TY  - JOUR
ED  - Zhou, B / Collaborator
ED  - Lu, Y / Collaborator
ED  - Hajifathalian, K / Collaborator
ED  - Bentham, J / Collaborator
ED  - Di Cesare, M / Collaborator
ED  - Danaei, G / Collaborator
ED  - Bixby, H / Collaborator
ED  - Cowan, M J / Collaborator
ED  - Ali, M K / Collaborator
ED  - Taddei, C / Collaborator
ED  - Lo, W C / Collaborator
ED  - Reis-Santos, B / Collaborator
ED  - Stevens, G A / Collaborator
ED  - Riley, L M / Collaborator
ED  - Miranda, J J / Collaborator
ED  - Bjerregaard, P / Collaborator
ED  - Rivera, J A / Collaborator
ED  - Fouad, H M / Collaborator
ED  - Ma, G / Collaborator
ED  - Mbanya, J C / Collaborator
ED  - McGarvey, S T / Collaborator
ED  - Mohan, V / Collaborator
ED  - Onat, A / Collaborator
ED  - Pilav, A / Collaborator
ED  - Ramachandran, A / Collaborator
ED  - Romdhane, H B / Collaborator
ED  - Paciorek, C J / Collaborator
ED  - Bennett, J E / Collaborator
ED  - Ezzati, M / Collaborator
ED  - Abdeen, Z A / Collaborator
ED  - Abdul Kadir, K / Collaborator
ED  - Abu-Rmeileh, N M / Collaborator
ED  - Acosta-Cazares, B / Collaborator
ED  - Adams, R / Collaborator
ED  - Aekplakorn, W / Collaborator
ED  - Aguilar-Salinas, C A / Collaborator
ED  - Agyemang, C / Collaborator
ED  - Ahmadvand, A / Collaborator
ED  - Al-Othman, A R / Collaborator
ED  - Alkerwi, A / Collaborator
ED  - Amouyel, P / Collaborator
ED  - Amuzu, A / Collaborator
ED  - Andersen, L B / Collaborator
ED  - Anderssen, S A / Collaborator
ED  - Anjana, R M / Collaborator
ED  - Aounallah-Skhiri, H / Collaborator
ED  - Aris, T / Collaborator
ED  - Arlappa, N / Collaborator
ED  - Arveiler, D / Collaborator
ED  - Assah, F K / Collaborator
ED  - Avdicová, M / Collaborator
ED  - Azizi, F / Collaborator
ED  - Balakrishna, N / Collaborator
ED  - Bandosz, P / Collaborator
ED  - Barbagallo, C M / Collaborator
ED  - Barceló, A / Collaborator
ED  - Batieha, A M / Collaborator
ED  - Baur, L A / Collaborator
ED  - Romdhane, H B / Collaborator
ED  - Benet, M / Collaborator
ED  - Bernabe-Ortiz, A / Collaborator
ED  - Bharadwaj, S / Collaborator
ED  - Bhargava, S K / Collaborator
ED  - Bi, Y / Collaborator
ED  - Bjerregaard, P / Collaborator
ED  - Bjertness, E / Collaborator
ED  - Bjertness, M B / Collaborator
ED  - Björkelund, C / Collaborator
ED  - Blokstra, A / Collaborator
ED  - Bo, S / Collaborator
ED  - Boehm, B O / Collaborator
ED  - Boissonnet, C P / Collaborator
ED  - Bovet, P / Collaborator
ED  - Brajkovich, I / Collaborator
ED  - Breckenkamp, J / Collaborator
ED  - Brenner, H / Collaborator
ED  - Brewster, L M / Collaborator
ED  - Brian, G R / Collaborator
ED  - Bruno, G / Collaborator
ED  - Bugge, A / Collaborator
ED  - Cabrera de León, A / Collaborator
ED  - Can, G / Collaborator
ED  - Cândido, A P / Collaborator
ED  - Capuano, V / Collaborator
ED  - Carlsson, A C / Collaborator
ED  - Carvalho, M J / Collaborator
