TY - JOUR AU - Komlósi, Zsolt AU - Kovács, N AU - Sokolowska, M AU - van, de Veen W AU - Akdis, M AU - Akdis, CA TI - Mechanisms of Subcutaneous and Sublingual Aeroallergen Immunotherapy: What Is New? JF - IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA J2 - IMMUNOL ALLERGY CLIN VL - 40 PY - 2020 IS - 1 SP - 1 EP - 14 PG - 14 SN - 0889-8561 DO - 10.1016/j.iac.2019.09.009 UR - https://m2.mtmt.hu/api/publication/31016987 ID - 31016987 N1 - Funding Agency and Grant Number: Hungarian Pediatric Oncology Network; Swiss National Science FoundationSwiss National Science Foundation (SNSF) Funding text: The laboratory of the corresponding author Z.I. Komlosi is supported by Hungarian Pediatric Oncology Network. The laboratories of the authors C.A. Akdis and M. Akdis are supported by the Swiss National Science Foundation. AB - Allergen immunotherapy (AIT) is considered to be the only treatment option with the promise of healing and induction of long-lasting allergen tolerance, persisting even after discontinuation of therapy. Despite a more than 100-year-long history, still only a minority of patients are being treated with AIT. Substantial developments took place in the last decade to overcome problems in standardization, efficacy, safety, high costs, long duration of treatment; and new guidelines have also been implemented. Major advancements in the understanding of AIT mechanisms with the focus on recent findings of subcutaneous and sublingual AIT have been summarized. © 2019 The Authors LA - English DB - MTMT ER - TY - JOUR AU - Komlósi, Zsolt AU - Kovacs, N AU - van de Veen, W AU - Kirsch, AI AU - Fahrner, HB AU - Wawrzyniak, M AU - Rebane, A AU - Stanic, B AU - Palomares, O AU - Ruckert, B AU - Menz, G AU - Akdis, M AU - Losonczy, György AU - Akdis, CA TI - Human CD40 ligand-expressing type 3 innate lymphoid cells induce IL-10-producing immature transitional regulatory B cells JF - JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY J2 - J ALLERGY CLIN IMMUN VL - 142 PY - 2018 IS - 1 SP - 178 EP - 194.e11 PG - 19 SN - 0091-6749 DO - 10.1016/j.jaci.2017.07.046 UR - https://m2.mtmt.hu/api/publication/3329077 ID - 3329077 AB - BACKGROUND: Type 3 innate lymphoid cells (ILC3s) are involved in maintenance of mucosal homeostasis; however, their role in immunoregulation has been unknown. Immature transitional regulatory B (itBreg) cells are innate-like B cells with immunosuppressive properties, and the in vivo mechanisms by which they are induced have not been fully clarified. OBJECTIVE: We aimed to investigate the ILC3-B-cell interaction that probably takes place in human tonsils. METHODS: ILC3s were isolated from peripheral blood and palatine tonsils, expanded, and cocultured with naive B cells. Tonsillar ILC3s and regulatory B cells were visualized with immunofluorescence histology. ILC3 frequencies were measured in tonsil tissue of allergic and nonallergic patients and in peripheral blood of allergic asthmatic patients and healthy control subjects. RESULTS: A mutually beneficial relationship was revealed between ILC3s and B cells: ILC3s induced IL-15 production in B cells through B cell-activating factor receptor, whereas IL-15, a potent growth factor for ILC3s, induced CD40 ligand (CD40L) expression on circulating and tonsillar ILC3s. IL-15-activated CD40L(+) ILC3s helped B-cell survival, proliferation, and differentiation of IL-10-secreting, PD-L1-expressing functional itBreg cells in a CD40L- and B cell-activating factor receptor-dependent manner. ILC3s and regulatory B cells were in close connection with each other in palatine tonsils. ILC3 frequency was reduced in tonsil tissue of allergic patients and in peripheral blood of allergic asthmatic patients. CONCLUSION: Human CD40L(+) ILC3s provide innate B-cell help and are involved in an innate immunoregulatory mechanism through induction of itBreg cell differentiation, which takes place in palatine tonsils in vivo. This mechanism, which can contribute to maintenance of immune tolerance, becomes insufficient in allergic diseases. LA - English DB - MTMT ER - TY - JOUR AU - Szekeres, Júlia TI - The Role of Progesterone in Feto-Maternal Immunological Cross Talk JF - MEDICAL PRINCIPLES AND PRACTICE J2 - MED PRIN PRACT VL - 27 PY - 2018 IS - 4 SP - 301 EP - 307 PG - 7 SN - 1011-7571 DO - 10.1159/000491576 UR - https://m2.mtmt.hu/api/publication/3424598 ID - 3424598 N1 - Department of Medical Biology, Central Electron Microscope Laboratory, Medical School, Pecs University, 12 Szigeti Street, Pecs, HU-7624, Hungary János Szentágothai Research Centre, Pecs University, Pecs, Hungary Endocrine Studies, Centre of Excellence, Pecs University, Pecs, Hungary Cited By :45 Export Date: 2 October 2023 CODEN: MPPRE LA - English DB - MTMT ER - TY - JOUR AU - Akdis, M AU - Aab, A AU - Altunbulakli, C AU - Azkur, K AU - Costa, RA AU - Crameri, R AU - Duan, S AU - Eiwegger, T AU - Eljaszewicz, A AU - Ferstl, R AU - Frei, R AU - Garbani, M AU - Globinska, A AU - Hess, L AU - Huitema, C AU - Kubo, T AU - Komlósi, Zsolt AU - Konieczna, P