TY - JOUR AU - Liu, Anli AU - Vöröslakos, Mihály AU - Kronberg, Greg AU - Henin, Simon AU - Krause, Matthew R AU - Huang, Yu AU - Opitz, Alexander AU - Mehta, Ashesh AU - Pack, Christopher C AU - Krekelberg, Bart AU - Berényi, Antal AU - Parra, Lucas C AU - Melloni, Lucia AU - Devinsky, Orrin AU - Buzsáki, György TI - Immediate neurophysiological effects of transcranial electrical stimulation JF - NATURE COMMUNICATIONS J2 - NAT COMMUN VL - 9 PY - 2018 IS - 1 PG - 12 SN - 2041-1723 DO - 10.1038/s41467-018-07233-7 UR - https://m2.mtmt.hu/api/publication/30424165 ID - 30424165 N1 - Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review New York University Comprehensive Epilepsy Center, 223 34th Street, New York, NY 10016, United States Department of Neurology, NYU Langone Health, 222 East 41st Street, 14th Floor, New York, NY 10016, United States MTA-SZTE ‘Momentum’ Oscillatory Neuronal Networks Research Group, Department of Physiology, Faculty of Medicine, University of Szeged, 10 Dom sq., Szeged, H-6720, Hungary New York University Neuroscience Institute, 435 East 30th Street, New York, NY 10016, United States Department of Biomedical Engineering, City College of New York, 160 Convent Ave, New York, NY 10031, United States Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada Department of Biomedical Engineering of Minnesota, 312 Church St. SE, Minneapolis, MN 55455, United States Department of Neurosurgery, Hofstra Northwell School of Medicine, 611 Northern Blvd, Great Neck, NY 11021, United States Feinstein Institute for Medical Research, Hofstra Northwell School of Medicine, 350 Community Drive, Manhasset, NY 11030, United States Center for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Avenue, Newark, NJ 07102, United States Max Planck Institute for Empirical Aesthetics, Grüneburgweg 14, Frankfurt am Main, 60322, Germany Cited By :21 Export Date: 25 January 2020 Correspondence Address: Liu, A.; New York University Comprehensive Epilepsy Center, 223 34th Street, United States; email: anli.liu@nyumc.org Funding Agency and Grant Number: NYU Finding a Cure Against Epilepsy and Seizures (FACES); [R01 MH 107396] Funding text: We thank NYU Finding a Cure Against Epilepsy and Seizures (FACES) for sponsoring the Minisymposium Current state of Transcranial Electrical Stimulation: Progress & Challenges, on December 18, 2017 where the discussions contained in this manuscript arose. In addition, A.L., S.H., O.D., and G.B. receive support from R01 MH 107396. New York University Comprehensive Epilepsy Center, 223 34th Street, New York, NY 10016, United States Department of Neurology, NYU Langone Health, 222 East 41st Street, 14th Floor, New York, NY 10016, United States MTA-SZTE ‘Momentum’ Oscillatory Neuronal Networks Research Group, Department of Physiology, Faculty of Medicine, University of Szeged, 10 Dom sq., Szeged, H-6720, Hungary New York University Neuroscience Institute, 435 East 30th Street, New York, NY 10016, United States Department of Biomedical Engineering, City College of New York, 160 Convent Ave, New York, NY 10031, United States Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada Department of Biomedical Engineering of Minnesota, 312 Church St. SE, Minneapolis, MN 55455, United States Department of Neurosurgery, Hofstra Northwell School of Medicine, 611 Northern Blvd, Great Neck, NY 11021, United States Feinstein Institute for Medical Research, Hofstra Northwell School of Medicine, 350 Community Drive, Manhasset, NY 11030, United States Center for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Avenue, Newark, NJ 07102, United States Max Planck Institute for Empirical Aesthetics, Grüneburgweg 14, Frankfurt am Main, 60322, Germany Cited By :21 Export Date: 1 February 2020 Correspondence Address: Liu, A.; New York University Comprehensive Epilepsy Center, 223 34th Street, United States; email: anli.liu@nyumc.org New York University Comprehensive Epilepsy Center, 223 34th Street, New York, NY 10016, United States Department