TY - JOUR AU - Bhatt, D.L. AU - Szarek, M. AU - Gabriel, Steg P. AU - Cannon, C.P. AU - Leiter, L.A. AU - McGuire, D.K. AU - Lewis, J.B. AU - Riddle, M.C. AU - Voors, A.A. AU - Metra, M. AU - Lund, L.H. AU - Komajda, M. AU - Testani, J.M. AU - Wilcox, C.S. AU - Ponikowski, P. AU - Lopes, R.D. AU - Verma, S. AU - Lapuerta, P. AU - Pitt, B. ED - Benedek, Imre-Sándor / Collaborator ED - Merkely, Béla Péter / Collaborator ED - Papp, Előd / Collaborator ED - Noori, Ebrahim / Collaborator ED - József, Lippai / Collaborator ED - Lupkovics, Géza / Collaborator ED - Istvan, Edes / Collaborator ED - Pálinkás, Attila / Collaborator ED - Ignác, Imre Szakál / Collaborator ED - Gabriella, Hodi / Collaborator ED - Róbert, Gábor Kiss / Collaborator ED - Kalman, Toth / Collaborator ED - András, Csaba Nagy / Collaborator ED - Andras, Papp / Collaborator ED - Lászó, Márk / Collaborator ED - Papp, Anikó / Collaborator ED - Robert, Jozsef Kirschner / Collaborator TI - Sotagliflozin in patients with diabetes and recent worsening heart failure JF - NEW ENGLAND JOURNAL OF MEDICINE J2 - NEW ENGL J MED VL - 384 PY - 2021 IS - 2 SP - 117 EP - 128 PG - 12 SN - 0028-4793 DO - 10.1056/NEJMoa2030183 UR - https://m2.mtmt.hu/api/publication/31969727 ID - 31969727 LA - English DB - MTMT ER - TY - JOUR AU - Cosentino, Francesco AU - Grant, Peter J AU - Aboyans, Victor AU - Bailey, Clifford J AU - Ceriello, Antonio AU - Delgado, Victoria AU - Federici, Massimo AU - Filippatos, Gerasimos AU - Grobbee, Diederick E AU - Hansen, Tina Birgitte AU - Huikuri, Heikki V AU - Johansson, Isabelle AU - Jüni, Peter AU - Lettino, Maddalena AU - Marx, Nikolaus AU - Mellbin, Linda G AU - Östgren, Carl J AU - Rocca, Bianca AU - Roffi, Marco AU - Sattar, Naveed AU - Seferović, Petar M AU - Sousa-Uva, Miguel AU - Valensi, Paul AU - Wheeler, David C ED - European, Association for the Study of Diabetes (EASD) / Collaborative Organization ED - Piepoli, Massimo Francesco / Collaborator ED - Birkeland, Kåre I / Collaborator ED - Adamopoulos, Stamatis / Collaborator ED - Ajjan, Ramzi / Collaborator ED - Avogaro, Angelo / Collaborator ED - Baigent, Colin / Collaborator ED - Brodmann, Marianne / Collaborator ED - Bueno, Héctor / Collaborator ED - Ceconi, Claudio / Collaborator ED - Chioncel, Ovidiu / Collaborator ED - Coats, Andrew / Collaborator ED - Collet, Jean-Philippe / Collaborator ED - Collins, Peter / Collaborator ED - Cosyns, Bernard / Collaborator ED - Di Mario, Carlo / Collaborator ED - Fisher, Miles / Collaborator ED - Fitzsimons, Donna / Collaborator ED - Halvorsen, Sigrun / Collaborator ED - Hansen, Dominique / Collaborator ED - Hoes, Arno / Collaborator ED - Holt, Richard I G / Collaborator ED - Home, Philip / Collaborator ED - Katus, Hugo A / Collaborator ED - Khunti, Kamlesh / Collaborator ED - Komajda, Michel / Collaborator ED - Lambrinou, Ekaterini / Collaborator ED - Landmesser, Ulf / Collaborator ED - Lewis, Basil S / Collaborator ED - Linde, Cecilia / Collaborator ED - Lorusso, Roberto / Collaborator ED - Mach, François / Collaborator ED - Mueller, Christian / Collaborator ED - Neumann, Franz-Josef / Collaborator ED - Persson, Frederik / Collaborator ED - Petersen, Steffen E / Collaborator ED - Petronio, Anna Sonia / Collaborator ED - Richter, Dimitrios J / Collaborator ED - Rosano, Giuseppe M C / Collaborator ED - Rossing, Peter / Collaborator ED - Rydén, Lars / Collaborator ED - Shlyakhto, Evgeny / Collaborator ED - Simpson, Iain A / Collaborator ED - Touyz, Rhian M / Collaborator ED - Wijns, William / Collaborator ED - Wilhelm, Matthias / Collaborator ED - Williams, Bryan / Collaborator ED - Aboyans, Victor / Collaborator ED - Bailey, Clifford J / Collaborator ED - Ceriello, Antonio / Collaborator ED - Delgado, Victoria / Collaborator ED - Federici, Massimo / Collaborator ED - Filippatos, Gerasimos / Collaborator ED - Grobbee, Diederick E / Collaborator ED - Hansen, Tina Birgitte / Collaborator ED - Huikuri, Heikki V / Collaborator ED - Johansson, Isabelle / Collaborator ED - Jüni, Peter / Collaborator ED - Lettino, Maddalena / Collaborator ED - Marx, Nikolaus / Collaborator ED - Mellbin, Linda G / Collaborator ED - Östgren, Carl J / Collaborator ED - Rocca, Bianca / Collaborator ED - Roffi, Marco / Collaborator ED - Sattar, Naveed / Collaborator ED - Seferović, Petar M / Collaborator ED - Sousa-Uva, Miguel / Collaborator ED - Valensi, Paul / Collaborator ED - Wheeler, David C / Collaborator ED - Windecker, Stephan / Collaborator ED - Aboyans, Victor / Collaborator ED - Baigent, Colin / Collaborator ED - Collet, Jean-Philippe / Collaborator ED - Dean, Veronica / Collaborator ED - Delgado, Victoria / Collaborator ED - Fitzsimons, Donna / Collaborator ED - Gale, Chris P / Collaborator ED - Grobbee, Diederick E / Collaborator ED - Halvorsen, Sigrun / Collaborator ED - Hindricks, Gerhard / Collaborator ED - Iung, Bernard / Collaborator ED - Jüni, Peter / Collaborator ED - Katus, Hugo A / Collaborator ED - Landmesser, Ulf / Collaborator ED - Leclercq, Christophe / Collaborator ED - Lettino, Maddalena / Collaborator ED - Lewis, Basil S / Collaborator ED - Merkely, Bela / Collaborator ED - Mueller, Christian / Collaborator ED - Petersen, Steffen E / Collaborator ED - Petronio, Anna Sonia / Collaborator ED - Richter, Dimitrios J / Collaborator ED - Roffi, Marco / Collaborator ED - Shlyakhto, Evgeny / Collaborator ED - Simpson, Iain A / Collaborator ED - Sousa-Uva, Miguel / Collaborator ED - Touyz, Rhian M / Collaborator ED - Zelveian, Parounak H / Collaborator ED - Scherr, Daniel / Collaborator ED - Jahangirov, Tofig / Collaborator ED - Lazareva, Irina / Collaborator ED - Shivalkar, Bharati / Collaborator ED - Naser, Nabil / Collaborator ED - Gruev, Ivan / Collaborator ED - Milicic, Davor / Collaborator ED - Petrou, Petros M / Collaborator ED - Linhart, Aleš / Collaborator ED - Hildebrandt, Per / Collaborator ED - Hasan-Ali, Hosam / Collaborator ED - Marandi, Toomas / Collaborator ED - Lehto, Seppo / Collaborator ED - Mansourati, Jacques / Collaborator ED - Kurashvili, Ramaz / Collaborator ED - Siasos, Gerasimos / Collaborator ED - Lengyel, Csaba Attila / Collaborator ED - Thrainsdottir, Inga S / Collaborator ED - Aronson, Doron / Collaborator ED - Di Lenarda, Andrea / Collaborator ED - Raissova, Aigul / Collaborator ED - Ibrahimi, Pranvera / Collaborator ED - Abilova, Saamai / Collaborator ED - Trusinskis, Karlis / Collaborator ED - Saade, Georges / Collaborator ED - Benlamin, Hisham / Collaborator ED - Petrulioniene, Zaneta / Collaborator ED - Banu, Cristiana / Collaborator ED - Magri, Caroline Jane / Collaborator ED - David, Lilia / Collaborator ED - Boskovic, Aneta / Collaborator ED - Alami, Mohamed / Collaborator ED - Liem, An Ho / Collaborator ED - Bosevski, Marijan / Collaborator ED - Svingen, Gard Frodahl Tveitevaag / Collaborator ED - Janion, Marianna / Collaborator ED - Gavina, Cristina / Collaborator ED - Vinereanu, Dragos / Collaborator ED - Nedogoda, Sergey / Collaborator ED - Mancini, Tatiana / Collaborator ED - Ilic, Marina Deljanin / Collaborator ED - Fabryova, Lubomira / Collaborator ED - Fras, Zlatko / Collaborator ED - Jiménez-Navarro, Manuel F / Collaborator ED - Norhammar, Anna / Collaborator ED - Lehmann, Roger / Collaborator ED - Mourali, Mohamed Sami / Collaborator ED - Ural, Dilek / Collaborator ED - Nesukay, Elena / Collaborator ED - Chowdhury, Tahseen Ahmad / Collaborator ED - Lengyel, Csaba / Collaborator TI - 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD JF - EUROPEAN HEART JOURNAL J2 - EUR HEART J VL - 41 PY - 2020 IS - 2 SP - 255 EP - 323 PG - 69 SN - 0195-668X DO - 10.1093/eurheartj/ehz486 UR - https://m2.mtmt.hu/api/publication/30804305 ID - 30804305 LA - English DB - MTMT ER - TY - JOUR AU - Packer, Milton AU - Anker, Stefan D. AU - Butler, Javed AU - Filippatos, Gerasimos AU - Pocock, Stuart J. AU - Carson, Peter AU - Januzzi, James AU - Verma, Subodh AU - Tsutsui, Hiroyuki AU - Brueckmann, Martina AU - Jamal, Waheed AU - Kimura, Karen AU - Schnee, Janet AU - Zeller, Cordula AU - Cotton, Daniel AU - Bocchi, Edimar AU - Böhm, Michael AU - Choi, Dong-Ju AU - Chopra, Vijay AU - Chuquiure, Eduardo AU - Giannetti, Nadia AU - Janssens, Stefan AU - Zhang, Jian AU - Gonzalez Juanatey, Jose R. AU - Kaul, Sanjay AU - Brunner-La Rocca, Hans-Peter AU - Merkely, Béla Péter AU - Nicholls, Stephen J. AU - Perrone, Sergio AU - Pina, Ileana AU - Ponikowski, Piotr AU - Sattar, Naveed AU - Senni, Michele AU - Seronde, Marie-France AU - Spinar, Jindrich AU - Squire, Iain AU - Taddei, Stefano AU - Wanner, Christoph AU - Zannad, Faiez TI - Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure JF - NEW ENGLAND JOURNAL OF MEDICINE J2 - NEW ENGL J MED VL - 383 PY - 2020 IS - 15 SP - 1413 EP - 1424 PG - 12 SN - 0028-4793 DO - 10.1056/NEJMoa2022190 UR - https://m2.mtmt.hu/api/publication/31591917 ID - 31591917 N1 - Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't LA - English DB - MTMT ER - TY - JOUR AU - McMurray, John J V AU - Solomon, Scott D AU - Inzucchi, Silvio E AU - Køber, Lars AU - Kosiborod, Mikhail N AU - Martinez, Felipe A AU - Ponikowski, Piotr AU - Sabatine, Marc S AU - Anand, Inder S AU - Bělohlávek, Jan AU - Böhm, Michael AU - Chiang, Chern-En AU - Chopra, Vijay K AU - de Boer, Rudolf A AU - Desai, Akshay S AU - Diez, Mirta AU - Drozdz, Jaroslaw AU - Dukát, Andrej AU - Ge, Junbo AU - Howlett, Jonathan G AU - Katova, Tzvetana AU - Kitakaze, Masafumi AU - Ljungman, Charlotta E A AU - Merkely, Béla Péter AU - Nicolau, Jose C AU - O'Meara, Eileen AU - Petrie, Mark C AU - Vinh, Pham N AU - Schou, Morten AU - Tereshchenko, Sergey AU - Verma, Subodh AU - Held, Claes AU - DeMets, David L AU - Docherty, Kieran F AU - Jhund, Pardeep S AU - Bengtsson, Olof AU - Sjöstrand, Mikaela AU - Langkilde, Anna-Maria ED - Masszi, Gabriella / Collaborator TI - Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction. JF - NEW ENGLAND JOURNAL OF MEDICINE J2 - NEW ENGL J MED VL - 381 PY - 2019 IS - 21 SP - 1995 EP - 2008 PG - 14 SN - 0028-4793 DO - 10.1056/NEJMoa1911303 UR - https://m2.mtmt.hu/api/publication/30828891 ID - 30828891 N1 - BHF Cardiovascular Research Centre, University of Glasgow, 126 University Pl., Glasgow, G128TA, United Kingdom Cardiovascular Division, TIMI Study Group, Brigham and Women's Hospital, Harvard Medical School, Boston, United States Section of Endocrinology, Yale University School of Medicine, New Haven, CT, United States Rigshospitalet Copenhagen University Hospital, Department of Cardiology, Gentofte University Hospital, Copenhagen, Denmark Department of Medicine, Saarland University Hospital, Homburg-Saar, Germany Saint Luke's Mid America Heart Institute, University of Missouri, Kansas City, United States National University of Cordoba, Cordoba, Spain Division of Cardiology, Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina Wroclaw Medical University, Wroclaw, Poland Department of Cardiology, Medical University of Lodz, Lodz, Poland Department of Cardiology, University of Minnesota, Minneapolis, United States 2nd Department of Internal Medicine, Department of Cardiovascular Medicine, General Teaching Hospital, 1st Faculty of Medicine, Charles University, Prague, Czech Republic Division of Cardiology, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan Department of Cardiology, Medanta, Gurgaon, India Department of Cardiology, University Medical Center, University of Groningen, Groningen, Netherlands 5th Department of Internal Medicine, Comenius University in Bratislava, Bratislava, Slovakia Department of Cardiology, Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University, Shanghai, China Cumming School of Medicine, Libin Cardiovascular Institute, University of Calgary, Calgary, AB, Canada Department of Cardiology, Montreal Heart Institute, Montreal, Canada Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria Cardiovascular Division of Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan Department of Molecular and Clinical Medicine and Cardiology, Sahlgrenska Academy, AstraZeneca, Gothenburg, Sweden Department of Medical Sciences, Cardiology, Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden Heart and Vascular Center, Semmelweis University, Budapest, Hungary Instituto Do Coracao, Hospital das Clinicas, Faculdade de Medicina, Universidade de Saõ Paolo, Saõ Paolo, Brazil Department of Internal Medicine, Tan Tao University, Tan Duc, Viet Nam Department of Myocardial Disease and Heart Failure, National Medical Research Center of Cardiology, Moscow, Russian Federation Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, United States Division of Cardiac Surgery, St. Michael's Hospital, University of Toronto, Toronto, Canada Cited By :1420 Export Date: 6 October 2021 CODEN: NEJMA Correspondence Address: McMurray, J.J.V.; BHF Cardiovascular Research Centre, 126 University Pl., United Kingdom; email: john.mcmurray@glasgow.ac.uk Chemicals/CAS: dapagliflozin, 461432-26-8; digitalis, 8031-42-3, 8053-83-6; sacubitril plus valsartan, 936623-90-4; glucoside, 50986-29-3; glycosylated hemoglobin, 9062-63-9; 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol; Benzhydryl Compounds; Cardiovascular Agents; Glucosides; Glycated Hemoglobin A; Sodium-Glucose Transporter 2 Inhibitors AB - In patients with type 2 diabetes, inhibitors of sodium-glucose cotransporter 2 (SGLT2) reduce the risk of a first hospitalization for heart failure, possibly through glucose-independent mechanisms. More data are needed regarding the effects of SGLT2 inhibitors in patients with established heart failure and a reduced ejection fraction, regardless of the presence or absence of type 2 diabetes.In this phase 3, placebo-controlled trial, we randomly assigned 4744 patients with New York Heart Association class II, III, or IV heart failure and an ejection fraction of 40% or less to receive either dapagliflozin (at a dose of 10 mg once daily) or placebo, in addition to recommended therapy. The primary outcome was a composite of worsening heart failure (hospitalization or an urgent visit resulting in intravenous therapy for heart failure) or cardiovascular death.Over a median of 18.2 months, the primary outcome occurred in 386 of 2373 patients (16.3%) in the dapagliflozin group and in 502 of 2371 patients (21.2%) in the placebo group (hazard ratio, 0.74; 95% confidence interval [CI], 0.65 to 0.85; P<0.001). A first worsening heart failure event occurred in 237 patients (10.0%) in the dapagliflozin group and in 326 patients (13.7%) in the placebo group (hazard ratio, 0.70; 95% CI, 0.59 to 0.83). Death from cardiovascular causes occurred in 227 patients (9.6%) in the dapagliflozin group and in 273 patients (11.5%) in the placebo group (hazard ratio, 0.82; 95% CI, 0.69 to 0.98); 276 patients (11.6%) and 329 patients (13.9%), respectively, died from any cause (hazard ratio, 0.83; 95% CI, 0.71 to 0.97). Findings in patients with diabetes were similar to those in patients without diabetes. The frequency of adverse events related to volume depletion, renal dysfunction, and hypoglycemia did not differ between treatment groups.Among patients with heart failure and a reduced ejection fraction, the risk of worsening heart failure or death from cardiovascular causes was lower among those who received dapagliflozin than among those who received placebo, regardless of the presence or absence of diabetes. (Funded by AstraZeneca; DAPA-HF ClinicalTrials.gov number, NCT03036124.). LA - English DB - MTMT ER - TY - JOUR AU - Perkovic, Vlado AU - Jardine, Meg J AU - Neal, Bruce AU - Bompoint, Severine AU - Heerspink, Hiddo J L AU - Charytan, David M AU - Edwards, Robert AU - Agarwal, Rajiv AU - Bakris, George AU - Bull, Scott AU - Cannon, Christopher P AU - Capuano, George AU - Chu, Pei-Ling AU - de Zeeuw, Dick AU - Greene, Tom AU - Levin, Adeera AU - Pollock, Carol AU - Wheeler, David C AU - Yavin, Yshai AU - Zhang, Hong AU - Zinman, Bernard AU - Meininger, Gary AU - Brenner, Barry M AU - Mahaffey, Kenneth W ED - Perkovic, Vlado / Collaborator ED - Mahaffey, Kenneth W / Collaborator ED - Agarwal, Rajiv / Collaborator ED - Bakris, George / Collaborator ED - Brenner, Barry M / Collaborator ED - Cannon, Christopher P / Collaborator ED - Charytan, David M / Collaborator ED - de Zeeuw, Dick / Collaborator ED - Greene, Tom / Collaborator ED - Jardine, Meg J / Collaborator ED - Heerspink, Hiddo J L / Collaborator ED - Levin, Adeera / Collaborator ED - Meininger, Gary / Collaborator ED - Neal, Bruce / Collaborator ED - Pollock, Carol / Collaborator ED - Wheeler, David C / Collaborator ED - Zhang, Hong / Collaborator ED - Zinman, Bernard / Collaborator ED - McGuire, Darren K / Collaborator ED - Holman, Rury / Collaborator ED - Home, Philip / Collaborator ED - Scharfstein, Dan / Collaborator ED - Parfrey, Patrick / Collaborator ED - Shahinfar, Shahnaz / Collaborator ED - August, Phyllis / Collaborator ED - Chang, Tara / Collaborator ED - Sinha, Arjun D / Collaborator ED - Januzzi, James / Collaborator ED - Kolansky, Daniel / Collaborator ED - Amerena, John / Collaborator ED - Hillis, Graham / Collaborator ED - Gorelick, Philip / Collaborator ED - Kissela, Brett / Collaborator ED - Kasner, Scott / Collaborator ED - Lindley, Richard / Collaborator ED - Fulcher, Greg / Collaborator ED - Ounadjela, Souhila / Collaborator ED - Hufert, Karina / Collaborator ED - von Ingersleben, Gabriele / Collaborator ED - Gaglia, Jason / Collaborator ED - Harris, Ronald / Collaborator ED - Hudson, Margo / Collaborator ED - Turchin, Alexander / Collaborator ED - Cheifetz, Adam / Collaborator ED - Sheth, Sunil / Collaborator ED - Feuerstein, Joseph / Collaborator ED - Cohen, Samuel / Collaborator ED - Jardine, Meg / Collaborator ED - Li, Nicole / Collaborator ED - Kolesnyk, Inna / Collaborator ED - Aizenberg, Diego / Collaborator ED - Pecoits-Filho, Roberto / Collaborator ED - Cherney, David / Collaborator ED - Obrador, Gregorio / Collaborator ED - Chertow, Glenn / Collaborator ED - Hawley, Carmel / Collaborator ED - Ji, Linong / Collaborator ED - Wada, Takashi / Collaborator ED - Jha, Vivekan / Collaborator ED - Lim, Soo Kun / Collaborator ED - Lim-Abrahan, Mary Anne / Collaborator ED - Santos, Florence / Collaborator ED - Chae, Dong-Wan / Collaborator ED - Hwang, Shang-Jyh / Collaborator ED - Vazelov, Evgueniy / Collaborator ED - Rychlík, Ivan / Collaborator ED - Hadjadj, Samy / Collaborator ED - Krane, Vera / Collaborator ED - Rosivall, László / Collaborator ED - De Nicola, Luca / Collaborator ED - Dreval, Alexander / Collaborator ED - Nowicki, Michał / Collaborator ED - Schiller, Adalbert / Collaborator ED - Distiller, Larry / Collaborator ED - Górriz, Jose L / Collaborator ED - Kolesnyk, Mykola / Collaborator ED - Morren, Fran / Collaborator ED - Goykhman, Svetlana / Collaborator ED - David, Caryl / Collaborator ED - Yost, Lori / Collaborator ED - Wang, Holly / Collaborator ED - Hettiarachchi, Manthi / Collaborator ED - Thimmaiah, Ramesh / Collaborator ED - Koppolu, Deepak / Collaborator ED - George, Sini / Collaborator ED - Schmidt, Manuela / Collaborator ED - Ignjatovic, Jelena / Collaborator ED - Chapin, Lincoln / Collaborator ED - Travis, Kim / Collaborator ED - Destree, Martine / Collaborator ED - Sood, Vivek / Collaborator ED - Coffee, Laura / Collaborator ED - De Brouwer, Kati / Collaborator ED - Zaviriukha, Viktor / Collaborator ED - Starzec, Agnieszka / Collaborator ED - Koizumi, Masahiro / Collaborator ED - Lin, Grace / Collaborator ED - Chen, Evaly / Collaborator ED - Lin, Peggy / Collaborator ED - Leia, Chen / Collaborator ED - Mascaro, Debbie / Collaborator ED - Amigo, Anabella / Collaborator ED - Limos, Ana / Collaborator ED - Abrahamsen, Ingrid / Collaborator ED - Jaffer, Sara / Collaborator ED - Ahuad Guerrero, Rodolfo Andres / Collaborator ED - Albisu, Juan Pablo / Collaborator ED - Alvarisqueta, Andres / Collaborator ED - Bartolacci, Ines / Collaborator ED - Berli, Mario Alberto / Collaborator ED - Bordonava, Anselmo / Collaborator ED - Calella, Pedro / Collaborator ED - Cantero, Maria Cecilia / Collaborator ED - Cartasegna, Luis Rodolfo / Collaborator ED - Cercos, Esteban / Collaborator ED - Coloma, Gabriela Cecilia / Collaborator ED - Colombo, Hugo / Collaborator ED - Commendatore, Victor / Collaborator ED - Cuadrado, Jesus / Collaborator ED - Cuneo, Carlos Alberto / Collaborator ED - Cusumano, Ana Maria / Collaborator ED - Douthat, Walter Guillermo / Collaborator ED - Dran, Ricardo Dario / Collaborator ED - Farias, Eduardo / Collaborator ED - Fernandez, Maria Florencia / Collaborator ED - Finkelstein, Hernan / Collaborator ED - Fragale, Guillermo / Collaborator ED - Fretes, Jose Osvaldo / Collaborator ED - Garcia, Nestor Horacio / Collaborator ED - Gastaldi, Anibal / Collaborator ED - Gelersztein, Elizabeth / Collaborator ED - Glenny, Jorge Archibaldo / Collaborator ED - Gonzalez, Joaquin Pablo / Collaborator ED - Gonzalez Colaso, Patricia Del Carmen / Collaborator ED - Goycoa, Claudia / Collaborator ED - Greloni, Gustavo Cristian / Collaborator ED - Guinsburg, Adrian / Collaborator ED - Hermida, Sonia / Collaborator ED - Juncos, Luis Isaias / Collaborator ED - Klyver, Maria Isabel / Collaborator ED - Kraft, Florencia / Collaborator ED - Krynski, Fernando / Collaborator ED - Lanchiotti, Paulina Virginia / Collaborator ED - Leon de la Fuente, Ricardo Alfonso / Collaborator ED - Marchetta, Nora / Collaborator ED - Mele, Pablo / Collaborator ED - Nicolai, Silvia / Collaborator ED - Novoa, Pablo Antonio / Collaborator ED - Orio, Silvia Ines / Collaborator ED - Otreras, Fabian / Collaborator ED - Oviedo, Alejandra / Collaborator ED - Raffaele, Pablo / Collaborator ED - Resk, Jorge Hector / Collaborator ED - Rista, Lucas / Collaborator ED - Rodriguez Papini, Nelson / Collaborator ED - Sala, Jorgelina / Collaborator ED - Santos, Juan Carlos / Collaborator ED - Schiavi, Lilia Beatriz / Collaborator ED - Sessa, Horacio / Collaborator ED - Smith Casabella, Tomas / Collaborator ED - Ulla, Maria Rosa / Collaborator ED - Valdez, Maria / Collaborator ED - Vallejos, Augusto / Collaborator ED - Villarino, Adriana / Collaborator ED - Visco, Virginia Esther / Collaborator ED - Wassermann, Alfredo / Collaborator ED - Zaidman, Cesar Javier / Collaborator ED - Cheung, Ngai Wah / Collaborator ED - Droste, Carolyn / Collaborator ED - Fraser, Ian / Collaborator ED - Johnson, David / Collaborator ED - Mah, Peak Mann / Collaborator ED - Nicholls, Kathy / Collaborator ED - Packham, David / Collaborator ED - Proietto, Joseph / Collaborator ED - Roberts, Anthony / Collaborator ED - Roger, Simon / Collaborator ED - Tsang, Venessa / Collaborator ED - Raduan, Roberto Abrão / Collaborator ED - Alves da Costa, Fernanco Augusto / Collaborator ED - Amodeo, Celso / Collaborator ED - Andreotti Turatti, Luiz Alberto / Collaborator ED - Bregman, Rachel / Collaborator ED - Camelo Sanches, Fernanda Cristina / Collaborator ED - Canani, Luis Henrique / Collaborator ED - Chacra, Antônio Roberto / Collaborator ED - Cunha Borges, João Lindolfo / Collaborator ED - Cunha Vêncio, Sérgio Alberto / Collaborator ED - da Silva Franco, Roberto Jorge / Collaborator ED - d'Avila, Domingos / Collaborator ED - de Souza Portes, Evandro / Collaborator ED - de Souza, Pedro / Collaborator ED - Deboni, Luciane Mônica / Collaborator ED - Filho, Fadlo Fraige / Collaborator ED - Geloneze Neto, Bruno / Collaborator ED - Gomes, Marcus / Collaborator ED - Kohara, Suely Keiko / Collaborator ED - Keitel, Elizete / Collaborator ED - Kerr Saraiva, Jose Francisco / Collaborator ED - Kurtz Lisboa, Hugo Roberto / Collaborator ED - de Carvalho Contieri, Fabiana Loss / Collaborator ED - Milagres, Rosângela / Collaborator ED - Montenegro Junior, Renan / Collaborator ED - Moreira de Brito, Claudia / Collaborator ED - Nazzer Hissa, Miguel / Collaborator ED - Nazario Sabbag, Ângela Regina / Collaborator ED - Noronha, Irene / Collaborator ED - Panarotto, Daniel / Collaborator ED - Pecoits Filho, Roberto / Collaborator ED - Pereira, Márcio Antônio / Collaborator ED - Saporito, Wladmir / Collaborator ED - Scotton, Antonio Scafuto / Collaborator ED - Schuch, Tiago / Collaborator ED - Simões de Almeida, Roberto / Collaborator ED - Slompo Ramos, Cássio / Collaborator ED - Soares Felício, João / Collaborator ED - Thomé, Fernando / Collaborator ED - Tibes Hachmann, Jean Carlo / Collaborator ED - Yamada, Sérgio / Collaborator ED - Yoiti Hayashida, Cesar / Collaborator ED - Zanata Petry, Tarissa Beatrice / Collaborator ED - Zanella, Maria Teresa / Collaborator ED - Andreeva, Viktoria / Collaborator ED - Angelova, Angelina / Collaborator ED - Dimitrov, Stefan / Collaborator ED - Genadieva, Veselka / Collaborator ED - Genova-Hristova, Gabriela / Collaborator ED - Hristozov, Kiril / Collaborator ED - Kamenov, Zdravko / Collaborator ED - Koundurdjiev, Atanas / Collaborator ED - Lozanov, Lachezar / Collaborator ED - Margaritov, Viktor / Collaborator ED - Nonchev, Boyan / Collaborator ED - Rangelov, Rangel / Collaborator ED - Shinkov, Alexander / Collaborator ED - Temelkova, Margarita / Collaborator ED - Velichkova, Ekaterina / Collaborator ED - Yakov, Andrian / Collaborator ED - Aggarwal, Naresh / Collaborator ED - Aronson, Ronnie / Collaborator ED - Bajaj, Harpreet / Collaborator ED - Chouinard, Guy / Collaborator ED - Conway, James / Collaborator ED - Cournoyer, Serge / Collaborator ED - DaRoza, Gerald / Collaborator ED - De Serres, Sacha / Collaborator ED - Dubé, François / Collaborator ED - Goldenberg, Ronald / Collaborator ED - Gupta, Anil / Collaborator ED - Gupta, Milan / Collaborator ED - Henein, Sam / Collaborator ED - Khandwala, Hasnain / Collaborator ED - Leiter, Lawrence / Collaborator ED - Madore, François / Collaborator ED - McMahon, Alan / Collaborator ED - Muirhead, Norman / Collaborator ED - Pichette, Vincent / Collaborator ED - Rabasa-Lhoret, Remi / Collaborator ED - Steele, Andrew / Collaborator ED - Tangri, Navdeep / Collaborator ED - Torshizi, Ali / Collaborator ED - Woo, Vincent / Collaborator ED - Zalunardo, Nadia / Collaborator ED - Fernández Montenegro, María Alicia / Collaborator ED - Godoy Jorquera, Juan Gonzalo / Collaborator ED - Medina Fariña, Marcelo / Collaborator ED - Saavedra Gajardo, Victor / Collaborator ED - Vejar, Margarita / Collaborator ED - Chen, Nan / Collaborator ED - Chen, Qinkai / Collaborator ED - Gan, Shenglian / Collaborator ED - Kong, Yaozhong / Collaborator ED - Li, Detian / Collaborator ED - Li, Wenge / Collaborator ED - Li, Xuemei / Collaborator ED - Lin, Hongli / Collaborator ED - Liu, Jian / Collaborator ED - Lu, Weiping / Collaborator ED - Mao, Hong / Collaborator ED - Ren, Yan / Collaborator ED - Song, Weihong / Collaborator ED - 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Wakida, Yasushi / Collaborator ED - Watanabe, Takayuki / Collaborator ED - Yamada, Masayo / Collaborator ED - Yanagida, Kazuhiro / Collaborator ED - Yanase, Toshihiko / Collaborator ED - Yumita, Wataru / Collaborator ED - Gaupsiene, Egle / Collaborator ED - Kozloviene, Dalia / Collaborator ED - Navickas, Antanas / Collaborator ED - Urbanaviciene, Egle / Collaborator ED - Abdul Ghani, Rohana / Collaborator ED - Abdul Kadir, Khalid / Collaborator ED - Ali, Norsiah / Collaborator ED - Che Yusof, Mohd Daud / Collaborator ED - Gan, Chye Lee / Collaborator ED - Ismail, Mastura / Collaborator ED - Kong, Wei Yen / Collaborator ED - Lam, Swee Win / Collaborator ED - Lee, Li Yuan / Collaborator ED - Loh, Chek Loong / Collaborator ED - Manocha, Anita Bhajan / Collaborator ED - Ng, Kee Sing / Collaborator ED - Nik Ahmad, Nik Nur Fatnoon / Collaborator ED - Ratnasingam, Vanassa / Collaborator ED - Bin Shudim, Saiful Shahrizal / Collaborator ED - Vengadasalam, Paranthaman / Collaborator ED - Abraira Munoz, Luis David / Collaborator ED - Salazar, Melchor Alpizar / Collaborator ED - Cruz, Juan Baas / Collaborator ED - Soto, Mario Burgos / Collaborator ED - Ramos, Jose Chevaile / Collaborator ED - Wong, Alfredo Chew / Collaborator ED - Correa Rotter, Jose Ricardo / Collaborator ED - Diaz Escalante, Tonatiu / Collaborator ED - Enriquez Sosa, Favio Edmundo / Collaborator ED - Flores Lozano, Fernando / Collaborator ED - Flota Cervera, Luis Fernando / Collaborator ED - Frenk Baron, Paul / Collaborator ED - Garcia Ballesteros, Cecilia / Collaborator ED - Gomez Rangel, Jose David / Collaborator ED - Herrera Jimenez, Luis Enrique / Collaborator ED - Irizar Santana, Sergio Saul / Collaborator ED - Jimenez Florez, Fernando / Collaborator ED - Laviada Molina, Hugo / Collaborator ED - Luna Ceballos, Rosa Isela / Collaborator ED - Martin Del Camp Blanco, Belia / Collaborator ED - Morales Franco, Guadalupe / Collaborator ED - Moreno Loza, Oscar Tarsicio / Collaborator ED - Mustieles Rocha, Cynthia / Collaborator ED - Obrador Vera, Gregorio / Collaborator ED - Orozco Castellanos, Richard / Collaborator ED - Peralta Calcaneo, Juan / Collaborator ED - Reyes Rosano, Migues Angel / Collaborator ED - Rodriguez Pattzi, Hiromi / Collaborator ED - Rosas Guzman, Juan / Collaborator ED - Rucker Joerg, Isabel Erika / Collaborator ED - Saaveddra Sanchez, Sandra Berenice / Collaborator ED - Sanchez Mijangos, Jose Hector / Collaborator ED - Serrano Sanson, Pablo / Collaborator ED - Tamayo Y Orozco, Juan Alfredo / Collaborator ED - Tellez Chavez, Eloisa / Collaborator ED - Valdes Depeda, Alejandro / Collaborator ED - Venegas Carrillo, Luis / Collaborator ED - Villagordoa Mesa, Juan / Collaborator ED - Zamarripa Escobedo, Rolando / Collaborator ED - Baker, John / Collaborator ED - Noonan, Paul / Collaborator ED - Scott, Russell / Collaborator ED - Walker, Robert / Collaborator ED - Watson, Edward / Collaborator ED - Williams, Michael / Collaborator ED - Young, Simon / Collaborator ED - Abejuela, Zaynab / Collaborator ED - Agra, Jeimeen / Collaborator ED - Aquitania, Grace / Collaborator ED - Caringal, Clodoaido / Collaborator ED - Comia, Rhea Severina / Collaborator ED - Delos Santos, Lalaine / Collaborator ED - Gomez, Olivert / Collaborator ED - Jimeno, Cecilia / Collaborator ED - Tan, Gerry / Collaborator ED - Tolentino, Marsha / Collaborator ED - Yao, Christy / Collaborator ED - Yap, Yvette Ethel / Collaborator ED - Ygpuara, Ma Dovie Lallaine / Collaborator ED - Bijata-Bronisz, Renata / Collaborator ED - Hotlos, Lucyna / Collaborator ED - Januszewicz, Andrzej / Collaborator ED - Kaczmarek, Barbara / Collaborator ED - Kaminska, Anna / Collaborator ED - Lazuka, Lech / Collaborator ED - Madej, Andrzej / Collaborator ED - Mazur, Stanislaw / Collaborator ED - Mlodawska-Choluj, Dorota / Collaborator ED - Nowicki, Michal / Collaborator ED - Orlowska-Kowalik, Grazyna / Collaborator ED - Popenda, Grazyna / Collaborator ED - Rewerska, Barbara / Collaborator ED - Sowinski, Dariusz / Collaborator ED - Angelescu, Liliana Monica / Collaborator ED - Anghel, Veronica / Collaborator ED - Avram, Rodica-Ioana / Collaborator ED - Busegeanu, Mihaela-Magdalena / Collaborator ED - Cif, Adriana / Collaborator ED - Cosma, Dana / Collaborator ED - Crisan, Carmen / Collaborator ED - Demian, Luiza Despina / Collaborator ED - Ferariu, Ioana Emilia / Collaborator ED - Halmagyi, Ildiko / Collaborator ED - Hancu, Nicolae / Collaborator ED - Munteanu, Mircea / Collaborator ED - Negru, Doru / Collaborator ED - Onaca, Adriana Gabriela / Collaborator ED - Petrica, Ligia / Collaborator ED - Popa, Amorin Remus / Collaborator ED - Ranetti, Aurelian-Emil / Collaborator ED - Serafinceanu, Cristian / Collaborator ED - Toarba, Cristina / Collaborator ED - Agafyina, Alina / Collaborator ED - Barbarash, Olga / Collaborator ED - Barysheva, Olga / Collaborator ED - Chizhov, Daniil / Collaborator ED - Dobronravov, Vladimir / Collaborator ED - Glinkina, Irina / Collaborator ED - Grineva, Elena / Collaborator ED - Khirmanov, Vladimir / Collaborator ED - Kolmakova, Elena / Collaborator ED - Koroleva, Tatiana / Collaborator ED - Kvitkova, Liudmila / Collaborator ED - Marasaev, Viacheslav / Collaborator ED - Mkrtumyan, Ashot / Collaborator ED - Morugova, Tatiana / Collaborator ED - Nagibovich, Galina / Collaborator ED - Nagibovich, Oleg / Collaborator ED - Nedogoda, Sergei / Collaborator ED - Osipova, Irina / Collaborator ED - Raskina, Tatiana / Collaborator ED - Samoylova, Yulia / Collaborator ED - Sazonova, Olga / Collaborator ED - Shamkhalova, Minara / Collaborator ED - Shutemova, Elena / Collaborator ED - Shwartz, Yuriy / Collaborator ED - Uriasyev, Oleg / Collaborator ED - Vorobyev, Sergey / Collaborator ED - Zateyshchikova, Anna / Collaborator ED - Zateyshshikov, Dmitry / Collaborator ED - Zykova, Tatyana / Collaborator ED - Antic, Slobodan / Collaborator ED - Djordjevic, Miodrag / Collaborator ED - Kendereski, Aleksandra / Collaborator ED - Lalic, Katarina / Collaborator ED - Lalic, Nebojsa / Collaborator ED - Popovic-Radinovic, Vesna / Collaborator ED - Babikova, Jana / Collaborator ED - Benusova, Olga / Collaborator ED - Buganova, Ingrid / Collaborator ED - Culak, Jan / Collaborator ED - Dzupina, Andrej / Collaborator ED - Dzuponova, Jana / Collaborator ED - Fulop, Peter / Collaborator ED - Ilavska, Adriana / Collaborator ED - Martinka, Emil / Collaborator ED - Ochodnicka, Zuzana / Collaborator ED - Pella, Daniel / Collaborator ED - Smatanova, Iveta / Collaborator ED - Ahmed, Fayzal / Collaborator ED - Badat, Aysha / Collaborator ED - Breedt, Johannes / Collaborator ED - Distiller, Lawrence / Collaborator ED - Govender, Vimladhevi / Collaborator ED - Govender, Ravendran / Collaborator ED - Joshi, Mukesh / Collaborator ED - Jurgens, Jaco / Collaborator ED - Latiff, Gulam / Collaborator ED - Lombard, Landman / Collaborator ED - Mookadam, Mohamed / Collaborator ED - Ngcakani, Nomangesi / Collaborator ED - Nortje, Hendrik / Collaborator ED - Oosthuizen, Helena / Collaborator ED - Pillay-Ramaya, Larisha / Collaborator ED - Prozesky, Hans / Collaborator ED - Reddy, Jeevren / Collaborator ED - Rheeder, Paul / Collaborator ED - Seeber, Mary / Collaborator ED - Cho, Young Min / Collaborator ED - Jeong, In-Kyung / Collaborator ED - Kim, Sin Gon / Collaborator ED - Kim, Yeong Hoon / Collaborator ED - Kwon, Hyuk-Sang / Collaborator ED - Kwon, Min Jeong / Collaborator ED - Lee, Byung-Wan / Collaborator ED - Lee, JungEun / Collaborator ED - Lee, Moon-Kyu / Collaborator ED - Nam, Moon-Suk / Collaborator ED - Oh, Kook-Hwan / Collaborator ED - Park, Cheol-Young / Collaborator ED - Park, Sun-Hee / Collaborator ED - Yoon, Kun Ho / Collaborator ED - Alvarez Garcia, Pere / Collaborator ED - Asmarats Mercadal, Luis / Collaborator ED - Barrios, Clara / Collaborator ED - Cereto Castro, Fernando / Collaborator ED - Cigarran Guldris, Secundino / Collaborator ED - Dominquez Lopez, Marta / Collaborator ED - Egido de Los Rios, Jesus / Collaborator ED - Fernandez Fresnedo, Gema / Collaborator ED - Galan Serrano, Antonio / Collaborator ED - Garcia, Isabel / Collaborator ED - Gonzalez Martinez, Fracisco Javier / Collaborator ED - Jodar Gimeno, Jose Esteban / Collaborator ED - Muñoz Lopez Mendoza, Manuel / Collaborator ED - Malek Marin, Tamara / Collaborator ED - Morales Portillo, Cristobal / Collaborator ED - Munar Vila, Maria Antonia / Collaborator ED - Muñoz Torres, Manuel / Collaborator ED - Nieto Iglesias, Javier / Collaborator ED - Pantoja Perez, Jonay / Collaborator ED - Perez Vera, Merce / Collaborator ED - Portoles Perez, Jose Ma / Collaborator ED - Quesada Simón, María Angustias / Collaborator ED - Simo Canonge, Rafael / Collaborator ED - Soto Gonzalez, Alfonso / Collaborator ED - Terns Riera, Manel / Collaborator ED - Tinahones Madueno, Franciso Jose / Collaborator ED - Plaza, Mercedes Velo / Collaborator ED - Chang, Chwen-Tzuei / Collaborator ED - Chuang, Lee-Ming / Collaborator ED - Hsia, Te-Lin / Collaborator ED - Hsieh, Chang-Hsun / Collaborator ED - Lin, Chih-Ching / Collaborator ED - Lu, Yung-Chuan / Collaborator ED - Sheu, Wayne H-H / Collaborator ED - Barna, Olga / Collaborator ED - Bilyk, Svitlana D / Collaborator ED - Botsyurko, Volodymyr / Collaborator ED - Dudar, Iryna / Collaborator ED - Fushtey, Ivan / Collaborator ED - Godlevska, Olga / Collaborator ED - Golovchenko, Oleksandr / Collaborator ED - Gyrina, Olga / Collaborator ED - Kazmirchuk, Anatoliy / Collaborator ED - Komisarenko, Iuliia / Collaborator ED - Korzh, Oleksii / Collaborator ED - Kravchun, Nonna / Collaborator ED - Legun, Oleg / Collaborator ED - Mankovskyy, Borys / Collaborator ED - Martynyuk, Liliya / Collaborator ED - Mostovoy, Yuriy / Collaborator ED - Pashkovska, Nataliia / Collaborator ED - Pererva, Larysa / Collaborator ED - Pertseva, Tetyana / Collaborator ED - Samoylov, Oleksandr / Collaborator ED - Smirnov, Ivan / Collaborator ED - Svyshchenko, Yevgeniya / Collaborator ED - Tomashkevych, Halyna / Collaborator ED - Topchii, Ivan / Collaborator ED - Tryshchuk, Nadiya / Collaborator ED - Tseluyko, Vira / Collaborator ED - Vizir, Vadym / Collaborator ED - Vlasenko, Maryna / Collaborator ED - Zlova, Tetiana / Collaborator ED - Zub, Liliia / Collaborator ED - Abusnana, Salah / Collaborator ED - Railey, Mohamed / Collaborator ED - Abouglila, Kamal / Collaborator ED - Ainsworth, Paul / Collaborator ED - Ali, Zishan / Collaborator ED - Arutchelvam, Vijayaraman / Collaborator ED - Barnard, Maria / Collaborator ED - Bellary, Srikanth / Collaborator ED - Davies, Emyr / Collaborator ED - Davies, Mark / Collaborator ED - Davies, Simon / Collaborator ED - Dawson, Alison / Collaborator ED - El Kossi, Mohsen / Collaborator ED - English, Patrick / Collaborator ED - Fraser, Donald / Collaborator ED - Gnudi, Luigi / Collaborator ED - Gunstone, Anthony / Collaborator ED - Hall, Timothy / Collaborator ED - Hanif, Wasim / Collaborator ED - Jackson, Alan / Collaborator ED - Johnson, Andrew / Collaborator ED - Joseph, Franklin / Collaborator ED - Krishnan, Singhan / Collaborator ED - Kumwenda, Mick / Collaborator ED - MacDougall, Iain / Collaborator ED - Nixon, Paul / Collaborator ED - O'Hare, Joseph / Collaborator ED - Philip, Sam / Collaborator ED - Ramtoola, Shenaz / Collaborator ED - Saxena, Manish / Collaborator ED - Sennik, Davesh / Collaborator ED - Simon, Godwin / Collaborator ED - Singh, Baldev / Collaborator ED - Stephens, Jeffrey / Collaborator ED - Strzelecka, Anna / Collaborator ED - Symonds, Rehan / Collaborator ED - Turner, Wayne / Collaborator ED - Wahba, Mona / Collaborator ED - Wakeling, John / Collaborator ED - Wheeler, David / Collaborator ED - Winocour, Peter / Collaborator ED - Abdallah, Joseph / Collaborator ED - Abdullah, Raied / Collaborator ED - Abramowitz, Matthew / Collaborator ED - Acosta, Idalia / Collaborator ED - Aiello, Joseph / Collaborator ED - Akright, Laura / Collaborator ED - Akyea-Djamson, Ayim / Collaborator ED - Alappan, Rajendran / Collaborator ED - Alicic, Radica / Collaborator ED - Al-Karadsheh, Amer / Collaborator ED - Allison, Dale Crawford / Collaborator ED - Arauz-Pacheco, Carlos / Collaborator ED - Arfeen, Shahabul / Collaborator ED - Arif, Ahmed / Collaborator ED - Arvind, Moogali / Collaborator ED - Atray, Naveen / Collaborator ED - Awad, Ahmed / Collaborator ED - Barnhill, Peggy / Collaborator ED - Barranco, Elizabeth / Collaborator ED - Barrera, Carlos / Collaborator ED - Beacom, Matthew / Collaborator ED - Behara, Venkata / Collaborator ED - Belo, Diogo / Collaborator ED - Bentley-Lewis, Rhonda / Collaborator ED - Berenguer, Ramon / Collaborator ED - Bermudez, Lidia / Collaborator ED - Bernardo, Marializa / Collaborator ED - Biscoveanu, Mihaela / Collaborator ED - Bowman-Stroud, Cynthia / Collaborator ED - Brandon, Donald / Collaborator ED - Brusco, Osvaldo / Collaborator ED - Busch, Robert / Collaborator ED - Canaan, Yamil / Collaborator ED - Chilito, Alicia / Collaborator ED - Christensen, Tom / Collaborator ED - Christiano, Cynthia / Collaborator ED - Christofides, Elena / Collaborator ED - Chuateco, Caroucel / Collaborator ED - Cohen, Kenneth / Collaborator ED - Cohen, Robert / Collaborator ED - Cohen-Stein, Debbie / Collaborator ED - Cook, Charles / Collaborator ED - Coyne, Daniel / Collaborator ED - Daboul, Nizar / Collaborator ED - Darwish, Riad / Collaborator ED - Daswani, Adarsh / Collaborator ED - Deck, Kenneth / Collaborator ED - Desouza, Cyrus / Collaborator ED - Dev, Devasmita / Collaborator ED - Dhillon, Monika / Collaborator ED - Dua, Sohan / Collaborator ED - Eder, Frank / Collaborator ED - Elosegui, Ana Maria / Collaborator ED - El-Shahawy, Mohamed / Collaborator ED - Ervin, John / Collaborator ED - Esquenazi, Alberto / Collaborator ED - Evans, John / Collaborator ED - Fishbane, Steven / Collaborator ED - Frias, Juan / Collaborator ED - Galindo-Ramos, Eugenia / Collaborator ED - Galphin, Claude / Collaborator ED - Ghazi, Adline / Collaborator ED - Gonzalez, Enrique / Collaborator ED - Gorson, David / Collaborator ED - Gowda, Anupama / Collaborator ED - Greco, Barbara / Collaborator ED - Grubb, Stephen / Collaborator ED - Gulati, Rakesh / Collaborator ED - Hammoud, Jamal / Collaborator ED - Handelsman, Stuart / Collaborator ED - Hartman, Israel / Collaborator ED - Hershon, Kenneth / Collaborator ED - Hiser, Daniel / Collaborator ED - Hon, George / Collaborator ED - Jacob, Radu / Collaborator ED - Jaime, Maria / Collaborator ED - Jamal, Aamir / Collaborator ED - Kaupke, Charles / Collaborator ED - Keightley, Gerald / Collaborator ED - Kern, Elizabeth / Collaborator ED - Khanna, Rakhi / Collaborator ED - Khitan, Zeid / Collaborator ED - Kim, Sun / Collaborator ED - Kopyt, Nelson / Collaborator ED - Kovesdy, Csaba / Collaborator ED - Krishna, Gopal / Collaborator ED - Kropp, Jeffrey / Collaborator ED - Kumar, Amrendra / Collaborator ED - Kumar, Jayant / Collaborator ED - Kumar, Neil / Collaborator ED - Kusnir, Jorge / Collaborator ED - Lane, Wendy / Collaborator ED - Lawrence, Mary / Collaborator ED - Lehrner, Lawrence / Collaborator ED - Lentz, John / Collaborator ED - Levinson, Dennis / Collaborator ED - Lewis, Derek / Collaborator ED - Liss, Kenneth / Collaborator ED - Maddux, Andreas / Collaborator ED - Maheshwari, Hiralal / Collaborator ED - Mandayam, Sreedhar / Collaborator ED - Marar, Isam / Collaborator ED - Mehta, Bhasker / Collaborator ED - Middleton, John / Collaborator ED - Mordujovich, Jorge / Collaborator ED - Moreda, Ramon / Collaborator ED - Moustafa, Moustafa / Collaborator ED - Mujica Trenche, Samuel / Collaborator ED - Narayanan, Mohanram / Collaborator ED - Narvarte, Javier / Collaborator ED - Nassar, Tareq / Collaborator ED - Newman, George / Collaborator ED - Nichol, Brian / Collaborator ED - Nicol, Philip / Collaborator ED - Nisnisan, Josier / Collaborator ED - Nossuli, A Kaldun / Collaborator ED - Obialo, Chamberlain / Collaborator ED - Olelewe, Sarah / Collaborator ED - Oliver, Michael / Collaborator ED - O'Shaughnessy, Andrew / Collaborator ED - Padron, John / Collaborator ED - Pankhaniya, Rohit / Collaborator ED - Parker, Reginald / Collaborator ED - Patel, Devesh / Collaborator ED - Patel, Gnyandev / Collaborator ED - Patel, Nina / Collaborator ED - Pavon, Humberto / Collaborator ED - Perez, Armando / Collaborator ED - Perez, Carlos / Collaborator ED - Perlman, Alan / Collaborator ED - Pettis, Karlton / Collaborator ED - Pharr, Walter / Collaborator ED - Phillips, Andrea / Collaborator ED - Purighalla, Raman / Collaborator ED - Quesada-Suarez, Luis / Collaborator ED - Ranjan, Rajiv / Collaborator ED - Rastogi, Sanjeev / Collaborator ED - Reddy, Jakkidi / Collaborator ED - Rendell, Marc / Collaborator ED - Rich, Lisa / Collaborator ED - Robinson, Michael / Collaborator ED - Rodriguez, Hector / Collaborator ED - Rosas, Sylvia / Collaborator ED - Saba, Fadi / Collaborator ED - Sankaram, Rallabhandi / Collaborator ED - Sarin, Ravi / Collaborator ED - Schreiman, Robert / Collaborator ED - Scott, David / Collaborator ED - Sekkarie, Mohamed / Collaborator ED - Sensenbrenner, John / Collaborator ED - Shakeel, Muhammad / Collaborator ED - Shanik, Michael / Collaborator ED - Shaw, Sylvia / Collaborator ED - Smith, Stephen / Collaborator ED - Solomon, Richard / Collaborator ED - Sprague, Amy / Collaborator ED - Spry, Leslie / Collaborator ED - Suchinda, Pusadee / Collaborator ED - Sultan, Senan / Collaborator ED - Surampudi, Prasanth / Collaborator ED - Sussman, Sherry / Collaborator ED - Tan, Anjanette / Collaborator ED - Terrelonge, Antonio / Collaborator ED - Thompson, Michael / Collaborator ED - Trespalacios, Fernando / Collaborator ED - Trippe, Bruce / Collaborator ED - Trueba, Pilar / Collaborator ED - Twahirwa, Marcel / Collaborator ED - Updegrove, John / Collaborator ED - Van Buren, Peter / Collaborator ED - Vannorsdall, Mark / Collaborator ED - Varghese, Freemu / Collaborator ED - Velasquez-Mieyer, Pedro / Collaborator ED - Ventrapragada, Sailaja / Collaborator ED - Vukotic, Goga / Collaborator ED - Wadud, Khurram / Collaborator ED - Warren, Mark / Collaborator ED - Watson, Henry / Collaborator ED - Watts, Ronald / Collaborator ED - Weiner, Daniel / Collaborator ED - Welker, James / Collaborator ED - Welsh, Jean / Collaborator ED - Williams, Shelley / Collaborator ED - Zaniewski-Singh, Michelle / Collaborator TI - Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy JF - NEW ENGLAND JOURNAL OF MEDICINE J2 - NEW ENGL J MED VL - 380 PY - 2019 IS - 24 SP - 2295 EP - 2306 PG - 12 SN - 0028-4793 DO - 10.1056/NEJMoa1811744 UR - https://m2.mtmt.hu/api/publication/33677430 ID - 33677430 N1 - Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't AB - Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium-glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes.In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin-angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically.The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P = 0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P = 0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P = 0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture.In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years. (Funded by Janssen Research and Development; CREDENCE ClinicalTrials.gov number, NCT02065791.). LA - English DB - MTMT ER - TY - JOUR AU - Schernthaner, Guntram AU - Drexel, Heinz AU - Moshkovich, Evgeny AU - Zilaitiene, Birute AU - Martinka, Emil AU - Czupryniak, Leszek AU - Várkonyi, Tamás AU - Janež, Andrej AU - Ducena, Kristine AU - Lalić, Katarina AU - Tankova, Tsvetalina AU - Prázný, Martin AU - Smirčić Duvnjak, Lea AU - Sukhareva, Olga AU - Sourij, Harald TI - SGLT2 inhibitors in T2D and associated comorbidities - differentiating within the class JF - BMC ENDOCRINE DISORDERS J2 - BMC ENDOCR DISORD VL - 19 PY - 2019 SN - 1472-6823 DO - 10.1186/s12902-019-0387-y UR - https://m2.mtmt.hu/api/publication/30744468 ID - 30744468 N1 - Correspondence, de idézettsége eléri a folyóirat adott évi impakt faktorának kétszeresét, ezért az MTA V. Osztályának ajánlása alapján besorolása rövid közlemény. (BCS, SZTE admin4) AB - For patients with type 2 diabetes (T2D), cardiovascular disease (CVD) is the single most common cause of mortality. In 2008 and 2012, the Federal Drug Administration (FDA) and the European Medicines Agency (EMA) respectively mandated cardiovascular outcomes trials (CVOTs) on all new anti-diabetic agents, as prospective trials statistically powered to rule out excess cardiovascular risk in patients with T2D. Unexpectedly, some of these CVOTs have demonstrated not only cardiovascular safety, but also cardioprotective effects, as was first shown for the SGLT2 inhibitor empagliflozin in EMPA-REG OUTCOME.To debate newly available CVOT data and to put them into context, we convened as a group of medical experts from the Central and Eastern European Region. Here we describe our discussions, focusing on the conclusions we can draw from EMPA-REG OUTCOME and other SGLT2 inhibitor CVOTs, including when considered alongside real-world evidence.CVOTs investigating SGLT2 inhibitors have suggested benefits beyond glucose lowering that have been confirmed in real-world evidence studies. LA - English DB - MTMT ER - TY - JOUR AU - Zinman, Bernard AU - Wanner, Christoph AU - Lachin, John M AU - Fitchett, David AU - Bluhmki, Erich AU - Hantel, Stefan AU - Mattheus, Michaela AU - Devins, Theresa AU - Johansen, Odd Erik AU - Woerle, Hans J AU - Broedl, Uli C AU - Inzucchi, Silvio E ED - Aizenberg, D / Collaborator ED - Ulla, M / Collaborator ED - Waitman, J / Collaborator ED - De Loredo, L / Collaborator ED - Farías, J / Collaborator ED - Fideleff, H / Collaborator ED - Lagrutta, M / Collaborator ED - Maldonado, N / Collaborator ED - Colombo, H / Collaborator ED - Ferre Pacora, F / Collaborator ED - Wasserman, A / Collaborator ED - Maffei, L / Collaborator ED - Lehman, R / Collaborator ED - Selvanayagam, J / Collaborator ED - d’Emden, M / Collaborator ED - Fasching, P / Collaborator ED - Paulweber, B / Collaborator ED - Toplak, H / Collaborator ED - Luger, A / Collaborator ED - Drexel, H / Collaborator ED - Prager, R / Collaborator ED - Schnack, C / Collaborator ED - Schernthaner, G / Collaborator ED - Fliesser-Görzer, E / Collaborator ED - Kaser, S / Collaborator ED - Scheen, A / Collaborator ED - Van Gaal, L / Collaborator ED - Hollanders, G / Collaborator ED - Kockaerts, Y / Collaborator ED - Capiau, L / Collaborator ED - Chachati, A / Collaborator ED - Persu, A / Collaborator ED - Hermans, M / Collaborator ED - Vantroyen, D / Collaborator ED - Vercammen, C / Collaborator ED - Van de Borne, P / Collaborator ED - Benhalima, K / Collaborator ED - Mathieu, C / Collaborator ED - Lienart, F / Collaborator ED - Mortelmans, J / Collaborator ED - Strivay, M / Collaborator ED - Vereecken, G / Collaborator ED - Keymeulen, B / Collaborator ED - Lamkanfi, F / Collaborator ED - Chacra, A / Collaborator ED - Eliaschewitz, F / Collaborator ED - Zanella, M / Collaborator ED - Faludi, A / Collaborator ED - Bertolami, M / Collaborator ED - Hayashida, C / Collaborator ED - Nunes Salles, J / Collaborator ED - Monte, O / Collaborator ED - Dinato, M / Collaborator ED - Manenti, E / Collaborator ED - Rassi, N / Collaborator ED - Halpern, A / Collaborator ED - Lima Filho, M / Collaborator ED - Ayoub, J / Collaborator ED - Felicio, J / Collaborator ED - Borges, J / Collaborator ED - Gross, J / Collaborator ED - Sgarbi, J / Collaborator ED - Betti, R / Collaborator ED - Tiburcio, A / Collaborator ED - Purisch, S / Collaborator ED - Schmid, H / Collaborator ED - Takahashi, M / Collaborator ED - Castro, M / Collaborator ED - Rea, R / Collaborator ED - Hissa, M / Collaborator ED - Geloneze Neto, B / Collaborator ED - Saraiva, J / Collaborator ED - Henein, S / Collaborator ED - Lochnan, H / Collaborator ED - Imran, S A / Collaborator ED - Clayton, D / Collaborator ED - Bayly, K / Collaborator ED - Berlingieri, J / Collaborator ED - Boucher, P / Collaborator ED - Chan, Y / Collaborator ED - Gupta, M / Collaborator ED - Chehayeb, R / Collaborator ED - Ouellett, A / Collaborator ED - Ur, E / Collaborator ED - Woo, V / Collaborator ED - St Amour, E / Collaborator ED - Terront Lozano, M / Collaborator ED - Yupanqui Lozno, H / Collaborator ED - Urina, M / Collaborator ED - Lopez Jaramillo, P / Collaborator ED - Jaramillo, N / Collaborator ED - Sanchez, G / Collaborator ED - Pérez, G / Collaborator ED - Tusek, S / Collaborator ED - Mirosevic, G / Collaborator ED - Goldoni, V / Collaborator ED - Jurisic-Erzen, D / Collaborator ED - Balasko, A / Collaborator ED - Balic, S / Collaborator ED - Drvodelic-Sunic, E / Collaborator ED - Canecki-Varzic, Silvija / Collaborator ED - Machkova, M / Collaborator ED - Weiner, P / Collaborator ED - Lastuvka, J / Collaborator ED - Olsovsky, J / Collaborator ED - Krarup, T / Collaborator ED - Ridderstråle, M / Collaborator ED - Tarnow, L / Collaborator ED - Sætre Lihn, A / Collaborator ED - Christensen, P / Collaborator ED - Juhl, H / Collaborator ED - Urhammer, S / Collaborator ED - Lund, P / Collaborator ED - Adojaan, B / Collaborator ED - Jakovlev, Ü / Collaborator ED - Lanno, R / Collaborator ED - Lubi, M / Collaborator ED - Marandi, T / Collaborator ED - Gouet, D / Collaborator ED - Courrèges, J / Collaborator ED - Zaoui, P / Collaborator ED - Choukroun, G / Collaborator ED - Petit, C / Collaborator ED - Formagne, L / Collaborator ED - Estour, B / Collaborator ED - Mabire, P / Collaborator ED - Daugenet, C / Collaborator ED - Lemarie, B / Collaborator ED - Clavel, S / Collaborator ED - Aure, P / Collaborator ED - Remaud, P / Collaborator ED - Halimi, J / Collaborator ED - Hadjadj, S / Collaborator ED - Couffinhal, T / Collaborator ED - Glonti, S / Collaborator ED - Metreveli, D / Collaborator ED - Lominadze, Z / Collaborator ED - Giorgadze, E / Collaborator ED - Burtchuladze, T / Collaborator ED - Javashvili, L / Collaborator ED - Kurashvili, G / Collaborator ED - Kurashvili, R / Collaborator ED - Virsaladze, D / Collaborator ED - Nadareishvili, L / Collaborator ED - Khomasuridze, A / Collaborator ED - Cahill, T / Collaborator ED - Green, F / Collaborator ED - MacRury, S / Collaborator ED - Waldron, M / Collaborator ED - Middleton, A / Collaborator ED - McKnight, J / Collaborator ED - Pearson, E / Collaborator ED - Butler, M / Collaborator ED - Choksi, M / Collaborator ED - Caldwell, I / Collaborator ED - Farmer, I / Collaborator ED - Wyatt, N / Collaborator ED - Patrick, J / Collaborator ED - O'Brien, I / Collaborator ED - Devers, M / Collaborator ED - Bousboulas, S / Collaborator ED - Pappas, S / Collaborator ED - Piaditis, G / Collaborator ED - Vryonidou, A / Collaborator ED - Tentolouris, N / Collaborator ED - Karamitsos, K / Collaborator ED - Manes, C / Collaborator ED - Benroubi, M / Collaborator ED - Avramidis, I / Collaborator ED - Ozaki, R / Collaborator ED - Tan, K / Collaborator ED - Siu, S / Collaborator ED - Ip, T / Collaborator ED - Tsang, C / Collaborator ED - Dudas, M / Collaborator ED - Nagy, K / Collaborator ED - Salamon, C / Collaborator ED - Gerő, László / Collaborator ED - Patkay, J / Collaborator ED - Tabák, Ádám / Collaborator ED - Tamas, G / Collaborator ED - Juhasz, F / Collaborator ED - Szentpeteri, I / Collaborator ED - Ghaisas, N / Collaborator ED - Bantwal, G / Collaborator ED - Mohan, V / Collaborator ED - Gupta, J / Collaborator ED - Sadhu, N / Collaborator ED - Kulkarni, A / Collaborator ED - Garg, N / Collaborator ED - Reddy, S / Collaborator ED - Deshpande, N / Collaborator ED - Gutlapalli, K / Collaborator ED - Pillai, M / Collaborator ED - Premchand, R / Collaborator ED - Badgandi, M / Collaborator ED - Jain, S / Collaborator ED - Aravind, S / Collaborator ED - Shamanna, P / Collaborator ED - Pandey, A / Collaborator ED - Gupta, S / Collaborator ED - Pramono, B / Collaborator