURE FP6 EC : LSH-CT-2006-037315, NeuroProbes EU IP IST-027017). PN: Part 11 INSERM U739, Faculté de Médecine Pitié-Salpêtrire, Paris, France Institute for Psychology, Hungarian Academy of Sciences, Szondi u. 83-85, 1068 Budapest, Hungary National Institute of Neurosurgery, Budapest, Hungary Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Epilepsy Unit, Hôpital Pitié-Salpêtrire, Paris, France Neurosurgery Unit, Hôpital Pitié-Salpêtrire, Paris, France Department of Information Technology, Péter Pázmány Catholic University, Budapest, Hungary Cited By :45 Export Date: 23 August 2019 CODEN: BRAIA Correspondence Address: Wittner, L.; Institute for Psychology, Hungarian Academy of Sciences, Szondi u. 83-85, 1068 Budapest, Hungary; email: wittner@cogpsyphy.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; biocytin, 576-19-2; parvalbumin, 56094-12-3, 83667-75-8; Chlorides; Sodium-Potassium-Chloride Symporters; Symporters; gamma-Aminobutyric Acid, 56-12-2; potassium-chloride symporters; sodium-potassium-chloride cotransporter 1 protein Funding details: Agence Nationale de la Recherche, OTKA49122, ETT135/2006 Funding details: IP IST-027017 Funding details: EPICURE FP6 EC LSH-CT-2006-037315 Funding details: European Commission Funding details: Institut National de la Santé et de la Recherche Médicale Funding details: NKTH-Fr38/2006 Funding text 1: INSERM (Poste vert to L.W.); the Bolyai János Research Fellowship (to L.W.); French and Hungarian governments (NKTH-Fr38/2006, ANR; OTKA49122, ETT135/2006); and the European Union (FP7 EPICURE FP6 EC LSH-CT-2006-037315, NeuroProbes EU IP IST-027017). INSERM U739, Faculté de Médecine Pitié-Salpêtrire, Paris, France Institute for Psychology, Hungarian Academy of Sciences, Szondi u. 83-85, 1068 Budapest, Hungary National Institute of Neurosurgery, Budapest, Hungary Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Epilepsy Unit, Hôpital Pitié-Salpêtrire, Paris, France Neurosurgery Unit, Hôpital Pitié-Salpêtrire, Paris, France Department of Information Technology, Péter Pázmány Catholic University, Budapest, Hungary Cited By :45 Export Date: 24 August 2019 CODEN: BRAIA Correspondence Address: Wittner, L.; Institute for Psychology, Hungarian Academy of Sciences, Szondi u. 83-85, 1068 Budapest, Hungary; email: wittner@cogpsyphy.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; biocytin, 576-19-2; parvalbumin, 56094-12-3, 83667-75-8; Chlorides; Sodium-Potassium-Chloride Symporters; Symporters; gamma-Aminobutyric Acid, 56-12-2; potassium-chloride symporters; sodium-potassium-chloride cotransporter 1 protein Funding details: Agence Nationale de la Recherche, OTKA49122, ETT135/2006 Funding details: IP IST-027017 Funding details: EPICURE FP6 EC LSH-CT-2006-037315 Funding details: European Commission Funding details: Institut National de la Santé et de la Recherche Médicale Funding details: NKTH-Fr38/2006 Funding text 1: INSERM (Poste vert to L.W.); the Bolyai János Research Fellowship (to L.W.); French and Hungarian governments (NKTH-Fr38/2006, ANR; OTKA49122, ETT135/2006); and the European Union (FP7 EPICURE FP6 EC LSH-CT-2006-037315, NeuroProbes EU IP IST-027017). INSERM U739, Faculté de Médecine Pitié-Salpêtrire, Paris, France Institute for Psychology, Hungarian Academy of Sciences, Szondi u. 83-85, 1068 Budapest, Hungary National Institute of Neurosurgery, Budapest, Hungary Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Epilepsy Unit, Hôpital Pitié-Salpêtrire, Paris, France Neurosurgery Unit, Hôpital Pitié-Salpêtrire, Paris, France Department of Information Technology, Péter Pázmány Catholic University, Budapest, Hungary Cited By :46 Export Date: 24 February 2020 CODEN: BRAIA Correspondence Address: Wittner, L.; Institute for Psychology, Hungarian Academy of Sciences, Szondi u. 83-85, 1068 Budapest, Hungary; email: wittner@cogpsyphy.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; biocytin, 576-19-2; parvalbumin, 56094-12-3, 83667-75-8; Chlorides; Sodium-Potassium-Chloride Symporters; Symporters; gamma-Aminobutyric Acid, 56-12-2; potassium-chloride symporters; sodium-potassium-chloride cotransporter 1 protein Funding details: Agence Nationale de la Recherche, ANR, OTKA49122, ETT135/2006 Funding details: European Commission, EC, FP7 EPICURE FP6 EC LSH-CT-2006-037315 Funding details: IP IST-027017 Funding details: Institut National de la Santé et de la Recherche Médicale, Inserm Funding details: NKTH-Fr38/2006 Funding text 1: INSERM (Poste vert to L.W.); the Bolyai János Research Fellowship (to L.W.); French and Hungarian governments (NKTH-Fr38/2006, ANR; OTKA49122, ETT135/2006); and the European Union (FP7 EPICURE FP6 EC LSH-CT-2006-037315, NeuroProbes EU IP IST-027017). INSERM U739, Faculté de Médecine Pitié-Salpêtrire, Paris, France Institute for Psychology, Hungarian Academy of Sciences, Szondi u. 83-85, 1068 Budapest, Hungary National Institute of Neurosurgery, Budapest, Hungary Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Epilepsy Unit, Hôpital Pitié-Salpêtrire, Paris, France Neurosurgery Unit, Hôpital Pitié-Salpêtrire, Paris, France Department of Information Technology, Péter Pázmány Catholic University, Budapest, Hungary Cited By :46 Export Date: 28 May 2020 CODEN: BRAIA Correspondence Address: Wittner, L.; Institute for Psychology, Hungarian Academy of Sciences, Szondi u. 83-85, 1068 Budapest, Hungary; email: wittner@cogpsyphy.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; biocytin, 576-19-2; parvalbumin, 56094-12-3, 83667-75-8; Chlorides; Sodium-Potassium-Chloride Symporters; Symporters; gamma-Aminobutyric Acid, 56-12-2; potassium-chloride symporters; sodium-potassium-chloride cotransporter 1 protein Funding details: Agence Nationale de la Recherche, ANR, OTKA49122, ETT135/2006 Funding details: European Commission, EC, FP7 EPICURE FP6 EC LSH-CT-2006-037315 Funding details: IP IST-027017 Funding details: Institut National de la Santé et de la Recherche Médicale, Inserm Funding details: NKTH-Fr38/2006 Funding text 1: INSERM (Poste vert to L.W.); the Bolyai János Research Fellowship (to L.W.); French and Hungarian governments (NKTH-Fr38/2006, ANR; OTKA49122, ETT135/2006); and the European Union (FP7 EPICURE FP6 EC LSH-CT-2006-037315, NeuroProbes EU IP IST-027017). LA - English DB - MTMT ER - TY - JOUR AU - Klausberger, T AU - Somogyi, Péter Pál TI - Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations. JF - SCIENCE J2 - SCIENCE VL - 321 PY - 2008 IS - 5885 SP - 53 EP - 57 PG - 5 SN - 0036-8075 DO - 10.1126/science.1149381 UR - https://m2.mtmt.hu/api/publication/2086363 ID - 2086363 N1 - Megjegyzés-27028849 Megjegyzés-10324201 [273006] Megjegyzés-21921752 Z9: 231 WC: Multidisciplinary Sciences Cited By :1085 Export Date: 21 August 2019 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1106 Export Date: 14 November 2019 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1133 Export Date: 6 March 2020 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1133 Export Date: 12 March 2020 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1140 Export Date: 15 April 2020 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1158 Export Date: 18 May 2020 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1161 Export Date: 20 May 2020 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1162 Export Date: 23 May 2020 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1162 Export Date: 24 May 2020 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1162 Export Date: 25 May 2020 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1235 Export Date: 18 March 2021 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, , Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1235 Export Date: 23 March 2021 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, , Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1239 Export Date: 31 March 2021 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, , Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1239 Export Date: 6 April 2021 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, , Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1239 Export Date: 7 April 2021 