TY  - JOUR
AU  - Mondello, S
AU  - Sorinola, Abayomi Akinrinsola
AU  - Czeiter, Endre
AU  - Vámos, Zoltán
AU  - Amrein, Krisztina
AU  - Synnot, A
AU  - Donoghue, EL
AU  - Sándor, János
AU  - Wang, KKW
AU  - Diaz-Arrastia, R
AU  - Steyerberg, EW
AU  - Menon, D
AU  - Maas, A
AU  - Büki, András
TI  - Blood-Based Protein Biomarkers for the Management of Traumatic Brain Injuries in Adults Presenting with Mild Head Injury to Emergency Departments : A Living Systematic Review and Meta-Analysis
JF  - JOURNAL OF NEUROTRAUMA
J2  - J NEUROTRAUM
VL  - 38
PY  - 2021
IS  - 8
SP  - 1086
EP  - 1106
PG  - 21
SN  - 0897-7151
DO  - 10.1089/neu.2017.5182
UR  - https://m2.mtmt.hu/api/publication/3280066
ID  - 3280066
N1  - Funding Agency and Grant Number: European Union FP 7th Framework program (CENTER-TBI) [602150]; Hungarian Brain Research Program [KTIA 13 NAP-A-II/8]
            Funding text: This work was supported by the European Union FP 7th Framework program (CENTER-TBI; Grant number: grant 602150) and the Hungarian Brain Research Program (Grant No. KTIA 13 NAP-A-II/8). We thank Dr. Ornella Clavisi for assistance with the search strategy.
AB  - Accurate diagnosis of traumatic brain injury (TBI) is critical to effective management and intervention, but can be challenging in patients with mild TBI. A substantial number of studies have reported the use of circulating biomarkers as signatures for TBI, capable of improving diagnostic accuracy and clinical decision-making beyond current practice standards. We performed a systematic review and meta-analysis to comprehensively and critically evaluate the existing body of evidence for the use of blood protein biomarkers (S100B, GFAP, NSE, UCH-L1, Tau and Neurofilament proteins) for diagnosis of intracranial lesions on CT following mild TBI. Effects of potential confounding factors and differential diagnostic performance of the included markers were explored. Furthermore, appropriateness of study design, analysis, quality and demonstration of clinical utility were assessed. Studies published up to October 2016 were identified through a MEDLINE, EMBASE and CINHAL search. Following screening of the identified articles, 26 were selected as relevant. We found that measurement of S100B can help informed decision making in the emergency department possibly reducing resource use, but there is insufficient evidence that any of the other markers is ready for clinical application. Our work pointed out serious problems in the design, analysis and reporting of many of the studies and identi fi ed a substantial heterogeneity and research gaps. These findings emphasize the importance of methodologically rigorous studies focused on a biomarker's intended use and defining standardized, validated and reproducible approaches. The living nature of this systematic review, which will summarize key updated information as it becomes available, can inform and guide future implementation of biomarkers in the clinical arena.
LA  - English
DB  - MTMT
ER  -