ED  - Casanueva, F F / Collaborator
ED  - Casas, J P / Collaborator
ED  - Caserta, C A / Collaborator
ED  - Castetbon, K / Collaborator
ED  - Chamukuttan, S / Collaborator
ED  - Chaturvedi, N / Collaborator
ED  - Chen, C J / Collaborator
ED  - Chen, F / Collaborator
ED  - Chen, S / Collaborator
ED  - Cheng, C Y / Collaborator
ED  - Chetrit, A / Collaborator
ED  - Chiou, S T / Collaborator
ED  - Cho, Y / Collaborator
ED  - Chudek, J / Collaborator
ED  - Cifkova, R / Collaborator
ED  - Claessens, F / Collaborator
ED  - Concin, H / Collaborator
ED  - Cooper, C / Collaborator
ED  - Cooper, R / Collaborator
ED  - Costanzo, S / Collaborator
ED  - Cottel, D / Collaborator
ED  - Cowell, C / Collaborator
ED  - Crujeiras, A B / Collaborator
ED  - D'Arrigo, G / Collaborator
ED  - Dallongeville, J / Collaborator
ED  - Dankner, R / Collaborator
ED  - Dauchet, L / Collaborator
ED  - de Gaetano, G / Collaborator
ED  - De Henauw, S / Collaborator
ED  - Deepa, M / Collaborator
ED  - Dehghan, A / Collaborator
ED  - Deschamps, V / Collaborator
ED  - Dhana, K / Collaborator
ED  - Di Castelnuovo, A F / Collaborator
ED  - Djalalinia, S / Collaborator
ED  - Doua, K / Collaborator
ED  - Drygas, W / Collaborator
ED  - Du, Y / Collaborator
ED  - Dzerve, V / Collaborator
ED  - Egbagbe, E E / Collaborator
ED  - Eggertsen, R / Collaborator
ED  - El Ati, J / Collaborator
ED  - Elosua, R / Collaborator
ED  - Erasmus, R T / Collaborator
ED  - Erem, C / Collaborator
ED  - Ergor, G / Collaborator
ED  - Eriksen, L / Collaborator
ED  - Escobedo-de la Peña, J / Collaborator
ED  - Fall, C H / Collaborator
ED  - Farzadfar, F / Collaborator
ED  - Felix-Redondo, F J / Collaborator
ED  - Ferguson, T S / Collaborator
ED  - Fernández-Bergés, D / Collaborator
ED  - Ferrari, M / Collaborator
ED  - Ferreccio, C / Collaborator
ED  - Feskens, E J / Collaborator
ED  - Finn, J D / Collaborator
ED  - Föger, B / Collaborator
ED  - Foo, L H / Collaborator
ED  - Forslund, A S / Collaborator
ED  - Fouad, H M / Collaborator
ED  - Francis, D K / Collaborator
ED  - Franco Mdo, C / Collaborator
ED  - Franco, O H / Collaborator
ED  - Frontera, G / Collaborator
ED  - Furusawa, T / Collaborator
ED  - Gaciong, Z / Collaborator
ED  - Garnett, S P / Collaborator
ED  - Gaspoz, J M / Collaborator
ED  - Gasull, M / Collaborator
ED  - Gates, L / Collaborator
ED  - Geleijnse, J M / Collaborator
ED  - Ghasemian, A / Collaborator
ED  - Ghimire, A / Collaborator
ED  - Giampaoli, S / Collaborator
ED  - Gianfagna, F / Collaborator
ED  - Giovannelli, J / Collaborator
ED  - Giwercman, A / Collaborator
ED  - Gross, M G / Collaborator
ED  - González Rivas, J P / Collaborator
ED  - Gorbea, M B / Collaborator
ED  - Gottrand, F / Collaborator
ED  - Grafnetter, D / Collaborator
ED  - Grodzicki, T / Collaborator
ED  - Grøntved, A / Collaborator
ED  - Gruden, G / Collaborator
ED  - Gu, D / Collaborator
ED  - Guan, O P / Collaborator