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, , Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1241 Export Date: 13 April 2021 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, , Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1241 Export Date: 14 April 2021 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, , Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1244 Export Date: 20 April 2021 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, , Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1244 Export Date: 26 April 2021 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, , Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 Cited By :1283 Export Date: 7 September 2021 CODEN: SCIEA Correspondence Address: Klausberger, T.; MRC Anatomical Neuropharmacology Unit, , Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2 AB - In the cerebral cortex, diverse types of neurons form intricate circuits and cooperate in time for the processing and storage of information. Recent advances reveal a spatiotemporal division of labor in cortical circuits, as exemplified in the CA1 hippocampal area. In particular, distinct GABAergic (gamma- aminobutyric acid-releasing) cell types subdivide the surface of pyramidal cells and act in discrete time windows, either on the same or on different subcellular compartments. They also interact with glutamatergic pyramidal cell inputs in a domain- specific manner and support synaptic temporal dynamics, network oscillations, selection of cell assemblies, and the implementation of brain states. The spatiotemporal specializations in cortical circuits reveal that cellular diversity and temporal dynamics coemerged during evolution, providing a basis for cognitive behavior. LA - English DB - MTMT ER - TY - JOUR AU - Ludányi, Anikó AU - Erőss, Loránd AU - Czirják, Sándor AU - Vajda, János AU - Halász, Péter AU - Watanabe, M AU - Palkovits, Miklós AU - Maglóczky, Zsófia AU - Freund, Tamás AU - Katona, István TI - Downregulation of the CB1 cannabinoid receptor and related molecular elements of the endocannabinoid system in epileptic human hippocampus JF - JOURNAL OF NEUROSCIENCE J2 - J NEUROSCI VL - 28 PY - 2008 IS - 12 SP - 2976 EP - 2990 PG - 15 SN - 0270-6474 DO - 10.1523/JNEUROSCI.4465-07.2008 UR - https://m2.mtmt.hu/api/publication/153972 ID - 153972 N1 - Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary National Institute of Neurosurgery, H-1145 Budapest, Hungary National Institute of Psychiatry and Neurology, Epilepsy Center, H-1021 Budapest, Hungary Department of Anatomy, Hokkaido University School of Medicine, 060-8638 Sapporo, Japan Neuromorphological and Neuroendocrine Research Laboratory, Department of Anatomy, Semmelweis University and Hungarian Academy of Sciences, H-1094 Budapest, Hungary Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony utca 43, H-1083 Budapest, Hungary Cited By :211 Export Date: 11 December 2024 CODEN: JNRSD Correspondence Address: Katona, I.; Institute of Experimental Medicine, Szigony utca 43, H-1083 Budapest, Hungary; email: katona@koki.hu Chemicals/CAS: acylglycerol lipase, 9040-75-9; anandamide, 94421-68-8; fatty acid amidase, 153301-19-0; lipoprotein lipase, 83137-80-8, 9004-02-8; phosphatidylethanolamine, 1405-71-6; phospholipase D, 9001-87-0; 4 aminobutyric acid, 28805-76-7, 56-12-2; carrier protein, 80700-39-6; CRIP1 protein, human; Carrier Proteins; Endocannabinoids; RNA, Messenger; Receptor, Cannabinoid, CB1; gamma-Aminobutyric Acid, 56-12-2 LA - English DB - MTMT ER - TY - JOUR AU - Molnár, Gábor AU - Oláh, Szabolcs AU - Komlósi, Gergely AU - Füle, Miklós Jenő AU - Szabadics, János AU - Varga, Csaba AU - Barzó, Pál AU - Tamás, Gábor TI - Complex Events Initiated by Individual Spikes in the Human Cerebral Cortex JF - PLOS BIOLOGY J2 - PLOS BIOL VL - 6 PY - 2008 IS - 9 SP - 1842 EP - 1849 PG - 8 SN - 1544-9173 DO - 10.1371/journal.pbio.0060222 UR - https://m2.mtmt.hu/api/publication/247844 ID - 247844 N1 - * Megosztott szerzőség LA - English DB - MTMT ER - TY - JOUR AU - Freund, Tamás AU - Katona, István TI - Perisomatic inhibition JF - NEURON J2 - NEURON VL - 56 PY - 2007 IS - 1 SP - 33 EP - 42 PG - 10 SN - 0896-6273 DO - 10.1016/j.neuron.2007.09.012 UR - https://m2.mtmt.hu/api/publication/109659 ID - 109659 N1 - Cited By :415 Export Date: 31 March 2021 CODEN: NERNE Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, POB 67, Budapest, H-1450, Hungary; email: freund@koki.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8; Cholecystokinin, 9011-97-6; Parvalbumins Funding details: Howard Hughes Medical Institute, HHMI Funding details: European Commission, EC, LSHM-CT-2004-005166 Funding details: Hungarian Scientific Research Fund, OTKA, F046407, T46820 Funding text 1: The authors are grateful to Drs. G. Buzsáki, A. Gulyás, N. Hájos, I. Mody, G. Nyiri, and V. Varga as well as to Dr. P. Somogyi and to the anonymous reviewers for their helpful comments on the manuscript and to Dr. G. Nyiri for his help with the summary diagrams. The study has been supported by EU (LSHM-CT-2004-005166) and by the Howard Hughes Medical Institute, OTKA (T46820) and (F046407). I.K. is a grantee of the János Bolyai scholarship. Cited By :416 Export Date: 1 April 2021 CODEN: NERNE Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, POB 67, Budapest, H-1450, Hungary; email: freund@koki.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8; Cholecystokinin, 9011-97-6; Parvalbumins Funding details: Howard Hughes Medical Institute, HHMI Funding details: European Commission, EC, LSHM-CT-2004-005166 Funding details: Hungarian Scientific Research Fund, OTKA, F046407, T46820 Funding text 1: The authors are grateful to Drs. G. Buzsáki, A. Gulyás, N. Hájos, I. Mody, G. Nyiri, and V. Varga as well as to Dr. P. Somogyi and to the anonymous reviewers for their helpful comments on the manuscript and to Dr. G. Nyiri for his help with the summary diagrams. The study has been supported by EU (LSHM-CT-2004-005166) and by the Howard Hughes Medical Institute, OTKA (T46820) and (F046407). I.K. is a grantee of the János Bolyai scholarship. Cited By :416 Export Date: 6 April 2021 CODEN: NERNE Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, POB 67, Budapest, H-1450, Hungary; email: freund@koki.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8; Cholecystokinin, 9011-97-6; Parvalbumins Funding details: Howard Hughes Medical Institute, HHMI Funding details: European Commission, EC, LSHM-CT-2004-005166 Funding details: Hungarian Scientific Research Fund, OTKA, F046407, T46820 Funding text 1: The authors are grateful to Drs. G. Buzsáki, A. Gulyás, N. Hájos, I. Mody, G. Nyiri, and V. Varga as well as to Dr. P. Somogyi and to the anonymous reviewers for their helpful comments on the manuscript and to Dr. G. Nyiri for his help with the summary diagrams. The study has been supported by EU (LSHM-CT-2004-005166) and by the Howard Hughes Medical Institute, OTKA (T46820) and (F046407). I.K. is a grantee of the János Bolyai scholarship. Cited By :416 Export Date: 12 April 2021 CODEN: NERNE Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, POB 67, Budapest, H-1450, Hungary; email: freund@koki.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8; Cholecystokinin, 9011-97-6; Parvalbumins Funding details: Howard Hughes Medical Institute, HHMI Funding details: European Commission, EC, LSHM-CT-2004-005166 Funding details: Hungarian Scientific Research Fund, OTKA, F046407, T46820 Funding text 1: The authors are grateful to Drs. G. Buzsáki, A. Gulyás, N. Hájos, I. Mody, G. Nyiri, and V. Varga as well as to Dr. P. Somogyi and to the anonymous reviewers for their helpful comments on the manuscript and to Dr. G. Nyiri for his help with the summary diagrams. The study has been supported by EU (LSHM-CT-2004-005166) and by the Howard Hughes Medical Institute, OTKA (T46820) and (F046407). I.K. is a grantee of the János Bolyai scholarship. Cited By :416 Export Date: 20 April 2021 CODEN: NERNE Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, POB 67, Budapest, H-1450, Hungary; email: freund@koki.