@article{MTMT:31312924,
	title = {An unsought and expensive way to make gold nanoparticles on the way to the development of SiO2@ZrO2 nanocarriers for cancer vaccination},
	url = {https://m2.mtmt.hu/api/publication/31312924},
	author = {Nagyné Naszályi, Lívia and Dhaene, E and Szigyártó, Imola Csilla and Mihály, Judith and May, Zoltán and Varga, Zoltán and Van Driessche, I and Martins, JC. and Fehér, Krisztina},
	doi = {10.1016/j.molliq.2020.113307},
	journal-iso = {J MOL LIQ},
	journal = {JOURNAL OF MOLECULAR LIQUIDS},
	volume = {311},
	unique-id = {31312924},
	issn = {0167-7322},
	abstract = {Silica@zirconia core@shell oxide nanoparticles of approx. 50 nm diameter were developed in view of an application as a novel carrier with adjuvant activities for cancer vaccines. To this end, the aim was to cover the surface of the nanocarrier by potent single stranded DNA (ssDNA) type immune stimulators used in cancer vaccination. Prior to characterizing the binding of ssDNA to the nanocarrier surface, the adsorption of deoxynucleoside monophosphate building blocks (dNMPs) was studied. After optimization of conditions for synthesis, solvent exchange and surface modification, the effects and possible interference of several buffers, such as HEPES, PIPES, MOPS and MOPSO, were also investigated. Formation of a new compound was revealed by UV–VIS spectroscopy during the recording of zeta potential vs. pH titration curves in the presence of HEPES and PIPES buffer in the neutral-acidic pH region. We identified this new species as gold ions etched from the electrode of the zeta cuvette, stabilized by the buffers via chelation, which is then followed by their conversion into gold nanoparticles.},
	year = {2020},
	eissn = {1873-3166},
	orcid-numbers = {Nagyné Naszályi, Lívia/0000-0003-2799-1150; Varga, Zoltán/0000-0002-5741-2669}
}

@article{MTMT:32045027,
	title = {mRNA vaccines - a new era in vaccinology},
	url = {https://m2.mtmt.hu/api/publication/32045027},
	author = {Pardi, Norbert and Hogan, Michael J. and Porter, Frederick W. and Weissman, Drew},
	doi = {10.1038/nrd.2017.243},
	journal-iso = {NAT REV DRUG DISCOV},
	journal = {NATURE REVIEWS DRUG DISCOVERY},
	volume = {17},
	unique-id = {32045027},
	issn = {1474-1776},
	abstract = {mRNA vaccines represent a promising alternative to conventional vaccine approaches because of their high potency, capacity for rapid development and potential for low-cost manufacture and safe administration. However, their application has until recently been restricted by the instability and inefficient in vivo delivery of mRNA. Recent technological advances have now largely overcome these issues, and multiple mRNA vaccine platforms against infectious diseases and several types of cancer have demonstrated encouraging results in both animal models and humans. This Review provides a detailed overview of mRNA vaccines and considers future directions and challenges in advancing this promising vaccine platform to widespread therapeutic use.},
	year = {2018},
	eissn = {1474-1784},
	pages = {261-279}
}

@article{MTMT:3071427,
	title = {Silica@zirconia@poly(malic acid) nanoparticle: a promising nanocarrier for theranostic applications},
	url = {https://m2.mtmt.hu/api/publication/3071427},
	author = {Nagyné Naszályi, Lívia and Polyák, András and Mihály, Judith and Szécsényi, Á and Szigyártó, Imola Csilla and Czégény, Zsuzsanna and Pekkerné Jakab, Emma and Németh, Péter and Magda, Balázs and Szabó, Pál Tamás and Veres, Zsuzsa and Jemnitz, Katalin and Bertóti, Imre and Jóba, Róbert Péter and Trencsényi, György and Balogh, L and Bóta, Attila},
	doi = {10.1039/c6tb01102k},
	journal-iso = {J MATER CHEM B},
	journal = {JOURNAL OF MATERIALS CHEMISTRY B},
	volume = {4},
	unique-id = {3071427},
	issn = {2050-750X},
	year = {2016},
	eissn = {2050-7518},
	pages = {4420-4429},
	orcid-numbers = {Nagyné Naszályi, Lívia/0000-0003-2799-1150; Németh, Péter/0000-0001-5592-5877; Szabó, Pál Tamás/0000-0003-2260-4641; Trencsényi, György/0000-0001-6456-6212}
}

@article{MTMT:2946826,
	title = {Inherently fluorescent and porous zirconia colloids: preparation, characterization and drug adsorption studies},
	url = {https://m2.mtmt.hu/api/publication/2946826},
	author = {Nagyné Naszályi, Lívia and Mihály, Judith and Polyák, András and Debreczeni, B and Csaszar, B and Szigyártó, Imola Csilla and Wacha, András Ferenc and Czégény, Zsuzsanna and Pekkerné Jakab, Emma and Klébert, Szilvia and Drotár, Eszter and Dabasi, Gabriella and Bóta, Attila and Balogh, Lajos and Kiss, Éva},
	doi = {10.1039/c5tb00832h},
	journal-iso = {J MATER CHEM B},
	journal = {JOURNAL OF MATERIALS CHEMISTRY B},
	volume = {3},
	unique-id = {2946826},
	issn = {2050-750X},
	abstract = {Porous, fluorescent zirconia particles of nearly 380 nm diameter were prepared without template molecules or labeling dyes. The porous structure is the result of aggregation-induced particle formation. The inherent fluorescence is assigned to coordinatively unsaturated Zr4+ ions at the sol-gel derived ZrO2 surface. After physico-chemical characterization of the native zirconia particles carboxyl and/or amine bearing drug molecules (d,l-[small alpha]-difluoromethylornithine - DFMO, ursolic acid - UA and doxorubicin - DOX) were adsorbed onto their surface, and the products were analyzed with Fourier-transform infrared spectroscopy (FTIR), thermogravimetry (TG), small-angle X-ray scattering (SAXS), fluorimetry and zeta potential vs. pH measurements. We have found that DOX complexes coordinatively unsaturated Zr4+ ions without dislocating them, while carboxyl-bearing drugs interact with basic surface Zr-OH sites eliminating some of the carbonate species. The adsorption of UA at the zirconia surface shifts considerably the isoelectric point of the surface and thus provides kinetic stability to the particles at physiological pH. An in vivo biodistribution study in two healthy dogs performed by SPECT/CT detection after 99mTc labeling of the nanocarriers has shown the possibility of drug delivery application.},
	year = {2015},
	eissn = {2050-7518},
	pages = {7529-7537},
	orcid-numbers = {Nagyné Naszályi, Lívia/0000-0003-2799-1150; Wacha, András Ferenc/0000-0002-9609-0893; Klébert, Szilvia/0000-0002-3107-3371; Dabasi, Gabriella/0000-0002-3484-1049; Kiss, Éva/0000-0002-4757-4437}
}