of Neurology, NYU Langone Health, 222 East 41st Street, 14th Floor, New York, NY 10016, United States MTA-SZTE ‘Momentum’ Oscillatory Neuronal Networks Research Group, Department of Physiology, Faculty of Medicine, University of Szeged, 10 Dom sq., Szeged, H-6720, Hungary New York University Neuroscience Institute, 435 East 30th Street, New York, NY 10016, United States Department of Biomedical Engineering, City College of New York, 160 Convent Ave, New York, NY 10031, United States Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada Department of Biomedical Engineering of Minnesota, 312 Church St. SE, Minneapolis, MN 55455, United States Department of Neurosurgery, Hofstra Northwell School of Medicine, 611 Northern Blvd, Great Neck, NY 11021, United States Feinstein Institute for Medical Research, Hofstra Northwell School of Medicine, 350 Community Drive, Manhasset, NY 11030, United States Center for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Avenue, Newark, NJ 07102, United States Max Planck Institute for Empirical Aesthetics, Grüneburgweg 14, Frankfurt am Main, 60322, Germany Cited By :24 Export Date: 12 March 2020 Correspondence Address: Liu, A.; New York University Comprehensive Epilepsy Center, 223 34th Street, United States; email: anli.liu@nyumc.org New York University Comprehensive Epilepsy Center, 223 34th Street, New York, NY 10016, United States Department of Neurology, NYU Langone Health, 222 East 41st Street, 14th Floor, New York, NY 10016, United States MTA-SZTE ‘Momentum’ Oscillatory Neuronal Networks Research Group, Department of Physiology, Faculty of Medicine, University of Szeged, 10 Dom sq., Szeged, H-6720, Hungary New York University Neuroscience Institute, 435 East 30th Street, New York, NY 10016, United States Department of Biomedical Engineering, City College of New York, 160 Convent Ave, New York, NY 10031, United States Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada Department of Biomedical Engineering of Minnesota, 312 Church St. SE, Minneapolis, MN 55455, United States Department of Neurosurgery, Hofstra Northwell School of Medicine, 611 Northern Blvd, Great Neck, NY 11021, United States Feinstein Institute for Medical Research, Hofstra Northwell School of Medicine, 350 Community Drive, Manhasset, NY 11030, United States Center for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Avenue, Newark, NJ 07102, United States Max Planck Institute for Empirical Aesthetics, Grüneburgweg 14, Frankfurt am Main, 60322, Germany Cited By :25 Export Date: 21 March 2020 Correspondence Address: Liu, A.; New York University Comprehensive Epilepsy Center, 223 34th Street, United States; email: anli.liu@nyumc.org New York University Comprehensive Epilepsy Center, 223 34th Street, New York, NY 10016, United States Department of Neurology, NYU Langone Health, 222 East 41st Street, 14th Floor, New York, NY 10016, United States MTA-SZTE ‘Momentum’ Oscillatory Neuronal Networks Research Group, Department of Physiology, Faculty of Medicine, University of Szeged, 10 Dom sq., Szeged, H-6720, Hungary New York University Neuroscience Institute, 435 East 30th Street, New York, NY 10016, United States Department of Biomedical Engineering, City College of New York, 160 Convent Ave, New York, NY 10031, United States Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada Department of Biomedical Engineering of Minnesota, 312 Church St. SE, Minneapolis, MN 55455, United States Department of Neurosurgery, Hofstra Northwell School of Medicine, 611 Northern Blvd, Great Neck, NY 11021, United States Feinstein Institute for Medical Research, Hofstra Northwell School of Medicine, 350 Community Drive, Manhasset, NY 11030, United States Center for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Avenue, Newark, NJ 07102, United States Max Planck Institute for Empirical Aesthetics, Grüneburgweg 14, Frankfurt am Main, 60322, Germany Cited By :41 Export Date: 10 August 2020 Correspondence Address: Liu, A.; New York University Comprehensive