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8; Cholecystokinin, 9011-97-6; Parvalbumins Funding details: Howard Hughes Medical Institute, HHMI Funding details: European Commission, EC, LSHM-CT-2004-005166 Funding details: Hungarian Scientific Research Fund, OTKA, F046407, T46820 Funding text 1: The authors are grateful to Drs. G. Buzsáki, A. Gulyás, N. Hájos, I. Mody, G. Nyiri, and V. Varga as well as to Dr. P. Somogyi and to the anonymous reviewers for their helpful comments on the manuscript and to Dr. G. Nyiri for his help with the summary diagrams. The study has been supported by EU (LSHM-CT-2004-005166) and by the Howard Hughes Medical Institute, OTKA (T46820) and (F046407). I.K. is a grantee of the János Bolyai scholarship. AB - Recent evidence supports the hypothesis of a functional dichotomy of perisomatic inhibition in the cerebral cortex: the parvalbumin- and cholecystokinin-containing basket cells that are specialized to control rhythm (as a clockwork) and "mood" (as a fine-tuning device), respectively, of network oscillations. Pathology extends this conclusion further, as the former is implicated in epilepsy and the latter in anxiety. The well-balanced cooperation of the two inhibitory systems is required for the normal network operations underlying the cognitive functions of the cerebral cortex. LA - English DB - MTMT ER - TY - JOUR AU - Katona, István AU - Katona-Urbán, Gabriella AU - Wallace, M AU - Ledent, C AU - Jung, KM AU - Piomelli, D AU - Mackie, K AU - Freund, Tamás TI - Molecular composition of the endocannabinoid system at glutamatergic synapses JF - JOURNAL OF NEUROSCIENCE J2 - J NEUROSCI VL - 26 PY - 2006 SP - 5628 EP - 5637 PG - 10 SN - 0270-6474 DO - 10.1523/JNEUROSCI.0309-06.2006 UR - https://m2.mtmt.hu/api/publication/109516 ID - 109516 N1 - Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary Department of Anesthesiology, University of Washington, Seattle, WA 98195, United States Université Libre de Bruxelles, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, 1070 Bruxelles, Belgium Department of Pharmacology, Center for Drug Discovery, University of California, Irvine, Irvine, CA 92697, United States Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony utca 43, H-1083 Budapest, Hungary Cited By :414 Export Date: 7 June 2023 CODEN: JNRSD Correspondence Address: Katona, I.; Institute of Experimental Medicine, Szigony utca 43, H-1083 Budapest, Hungary; email: katona@koki.hu Chemicals/CAS: acylglycerol, 64706-27-0; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; lipoprotein lipase, 83137-80-8, 9004-02-8; 2-arachidonylglycerol, 53847-30-6; Arachidonic Acids; Glutamic Acid, 56-86-0; Glycerides; Lipoprotein Lipase, EC 3.1.1.34; Receptor, Cannabinoid, CB1 Funding details: National Institute on Drug Abuse, NIDA, K02DA000286, R01DA011322, R01DA012413, R01DA012447 Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R01NS030549 LA - English DB - MTMT ER - TY - JOUR AU - Klausberger, T AU - Marton, LF AU - O, Neill J AU - Huck, JH AU - Dalezios, Y AU - Fuentealba, P AU - Suen, WY AU - Papp, Edit AU - Kaneko, T AU - Watanabe, M AU - Csicsvari, J AU - Somogyi, Péter Pál TI - Complementary roles of cholecystokinin- and parvalbumin-expressing GABAergic neurons in hippocampal network oscillations JF - JOURNAL OF NEUROSCIENCE J2 - J NEUROSCI VL - 25 PY - 2005 IS - 42 SP - 9782 EP - 9793 PG - 12 SN - 0270-6474 DO - 10.1523/JNEUROSCI.3269-05.2005 UR - https://m2.mtmt.hu/api/publication/109559 ID - 109559 N1 - Megjegyzés-25003763 Megjegyzés-21899100 Z9: 111 Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom Center for Brain Research, Medical University, 1090 Vienna, Austria Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan Department of Anatomy, Hokkaido University School of Medicine, 060-3638 Sapporo, Japan Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Mansfield Road, Oxford OX1 3TH, United Kingdom Cited By :266 Export Date: 21 August 2019 CODEN: JNRSD Correspondence Address: Klausberger, T.; Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Mansfield Road, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8; Cholecystokinin, 9011-97-6; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Receptors, GABA Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom Center for Brain Research, Medical University, 1090 Vienna, Austria Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan Department of Anatomy, Hokkaido University School of Medicine, 060-3638 Sapporo, Japan Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Mansfield Road, Oxford OX1 3TH, United Kingdom Cited By :271 Export Date: 12 March 2020 CODEN: JNRSD Correspondence Address: Klausberger, T.; Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Mansfield Road, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8; Cholecystokinin, 9011-97-6; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Receptors, GABA Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom Center for Brain Research, Medical University, 1090 Vienna, Austria Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan Department of Anatomy, Hokkaido University School of Medicine, 060-3638 Sapporo, Japan Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Mansfield Road, Oxford OX1 3TH, United Kingdom Cited By :273 Export Date: 11 May 2020 CODEN: JNRSD Correspondence Address: Klausberger, T.; Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Mansfield Road, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8; Cholecystokinin, 9011-97-6; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Receptors, GABA Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom Center for Brain Research, Medical University, 1090 Vienna, Austria Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan Department of Anatomy, Hokkaido University School of Medicine, 060-3638 Sapporo, Japan Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Mansfield Road, Oxford OX1 3TH, United Kingdom Cited By :274 Export Date: 20 May 2020 CODEN: JNRSD Correspondence Address: Klausberger, T.; Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Mansfield Road, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8; Cholecystokinin, 9011-97-6; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Receptors, GABA Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom Center for Brain Research, Medical University, 1090 Vienna, Austria Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan Department of Anatomy, Hokkaido University School of Medicine, 060-3638 Sapporo, Japan Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Mansfield Road, Oxford OX1 3TH, United Kingdom Cited By :274 Export Date: 24 May 2020 CODEN: JNRSD Correspondence Address: Klausberger, T.; Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Mansfield Road, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8; Cholecystokinin, 9011-97-6; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Receptors, GABA Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom Center for Brain Research, Medical University, 1090 Vienna, Austria Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan Department of Anatomy, Hokkaido University School of Medicine, 060-3638 Sapporo, Japan Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Mansfield Road, Oxford OX1 3TH, United Kingdom Cited By :274 Export Date: 25 May 2020 CODEN: JNRSD Correspondence Address: Klausberger, T.; Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Mansfield Road, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8; Cholecystokinin, 9011-97-6; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Receptors, GABA Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom Center for Brain Research, Medical University, 1090 Vienna, Austria Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan Department of Anatomy, Hokkaido University School of Medicine, 060-3638 Sapporo, Japan Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Mansfield Road, Oxford OX1 3TH, United Kingdom Cited By :295 Export Date: 19 March 2021 CODEN: JNRSD Correspondence Address: Klausberger, T.; Medical Research Council Anatomical Neuropharmacology Unit, Mansfield Road, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8; Cholecystokinin, 9011-97-6; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Receptors, GABA Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom Center for Brain Research, Medical University, 1090 Vienna, Austria Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan Department of Anatomy, Hokkaido University School of Medicine, 060-3638 Sapporo, Japan Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Mansfield Road, Oxford OX1 3TH, United Kingdom Cited By :295 Export Date: 23 March 2021 CODEN: JNRSD Correspondence Address: Klausberger, T.; Medical Research Council Anatomical Neuropharmacology Unit, Mansfield Road, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8; Cholecystokinin, 9011-97-6; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Receptors, GABA Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom Center for Brain Research, Medical University, 1090 Vienna, Austria Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan Department of Anatomy, Hokkaido University School of Medicine, 060-3638 Sapporo, Japan Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Mansfield Road, Oxford OX1 3TH, United Kingdom Cited By :296 Export Date: 31 March 2021 CODEN: JNRSD Correspondence Address: Klausberger, T.; Medical Research Council Anatomical Neuropharmacology Unit, Mansfield Road, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8; Cholecystokinin, 9011-97-6; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Receptors, GABA Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom Center for Brain Research, Medical University, 1090 Vienna, Austria Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan Department of Anatomy, Hokkaido University School of Medicine, 060-3638 Sapporo, Japan Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Mansfield Road, Oxford OX1 3TH, United Kingdom Cited By :296 Export Date: 1 April 2021 CODEN: JNRSD Correspondence Address: Klausberger, T.; Medical Research Council Anatomical Neuropharmacology Unit, Mansfield Road, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8; Cholecystokinin, 9011-97-6; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Receptors, GABA Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom Center for Brain Research, Medical University, 1090 Vienna, Austria Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan Department of Anatomy, Hokkaido University School of Medicine, 060-3638 Sapporo, Japan Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Mansfield Road, Oxford OX1 3TH, United Kingdom Cited By :296 Export Date: 13 April 2021 CODEN: JNRSD Correspondence Address: Klausberger, T.; Medical Research Council Anatomical Neuropharmacology Unit, Mansfield Road, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8; Cholecystokinin, 9011-97-6; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Receptors, GABA Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom Center for Brain Research, Medical University, 1090 Vienna, Austria Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan Department of Anatomy, Hokkaido University School of Medicine, 060-3638 Sapporo, Japan Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Mansfield Road, Oxford OX1 3TH, United Kingdom Cited By :296 Export Date: 14 April 2021 CODEN: JNRSD Correspondence Address: Klausberger, T.; Medical Research Council Anatomical Neuropharmacology Unit, Mansfield Road, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8; Cholecystokinin, 9011-97-6; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Receptors, GABA Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom Center for Brain Research, Medical University, 1090 Vienna, Austria Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan Department of Anatomy, Hokkaido University School of Medicine, 060-3638 Sapporo, Japan Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Mansfield Road, Oxford OX1 3TH, United Kingdom Cited By :296 Export Date: 26 April 2021 CODEN: JNRSD Correspondence Address: Klausberger, T.; Medical Research Council Anatomical Neuropharmacology Unit, Mansfield Road, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8; Cholecystokinin, 9011-97-6; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Receptors, GABA Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom Center for Brain Research, Medical University, 1090 Vienna, Austria Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan Department of Anatomy, Hokkaido University School of Medicine, 060-3638 Sapporo, Japan Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Mansfield Road, Oxford OX1 3TH, United Kingdom Cited By :301 Export Date: 7 September 2021 CODEN: JNRSD Correspondence Address: Klausberger, T.; Medical Research Council Anatomical Neuropharmacology Unit, Mansfield Road, Oxford OX1 3TH, United Kingdom; email: thomas.klausberger@pharm.ox.ac.uk Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8; Cholecystokinin, 9011-97-6; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins; Receptors, GABA AB - In the hippocampal CA1 area, a relatively homogenous population of pyramidal cells is accompanied by a diversity of GABAergic interneurons. Previously, we found that parvalbumin-expressing basket, axo-axonic, bistratified, and oriens-lacunosum moleculare cells, innervating different domains of pyramidal cells, have distinct firing patterns during network oscillations in vivo. A second family of interneurons, expressing cholecystokinin but not parvalbumin, is known to target the same domains of pyramidal cells as do the parvalbumin cells. To test the temporal activity of these independent and parallel GABAergic inputs, we recorded the precise spike timing of identified cholecystokinin interneurons during hippocampal network oscillations in anesthetized rats and determined their molecular expression profiles and synaptic targets. The cells were cannabinoid receptor type 1 immunopositive. Contrary to the stereotyped firing of parvalbumin interneurons, cholecystokinin-expressing basket and dendrite-innervating cells discharge, on average, with 1.7 +/- 2.0 Hz during high-frequency ripple oscillations in an episode- dependent manner. During theta oscillations, cholecystokinin-expressing interneurons fire with 8.8 +/- 3.3 Hz at a characteristic time on the ascending phase of theta waves (155 +/- 81), when place cells start firing in freely moving animals. The firing patterns of some interneurons recorded in drug- free behaving rats were similar to cholecystokinin cells in anesthetized animals. Our results demonstrate that cholecystokinin- and parvalbumin- expressing interneurons make different contributions to network oscillations and play distinct roles in different brain states. We suggest that the specific spike timing of cholecystokinin interneurons and their sensitivity to endocannabinoids might contribute to differentiate subgroups of pyramidal cells forming neuronal assemblies, whereas parvalbumin interneurons contribute to synchronizing the entire network. LA - English DB - MTMT ER - TY - JOUR AU - Maglóczky, Zsófia AU - Freund, Tamás TI - Impaired and repaired inhibitory circuits in the epileptic human hippocampus JF - TRENDS IN NEUROSCIENCES J2 - TRENDS NEUROSCI VL - 28 PY - 2005 SP - 334 EP - 340 PG - 7 SN - 0166-2236 DO - 10.1016/j.tins.2005.04.002 UR - https://m2.mtmt.hu/api/publication/109599 ID - 109599 N1 - Megjegyzés-20620036 Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamate decarboxylase, 9024-58-2; neuropeptide Y, 82785-45-3, 83589-17-7; somatostatin, 38916-34-6, 51110-01-1; calbindin; Calcium-Binding Protein, Vitamin D-Dependent; gamma-Aminobutyric Acid, 56-12-2; Parvalbumins Cited By :136 Export Date: 23 August 2019 CODEN: TNSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, POB 67, Budapest, H-1450, Hungary; email: freund@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamate decarboxylase, 9024-58-2; neuropeptide Y, 82785-45-3, 83589-17-7; somatostatin, 38916-34-6, 51110-01-1 Funding details: Howard Hughes Medical Institute, 46820 Funding details: National Institutes of Health, MH54671 Funding text 1: This work was supported by National Institutes of Health Grant MH54671, the Howard Hughes Medical Institute, Országos Tudományos Kutatási Alapprogramok Grants T 46820. We also thank Katalin Lengyel, Emőke Simon, and Győző Goda