ED - Dante Saksono, H / Collaborator ED - Agung, P / Collaborator ED - Djoko Wahono, S / Collaborator ED - Suastika, K / Collaborator ED - Tanggo, Y / Collaborator ED - Juwana, Y / Collaborator ED - Siswanto, B / Collaborator ED - Adawi, F / Collaborator ED - Efrati, S / Collaborator ED - Mazen, E / Collaborator ED - Bashkin, A / Collaborator ED - Herskovits, T / Collaborator ED - Jaffe, A / Collaborator ED - Schiff, E / Collaborator ED - Wainstein, J / Collaborator ED - Taddei, S / Collaborator ED - Aiello, A / Collaborator ED - Arca, M / Collaborator ED - Calabro, P / Collaborator ED - Cignarelli, M / Collaborator ED - Fioretto, P / Collaborator ED - Marchesini Reggiani, G / Collaborator ED - Gnasso, A / Collaborator ED - Marchionni, N / Collaborator ED - Marsilii, A / Collaborator ED - Bucci, M / Collaborator ED - Mezzetti, A / Collaborator ED - Pozzilli, P / Collaborator ED - Colivicchi, F / Collaborator ED - Santini, M / Collaborator ED - Moro, E / Collaborator ED - Semplicini, A / Collaborator ED - Toscano, V / Collaborator ED - Fucili, A / Collaborator ED - Monno, S / Collaborator ED - Furui, K / Collaborator ED - Higashiue, S / Collaborator ED - Hiramatsu, N / Collaborator ED - Kawamitsu, K / Collaborator ED - Takenaka, T / Collaborator ED - Takahashi, H / Collaborator ED - Hojo, F / Collaborator ED - Onishi, Y / Collaborator ED - Izumino, K / Collaborator ED - Okubo, M / Collaborator ED - Wakida, Y / Collaborator ED - Kondo, Y / Collaborator ED - Hieshima, K / Collaborator ED - Jinnouchi, H / Collaborator ED - Suzuki, A / Collaborator ED - Ito, M / Collaborator ED - Park, S / Collaborator ED - Kim, Y / Collaborator ED - Hong, T / Collaborator ED - Park, H / Collaborator ED - Gwon, H / Collaborator ED - Kim, H / Collaborator ED - Kang, K / Collaborator ED - Lee, S / Collaborator ED - Jeong, M / Collaborator ED - Seung, K / Collaborator ED - Lim, D / Collaborator ED - Rha, S / Collaborator ED - Tahk, S / Collaborator ED - Yang, J / Collaborator ED - Yoon, J / Collaborator ED - Shin, M / Collaborator ED - Kim, D / Collaborator ED - Jeong, J / Collaborator ED - Nik Ahmad, N / Collaborator ED - Mustafa, N / Collaborator ED - Wan Mohamed, W / Collaborator ED - Fung, Y / Collaborator ED - Abdul Ghani, R / Collaborator ED - Chandramouli, A / Collaborator ED - Chee, K / Collaborator ED - Abdul Kadir, K / Collaborator ED - Ling, K / Collaborator ED - Abu Hassan, M / Collaborator ED - Foo, S / Collaborator ED - Garcia Hernandez, P / Collaborator ED - Aguilar-Salinas, C / Collaborator ED - Vidrio Velazquez, M / Collaborator ED - Flores, F / Collaborator ED - Alpizar Salazar, M / Collaborator ED - Micher Escalante, D / Collaborator ED - Garcia Soria, M / Collaborator ED - Cardona Muñoz, E / Collaborator ED - Storms, G / Collaborator ED - Schaper, N / Collaborator ED - Kooy, A / Collaborator ED - Krekels, M / Collaborator ED - vab Bemmel, T / Collaborator ED - Verhoeven, R / Collaborator ED - Mulder, H / Collaborator ED - Oldenburg-Ligtenberg, P / Collaborator ED - Gonkel, F / Collaborator ED - de Jong, A / Collaborator ED - van Soest, J / Collaborator ED - Viergever, P / Collaborator ED - Mevissen, H / Collaborator ED - Lochorn, G / Collaborator ED - Zwiers, G / Collaborator ED - Hoogslag, P / Collaborator ED - Ronner, E / Collaborator ED - Nierop, P / Collaborator ED - Al-Windy, N / Collaborator ED - Kragten, J / Collaborator ED - Dekelver, P / Collaborator ED - Benatar, J / Collaborator ED - Krebs, J / Collaborator ED - Scott, R / Collaborator ED - Heggen, E / Collaborator ED - Berz, A / Collaborator ED - Fossum, C / Collaborator ED - Hurtig, U / Collaborator ED - Langslet, G / Collaborator ED - Baranowski, M / Collaborator ED - Sparby, J / Collaborator ED - Karlsson, T / Collaborator ED - Delgado Torres, C / Collaborator ED - Rodriguez Escudero, A / Collaborator ED - Lisson, R / Collaborator ED - Allemant Maldonado, A / Collaborator ED - Gallardo Rojas, W / Collaborator ED - Gonzales Bravo, L / Collaborator ED - Lema Osores, J / Collaborator ED - Farfan, J / Collaborator ED - Zapata, L / Collaborator ED - Godoy Junchaya, J / Collaborator ED - Roldan Concha, Y / Collaborator ED - Urquiaga Calderon, J / Collaborator ED - Sy, R / Collaborator ED - Tan, G / Collaborator ED - Aquitania, G / Collaborator ED - De Los Santos, G / Collaborator ED - Panelo, A / Collaborator ED - Roderos, O / Collaborator ED - Rosales, R / Collaborator ED - Toledo, R / Collaborator ED - Liwag, A / Collaborator ED - Ramoncito, H / Collaborator ED - Skokowska, E / Collaborator ED - Krzyzagorska, E / Collaborator ED - Ogorek, M / Collaborator ED - Wojnowski, L / Collaborator ED - Spyra, J / Collaborator ED - Konieczny, M / Collaborator ED - Piesiewicz, W / Collaborator ED - Kus, W / Collaborator ED - Ocicka-Kozakiewicz, A / Collaborator ED - Orlowska-Kunikowska, E / Collaborator ED - Zmuda, W / Collaborator ED - Duarte, S / Collaborator ED - Leitão, A / Collaborator ED - Monteiro, P / Collaborator ED - Rita, H / Collaborator ED - Salgado, V / Collaborator ED - Pinto, L / Collaborator ED - Queirós, J / Collaborator ED - Teixeira, J / Collaborator ED - Rogado, C / Collaborator ED - Duarte, R / Collaborator ED - Sobral do Rosário, F / Collaborator ED - Silva, A / Collaborator ED - Andrade, L / Collaborator ED - Velez, M / Collaborator ED - Brazão, M / Collaborator ED - Istratoaie, O / Collaborator ED - Lichiardopol, R / Collaborator ED - Catrinoiu, D / Collaborator ED - Militaru, C / Collaborator ED - Zetu, C / Collaborator ED - Barbonta, D / Collaborator ED - Cosma, D / Collaborator ED - Crisan, C / Collaborator ED - Pop, L / Collaborator ED - Esip, V / Collaborator ED - Arutyunov, G / Collaborator ED - Boyarkin, M / Collaborator ED - Agafyina, A / Collaborator ED - Vorokhobina, N / Collaborator ED - Petunina, N / Collaborator ED - Libov, I / Collaborator ED - Zalevskaya, A / Collaborator ED - Nikolaev, K / Collaborator ED - Barbarash, O / Collaborator ED - Potemkin, V / Collaborator ED - Bystrova, A / Collaborator ED - Krasilnikova, E / Collaborator ED - Barbarich, V / Collaborator ED - Chumakova, G / Collaborator ED - Tarasov, N / Collaborator ED - Meleshkevich, T / Collaborator ED - Zateyshchikov, D / Collaborator ED - Lantseva, O / Collaborator ED - Belenkiy, D / Collaborator ED - Obrezan, A / Collaborator ED - Rossolko, L / Collaborator ED - Fillipova, E / Collaborator ED - Yakhontova, P / Collaborator ED - Khokhlov, A / Collaborator ED - Tan, R / Collaborator ED - Sum, C / Collaborator ED - Chang, H / Collaborator ED - Distiller, L / Collaborator ED - Pretorius, M / Collaborator ED - Nortje, H / Collaborator ED - Mitha, E / Collaborator ED - Burgess, L / Collaborator ED - Blignaut, S / Collaborator ED - Venter, T / Collaborator ED - Moodley, R / Collaborator ED - Lombaard, J / Collaborator ED - Govind, U / Collaborator ED - Naidoo, V / Collaborator ED - Mookadam, M / Collaborator ED - Engelbrecht, J / Collaborator ED - Omar, M / Collaborator ED - Jurgens, J / Collaborator ED - Podgorski, G / Collaborator ED - Vawda, H / Collaborator ED - Naidoo, D / Collaborator ED - Emanuel, S / Collaborator ED - Roodt, A / Collaborator ED - Amod, A / Collaborator ED - Van Zyl, L / Collaborator ED - Segura, J / Collaborator ED - Brito, M / Collaborator ED - Fernandez-Cruz, A / Collaborator ED - Artola, S / Collaborator ED - Iglesias, R / Collaborator ED - Toural, E / Collaborator ED - Garcia-Ortiz, L / Collaborator ED - Saban, J / Collaborator ED - Mesa, J / Collaborator ED - Vidal, J / Collaborator ED - Linares, J / Collaborator ED - del Cañizo, F / Collaborator ED - Rigla, M / Collaborator ED - Suarez, C / Collaborator ED - Llorente, I / Collaborator ED - Moreno, B / Collaborator ED - Antoli, A / Collaborator ED - Gomez Peralta, F / Collaborator ED - Iglesias, M / Collaborator ED - Pereg, V / Collaborator ED - de Teresa, L / Collaborator ED - Camafort, M / Collaborator ED - Trescoli, C / Collaborator ED - Satarasinghe, R / Collaborator ED - Somasundaram, N / Collaborator ED - Siyambalapitiya, S / Collaborator ED - Antonypillai, C / Collaborator ED - Bulugahapitiya, D / Collaborator ED - Medagama, U / Collaborator ED - Huang, C / Collaborator ED - Lu, Y / Collaborator ED - Hwang, J / Collaborator ED - Chiang, C / Collaborator ED - Wen, M / Collaborator ED - Chen, J / Collaborator ED - Lai, W / Collaborator ED - Chang, K / Collaborator ED - Wang, J / Collaborator ED - Yeh, H / Collaborator ED - Kriangsak, P / Collaborator ED - Deerochanawong, C / Collaborator ED - Suwanwalaikorn, S / Collaborator ED - Mangklabruks, A / Collaborator ED - Kaewsuwanna, P / Collaborator ED - Piyayotai, D / Collaborator ED - Iabluchanskyi, M / Collaborator ED - Samoylov, O / Collaborator ED - Godlevska, O / Collaborator ED - Kovalyova, O / Collaborator ED - Voloshyna, O / Collaborator ED - Tseluyko, V / Collaborator ED - Zotov, S / Collaborator ED - Vykhovanyuk, I / Collaborator ED - Dulgeroff, A / Collaborator ED - Mayfield, R / Collaborator ED - Zaniewski-Singh, M / Collaborator ED - Ullal, J / Collaborator ED - Aloi, J / Collaborator ED - De La Rosa, R / Collaborator ED - Mosely, J / Collaborator ED - Wittmer, B / Collaborator ED - Aronoff, S / Collaborator ED - Rosenfeld, J / Collaborator ED - Seidner, M / Collaborator ED - Warren, M / Collaborator ED - Fishman, N / Collaborator ED - Weiss, R / Collaborator ED - Arif, A / Collaborator ED - Sandberg, M / Collaborator ED - Lewis, D / Collaborator ED - Ball, E / Collaborator ED - Graf, R / Collaborator ED - Breton, C / Collaborator ED - Tamayo, R / Collaborator ED - Richards, R / Collaborator ED - Cefalu, W / Collaborator ED - Uwaifo, G / Collaborator ED - Zayour, D / Collaborator ED - Hoffman, J / Collaborator ED - Fitz-Patrick, D / Collaborator ED - Khan, B / Collaborator ED - Blaze, K / Collaborator ED - Bressler, P / Collaborator ED - Halpern, S / Collaborator ED - Chappell, D / Collaborator ED - Bergenstal, R / Collaborator ED - Cuddihy, R / Collaborator ED - Matfin, G / Collaborator ED - Freedman, Z / Collaborator ED - Gonzalez-Campoy, J / Collaborator ED - Lerman, S / Collaborator ED - Rendell, M / Collaborator ED - Sitar, S / Collaborator ED - Reeves, M / Collaborator ED - Howard, T / Collaborator ED - Soufer, J / Collaborator ED - Miranda-Palma, B / Collaborator ED - Laliotis, A / Collaborator ED - Shomali, M / Collaborator ED - Teltser, M / Collaborator ED - Hurley, D / Collaborator ED - Morawski, E / Collaborator ED - Cherlin, R / Collaborator ED - Houchin, V / Collaborator ED - Welch, M / Collaborator ED - Goytia-Leos, D / Collaborator ED - Syed, M / Collaborator ED - Kowaloff, E / Collaborator ED - Weinrauch, L / Collaborator ED - Peniston, J / Collaborator ED - Brockmyre, A / Collaborator ED - First, B / Collaborator ED - Feld, L / Collaborator ED - Huffman, D / Collaborator ED - Nassim, O / Collaborator ED - Gottschlich, G / Collaborator ED - Patel, A / Collaborator ED - Knopke, C / Collaborator ED - Hernandez, M / Collaborator ED - Diaz, J / Collaborator ED - Giugliano, G / Collaborator ED - Nicasio, J / Collaborator ED - Eagerton, D / Collaborator ED - Huntley, R / Collaborator ED - Reed, J / Collaborator ED - Magee, M / Collaborator ED - Hippert, R / Collaborator ED - Sofley, C / Collaborator ED - Alzohaili, O / Collaborator ED - Levins, P / Collaborator ED - Anspach, R / Collaborator ED - Shah, S / Collaborator ED - Brusco, O / Collaborator ED - Naidu, J / Collaborator ED - Lindenbaum, J / Collaborator ED - Jacks, R / Collaborator ED - Hammond, G / Collaborator ED - Arena, C / Collaborator ED - Saxman, K / Collaborator ED - Mach, M / Collaborator ED - Kerstein, H / Collaborator ED - Kereiakes, D / Collaborator ED - Wahlen, J / Collaborator ED - Wehmeier, K / Collaborator ED - Chaykin, L / Collaborator ED - Rothman, J / Collaborator ED - Fogelfeld, L / Collaborator ED - Stroger, J / Collaborator ED - Bittar, N / Collaborator ED - Rosenstock, J / Collaborator ED - Kayne, D / Collaborator ED - Navarro, J / Collaborator ED - Colfer, H / Collaborator ED - Mokshagundam, S / Collaborator ED - Shandilya, L / Collaborator ED - Connery, L / Collaborator ED - Wysham, C / Collaborator ED - Dela Llana, A / Collaborator ED - Jardula, M / Collaborator ED - MacAdams, M / Collaborator ED - Flippo, G / Collaborator ED - Heurich, E / Collaborator ED - Curtis, C / Collaborator ED - Sanders, D / Collaborator ED - Rawls, R / Collaborator ED - Velazquez, F / Collaborator ED - Osea, E / Collaborator ED - Mahood, K / Collaborator ED - Feldman, G / Collaborator ED - Eder, F / Collaborator ED - Riley, E / Collaborator ED - Jain, M / Collaborator ED - Fowler, W / Collaborator ED - Shepard, M / Collaborator ED - Schear, M / Collaborator ED - Barker, B / Collaborator ED - Strout, C / Collaborator ED - Obiekwe, O / Collaborator ED - Shanik, M / Collaborator ED - Green, C / Collaborator ED - Blakney, E / Collaborator ED - Roberson, K / Collaborator ED - Bretton, E / Collaborator ED - Pish, R / Collaborator ED - Kaveh, K / Collaborator ED - Maynard, B / Collaborator ED - Barager, W / Collaborator ED - Soldyshev, R / Collaborator ED - Austin, B / Collaborator ED - Parmar, P / Collaborator ED - Simpson, R / Collaborator ED - Chauhan, A / Collaborator ED - Kasper, J / Collaborator ED - Burr, R / Collaborator ED - Patel, N / Collaborator ED - Mariano, H / Collaborator ED - Pluto, T / Collaborator ED - Bratcher, C / Collaborator ED - Juarez, M / Collaborator ED - Levinson, L / Collaborator ED - Awad, A / Collaborator ED - Longshaw, K / Collaborator ED - Hoffman, K / Collaborator ED - Richwine, R / Collaborator ED - Molter, D / Collaborator ED - Boscia, J / Collaborator ED - Kowalyk, S / Collaborator ED - Lemis, P / Collaborator ED - Liss, J / Collaborator ED - Orr, R / Collaborator ED - Riser, J / Collaborator ED - Wood, J / Collaborator ED - Ubani, A / Collaborator ED - Paine, W / Collaborator ED - Hassani, F / Collaborator ED - Miranda, F / Collaborator ED - Hansen, V / Collaborator ED - Farris, N / Collaborator ED - Bowden, R / Collaborator ED - Ajani, D / Collaborator ED - Maw, K / Collaborator ED - Andersen, J / Collaborator ED - Bergman, B / Collaborator ED - Dunmyer, S / Collaborator ED - Brandon, D / Collaborator ED - Anderson, M / Collaborator ED - Bononi, P / Collaborator ED - Prawer, J / Collaborator ED - Seidman, B / Collaborator ED - Cruz, H / Collaborator ED - Wilks, K / Collaborator ED - DiSanto, L / Collaborator ED - Buynak, R / Collaborator ED - Christensen, T / Collaborator ED - Denker, P / Collaborator ED - Koppel, W / Collaborator ED - Stedman, M / Collaborator ED - Lewy-Alterbaum, L / Collaborator ED - Karim, S / Collaborator ED - Shapiro, J / Collaborator ED - Gardner, T / Collaborator ED - Oskin, T / Collaborator ED - Gabra, N / Collaborator ED - Malano, J / Collaborator ED - Welty, Francine K / Collaborator ED - Parhofer, Klaus G / Collaborator ED - Pedersen, Terje R / Collaborator ED - Lees, Kennedy R / Collaborator ED - Clayton, Tim / Collaborator ED - Pocock, Stuart / Collaborator ED - Palmer, Mike / Collaborator ED - Clemmensen, Peter / Collaborator ED - Grande, Peer / Collaborator ED - Pehrson, Steen / Collaborator ED - Januzzi, James / Collaborator ED - Wood, Malissa J / Collaborator ED - Petrie, Mark / Collaborator ED - Sairanen, Tiina / Collaborator ED - Tatlisumak, Turgut / Collaborator ED - Soinne, Lauri / Collaborator ED - Kase, Carlos / Collaborator ED - Turan, Tanya / Collaborator ED - Watkins, Paul / Collaborator ED - Lewis, James / Collaborator ED - Freston, James / Collaborator ED - Schenker, Steven / Collaborator ED - Heist, Rebecca / Collaborator ED - Lee, Richard J / Collaborator ED - Natale, Ronald B / Collaborator ED - Sullivan, Ryan J / Collaborator ED - Buchbinder, Elizabeth I / Collaborator ED - Chodak, Gerald / Collaborator ED - Schumacher, Martin / Collaborator ED - Schmoor, Claudia / Collaborator ED - Hieke, Stefanie / Collaborator ED - Ohneberg, Kristin / Collaborator TI - Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes. JF - NEW ENGLAND JOURNAL OF MEDICINE J2 - NEW ENGL J MED VL - 373 PY - 2015 IS - 22 SP - 2117 EP - 2128 PG - 12 SN - 0028-4793 DO - 10.1056/NEJMoa1504720 UR - https://m2.mtmt.hu/api/publication/33698770 ID - 33698770 AB - The effects of empagliflozin, an inhibitor of sodium-glucose cotransporter 2, in addition to standard care, on cardiovascular morbidity and mortality in patients with type 2 diabetes at high cardiovascular risk are not known.We randomly assigned patients to receive 10 mg or 25 mg of empagliflozin or placebo once daily. The primary composite outcome was death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke, as analyzed in the pooled empagliflozin group versus the placebo group. The key secondary composite outcome was the primary outcome plus hospitalization for unstable angina.A total of 7020 patients were treated (median observation time, 3.1 years). The primary outcome occurred in 490 of 4687 patients (10.5%) in the pooled empagliflozin group and in 282 of 2333 patients (12.1%) in the placebo group (hazard ratio in the empagliflozin group, 0.86; 95.02% confidence interval, 0.74 to 0.99; P=0.04 for superiority). There were no significant between-group differences in the rates of myocardial infarction or stroke, but in the empagliflozin group there were significantly lower rates of death from cardiovascular causes (3.7%, vs. 5.9% in the placebo group; 38% relative risk reduction), hospitalization for heart failure (2.7% and 4.1%, respectively; 35% relative risk reduction), and death from any cause (5.7% and 8.3%, respectively; 32% relative risk reduction). There was no significant between-group difference in the key secondary outcome (P=0.08 for superiority). Among patients receiving empagliflozin, there was an increased rate of genital infection but no increase in other adverse events.Patients with type 2 diabetes at high risk for cardiovascular events who received empagliflozin, as compared with placebo, had a lower rate of the primary composite cardiovascular outcome and of death from any cause when the study drug was added to standard care. (Funded by Boehringer Ingelheim and Eli Lilly; EMPA-REG OUTCOME ClinicalTrials.gov number, NCT01131676.). LA - English DB - MTMT ER -