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Nagysejtes neuroendocrin carcinoma - a kórisme és a kezelés nehézségei [Large-cell neuroendocrine carcinoma of the lung - challenges of diagnosis and treatment]
[esetismertetés]
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Abstract: Small-cell lung carcinoma (SCLC) and the rare large-cell neuroendocrine carcinoma belong to the high grade pulmonary neuroendocrine carcinomas. Making the correct diagnosis and selection of treatment modalities require multidisciplinary meetings due to the morphological overlaps, aggressive behaviour and debated therapeutic guidelines of these entities. A 52-year-old woman was admitted to the hospital because of headache, nausea and tenebrous vision. The CT revealed metastatic tumour mass in the occipital lobe and in the cerebellum. Both tumours were removed and resulted in histological diagnosis of metastatic neuroendocrine carcinoma. Chest X-ray established contrast-enhancing lesion in the left lung. Bronchoscopy was performed and histological examination revealed large-cell neuroendocrine carcinoma. Postoperative skull irradiation and small-cell lung cancer chemotherapy protocol were utilized. Due to atelectasis and progression, chest irradiation was initiated, which was interrupted because of novel brain metastases. Further chemotherapy followed the non-small-cell lung cancer protocol. After 3 months, thoracic progression, brain and disseminated bone metastases were diagnosed. After a 14-month-long therapy, the patient deceased. Large-cell neuroendocrine carcinoma has a poor prognosis, the incidence of brain metastasis is 25?50%. In early stage large-cell neuroendocrine carcinoma, lobectomy is the standard treatment and adjuvant chemotherapy should also be considered. Although the non-small-cell lung cancer chemotherapy protocol is approved widely in the treatment of large-cell neuroendocrine carcinoma, the utility of SCLC scheme has also been suggested. Orv Hetil. 2020; 161(8): 313?319.
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Orvosi Hetilap szerkesztősége (Kiadók / MTA KFB); Pathológiai Intézet (SZTE / SZAOK); Sebészeti Klinika (SZTE / SZAOK); Tüdőgyógyászati Tanszék (SZTE / SZAOK)
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10059929"> <a href="/gui2/?type=authors&mode=browse&sel=10059929" target="_blank">Zombori, Tamás ✉</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Juhász-Nagy, Gréta </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10009640"> <a href="/gui2/?type=authors&mode=browse&sel=10009640" target="_blank">Tiszlavicz, László</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10000549"> <a href="/gui2/?type=authors&mode=browse&sel=10000549" target="_blank">Cserni, Gábor</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10028656"> <a href="/gui2/?type=authors&mode=browse&sel=10028656" target="_blank">Furák, József</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10028612"> <a href="/gui2/?type=authors&mode=browse&sel=10028612" target="_blank">Szalontai, Klára</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10028611"> <a href="/gui2/?type=authors&mode=browse&sel=10028611" target="_blank">Pálföldi, Regina</a> </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;31187860" mtid="31187860" target="_blank">Nagysejtes neuroendocrin carcinoma - a kórisme és a kezelés nehézségei [Large-cell neuroendocrine carcinoma of the lung - challenges of diagnosis and treatment]<span class="subTitle">: [esetismertetés]</span></a></div> <div class="pub-info"> <span class="journal-title">ORVOSI HETILAP</span> <span class="journal-volume">161</span> : <span class="journal-issue">8</span> <span class="page"> pp. 313-319. , 7 p. </span> <span class="year">(2020)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1556/650.2020.31581" target="_blank" href="https://doi.org/10.1556/650.2020.31581"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000514829600005" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000514829600005"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="108068" target="_blank" href="http://real.mtak.hu/108068"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85080844509" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85080844509"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="32073294" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32073294&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="2928447" target="_blank" href="http://www.matarka.hu/egy-kozlemeny-oldala.php?MatarkaID=2928447"> Matarka </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="141428" target="_blank" href="https://mob.aeek.hu/detailsperm.jsp?PERMID=141428"> MOB </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="18868" target="_blank" href="http://publicatio.bibl.u-szeged.hu/18868"> SZTE Publicatio </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:31187860 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 7</span> | Független: 6 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 7 | Scopus jelölt: 6 | WoS/Scopus jelölt: 7 | DOI jelölt: 7 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
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<span class="authorAux-mtmt"> pathologia</span>)
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<span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Tüdőgyógyászati Tanszék</span>
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;31187860" target="_blank">Nagysejtes neuroendocrin carcinoma - a kórisme és a kezelés nehézségei [Large-cell neuroendocrine carcinoma of the lung - challenges of diagnosis and treatment] : [esetismertetés].</a></div> <div> <span class="journal-title">ORVOSI HETILAP</span>
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<div class="lastModified">Utolsó módosítás: 2022.03.06. 19:24 Bernátskyné Babus Csilla (SZTE admin4)
</div>
<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Szövegében 3 oldalnál hosszabb esetismertetés, ezért besorolása szakcikk az MTA V. Osztályának ajánlása alapján. (BCS, SZTE admin4)</pre>
</div></div>