ED  - Guerrero, R / Collaborator
ED  - Guessous, I / Collaborator
ED  - Guimaraes, A L / Collaborator
ED  - Gutierrez, L / Collaborator
ED  - Hambleton, I R / Collaborator
ED  - Hardy, R / Collaborator
ED  - Hari Kumar, R / Collaborator
ED  - Hata, J / Collaborator
ED  - He, J / Collaborator
ED  - Heidemann, C / Collaborator
ED  - Herrala, S / Collaborator
ED  - Hihtaniemi, I T / Collaborator
ED  - Ho, S Y / Collaborator
ED  - Ho, S C / Collaborator
ED  - Hofman, A / Collaborator
ED  - Hormiga, C M / Collaborator
ED  - Horta, B L / Collaborator
ED  - Houti, L / Collaborator
ED  - Howitt, C / Collaborator
ED  - Htay, T T / Collaborator
ED  - Htet, A S / Collaborator
ED  - Htike, M M / Collaborator
ED  - Hu, Y / Collaborator
ED  - Hussieni, A S / Collaborator
ED  - Huybrechts, I / Collaborator
ED  - Hwalla, N / Collaborator
ED  - Iacoviello, L / Collaborator
ED  - Iannone, A G / Collaborator
ED  - Ibrahim, M M / Collaborator
ED  - Ikeda, N / Collaborator
ED  - Ikram, M A / Collaborator
ED  - Irazola, V E / Collaborator
ED  - Islam, M / Collaborator
ED  - Iwasaki, M / Collaborator
ED  - Jacobs, J M / Collaborator
ED  - Jafar, T / Collaborator
ED  - Jamil, K M / Collaborator
ED  - Jasienska, G / Collaborator
ED  - Jiang, C Q / Collaborator
ED  - Jonas, J B / Collaborator
ED  - Joshi, P / Collaborator
ED  - Kafatos, A / Collaborator
ED  - Kalter-Leibovici, O / Collaborator
ED  - Kasaeian, A / Collaborator
ED  - Katz, J / Collaborator
ED  - Kaur, P / Collaborator
ED  - Kavousi, M / Collaborator
ED  - Keinänen-Kiukaanniemi, S / Collaborator
ED  - Kelishadi, R / Collaborator
ED  - Kengne, A P / Collaborator
ED  - Kersting, M / Collaborator
ED  - Khader, Y S / Collaborator
ED  - Khalili, D / Collaborator
ED  - Khang, Y H / Collaborator
ED  - Kiechl, S / Collaborator
ED  - Kim, J / Collaborator
ED  - Kolsteren, P / Collaborator
ED  - Korrovits, P / Collaborator
ED  - Kratzer, W / Collaborator
ED  - Kromhout, D / Collaborator
ED  - Kujala, U M / Collaborator
ED  - Kula, K / Collaborator
ED  - Kyobutungi, C / Collaborator
ED  - Laatikainen, T / Collaborator
ED  - Lachat, C / Collaborator
ED  - Laid, Y / Collaborator
ED  - Lam, T H / Collaborator
ED  - Landrove, O / Collaborator
ED  - Lanska, V / Collaborator
ED  - Lappas, G / Collaborator
ED  - Laxmaiah, A / Collaborator
ED  - Leclercq, C / Collaborator
ED  - Lee, J / Collaborator
ED  - Lee, J / Collaborator
ED  - Lehtimäki, T / Collaborator
ED  - Lekhraj, R / Collaborator
ED  - León-Muñoz, L M / Collaborator
ED  - Li, Y / Collaborator
ED  - Lim, W Y / Collaborator
ED  - Lima-Costa, M F / Collaborator
ED  - Lin, H H / Collaborator
ED  - Lin, X / Collaborator
ED  - Lissner, L / Collaborator
ED  - Lorbeer, R / Collaborator
ED  - Lozano, J E / Collaborator
ED  - Luksiene, D / Collaborator
ED  - Lundqvist, A / Collaborator
ED  - Lytsy, P / Collaborator
ED  - Ma, G / Collaborator
