@article{MTMT:2222611,
	title = {Neuronal and Astroglial Correlates Underlying Spatiotemporal Intrinsic Optical Signal in the Rat Hippocampal Slice},
	url = {https://m2.mtmt.hu/api/publication/2222611},
	author = {Pál, Ildikó and Nyitrai, Gabriella and Kardos, Julianna and Héja, László},
	doi = {10.1371/journal.pone.0057694},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {8},
	unique-id = {2222611},
	issn = {1932-6203},
	year = {2013},
	eissn = {1932-6203},
	orcid-numbers = {Pál, Ildikó/0000-0003-2124-9967}
}

@article{MTMT:1121150,
	title = {Coupling of the cortical hemodynamic response to cortical and thalamic neuronal activity.},
	url = {https://m2.mtmt.hu/api/publication/1121150},
	author = {Devor, A and Ulbert, István and Dunn, AK and Narayanan, SN and Jones, SR and Andermann, ML and Boas, DA and Dale, AM},
	doi = {10.1073/pnas.0407789102},
	journal-iso = {P NATL ACAD SCI USA},
	journal = {PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA},
	volume = {102},
	unique-id = {1121150},
	issn = {0027-8424},
	abstract = {Accurate interpretation of functional MRI (fMRI) signals requires knowledge of
		the relationship between the hemodynamic response and the neuronal activity that 
		underlies it. Here we address the question of coupling between pre- and
		postsynaptic neuronal activity and the hemodynamic response in rodent
		somatosensory (Barrel) cortex in response to single-whisker deflection. Using
		full-field multiwavelength optical imaging of hemoglobin oxygenation and
		electrophysiological recordings of spiking activity and local field potentials,
		we demonstrate that a point hemodynamic measure is influenced by neuronal
		activity across multiple cortical columns. We demonstrate that the hemodynamic
		response is a spatiotemporal convolution of the neuronal activation. Therefore,
		positive hemodynamic response in one cortical column might be explained by
		neuronal activity not only in that column but also in the neighboring columns.
		Thus, attempts at characterizing the neurovascular relationship based on point
		measurements of electrophysiology and hemodynamics may yield inconsistent
		results, depending on the spatial extent of neuronal activation. The finding that
		the hemodynamic signal observed at a given location is a function of
		electrophysiological activity over a broad spatial region helps explain a
		previously observed increase of local vascular response beyond the saturation of 
		local neuronal activity. We also demonstrate that the oxy- and total-hemoglobin
		hemodynamic responses can be well approximated by space-time separable functions 
		with an antagonistic center-surround spatial pattern extending over several
		millimeters. The surround "negative" hemodynamic activity did not correspond to
		observable changes in neuronal activity. The complex spatial integration of the
		hemodynamic response should be considered when interpreting fMRI data.},
	year = {2005},
	eissn = {1091-6490},
	pages = {3822-3827},
	orcid-numbers = {Ulbert, István/0000-0001-9941-9159}
}

@article{MTMT:1121144,
	title = {Coupling of total hemoglobin concentration, oxygenation, and neural activity in rat somatosensory cortex.},
	url = {https://m2.mtmt.hu/api/publication/1121144},
	author = {Devor, A and Dunn, AK and Andermann, ML and Ulbert, István and Boas, DA and Dale, AM},
	doi = {10.1016/S0896-6273(03)00403-3},
	journal-iso = {NEURON},
	journal = {NEURON},
	volume = {39},
	unique-id = {1121144},
	issn = {0896-6273},
	abstract = {Recent advances in brain imaging techniques, including functional magnetic
		resonance imaging (fMRI), offer great promise for noninvasive mapping of brain
		function. However, the indirect nature of the imaging signals to the underlying
		neural activity limits the interpretation of the resulting maps. The present
		report represents the first systematic study with sufficient statistical power to
		quantitatively characterize the relationship between changes in blood oxygen
		content and the neural spiking and synaptic activity. Using two-dimensional
		optical measurements of hemodynamic signals, simultaneous recordings of neural
		activity, and an event-related stimulus paradigm, we demonstrate that (1) there
		is a strongly nonlinear relationship between electrophysiological measures of
		neuronal activity and the hemodynamic response, (2) the hemodynamic response
		continues to grow beyond the saturation of electrical activity, and (3) the
		initial increase in deoxyhemoglobin that precedes an increase in blood volume is 
		counterbalanced by an equal initial decrease in oxyhemoglobin.},
	year = {2003},
	eissn = {1097-4199},
	pages = {353-359},
	orcid-numbers = {Ulbert, István/0000-0001-9941-9159}
}