@article{MTMT:30424165,
	title = {Immediate neurophysiological effects of transcranial electrical stimulation},
	url = {https://m2.mtmt.hu/api/publication/30424165},
	author = {Liu, Anli and Vöröslakos, Mihály and Kronberg, Greg and Henin, Simon and Krause, Matthew R and Huang, Yu and Opitz, Alexander and Mehta, Ashesh and Pack, Christopher C and Krekelberg, Bart and Berényi, Antal and Parra, Lucas C and Melloni, Lucia and Devinsky, Orrin and Buzsáki, György},
	doi = {10.1038/s41467-018-07233-7},
	journal-iso = {NAT COMMUN},
	journal = {NATURE COMMUNICATIONS},
	volume = {9},
	unique-id = {30424165},
	issn = {2041-1723},
	abstract = {Noninvasive brain stimulation techniques are used in experimental and clinical fields for their potential effects on brain network dynamics and behavior. Transcranial electrical stimulation (TES), including transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS), has gained popularity because of its convenience and potential as a chronic therapy. However, a mechanistic understanding of TES has lagged behind its widespread adoption. Here, we review data and modelling on the immediate neurophysiological effects of TES in vitro as well as in vivo in both humans and other animals. While it remains unclear how typical TES protocols affect neural activity, we propose that validated models of current flow should inform study design and artifacts should be carefully excluded during signal recording and analysis. Potential indirect effects of TES (e.g., peripheral stimulation) should be investigated in more detail and further explored in experimental designs. We also consider how novel technologies may stimulate the next generation of TES experiments and devices, thus enhancing validity, specificity, and reproducibility.},
	year = {2018},
	eissn = {2041-1723},
	orcid-numbers = {Vöröslakos, Mihály/0000-0002-1022-1355}
}

@article{MTMT:24223465,
	title = {Noninvasive optical inhibition with a red-shifted microbial rhodopsin},
	url = {https://m2.mtmt.hu/api/publication/24223465},
	author = {Chuong, AS and Miri, ML and Busskamp, V and Matthews, GAC and Acker, LC and Sørensen, AT and Young, A and Klapoetke, NC and Henninger, MA and Kodandaramaiah, SB and Ogawa, M and Ramanlal, SB and Bandler, RC and Allen, BD and Forest, CR and Chow, BY and Han, X and Lin, Y and Tye, KM and Roska, Botond and Cardin, JA and Boyden, ES},
	doi = {10.1038/nn.3752},
	journal-iso = {NAT NEUROSCI},
	journal = {NATURE NEUROSCIENCE},
	volume = {17},
	unique-id = {24223465},
	issn = {1097-6256},
	year = {2014},
	eissn = {1546-1726},
	pages = {1123-1129}
}

@article{MTMT:2568952,
	title = {Local and reversible blood-brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications.},
	url = {https://m2.mtmt.hu/api/publication/2568952},
	author = {Hynynen, K and McDannold, N and Sheikov, NA and Jolesz, Ferenc and Vykhodtseva, N},
	doi = {10.1016/j.neuroimage.2004.06.046},
	journal-iso = {NEUROIMAGE},
	journal = {NEUROIMAGE},
	volume = {24},
	unique-id = {2568952},
	issn = {1053-8119},
	abstract = {The purpose of this study was to test the hypothesis that burst ultrasound in the presence of an ultrasound contrast agent can disrupt the blood-brain barrier (BBB) with acoustic parameters suitable for completely noninvasive exposure through the skull. The 10-ms exposures were targeted in the brains of 22 rabbits with a frequency of 690 kHz, a repetition frequency of 1 Hz, and peak rarefactional pressure amplitudes up to 3.1 MPa. The total exposure (sonication) time was 20 s. Prior to each sonication, a bolus of ultrasound contrast agent was injected intravenously. Contrast-enhanced MR images were obtained after the sonications to detect localized BBB disruption via local enhancement in the brain. Brain sections were stained with H&E, TUNEL, and vanadium acid fuchsin (VAF)-toluidine blue staining. In addition, horseradish peroxidase (HRP) was injected into four rabbits prior to sonications and transmission electron microscopy was performed. The MRI contrast enhancement demonstrated BBB disruption at pressure amplitudes starting at 0.4 MPa with approximately 50%; at 0.8 MPa, 90%; and at 1.4 MPa, 100% of the sonicated locations showed enhancement. The histology findings following 4 h survival indicated that brain tissue necrosis was induced in approximately 70-80% of the sonicated locations at a pressure amplitude level of 2.3 MPa or higher. At lower pressure amplitudes, however, small areas of erythrocyte extravasation were seen. The electron microscopy findings demonstrated HRP passage through vessel walls via both transendothelial and paraendothelial routes. These results demonstrate that completely noninvasive focal disruption of the BBB is possible.},
	keywords = {Animals; Male; RABBITS; NECROSIS; Microscopy, Electron; In Situ Nick-End Labeling; Magnetic Resonance Imaging; Brain/pathology; Contrast Media; Apoptosis/physiology; Gadolinium DTPA/diagnostic use; Extravasation of Diagnostic and Therapeutic Materials/pathology; Echoencephalography/*adverse effects; Blood-Brain Barrier/*injuries/pathology},
	year = {2005},
	eissn = {1095-9572},
	pages = {12-20}
}