ED  - Machado-Coelho, G L / Collaborator
ED  - Machi, S / Collaborator
ED  - Maggi, S / Collaborator
ED  - Magliano, D J / Collaborator
ED  - Makdisse, M / Collaborator
ED  - Mallikharjuna Rao, K / Collaborator
ED  - Manios, Y / Collaborator
ED  - Manzato, E / Collaborator
ED  - Margozzini, P / Collaborator
ED  - Marques-Vidal, P / Collaborator
ED  - Martorell, R / Collaborator
ED  - Masoodi, S R / Collaborator
ED  - Mathiesen, E B / Collaborator
ED  - Matsha, T E / Collaborator
ED  - Mbanya, J C / Collaborator
ED  - McFarlane, S R / Collaborator
ED  - McGarvey, S T / Collaborator
ED  - McLachlan, S / Collaborator
ED  - McNulty, B A / Collaborator
ED  - Mediene-Benchekor, S / Collaborator
ED  - Meirhaeghe, A / Collaborator
ED  - Menezes, A M / Collaborator
ED  - Merat, S / Collaborator
ED  - Meshram, I I / Collaborator
ED  - Mi, J / Collaborator
ED  - Miquel, J F / Collaborator
ED  - Miranda, J J / Collaborator
ED  - Mohamed, M K / Collaborator
ED  - Mohammad, K / Collaborator
ED  - Mohammadifard, N / Collaborator
ED  - Mohan, V / Collaborator
ED  - Mohd Yusoff, M F / Collaborator
ED  - Møller, N C / Collaborator
ED  - Molnár, Dénes / Collaborator
ED  - Mondo, C K / Collaborator
ED  - Morejon, A / Collaborator
ED  - Moreno, L A / Collaborator
ED  - Morgan, K / Collaborator
ED  - Moschonis, G / Collaborator
ED  - Mossakowska, M / Collaborator
ED  - Mostafa, A / Collaborator
ED  - Mota, J / Collaborator
ED  - Motta, J / Collaborator
ED  - Mu, T T / Collaborator
ED  - Muiesan, M L / Collaborator
ED  - Müller-Nurasyid, M / Collaborator
ED  - Mursu, J / Collaborator
ED  - Nagel, G / Collaborator
ED  - Námešná, J / Collaborator
ED  - Nang, E E / Collaborator
ED  - NangThetia, V B / Collaborator
ED  - Navarrete-Muñoz, E M / Collaborator
ED  - Ndiaye, N C / Collaborator
ED  - Nenko, I / Collaborator
ED  - Nervi, F / Collaborator
ED  - Nguyen, N D / Collaborator
ED  - Nguyen, Q N / Collaborator
ED  - Nieto-Martínez, R E / Collaborator
ED  - Ning, G / Collaborator
ED  - Ninomiya, T / Collaborator
ED  - Noale, M / Collaborator
ED  - Noto, D / Collaborator
ED  - Nsour, M A / Collaborator
ED  - Ochoa-Avilés, A M / Collaborator
ED  - Oh, K / Collaborator
ED  - Onat, A / Collaborator
ED  - Ordunez, P / Collaborator
ED  - Osmond, C / Collaborator
ED  - Otero, J A / Collaborator
ED  - Owusu-Dabo, E / Collaborator
ED  - Pahomova, E / Collaborator
ED  - Palmieri, L / Collaborator
ED  - Panda-Jonas, S / Collaborator
ED  - Panza, F / Collaborator
ED  - Parsaeian, M / Collaborator
ED  - Peixoto, S V / Collaborator
ED  - Pelletier, C / Collaborator
ED  - Peltonen, M / Collaborator
ED  - Peters, A / Collaborator
ED  - Peykari, N / Collaborator
ED  - Pham, S T / Collaborator
ED  - Pilav, A / Collaborator
ED  - Pitakaka, F / Collaborator
ED  - Piwonska, A / Collaborator
ED  - Piwonski, J / Collaborator
ED  - Plans-Rubió, P / Collaborator
ED  - Porta, M / Collaborator