Epilepsy Center, 223 34th Street, United States; email: anli.liu@nyumc.org New York University Comprehensive Epilepsy Center, 223 34th Street, New York, NY 10016, United States Department of Neurology, NYU Langone Health, 222 East 41st Street, 14th Floor, New York, NY 10016, United States MTA-SZTE ‘Momentum’ Oscillatory Neuronal Networks Research Group, Department of Physiology, Faculty of Medicine, University of Szeged, 10 Dom sq., Szeged, H-6720, Hungary New York University Neuroscience Institute, 435 East 30th Street, New York, NY 10016, United States Department of Biomedical Engineering, City College of New York, 160 Convent Ave, New York, NY 10031, United States Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada Department of Biomedical Engineering of Minnesota, 312 Church St. SE, Minneapolis, MN 55455, United States Department of Neurosurgery, Hofstra Northwell School of Medicine, 611 Northern Blvd, Great Neck, NY 11021, United States Feinstein Institute for Medical Research, Hofstra Northwell School of Medicine, 350 Community Drive, Manhasset, NY 11030, United States Center for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Avenue, Newark, NJ 07102, United States Max Planck Institute for Empirical Aesthetics, Grüneburgweg 14, Frankfurt am Main, 60322, Germany Cited By :41 Export Date: 11 August 2020 Correspondence Address: Liu, A.; New York University Comprehensive Epilepsy Center, 223 34th Street, United States; email: anli.liu@nyumc.org New York University Comprehensive Epilepsy Center, 223 34th Street, New York, NY 10016, United States Department of Neurology, NYU Langone Health, 222 East 41st Street, 14th Floor, New York, NY 10016, United States MTA-SZTE ‘Momentum’ Oscillatory Neuronal Networks Research Group, Department of Physiology, Faculty of Medicine, University of Szeged, 10 Dom sq., Szeged, H-6720, Hungary New York University Neuroscience Institute, 435 East 30th Street, New York, NY 10016, United States Department of Biomedical Engineering, City College of New York, 160 Convent Ave, New York, NY 10031, United States Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada Department of Biomedical Engineering of Minnesota, 312 Church St. SE, Minneapolis, MN 55455, United States Department of Neurosurgery, Hofstra Northwell School of Medicine, 611 Northern Blvd, Great Neck, NY 11021, United States Feinstein Institute for Medical Research, Hofstra Northwell School of Medicine, 350 Community Drive, Manhasset, NY 11030, United States Center for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Avenue, Newark, NJ 07102, United States Max Planck Institute for Empirical Aesthetics, Grüneburgweg 14, Frankfurt am Main, 60322, Germany Cited By :66 Export Date: 21 February 2021 Correspondence Address: Liu, A.; New York University Comprehensive Epilepsy Center, 223 34th Street, United States; email: anli.liu@nyumc.org Funding Agency and Grant Number: NYU Finding a Cure Against Epilepsy and Seizures (FACES); [R01 MH 107396]; NATIONAL INSTITUTE OF MENTAL HEALTHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Mental Health (NIMH) [R01MH107396, R01MH107396, R01MH107396, R01MH107396] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Neurological Disorders & Stroke (NINDS) [K23NS104252, K23NS104252, K23NS104252] Funding Source: NIH RePORTER Funding text: We thank NYU Finding a Cure Against Epilepsy and Seizures (FACES) for sponsoring the Minisymposium Current state of Transcranial Electrical Stimulation: Progress & Challenges, on December 18, 2017 where the discussions contained in this manuscript arose. In addition, A.L., S.H., O.D., and G.B. receive support from R01 MH 107396. New York University Comprehensive Epilepsy Center, 223 34th Street, New York, NY 10016, United States Department of Neurology, NYU Langone Health, 222 East 41st Street, 14th Floor, New York, NY 10016, United States MTA-SZTE ‘Momentum’ Oscillatory Neuronal Networks Research Group, Department of Physiology, Faculty of Medicine, University of Szeged, 10 Dom