AU - Kovacs, N AU - Kucuksezer, UC AU - Meyer, N AU - Morita, H AU - Olzhausen, J AU - O'Mahony, L AU - Pezer, M AU - Prati, M AU - Rebane, A AU - Rhyner, C AU - Rinaldi, A AU - Sokolowska, M AU - Stanic, B AU - Sugita, K AU - Treis, A AU - van de Veen, W AU - Wanke, K AU - Wawrzyniak, M AU - Wawrzyniak, P AU - Wirz, OF AU - Zakzuk, JS AU - Akdis, CA TI - Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases JF - JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY J2 - J ALLERGY CLIN IMMUN VL - 138 PY - 2016 IS - 4 SP - 984 EP - 1010 PG - 27 SN - 0091-6749 DO - 10.1016/j.jaci.2016.06.033 UR - https://m2.mtmt.hu/api/publication/3329078 ID - 3329078 N1 - Cited By :413 Export Date: 21 August 2022 CODEN: JACIB Correspondence Address: Akdis, M.; Swiss Institute of Allergy and Asthma Research (SIAF), Obere Strasse 22, Switzerland; email: akdism@siaf.uzh.ch AB - There have been extensive developments on cellular and molecular mechanisms of immune regulation in allergy, asthma, autoimmune diseases, tumor development, organ transplantation, and chronic infections during the last few years. Better understanding the functions, reciprocal regulation, and counterbalance of subsets of immune and inflammatory cells that interact through interleukins, interferons, TNF-alpha, and TGF-beta offer opportunities for immune interventions and novel treatment modalities in the era of development of biological immune response modifiers particularly targeting these molecules or their receptors. More than 60 cytokines have been designated as interleukins since the initial discoveries of monocyte and lymphocyte interleukins (called IL-1 and IL-2, respectively). Studies of transgenic or gene-deficient mice with altered expression of these cytokines or their receptors and analyses of mutations and polymorphisms in human genes that encode these products have provided essential information about their functions. Here we review recent developments on IL-1 to IL-38, TNF-alpha, TGF-beta, and interferons. We highlight recent advances during the last few years in this area and extensively discuss their cellular sources, targets, receptors, signaling pathways, and roles in immune regulation in patients with allergy and asthma and other inflammatory diseases. LA - English DB - MTMT ER - TY - JOUR AU - Komlósi, Zsolt AU - Pozsonyi, E AU - Tábi, Tamás AU - Szökő, Éva AU - Nagy, A AU - Bartos, B AU - Kozma, Gergely Tibor AU - Tamási, Lilla AU - Orosz, Márta AU - Magyar, Pál AU - Losonczy, György TI - Lipopolysaccharide exposure makes allergic airway inflammation and hyper-responsiveness less responsive to dexamethasone and inhibition of iNOS JF - CLINICAL AND EXPERIMENTAL ALLERGY J2 - CLIN EXP ALLERGY VL - 36 PY - 2006 IS - 7 SP - 951 EP - 959 PG - 9 SN - 0954-7894 DO - 10.1111/j.1365-2222.2006.02514.x UR - https://m2.mtmt.hu/api/publication/1303081 ID - 1303081 N1 - A WoS-ban a szerzőség elírva, hiányosan szerepel (hiányzó szerző: Kozma GT Department of Pulmonology, Semmelweis University, Budapest, Hungary Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary 1st Department of Pediatrics, Semmelweis University, Budapest, Hungary Pulmonology, Semmelweis University, Diós árok 1/C, Budapest 1125, Hungary Cited By :20 Export Date: 16 September 2020 CODEN: CLEAE Correspondence Address: Losonczy, G.; Pulmonology, Semmelweis University, Diós árok 1/C, Budapest 1125, Hungary; email: losonczy@pulm.sote.hu AB - Allergic airway disease can be refractory to anti-inflammatory treatment, whose cause is unclarified. Therefore, in the present experiment, we have tested the hypothesis that co-exposure to lipopolysacharide (Lps) and allergen results in glucocorticoid- resistant eosinophil airway inflammation and hyper- responsiveness (AHR). Ovalbumin (Ova)-sensitized BALB/c mice were primed with 10 mu g intranasal Lps 24 h before the start of Ova challenges (20 min on 3 consecutive days). Dexamethasone (5 mg/kg/day) was given on the last 2 days of Ova challenges. AHR, cellular build-up, cytokine and nitrite concentrations of bronchoalveolar lavage fluid (BALF) and lung histology were examined. To assess the role of iNOS-derived NO in airway responsiveness, mice were treated with a selective inhibitor of this enzyme (1400W) 2 h before AHR measurements. More severe eosinophil inflammation and higher nitrite formation were found in Lps-primed than in non-primed allergized mice. After Lps priming, AHR and concentrations of T-helper type 2 cytokines in BALF were decreased, but still remained significantly higher than in controls. Eosinophil inflammation was partially, while nitrite production and AHR were observed to be largely dexamethasone resistant in Lps-primed allergized animals. 1400W effectively and rapidly diminished the AHR in Ova-sensitized and challenged mice, but failed to affect it after Lps priming plus allergization. In conclusion, Lps inhalation may exaggerate eosinophil inflammation and reduce responsiveness to anti- inflammatory treatment in allergic airway disease. LA - English DB - MTMT ER -