for technical help. Cited By :136 Export Date: 24 August 2019 CODEN: TNSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, POB 67, Budapest, H-1450, Hungary; email: freund@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamate decarboxylase, 9024-58-2; neuropeptide Y, 82785-45-3, 83589-17-7; somatostatin, 38916-34-6, 51110-01-1 Funding details: Howard Hughes Medical Institute, 46820 Funding details: National Institutes of Health, MH54671 Funding text 1: This work was supported by National Institutes of Health Grant MH54671, the Howard Hughes Medical Institute, Országos Tudományos Kutatási Alapprogramok Grants T 46820. We also thank Katalin Lengyel, Emőke Simon, and Győző Goda for technical help. Cited By :136 Export Date: 24 February 2020 CODEN: TNSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, POB 67, Budapest, H-1450, Hungary; email: freund@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamate decarboxylase, 9024-58-2; neuropeptide Y, 82785-45-3, 83589-17-7; somatostatin, 38916-34-6, 51110-01-1 Funding details: Howard Hughes Medical Institute, HHMI Funding details: National Institutes of Health, NIH, MH54671 Funding details: 46820 Funding text 1: This work was supported by National Institutes of Health Grant MH54671, the Howard Hughes Medical Institute, Országos Tudományos Kutatási Alapprogramok Grants T 46820. We also thank Katalin Lengyel, Emőke Simon, and Győző Goda for technical help. Cited By :137 Export Date: 12 March 2020 CODEN: TNSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, POB 67, Budapest, H-1450, Hungary; email: freund@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamate decarboxylase, 9024-58-2; neuropeptide Y, 82785-45-3, 83589-17-7; somatostatin, 38916-34-6, 51110-01-1 Funding details: Howard Hughes Medical Institute, HHMI Funding details: National Institutes of Health, NIH, MH54671 Funding details: 46820 Funding text 1: This work was supported by National Institutes of Health Grant MH54671, the Howard Hughes Medical Institute, Országos Tudományos Kutatási Alapprogramok Grants T 46820. We also thank Katalin Lengyel, Emőke Simon, and Győző Goda for technical help. Cited By :139 Export Date: 25 May 2020 CODEN: TNSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, POB 67, Budapest, H-1450, Hungary; email: freund@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamate decarboxylase, 9024-58-2; neuropeptide Y, 82785-45-3, 83589-17-7; somatostatin, 38916-34-6, 51110-01-1 Funding details: Howard Hughes Medical Institute, HHMI Funding details: National Institutes of Health, NIH, MH54671 Funding details: 46820 Funding text 1: This work was supported by National Institutes of Health Grant MH54671, the Howard Hughes Medical Institute, Országos Tudományos Kutatási Alapprogramok Grants T 46820. We also thank Katalin Lengyel, Emőke Simon, and Győző Goda for technical help. Cited By :139 Export Date: 28 May 2020 CODEN: TNSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, POB 67, Budapest, H-1450, Hungary; email: freund@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamate decarboxylase, 9024-58-2; neuropeptide Y, 82785-45-3, 83589-17-7; somatostatin, 38916-34-6, 51110-01-1 Funding details: Howard Hughes Medical Institute, HHMI Funding details: National Institutes of Health, NIH, MH54671 Funding details: 46820 Funding text 1: This work was supported by National Institutes of Health Grant MH54671, the Howard Hughes Medical Institute, Országos Tudományos Kutatási Alapprogramok Grants T 46820. We also thank Katalin Lengyel, Emőke Simon, and Győző Goda for technical help. Cited By :152 Export Date: 31 March 2021 CODEN: TNSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, POB 67, Budapest, H-1450, Hungary; email: freund@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamate decarboxylase, 9024-58-2; neuropeptide Y, 82785-45-3, 83589-17-7; somatostatin, 38916-34-6, 51110-01-1 Funding details: 46820 Funding details: National Institutes of Health, NIH, MH54671 Funding details: Howard Hughes Medical Institute, HHMI Funding text 1: This work was supported by National Institutes of Health Grant MH54671, the Howard Hughes Medical Institute, Országos Tudományos Kutatási Alapprogramok Grants T 46820. We also thank Katalin Lengyel, Emőke Simon, and Győző Goda for technical help. Cited By :152 Export Date: 1 April 2021 CODEN: TNSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, POB 67, Budapest, H-1450, Hungary; email: freund@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamate decarboxylase, 9024-58-2; neuropeptide Y, 82785-45-3, 83589-17-7; somatostatin, 38916-34-6, 51110-01-1 Funding details: 46820 Funding details: National Institutes of Health, NIH, MH54671 Funding details: Howard Hughes Medical Institute, HHMI Funding text 1: This work was supported by National Institutes of Health Grant MH54671, the Howard Hughes Medical Institute, Országos Tudományos Kutatási Alapprogramok Grants T 46820. We also thank Katalin Lengyel, Emőke Simon, and Győző Goda for technical help. Cited By :152 Export Date: 6 April 2021 CODEN: TNSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, POB 67, Budapest, H-1450, Hungary; email: freund@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamate decarboxylase, 9024-58-2; neuropeptide Y, 82785-45-3, 83589-17-7; somatostatin, 38916-34-6, 51110-01-1 Funding details: 46820 Funding details: National Institutes of Health, NIH, MH54671 Funding details: Howard Hughes Medical Institute, HHMI Funding text 1: This work was supported by National Institutes of Health Grant MH54671, the Howard Hughes Medical Institute, Országos Tudományos Kutatási Alapprogramok Grants T 46820. We also thank Katalin Lengyel, Emőke Simon, and Győző Goda for technical help. Cited By :152 Export Date: 14 April 2021 CODEN: TNSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, POB 67, Budapest, H-1450, Hungary; email: freund@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamate decarboxylase, 9024-58-2; neuropeptide Y, 82785-45-3, 83589-17-7; somatostatin, 38916-34-6, 51110-01-1 Funding details: 46820 Funding details: National Institutes of Health, NIH, MH54671 Funding details: Howard Hughes Medical Institute, HHMI Funding text 1: This work was supported by National Institutes of Health Grant MH54671, the Howard Hughes Medical Institute, Országos Tudományos Kutatási Alapprogramok Grants T 46820. We also thank Katalin Lengyel, Emőke Simon, and Győző Goda for technical help. Cited By :156 Export Date: 7 September 2021 CODEN: TNSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, POB 67, Budapest, H-1450, Hungary; email: freund@koki.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamate decarboxylase, 9024-58-2; neuropeptide Y, 82785-45-3, 83589-17-7; somatostatin, 38916-34-6, 51110-01-1 Funding details: 46820 Funding details: National Institutes of Health, NIH, MH54671 Funding details: Howard Hughes Medical Institute, HHMI Funding text 1: This work was supported by National Institutes of Health Grant MH54671, the Howard Hughes Medical Institute, Országos Tudományos Kutatási Alapprogramok Grants T 46820. We also thank Katalin Lengyel, Emőke Simon, and Győző Goda for technical help. LA - English DB - MTMT ER - TY - JOUR AU - Wittner, Lucia AU - Erőss, Loránd AU - Czirják, Sándor AU - Halász, Péter AU - Freund, Tamás AU - Maglóczky, Zsófia TI - Surviving CA1 pyramidal cells receive intact perisomatic inhibitory input in the human epileptic hippocampus JF - BRAIN J2 - BRAIN VL - 128 PY - 2005 SP - 138 EP - 152 PG - 15 SN - 0006-8950 DO - 10.1093/brain/awh339 UR - https://m2.mtmt.hu/api/publication/109379 ID - 109379 N1 - Institute of Experimental Medicine, Hungarian Academy of Science, Budapest, Hungary Neurosurgical Department, MÁV Hospital Budapest, Budapest, Hungary National Institute of Neurosurgery, Budapest, Hungary Natl. Inst. of Psychiat. and Neurol., Epilepsy Center, Budapest, Hungary Institute of Experimental Medicine, Hungarian Academy of Sciences, POB 67, H-1450 Budapest, Hungary Cited By :95 Export Date: 13 February 2025 CODEN: BRAIA Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, POB 67, H-1450 Budapest, Hungary; email: freund@koki.hu Chemicals/CAS: parvalbumin, 56094-12-3, 83667-75-8 Funding details: National Institutes of Health, NIH, MH 54671 Funding details: Howard Hughes Medical Institute, HHMI, 55000307 Funding details: Hungarian Scientific Research Fund, OTKA, T032251 Funding text 1: We wish to thank Drs M. Palkovits, P. Sótonyi and Zs. Borostyánkoi (Semmelweis University, Budapest) for providing control human tissue, and Ms K. Lengyel, E. Simon and Mr Gy. Goda for excellent technical assistance. This study was supported by grants from the NIH (MH 54671), the Howard Hughes Medical Institute (55000307) and OTKA (T032251) Hungary. LA - English DB - MTMT ER - TY - JOUR AU - Freund, Tamás TI - Interneuron diversity series: Rhythm and mood in perisomatic inhibition JF - TRENDS IN NEUROSCIENCES J2 - TRENDS NEUROSCI VL - 26 PY - 2003 SP - 489 EP - 495 PG - 7 SN - 0166-2236 DO - 10.1016/S0166-2236(03)00227-3 UR - https://m2.mtmt.hu/api/publication/109314 ID - 109314 N1 - Cited By :523 Export Date: 1 June 2023 CODEN: TNSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, PO Box 67, Budapest, H-1450, Hungary; email: freund@koki.hu Chemicals/CAS: cholecystokinin, 9011-97-6, 93443-27-7; parvalbumin, 56094-12-3, 83667-75-8; vasoactive intestinal polypeptide, 37221-79-7 Funding details: National Institutes of Health, NIH, MH 54671 Funding details: Howard Hughes Medical Institute, HHMI Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R01NS030549 Funding details: Hungarian Scientific Research Fund, OTKA, T 32251 Funding text 1: I am grateful to all members of my team for valuable contributions to the original studies that underlie this review, as well as for discussion and comments on the manuscript. The help of Gábor Nyiri, Ágnes Bodor and István Katona with the figures, and the assistance of Katalin Iványi and Katalin Lengyel in the preparation of the manuscript, is also acknowledged. My work is supported by the Howard Hughes Medical Institute (USA), NIH (MH 54671, NS30549), Philip Morris External Research Program and OTKA (T 32251) Hungary. LA - English DB - MTMT ER - TY - JOUR AU - Freund, Tamás AU - Katona, István AU - Piomelli, D TI - Role of endogenous cannabinoids in synaptic signaling JF - PHYSIOLOGICAL REVIEWS J2 - PHYSIOL REV VL - 83 PY - 2003 SP - 1017 EP - 1066 PG - 50 SN - 0031-9333 DO - 10.1152/physrev.00004.2003 UR - https://m2.mtmt.hu/api/publication/109323 ID - 109323 N1 - Megjegyzés-25002785 Megjegyzés-21894621 Z9: 598 Cited By :1097 Export Date: 11 August 2019 CODEN: PHREA Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u.43, Budapest 8 H-1083, Hungary; email: freund@koki.hu Chemicals/CAS: cannabis, 8001-45-4, 8063-14-7; dronabinol, 7663-50-5 Cited By :1097 Export Date: 21 August 2019 CODEN: PHREA Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u.43, Budapest 8 H-1083, Hungary; email: freund@koki.hu Chemicals/CAS: cannabis, 8001-45-4, 8063-14-7; dronabinol, 7663-50-5 Cited By :1106 Export Date: 14 November 2019 CODEN: PHREA Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u.43, Budapest 8 H-1083, Hungary; email: freund@koki.hu Chemicals/CAS: cannabis, 8001-45-4, 8063-14-7; dronabinol, 7663-50-5 Cited By :1127 Export Date: 6 March 2020 CODEN: PHREA Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u.43, Budapest 8 H-1083, Hungary; email: freund@koki.hu Chemicals/CAS: cannabis, 8001-45-4, 8063-14-7; dronabinol, 7663-50-5 Cited By :1127 Export Date: 12 March 2020 CODEN: PHREA Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u.43, Budapest 8 H-1083, Hungary; email: freund@koki.hu Chemicals/CAS: cannabis, 8001-45-4, 8063-14-7; dronabinol, 7663-50-5 Cited By :1131 Export Date: 18 April 2020 CODEN: PHREA Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u.43, Budapest 8 H-1083, Hungary; email: freund@koki.hu Chemicals/CAS: cannabis, 8001-45-4, 8063-14-7; dronabinol, 7663-50-5 Cited By :1131 Export Date: 19 April 2020 CODEN: PHREA Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u.43, Budapest 8 H-1083, Hungary; email: freund@koki.hu Chemicals/CAS: cannabis, 8001-45-4, 8063-14-7; dronabinol, 7663-50-5 Cited By :1135 Export Date: 20 May 2020 CODEN: PHREA Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u.43, Budapest 8 H-1083, Hungary; email: freund@koki.hu Chemicals/CAS: cannabis, 8001-45-4, 8063-14-7; dronabinol, 7663-50-5 Cited By :1136 Export Date: 24 May 2020 CODEN: PHREA Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u.43, Budapest 8 H-1083, Hungary; email: freund@koki.hu Chemicals/CAS: cannabis, 8001-45-4, 8063-14-7; dronabinol, 7663-50-5 Cited By :1136 Export Date: 25 May 2020 CODEN: PHREA Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u.43, Budapest 8 H-1083, Hungary; email: freund@koki.hu Chemicals/CAS: cannabis, 8001-45-4, 8063-14-7; dronabinol, 7663-50-5 Cited By :1136 Export Date: 28 May 2020 CODEN: PHREA Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u.43, Budapest 8 H-1083, Hungary; email: freund@koki.hu Chemicals/CAS: cannabis, 8001-45-4, 8063-14-7; dronabinol, 7663-50-5 Cited By :1165 Export Date: 30 December 2020 CODEN: PHREA Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u.43, Budapest 8 H-1083, Hungary; email: freund@koki.hu Chemicals/CAS: cannabis, 8001-45-4, 8063-14-7; dronabinol, 7663-50-5 Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R01NS030549, R37NS030549 Cited By :1175 Export Date: 9 March 2021 CODEN: PHREA Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Szigony u.43, Budapest 8 H-1083, Hungary; email: freund@koki.hu Chemicals/CAS: cannabis, 8001-45-4, 8063-14-7; dronabinol, 7663-50-5 Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R01NS030549 Cited By :1177 Export Date: 23 March 2021 CODEN: PHREA Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Szigony u.43, Budapest 8 H-1083, Hungary; email: freund@koki.hu Chemicals/CAS: cannabis, 8001-45-4, 8063-14-7; dronabinol, 7663-50-5 Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R01NS030549 Cited By :1178 Export Date: 1 April 2021 CODEN: PHREA Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Szigony u.43, Budapest 8 H-1083, Hungary; email: freund@koki.hu Chemicals/CAS: cannabis, 8001-45-4, 8063-14-7; dronabinol, 7663-50-5 Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R01NS030549 Cited By :1178 Export Date: 6 April 2021 CODEN: PHREA Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Szigony u.43, Budapest 8 H-1083, Hungary; email: freund@koki.hu Chemicals/CAS: cannabis, 8001-45-4, 8063-14-7; dronabinol, 7663-50-5 Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R01NS030549 Cited By :1179 Export Date: 20 April 2021 CODEN: PHREA Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Szigony u.43, Budapest 8 H-1083, Hungary; email: freund@koki.hu Chemicals/CAS: cannabis, 8001-45-4, 8063-14-7; dronabinol, 7663-50-5 Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R01NS030549 Cited By :1197 Export Date: 7 September 2021 CODEN: PHREA Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Szigony u.43, Budapest 8 H-1083, Hungary; email: freund@koki.hu Chemicals/CAS: cannabis, 8001-45-4, 8063-14-7; dronabinol, 7663-50-5 Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R01NS030549 LA - English DB - MTMT ER - TY - JOUR AU - Wittner, Lucia AU - Erőss, Loránd AU - Szabó, Z AU - Tóth, Sz AU - Czirják, Sándor AU - Halász, Péter AU - Freund, Tamás AU - Maglóczky, Zsófia TI - Synaptic reorganization of calbindin-positive neurons in the human hippocampal CA1 region in temporal lobe epilepsy JF - NEUROSCIENCE J2 - NEUROSCIENCE VL - 115 PY - 2002 IS - 3 SP - 961 EP - 978 PG - 18 SN - 0306-4522 DO - 10.1016/S0306-4522(02)00264-6 UR - https://m2.mtmt.hu/api/publication/109357 ID - 109357 N1 - Institute of Experimental Medicine, Hungarian Academy of Sciences, P.O. Box 67, H-1450 Budapest, Hungary Neurosurgical Department, MÁV Hospital Budapest, H-1062 Budapest, Hungary National Institute of Neurosurgery, H-1577 Budapest, Hungary Department of Neurology, Health Science Faculty, Semmelweis University, P.O. Box 1, H-1281 Budapest, Hungary Cited By :78 Export Date: 14 February 2025 CODEN: NRSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, P.O. Box 67, H-1450 Budapest, Hungary; email: freund@koki.hu Chemicals/CAS: calbindin; Calcium-Binding