sq., Szeged, H-6720, Hungary New York University Neuroscience Institute, 435 East 30th Street, New York, NY 10016, United States Department of Biomedical Engineering, City College of New York, 160 Convent Ave, New York, NY 10031, United States Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada Department of Biomedical Engineering of Minnesota, 312 Church St. SE, Minneapolis, MN 55455, United States Department of Neurosurgery, Hofstra Northwell School of Medicine, 611 Northern Blvd, Great Neck, NY 11021, United States Feinstein Institute for Medical Research, Hofstra Northwell School of Medicine, 350 Community Drive, Manhasset, NY 11030, United States Center for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Avenue, Newark, NJ 07102, United States Max Planck Institute for Empirical Aesthetics, Grüneburgweg 14, Frankfurt am Main, 60322, Germany Cited By :72 Export Date: 21 March 2021 Correspondence Address: Liu, A.; New York University Comprehensive Epilepsy Center, 223 34th Street, United States; email: anli.liu@nyumc.org New York University Comprehensive Epilepsy Center, 223 34th Street, New York, NY 10016, United States Department of Neurology, NYU Langone Health, 222 East 41st Street, 14th Floor, New York, NY 10016, United States MTA-SZTE ‘Momentum’ Oscillatory Neuronal Networks Research Group, Department of Physiology, Faculty of Medicine, University of Szeged, 10 Dom sq., Szeged, H-6720, Hungary New York University Neuroscience Institute, 435 East 30th Street, New York, NY 10016, United States Department of Biomedical Engineering, City College of New York, 160 Convent Ave, New York, NY 10031, United States Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada Department of Biomedical Engineering of Minnesota, 312 Church St. SE, Minneapolis, MN 55455, United States Department of Neurosurgery, Hofstra Northwell School of Medicine, 611 Northern Blvd, Great Neck, NY 11021, United States Feinstein Institute for Medical Research, Hofstra Northwell School of Medicine, 350 Community Drive, Manhasset, NY 11030, United States Center for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Avenue, Newark, NJ 07102, United States Max Planck Institute for Empirical Aesthetics, Grüneburgweg 14, Frankfurt am Main, 60322, Germany Cited By :72 Export Date: 28 March 2021 Correspondence Address: Liu, A.; New York University Comprehensive Epilepsy Center, 223 34th Street, United States; email: anli.liu@nyumc.org Funding Agency and Grant Number: NYU Finding a Cure Against Epilepsy and Seizures (FACES); [R01 MH 107396]; NATIONAL INSTITUTE OF MENTAL HEALTHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Mental Health (NIMH) [R01MH107396] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Neurological Disorders & Stroke (NINDS) [K23NS104252] Funding Source: NIH RePORTER Funding text: We thank NYU Finding a Cure Against Epilepsy and Seizures (FACES) for sponsoring the Minisymposium Current state of Transcranial Electrical Stimulation: Progress & Challenges, on December 18, 2017 where the discussions contained in this manuscript arose. In addition, A.L., S.H., O.D., and G.B. receive support from R01 MH 107396. New York University Comprehensive Epilepsy Center, 223 34th Street, New York, NY 10016, United States Department of Neurology, NYU Langone Health, 222 East 41st Street, 14th Floor, New York, NY 10016, United States MTA-SZTE ‘Momentum’ Oscillatory Neuronal Networks Research Group, Department of Physiology, Faculty of Medicine, University of Szeged, 10 Dom sq., Szeged, H-6720, Hungary New York University Neuroscience Institute, 435 East 30th Street, New York, NY 10016, United States Department of Biomedical Engineering, City College of New York, 160 Convent Ave, New York, NY 10031, United States Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada Department of Biomedical Engineering of Minnesota, 312 Church St. SE, Minneapolis, MN 55455, United States Department of Neurosurgery, Hofstra Northwell School of Medicine, 611 Northern Blvd, Great Neck, NY 