@article{MTMT:30924863,
	title = {Molecular Diversity of Plasma Membrane Ca2+ Transporting ATPases: Their Function Under Normal and Pathological Conditions},
	url = {https://m2.mtmt.hu/api/publication/30924863},
	author = {Hegedűs, L. and Zámbó, Boglárka and Pászty, Katalin and Padányi, Rita and Varga, Karolina and Penniston, J.T. and Enyedi, Ágnes},
	doi = {10.1007/978-3-030-12457-1_5},
	journal-iso = {ADV EXP MED BIOL},
	journal = {ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY},
	volume = {1131},
	unique-id = {30924863},
	issn = {0065-2598},
	abstract = {Plasma membrane Ca2+ transport ATPases (PMCA1-4, ATP2B1-4) are responsible for removing excess Ca2+ from the cell in order to keep the cytosolic Ca2+ ion concentration at the low level essential for normal cell function. While these pumps take care of cellular Ca2+ homeostasis they also change the duration and amplitude of the Ca2+ signal and can create Ca2+ gradients across the cell. This is accomplished by generating more than twenty PMCA variants each having the character – fast or slow response, long or short memory, distinct interaction partners and localization signals – that meets the specific needs of the particular cell-type in which they are expressed. It has become apparent that these pumps are essential to normal tissue development and their malfunctioning can be linked to different pathological conditions such as certain types of neurodegenerative and heart diseases, hearing loss and cancer. In this chapter we summarize the complexity of PMCA regulation and function under normal and pathological conditions with particular attention to recent developments of the field. © Springer Nature Switzerland AG 2020.},
	keywords = {Animals; Humans; metabolism; GENETICS; CALMODULIN; human; animal; physiology; Cell Membrane; pathology; enzymology; Homeostasis; Genetic Variation; Cytosol; actin cytoskeleton; Plasma Membrane Calcium-Transporting ATPases; plasma membrane calcium transporting adenosine triphosphatase; ALTERED EXPRESSION; Ca2+ signal; Alternative splice; ATP2B1-4; Pathological condition; Phosphatidylinositol-45-bisphosphate; Plasma membrane Ca2+ ATPase (PMCA)},
	year = {2020},
	eissn = {2214-8019},
	pages = {93-129},
	orcid-numbers = {Pászty, Katalin/0000-0003-2457-8555; Padányi, Rita/0000-0001-7798-0463; Varga, Karolina/0000-0003-4746-8738; Enyedi, Ágnes/0000-0002-7366-9376}
}

@article{MTMT:3190054,
	title = {Decreased calcium pump expression in human erythrocytes is connected to a minor haplotype in the ATP2B4 gene},
	url = {https://m2.mtmt.hu/api/publication/3190054},
	author = {Zámbó, Boglárka and Várady, György and Padányi, Rita and Szabó, Edit Zsuzsanna and Németh, Adrienn and Langó, Tamás and Enyedi, Ágnes and Sarkadi, Balázs},
	doi = {10.1016/j.ceca.2017.02.001},
	journal-iso = {CELL CALCIUM},
	journal = {CELL CALCIUM},
	volume = {65},
	unique-id = {3190054},
	issn = {0143-4160},
	abstract = {Plasma membrane Ca2+-ATPases are key calcium exporter proteins in most tissues, and PMCA4b is the main calcium transporter in the human red blood cells (RBCs). In order to assess the expression level of PMCA4b, we have developed a flow cytometry and specific antibody binding method to quantitatively detect this protein in the erythrocyte membrane. Interestingly, we found several healthy volunteers showing significantly reduced expression of RBC-PMCA4b. Western blot analysis of isolated RBC membranes confirmed this observation, and indicated that there are no compensatory alterations in other PMCA isoforms. In addition, reduced PMCA4b levels correlated with a lower calcium extrusion capacity in these erythrocytes. When exploring the potential genetic background of the reduced PMCA4b levels, we found no missense mutations in the ATP2B4 coding regions, while a formerly unrecognized minor haplotype in the predicted second promoter region closely correlated with lower erythrocyte PMCA4b protein levels. In recent GWA studies, SNPs in this ATP2B4 haplotype have been linked to reduced mean corpuscular hemoglobin concentrations (MCHC), and to protection against malaria infection. Our data suggest that an altered regulation of gene expression is responsible for the reduced RBC-PMCA4b levels that is probably linked to the development of human disease-related phenotypes.},
	year = {2017},
	eissn = {1532-1991},
	pages = {73-79},
	orcid-numbers = {Várady, György/0000-0003-2012-9680; Padányi, Rita/0000-0001-7798-0463; Enyedi, Ágnes/0000-0002-7366-9376; Sarkadi, Balázs/0000-0003-0592-4539}
}

@article{MTMT:3015469,
	title = {Multifaceted plasma membrane Ca2+ pumps: From structure to intracellular Ca2+ handling and cancer},
	url = {https://m2.mtmt.hu/api/publication/3015469},
	author = {Padányi, Rita and Pászty, Katalin and Hegedűs, Luca and Varga, Karolina and Béla, Papp and John, T Penniston and Enyedi, Ágnes},
	doi = {10.1016/j.bbamcr.2015.12.011},
	journal-iso = {BBA-MOL CELL RES},
	journal = {BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH},
	volume = {1863},
	unique-id = {3015469},
	issn = {0167-4889},
	year = {2016},
	eissn = {1879-2596},
	pages = {1351-1363},
	orcid-numbers = {Padányi, Rita/0000-0001-7798-0463; Pászty, Katalin/0000-0003-2457-8555; Varga, Karolina/0000-0003-4746-8738; Enyedi, Ágnes/0000-0002-7366-9376}
}