Protein, Vitamin D-Dependent Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R01NS030549 AB - The distribution, morphology, synaptic coverage and postsynaptic targets of calbindin-containing interneurons and afferent pathways have been analyzed in the control and epileptic CA1 region of the human hippocampus. Numerous calbindin-positive interneurons are preserved even in the strongly sclerotic CA1 region. The morphology of individual cells is altered: the cell body and dendrites become spiny, the radially oriented dendrites disappear, and are replaced by a large number of curved, distorted dendrites. Even in the non-sclerotic epileptic samples, where pyramidal cells are present and calbindin-immunoreactive interneurons seem to be unchanged, some modifications could be observed at the electron microscopic level: they received more inhibitory synaptic input, and the calbindin-positive excitatory afferents - presumably derived from the CA1, the CA2 and/or the dentate gyrus - are sprouted. In the strongly sclerotic tissue, with the death of pyramidal cells, calbindin-positive terminals (belonging to interneurons and the remaining excitatory afferents) change their targets. Our data suggest that an intense synaptic reorganization takes place in the epileptic CA1 region, even in the non-sclerotic tissue, before the death of considerable numbers of pyramidal cells. Calbindin-positive interneurons participate in this reorganization: they show plastic changes in response to epilepsy. The enhanced inhibition of inhibitory interneurons may result in the disinhibition of pyramidal cells or in an abnormal synchrony in the output region of the hippocampus. © 2002 IBRO. Published by Elsevier Science Ltd. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Wittner, Lucia AU - Maglóczky, Zsófia AU - Borhegyi, Zsolt AU - Halász, Péter AU - Tóth, Sz AU - Erőss, Loránd AU - Szabó, Z AU - Freund, Tamás TI - Preservation of perisomatic inhibitory input of granule cells in the epileptic human dentate gyrus JF - NEUROSCIENCE J2 - NEUROSCIENCE VL - 108 PY - 2001 SP - 587 EP - 600 PG - 14 SN - 0306-4522 DO - 10.1016/S0306-4522(01)00446-8 UR - https://m2.mtmt.hu/api/publication/109168 ID - 109168 N1 - Institute of Experimental Medicine, Hungarian Academy of Sciences, P.O. Box 67, H-1450 Budapest, Hungary Department of Neurology, Semmelweis Univ. Hlth. Sci. Faculty, P.O. Box 1, H-1281 Budapest, Hungary Neurosurgery Department, MÁV Hospital Budapest, H-1062 Budapest, Hungary Cited By :152 Export Date: 14 February 2025 CODEN: NRSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, P.O. Box 67, H-1450 Budapest, Hungary; email: freund@koki.hu Chemicals/CAS: gamma-Aminobutyric Acid, 56-12-2; Parvalbumins Funding details: Howard Hughes Medical Institute, HHMI Funding details: National Institute of Mental Health, NIMH, MH54671 Funding details: Hungarian Scientific Research Fund, OTKA, T/032251 Funding text 1: The authors are grateful to Drs. M. Palkovits, P. Sótonyi and Zs. Borostyánkői (Semmelweis University, Budapest) for providing control human tissue, and to Drs. Zs. Emri, I. Mody and L. Seress for helpful discussions. The mouse anti-CCK antibody was kindly provided by the Cure Gastroenteric Biology Center, Antibody/RIA Core, National Institute of Health Grant DK 41301. We are grateful to Dr. T. Görcs for NPY and SOM antibodies. The excellent technical assistance of Ms. K. Lengyel, E. Oszwald and Mr. Gy. Goda is also acknowledged. This study was supported by OTKA (T/032251), Hungary, the Howard Hughes Medical Institute, NIMH (MH54671) and the Bolyai Scholarship. LA - English DB - MTMT ER - TY - JOUR AU - Hájos, Norbert AU - Katona, István AU - Naiem, SS AU - Mackie, K AU - Ledent, C AU - Mody, I AU - Freund, Tamás TI - Cannabinoids inhibit hippocampal GABAergic transmission and network oscillations JF - EUROPEAN JOURNAL OF NEUROSCIENCE J2 - EUR J NEUROSCI VL - 12 PY - 2000 SP - 3239 EP - 3249 PG - 11 SN - 0953-816X DO - 10.1046/j.1460-9568.2000.00217.x UR - https://m2.mtmt.hu/api/publication/109087 ID - 109087 N1 - Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Szigony u. 43, 1083, Hungary Departments of Neurology and Physiology, UCLA, School of Medicine, Los Angeles, CA 90095-1769, United States Departments of Anaesthesiology, and Physiology and Biophysics, University of Washington, Seattle, WA 98195, United States IRIBHN, Université Libre de Bruxelles, Brussels, Belgium Cited By :435 Export Date: 22 June 2023 CODEN: EJONE Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, Szigony u. 43, Budapest 1083, Hungary; email: freund@koki.hu Chemicals/CAS: 2,3 dihydro 5 methyl 3 (morpholinomethyl) 6 (1 naphthoyl)pyrrolo[1,2,3 de][1,4]benzoxazine, 134959-51-6; 4 (1,1 dimethylheptyl) 1',2',3',4',5',6' hexahydro 2,3' dihydroxy 6' (3 hydroxypropyl)biphenyl, 83003-12-7; cholecystokinin, 9011-97-6, 93443-27-7; kainic acid, 487-79-6; rimonabant, 158681-13-1, 168273-06-1 Funding details: National Institute on Drug Abuse, NIDA, K02DA000286, R01DA011322 Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R01NS030549 LA - English DB - MTMT ER - TY - JOUR AU - Katona, István AU - Sperlágh, Beáta AU - Sík, Attila AU - Kőfalvi, Attila AU - Vizi, E. Szilveszter AU - Mackie, K AU - Freund, Tamás TI - Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons JF - JOURNAL OF NEUROSCIENCE J2 - J NEUROSCI VL - 19 PY - 1999 SP - 4544 EP - 4558 PG - 15 SN - 0270-6474 DO - 10.1523/jneurosci.19-11-04544.1999 UR - https://m2.mtmt.hu/api/publication/108986 ID - 108986 LA - English DB - MTMT ER - TY - JOUR AU - Hájos, Norbert AU - Papp, Edit AU - Acsády, László AU - Levey, AI AU - Freund, Tamás TI - Distinct interneuron types express M2 muscarinic receptor immunoreactivity on their dendrites or axon terminals in the hippocampus JF - NEUROSCIENCE J2 - NEUROSCIENCE VL - 82 PY - 1998 IS - 2 SP - 355 EP - 376 PG - 22 SN - 0306-4522 DO - 10.1016/S0306-4522(97)00300-X UR - https://m2.mtmt.hu/api/publication/108286 ID - 108286 N1 - Institute of Experimental Medicine, Hungarian Academy of Science, P.O.B. 67, Budapest H-1450, Hungary Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, United States Cited By :189 Export Date: 1 August 2023 CODEN: NRSCD Correspondence Address: Freund, T.F.; Institute of Experimental Medicine, P.O.B. 67, Budapest H-1450, Hungary Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; acetylcholine, 51-84-3, 60-31-1, 66-23-9; cholecystokinin, 9011-97-6, 93443-27-7; colloidal gold, 117924-90-0; diaminobenzidine, 7411-49-6, 91-95-2; parvalbumin, 56094-12-3, 83667-75-8; somatostatin, 38916-34-6, 51110-01-1; vasoactive intestinal polypeptide, 37221-79-7 Funding details: Howard Hughes Medical Institute, HHMI Funding details: National Institute of Neurological Disorders and Stroke, NINDS, R01NS030454 Funding details: Hungarian Scientific Research Fund, OTKA, T16963 Funding text 1: We are grateful to Drs K. G. Baimbridge and M. R. Celio for antisera against parvalbumin and calbindin; Dr T. J. Görcs for antisera against VIP and CCK; Dr J. H. Rogers for anti-calretinin; and Drs P. Somogyi, C. Beaulieu and I. Virtanen for anti-GABA antisera. The excellent technical assistance of Mrs E. Borók, Mrs A. Z. Szabóné and Mr G. Terstyánszky is also acknowledged. This work was supported by the Howard Hughes Medical Institute, the Human Frontier Science Program Organization, NS30454 (to A.I.L.) and OTKA (T16963), Hungary. LA - English DB - MTMT ER - TY - JOUR AU - Gulyás, Attila AU - Freund, Tamás TI - Inhibitory control of GABAergic interneurons in the hippocampus JF - CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY J2 - CAN J PHYSIOL PHARM VL - 75 PY - 1997 IS - 5 SP - 479 EP - 487 PG - 9 SN - 0008-4212 DO - 10.1139/y97-033 UR - https://m2.mtmt.hu/api/publication/34087848 ID - 34087848 AB - Hippocampal GABAergic interneurons are responsible for controlling the output and efficacy of synaptic input of large principal cell populations and, thereby, determine the oscillatory discharge patterns and synaptic plasticity in the hippocampus. Single interneurons are able to prevent repetitive firing of postsynaptic pyramidal cells (R. Miles, K. Toth, A.I. Gulyas, N. Hajos, and