11021, United States Feinstein Institute for Medical Research, Hofstra Northwell School of Medicine, 350 Community Drive, Manhasset, NY 11030, United States Center for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Avenue, Newark, NJ 07102, United States Max Planck Institute for Empirical Aesthetics, Grüneburgweg 14, Frankfurt am Main, 60322, Germany Cited By :108 Export Date: 21 September 2021 Correspondence Address: Liu, A.; New York University Comprehensive Epilepsy Center, 223 34th Street, United States; email: anli.liu@nyumc.org New York University Comprehensive Epilepsy Center, 223 34th Street, New York, NY 10016, United States Department of Neurology, NYU Langone Health, 222 East 41st Street, 14th Floor, New York, NY 10016, United States MTA-SZTE ‘Momentum’ Oscillatory Neuronal Networks Research Group, Department of Physiology, Faculty of Medicine, University of Szeged, 10 Dom sq., Szeged, H-6720, Hungary New York University Neuroscience Institute, 435 East 30th Street, New York, NY 10016, United States Department of Biomedical Engineering, City College of New York, 160 Convent Ave, New York, NY 10031, United States Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada Department of Biomedical Engineering of Minnesota, 312 Church St. SE, Minneapolis, MN 55455, United States Department of Neurosurgery, Hofstra Northwell School of Medicine, 611 Northern Blvd, Great Neck, NY 11021, United States Feinstein Institute for Medical Research, Hofstra Northwell School of Medicine, 350 Community Drive, Manhasset, NY 11030, United States Center for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Avenue, Newark, NJ 07102, United States Max Planck Institute for Empirical Aesthetics, Grüneburgweg 14, Frankfurt am Main, 60322, Germany Cited By :109 Export Date: 23 September 2021 Correspondence Address: Liu, A.; New York University Comprehensive Epilepsy Center, 223 34th Street, United States; email: anli.liu@nyumc.org AB - Noninvasive brain stimulation techniques are used in experimental and clinical fields for their potential effects on brain network dynamics and behavior. Transcranial electrical stimulation (TES), including transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS), has gained popularity because of its convenience and potential as a chronic therapy. However, a mechanistic understanding of TES has lagged behind its widespread adoption. Here, we review data and modelling on the immediate neurophysiological effects of TES in vitro as well as in vivo in both humans and other animals. While it remains unclear how typical TES protocols affect neural activity, we propose that validated models of current flow should inform study design and artifacts should be carefully excluded during signal recording and analysis. Potential indirect effects of TES (e.g., peripheral stimulation) should be investigated in more detail and further explored in experimental designs. We also consider how novel technologies may stimulate the next generation of TES experiments and devices, thus enhancing validity, specificity, and reproducibility. LA - English DB - MTMT ER - TY - JOUR AU - Chuong, AS AU - Miri, ML AU - Busskamp, V AU - Matthews, GAC AU - Acker, LC AU - Sørensen, AT AU - Young, A AU - Klapoetke, NC AU - Henninger, MA AU - Kodandaramaiah, SB AU - Ogawa, M AU - Ramanlal, SB AU - Bandler, RC AU - Allen, BD AU - Forest, CR AU - Chow, BY AU - Han, X AU - Lin, Y AU - Tye, KM AU - Roska, Botond AU - Cardin, JA AU - Boyden, ES TI - Noninvasive optical inhibition with a red-shifted microbial rhodopsin JF - NATURE NEUROSCIENCE J2 - NAT NEUROSCI VL - 17 PY - 2014 IS - 8 SP - 1123 EP - 1129 PG - 7 SN - 1097-6256 DO - 10.1038/nn.3752 UR - https://m2.mtmt.hu/api/publication/24223465 ID - 24223465 N1 - N1 Molecular Sequence Numbers: GENBANK: KM000925, KM000926, KM000927; N1 Funding Details: ERC, National Institutes of Health N1 Funding Details: HFSP, National Institutes of Health N1 Funding Details: 1DP2OD002002, NIH, National Institutes of Health N1 