ED  - Portegies, M L / Collaborator
ED  - Poustchi, H / Collaborator
ED  - Pradeepa, R / Collaborator
ED  - Price, J F / Collaborator
ED  - Punab, M / Collaborator
ED  - Qasrawi, R F / Collaborator
ED  - Qorbani, M / Collaborator
ED  - Radisauskas, R / Collaborator
ED  - Rahman, M / Collaborator
ED  - Raitakari, O / Collaborator
ED  - Rao, S R / Collaborator
ED  - Ramachandran, A / Collaborator
ED  - Ramke, J / Collaborator
ED  - Ramos, R / Collaborator
ED  - Rampal, S / Collaborator
ED  - Rathmann, W / Collaborator
ED  - Redon, J / Collaborator
ED  - Reganit, P F / Collaborator
ED  - Rigo, F / Collaborator
ED  - Robinson, S M / Collaborator
ED  - Robitaille, C / Collaborator
ED  - Rodríguez-Artalejo, F / Collaborator
ED  - Rodriguez-Perez Mdel, C / Collaborator
ED  - Rodríguez-Villamizar, L A / Collaborator
ED  - Rojas-Martinez, R / Collaborator
ED  - Ronkainen, K / Collaborator
ED  - Rosengren, A / Collaborator
ED  - Rubinstein, A / Collaborator
ED  - Rui, O / Collaborator
ED  - Ruiz-Betancourt, B S / Collaborator
ED  - Russo Horimoto, R V / Collaborator
ED  - Rutkowski, M / Collaborator
ED  - Sabanayagam, C / Collaborator
ED  - Sachdev, H S / Collaborator
ED  - Saidi, O / Collaborator
ED  - Sakarya, S / Collaborator
ED  - Salanave, B / Collaborator
ED  - Salonen, J T / Collaborator
ED  - Salvetti, M / Collaborator
ED  - Sánchez-Abanto, J / Collaborator
ED  - Santos, D / Collaborator
ED  - Dos Santos, R N / Collaborator
ED  - Santos, R / Collaborator
ED  - Saramies, J L / Collaborator
ED  - Sardinha, L B / Collaborator
ED  - Sarrafzadegan, N / Collaborator
ED  - Saum, K U / Collaborator
ED  - Scazufca, M / Collaborator
ED  - Schargrodsky, H / Collaborator
ED  - Scheidt-Nave, C / Collaborator
ED  - Sein, A A / Collaborator
ED  - Sharma, S K / Collaborator
ED  - Shaw, J E / Collaborator
ED  - Shibuya, K / Collaborator
ED  - Shin, Y / Collaborator
ED  - Shiri, R / Collaborator
ED  - Siantar, R / Collaborator
ED  - Sibai, A M / Collaborator
ED  - Simon, M / Collaborator
ED  - Simons, J / Collaborator
ED  - Simons, L A / Collaborator
ED  - Sjostrom, M / Collaborator
ED  - Slowikowska-Hilczer, J / Collaborator
ED  - Slusarczyk, P / Collaborator
ED  - Smeeth, L / Collaborator
ED  - Snijder, M B / Collaborator
ED  - So, H K / Collaborator
ED  - Sobngwi, E / Collaborator
ED  - Söderberg, S / Collaborator
ED  - Solfrizzi, V / Collaborator
ED  - Sonestedt, E / Collaborator
ED  - Soumare, A / Collaborator
ED  - Staessen, J A / Collaborator
ED  - Stathopoulou, M G / Collaborator
ED  - Steene-Johannessen, J / Collaborator
ED  - Stehle, P / Collaborator
ED  - Stein, A D / Collaborator
ED  - Stessman, J / Collaborator
ED  - Stöckl, D / Collaborator
ED  - Stokwiszewski, J / Collaborator
ED  - Stronks, K / Collaborator
ED  - Strufaldi, M W / Collaborator
ED  - Sun, C A / Collaborator
ED  - Sundström, J / Collaborator
ED  - Sung, Y T / Collaborator