@article{MTMT:2569022,
	title = {Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits.},
	url = {https://m2.mtmt.hu/api/publication/2569022},
	author = {Hynynen, K and McDannold, N and Vykhodtseva, N and Jolesz, Ferenc},
	doi = {10.1148/radiol.2202001804},
	journal-iso = {RADIOLOGY},
	journal = {RADIOLOGY},
	volume = {220},
	unique-id = {2569022},
	issn = {0033-8419},
	abstract = {PURPOSE: To determine if focused ultrasound beams can be used to locally open the blood-brain barrier without damage to surrounding brain tissue and if magnetic resonance (MR) imaging can be used to monitor this procedure. MATERIALS AND METHODS: The brains of 18 rabbits were sonicated (pulsed sonication) in four to six locations, with temporal peak acoustic power ranging from 0.2 to 11.5 W. Prior to each sonication, a bolus of ultrasonographic (US) contrast agent was injected into the ear vein of the rabbit. A series of fast or spoiled gradient-echo MR images were obtained during the sonications to monitor the temperature elevation and potential tissue changes. Contrast material-enhanced MR images obtained minutes after sonications and repeated 1-48 hours later were used to depict blood-brain barrier opening. Whole brain histologic evaluation was performed. RESULTS: Opening of the blood-brain barrier was confirmed with detection of MR imaging contrast agent at the targeted locations. The lowest power levels used produced blood-brain barrier opening without damage to the surrounding neurons. Contrast enhancement correlated with the focal signal intensity changes in the magnitude fast spoiled gradient-echo MR images. CONCLUSION: The blood-brain barrier can be consistently opened with focused ultrasound exposures in the presence of a US contrast agent. MR imaging signal intensity changes may be useful in the detection of blood-brain barrier opening during sonication.},
	keywords = {Animals; Male; RABBITS; Brain/pathology; Magnetic Resonance Imaging/*methods; Blood-Brain Barrier/*physiology; *Ultrasonics},
	year = {2001},
	eissn = {1527-1315},
	pages = {640-646}
}

@article{MTMT:2569207,
	title = {MR temperature mapping of focused ultrasound surgery.},
	url = {https://m2.mtmt.hu/api/publication/2569207},
	author = {Cline, HE and Hynynen, K and Hardy, CJ and Watkins, RD and Schenck, JF and Jolesz, Ferenc},
	doi = {10.1002/mrm.1910310608},
	journal-iso = {MAGN RESON MED},
	journal = {MAGNETIC RESONANCE IN MEDICINE},
	volume = {31},
	unique-id = {2569207},
	issn = {0740-3194},
	abstract = {Deep lying soft tissue tumors may be treated by a nonincisional surgical procedure executed inside an MR imaging system using a thermal effect delivered by a focused ultrasound transducer. A prototype system is constructed to assess MRI thermal monitoring and the localization of the heat zone in muscle. The temperature distribution of the focal spot is imaged with MRI while mechanically moving the transducer with an hydraulic 3-axis positioner. Acoustic power is applied with a spherical shell transducer using 1- to 10-s duration pulses at frequencies of 1.5 MHz to selectively coagulate tissue at 60-70 degrees C. The procedure is monitored with a series of fast second gradient echo, T1-weighted, temperature sensitive MR sequences. Acquisitions are optimized for high temperature sensitive images that yield the thermal diffusivity, heat flow time constant and the focal spot size in muscle. MR temperature maps of muscle provide localization and dosimetry both in the focal region and near field.},
	keywords = {Animals; *Magnetic Resonance Imaging; CATTLE; Time Factors; Hot Temperature; Models, Structural; thermal conductivity; Gels; *Body Temperature; Transducers; Thermometers; *Ultrasonic Therapy/instrumentation/methods; Muscles/pathology/physiopathology/*surgery},
	year = {1994},
	eissn = {1522-2594},
	pages = {628-636}
}