Funding Details: 1R01DA029639, NIH, National Institutes of Health N1 Funding Details: 5R00MH085944, NIMH, National Institutes of Health N1 Funding Details: R01 MH102365, NIH, National Institutes of Health N1 Funding Details: NIH, National Institutes of Health N1 Funding Details: NSF, National Institutes of Health N1 Funding Details: DGE 1122492, NSF, National Institutes of Health N1 Funding Details: DMS0848804, NSF, National Institutes of Health N1 Funding Details: EFRI0835878, NSF, National Institutes of Health N1 Funding Details: R00 EY018407, NIH, National Institutes of Health N1 Funding Details: R01 EY022951, NIH, National Institutes of Health N1 Funding Details: SF, National Institutes of Health N1 Funding Details: SNSF, National Institutes of Health N1 Funding Details: WHCF, National Institutes of Health N1 Funding Details: National Institutes of Health N1 Funding Details: RO1 MH091220-01, NIH, National Institutes of Health N1 Funding Details: National Institutes of Health N1 Funding Details: DP2-OD-017366-01, NIMH, National Institutes of Health N1 Funding Details: R01-MH102441-01, NIMH, National Institutes of Health Megjegyzés-24223327 N1 Molecular Sequence Numbers: GENBANK: KM000925, KM000926, KM000927; N1 Funding Details: ERC, National Institutes of Health N1 Funding Details: HFSP, National Institutes of Health N1 Funding Details: 1DP2OD002002, NIH, National Institutes of Health N1 Funding Details: 1R01DA029639, NIH, National Institutes of Health N1 Funding Details: 5R00MH085944, NIMH, National Institutes of Health N1 Funding Details: R01 MH102365, NIH, National Institutes of Health N1 Funding Details: NIH, National Institutes of Health N1 Funding Details: NSF, National Institutes of Health N1 Funding Details: DGE 1122492, NSF, National Institutes of Health N1 Funding Details: DMS0848804, NSF, National Institutes of Health N1 Funding Details: EFRI0835878, NSF, National Institutes of Health N1 Funding Details: R00 EY018407, NIH, National Institutes of Health N1 Funding Details: R01 EY022951, NIH, National Institutes of Health N1 Funding Details: SF, National Institutes of Health N1 Funding Details: SNSF, National Institutes of Health N1 Funding Details: WHCF, National Institutes of Health N1 Funding Details: National Institutes of Health N1 Funding Details: RO1 MH091220-01, NIH, National Institutes of Health N1 Funding Details: National Institutes of Health N1 Funding Details: DP2-OD-017366-01, NIMH, National Institutes of Health N1 Funding Details: R01-MH102441-01, NIMH, National Institutes of Health LA - English DB - MTMT ER - TY - JOUR AU - Hynynen, K AU - McDannold, N AU - Sheikov, NA AU - Jolesz, Ferenc AU - Vykhodtseva, N TI - Local and reversible blood-brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications. JF - NEUROIMAGE J2 - NEUROIMAGE VL - 24 PY - 2005 IS - 1 SP - 12 EP - 20 PG - 9 SN - 1053-8119 DO - 10.1016/j.neuroimage.2004.06.046 UR - https://m2.mtmt.hu/api/publication/2568952 ID - 2568952 AB - The purpose of this study was to test the hypothesis that burst ultrasound in the presence of an ultrasound contrast agent can disrupt the blood-brain barrier (BBB) with acoustic parameters suitable for completely noninvasive exposure through the skull. The 10-ms exposures were targeted in the brains of 22 rabbits with a frequency of 690 kHz, a repetition frequency of 1 Hz, and peak rarefactional pressure amplitudes up to 3.1 MPa. The total exposure (sonication) time was 20 s. Prior to each sonication, a bolus of ultrasound contrast agent was injected intravenously. Contrast-enhanced MR images were obtained after the sonications to detect localized BBB disruption via local enhancement in the brain. Brain sections were stained with H&E, TUNEL, and vanadium acid fuchsin (VAF)-toluidine blue staining. In addition, horseradish peroxidase (HRP) was injected into four rabbits prior to sonications and transmission electron microscopy was performed. The MRI contrast enhancement demonstrated BBB disruption at pressure amplitudes starting