T.F. Freund. Neuron, 16: 815-823, 1996), whereas on occasion a single pyramidal cell may be able to activate an interneuron under in vitro conditions (A.I. Gulyas, R. Miles, A. Sik, K. Toth, N. Tamamaki, and T.F. Freund. Nature (London), 366: 683-687, 1993). Inhibition is therefore extremely powerful. Transient suppression of interneuronal activity allows the precise timing and synchronization of inhibitory postsynaptic potentials arriving at principal cells. A rhythmic suppression or modulation of interneuron discharge may be brought about by input from at least two major sources: (i) from other local interneurons or (ii) from subcortical centers. Of the possible local sources, in the present review particular attention will be paid to GABAergic neurons specialized to innervate other interneurons. Subcortical pathways known to modulate specific inhibitory functions in the hippocampus, i.e., the GABAergic and cholinergic septohippocampal and the serotonergic raphe hippocampal pathways, will also be reviewed. Roles of these control mechanisms may include the generation of theta and higher frequency oscillations, and the selective removal of inhibition from the termination zone of specific excitatory afferents, thereby increasing their efficacy and (or) plasticity. LA - English DB - MTMT ER - TY - JOUR AU - Freund, Tamás AU - Buzsáki, György TI - Interneurons of the hippocampus JF - HIPPOCAMPUS J2 - HIPPOCAMPUS VL - 6 PY - 1996 SP - 347 EP - 470 PG - 124 SN - 1050-9631 DO - 10.1002/(SICI)1098-1063(1996)6:4<347::AID-HIPO1>3.0.CO;2-I UR - https://m2.mtmt.hu/api/publication/107931 ID - 107931 N1 - Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ, United States Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest H-1450, P.O. Box 67, Hungary Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, United States Export Date: 22 March 2025; Cited By: 2940; Correspondence Address: T.F. Freund; Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest H-1450, P.O. Box 67, Hungary; email: freund@koki.hu; CODEN: HIPPE LA - English DB - MTMT ER - TY - JOUR AU - Miles, R AU - Tóth, Katalin AU - Gulyás, Attila AU - Hájos, Norbert AU - Freund, Tamás TI - Differences between somatic and dendritic inhibition in the hippocampus JF - NEURON J2 - NEURON VL - 16 PY - 1996 IS - 4 SP - 815 EP - 823 PG - 9 SN - 0896-6273 DO - 10.1016/S0896-6273(00)80101-4 UR - https://m2.mtmt.hu/api/publication/107721 ID - 107721 N1 - Megjegyzés-25002645 Megjegyzés-21894988 Z9: 477 Lab. de Neurobiologie Cellulaire, Institut Pasteur, 25 rue de Dr. Roux, 75724 Paris, France Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1450 Budapest, Hungary Cited By :713 Export Date: 24 March 2021 CODEN: NERNE Correspondence Address: Miles, R.; Lab. de Neurobiologie Cellulaire, 25 rue de Dr. Roux, 75724 Paris, France Chemicals/CAS: biocytin, 576-19-2 Funding details: European Science Foundation, ESF Funding details: Human Frontier Science Program, HFSP Funding details: Hungarian Scientific Research Fund, OTKA, T5532 Funding text 1: Correspondence should be addressed to R. M. This work was supported by the Human Science Frontier Program, the European Science Foundation, the Ministére de la Recherche et de la Technologie, and OTKA (T5532) Hungary. We thank B. Barbour for helpful comments and E. Borók, I. Weisz, and G. Terstyánszky for excellent technical assistance. Lab. de Neurobiologie Cellulaire, Institut Pasteur, 25 rue de Dr. Roux, 75724 Paris, France Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1450 Budapest, Hungary Cited By :714 Export Date: 6 April 2021 CODEN: NERNE Correspondence Address: Miles, R.; Lab. de Neurobiologie Cellulaire, 25 rue de Dr. Roux, 75724 Paris, France Chemicals/CAS: biocytin, 576-19-2 Funding details: European Science Foundation, ESF Funding details: Human Frontier Science Program, HFSP Funding details: Hungarian Scientific Research Fund, OTKA, T5532 Funding text 1: Correspondence should be addressed to R. M. This work was supported by the Human Science Frontier Program, the European Science Foundation, the Ministére de la Recherche et de la Technologie, and OTKA (T5532) Hungary. We thank B. Barbour for helpful comments and E. Borók, I. Weisz, and G. Terstyánszky for excellent technical assistance. LA - English DB - MTMT ER - TY - JOUR AU - Seress, László AU - Gulyás, Attila AU - Ferrer, I AU - Tunon, T AU - Soriano, E AU - Freund, Tamás TI - Distribution, morphological features, and synaptic connections of parvalbumin- and calbindin D28K-immunoreactive neurons in the human hippocampal formation JF - JOURNAL OF COMPARATIVE NEUROLOGY J2 - J COMP NEUROL VL - 337 PY - 1993 IS - 2 SP - 208 EP - 230 PG - 23 SN - 0021-9967 DO - 10.1002/cne.903370204 UR - https://m2.mtmt.hu/api/publication/107598 ID - 107598 AB - Calcium binding proteins calbindin D28k (CaBP) and parvalbumin (PV) are known to form distinct subpopulations of gamma‐aminobutyric acid (GABA)ergic neurons in the rodent hippocampal formation. Light and electron microscopic morphology and connections of these protein‐containing neurons are only partly known in the primate hippocampus. In this study, CaBP and PV were localized in neurons of the human hippocampal formation including the subicular complex (prosubiculum, subiculum, and presubiculum) in order to explore to what extent these subpopulations of hippocampal neurons differ in phylogenetically distant species. CaBP immunoreactivity was present in virtually all granule cells of the dentate gyrus and in a proportion of pyramidal neurons in the CA1 and CA2 regions. A distinct population of CaBP‐positive local circuit neurons was found in all layers of the dentate gyrus and Ammon's horn. Most frequently they were located in the molecular layer of the dentate gyrus and the pyramidal layer of Ammon's horn. In the subicular complex pyramidal neurons were not immunoreactive for CaBP. In the prosubiculum and subiculum immunoreactive nonpyramidal neurons were equally distributed in all layers, whereas in the presubiculum they occurred mainly in the superficial layers. Electron microscopy showed typical somatic and dendritic features of the granule, pyramidal, and local circuit neurons. CaBP‐positive mossy fiber terminals in the hilus of the dentate gyrus and terminals of presumed pyramidal neurons of Ammon's horn formed asymmetric synapses with dendrites and spines. CaBP‐positive terminals of nonprincipal neurons formed symmetric synapses with dendrites and dendritic spines, but never with somata or axon initial segments. PV was exclusively present in local circuit neurons in both the hippocampal formation and subicular complex. Most of the PV‐positive cell bodies were located among or close to the principal cell layers. However, large numbers of immunoreactive neurons were also found in the molecular layer of the dentate gyrus and in strata oriens of Ammon's horn. PV‐positive cells were equally distributed in all layers of the subicular complex. Electron microscopy showed the characteristic somatic and dendritic features of local circuit neurons. PV‐positive axon terminals formed exclusively symmetric synapses with somata, axon initial segments and dendritic shafts, and in a few cases with dendritic spines. The CaBP‐ and PV‐containing neurons formed similar subpopulations in rodents, monkeys, and humans, although the human hippocampus displayed the largest variability of these immunoreactive neurons in their morphology and location. Calcium binding protein‐containing neurons frequently occurred in the molecular layer of the human dentate gyrus and in the stratum lacunosum‐moleculare of Ammon's horn. The corresponding areas of the rat or monkey hippocampus were devoid of such neurons. In both rodents and primates similar populations of principal neurons contained CaBP. In addition, CaBP and PV were localized in distinct and nonoverlapping populations of nonprincipal cells. Their target selectivity did not change during phylogeny (e.g., PV‐positive cells mainly innervate the perisomatic region and CaBP‐positive cells the distal dendritic region of principal cells). © 1993 Wiley‐Liss,Inc. Copyright © 1993 Wiley‐Liss, Inc. LA - English DB - MTMT ER -