at 0.4 MPa with approximately 50%; at 0.8 MPa, 90%; and at 1.4 MPa, 100% of the sonicated locations showed enhancement. The histology findings following 4 h survival indicated that brain tissue necrosis was induced in approximately 70-80% of the sonicated locations at a pressure amplitude level of 2.3 MPa or higher. At lower pressure amplitudes, however, small areas of erythrocyte extravasation were seen. The electron microscopy findings demonstrated HRP passage through vessel walls via both transendothelial and paraendothelial routes. These results demonstrate that completely noninvasive focal disruption of the BBB is possible. LA - English DB - MTMT ER - TY - JOUR AU - Hynynen, K AU - McDannold, N AU - Vykhodtseva, N AU - Jolesz, Ferenc TI - Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits. JF - RADIOLOGY J2 - RADIOLOGY VL - 220 PY - 2001 IS - 3 SP - 640 EP - 646 PG - 7 SN - 0033-8419 DO - 10.1148/radiol.2202001804 UR - https://m2.mtmt.hu/api/publication/2569022 ID - 2569022 N1 - Hiányzó Besorolás: 'Journal Article\n\nResearch Support, U.S. Gov\'t, P.H.S.',24 AB - PURPOSE: To determine if focused ultrasound beams can be used to locally open the blood-brain barrier without damage to surrounding brain tissue and if magnetic resonance (MR) imaging can be used to monitor this procedure. MATERIALS AND METHODS: The brains of 18 rabbits were sonicated (pulsed sonication) in four to six locations, with temporal peak acoustic power ranging from 0.2 to 11.5 W. Prior to each sonication, a bolus of ultrasonographic (US) contrast agent was injected into the ear vein of the rabbit. A series of fast or spoiled gradient-echo MR images were obtained during the sonications to monitor the temperature elevation and potential tissue changes. Contrast material-enhanced MR images obtained minutes after sonications and repeated 1-48 hours later were used to depict blood-brain barrier opening. Whole brain histologic evaluation was performed. RESULTS: Opening of the blood-brain barrier was confirmed with detection of MR imaging contrast agent at the targeted locations. The lowest power levels used produced blood-brain barrier opening without damage to the surrounding neurons. Contrast enhancement correlated with the focal signal intensity changes in the magnitude fast spoiled gradient-echo MR images. CONCLUSION: The blood-brain barrier can be consistently opened with focused ultrasound exposures in the presence of a US contrast agent. MR imaging signal intensity changes may be useful in the detection of blood-brain barrier opening during sonication. LA - English DB - MTMT ER - TY - JOUR AU - Cline, HE AU - Hynynen, K AU - Hardy, CJ AU - Watkins, RD AU - Schenck, JF AU - Jolesz, Ferenc TI - MR temperature mapping of focused ultrasound surgery. JF - MAGNETIC RESONANCE IN MEDICINE J2 - MAGN RESON MED VL - 31 PY - 1994 IS - 6 SP - 628 EP - 636 PG - 9 SN - 0740-3194 DO - 10.1002/mrm.1910310608 UR - https://m2.mtmt.hu/api/publication/2569207 ID - 2569207 AB - Deep lying soft tissue tumors may be treated by a nonincisional surgical procedure executed inside an MR imaging system using a thermal effect delivered by a focused ultrasound transducer. A prototype system is constructed to assess MRI thermal monitoring and the localization of the heat zone in muscle. The temperature distribution of the focal spot is imaged with MRI while mechanically moving the transducer with an hydraulic 3-axis positioner. Acoustic power is applied with a spherical shell transducer using 1- to 10-s duration pulses at frequencies of 1.5 MHz to selectively coagulate tissue at 60-70 degrees C. The procedure is monitored with a series of fast second gradient echo, T1-weighted, temperature sensitive MR sequences. Acquisitions are optimized for high temperature sensitive images that yield the thermal diffusivity, heat flow time constant and the focal spot size in muscle. MR temperature maps of muscle provide localization and dosimetry both in the focal region and near field. LA - English DB - MTMT ER -