ED  - Suriyawongpaisal, P / Collaborator
ED  - Sy, R G / Collaborator
ED  - Tai, E S / Collaborator
ED  - Tamosiunas, A / Collaborator
ED  - Tang, L / Collaborator
ED  - Tarawneh, M / Collaborator
ED  - Tarqui-Mamani, C B / Collaborator
ED  - Taylor, A / Collaborator
ED  - Theobald, H / Collaborator
ED  - Thijs, L / Collaborator
ED  - Thuesen, B H / Collaborator
ED  - Tolonen, H K / Collaborator
ED  - Tolstrup, J S / Collaborator
ED  - Topbas, M / Collaborator
ED  - Torrent, M / Collaborator
ED  - Traissac, P / Collaborator
ED  - Trinh, O T / Collaborator
ED  - Tulloch-Reid, M K / Collaborator
ED  - Tuomainen, T P / Collaborator
ED  - Turley, M L / Collaborator
ED  - Tzourio, C / Collaborator
ED  - Ueda, P / Collaborator
ED  - Ukoli, F A / Collaborator
ED  - Ulmer, H / Collaborator
ED  - Uusitalo, H M / Collaborator
ED  - Valdivia, G / Collaborator
ED  - Valvi, D / Collaborator
ED  - van Rossem, L / Collaborator
ED  - van Valkengoed, I G / Collaborator
ED  - Vanderschueren, D / Collaborator
ED  - Vanuzzo, D / Collaborator
ED  - Vega, T / Collaborator
ED  - Velasquez-Melendez, G / Collaborator
ED  - Veronesi, G / Collaborator
ED  - Verschuren, W M / Collaborator
ED  - Verstraeten, R / Collaborator
ED  - Viet, L / Collaborator
ED  - Vioque, J / Collaborator
ED  - Virtanen, J K / Collaborator
ED  - Visvikis-Siest, S / Collaborator
ED  - Viswanathan, B / Collaborator
ED  - Vollenweider, P / Collaborator
ED  - Voutilainen, S / Collaborator
ED  - Vrijheid, M / Collaborator
ED  - Wade, A N / Collaborator
ED  - Wagner, A / Collaborator
ED  - Walton, J / Collaborator
ED  - Wan Mohamud, W N / Collaborator
ED  - Wang, F / Collaborator
ED  - Wang, M D / Collaborator
ED  - Wang, Q / Collaborator
ED  - Wang, Y X / Collaborator
ED  - Wannamethee, S G / Collaborator
ED  - Weerasekera, D / Collaborator
ED  - Whincup, P H / Collaborator
ED  - Widhalm, K / Collaborator
ED  - Wiecek, A / Collaborator
ED  - Wijga, A H / Collaborator
ED  - Wilks, R J / Collaborator
ED  - Willeit, J / Collaborator
ED  - Wilsgaard, T / Collaborator
ED  - Wojtyniak, B / Collaborator
ED  - Wong, T Y / Collaborator
ED  - Woo, J / Collaborator
ED  - Woodward, M / Collaborator
ED  - Wu, F C / Collaborator
ED  - Wu, S L / Collaborator
ED  - Xu, H / Collaborator
ED  - Yan, W / Collaborator
ED  - Yang, X / Collaborator
ED  - Ye, X / Collaborator
ED  - Yoshihara, A / Collaborator
ED  - Younger-Coleman, N O / Collaborator
ED  - Zambon, S / Collaborator
ED  - Zargar, A H / Collaborator
ED  - Zdrojewski, T / Collaborator
ED  - Zhao, W / Collaborator
ED  - Zheng, Y / Collaborator
ED  - Zuñiga Cisneros, J / Collaborator
TI  - Worldwide trends in diabetes since 1980. a pooled analysis of 751 population-based studies with 4.4 million participants.
TS  - a pooled analysis of 751 population-based studies with 4.4 million participants.
JF  - LANCET
J2  - LANCET
VL  - 387
PY  - 2016
IS  - 10027
SP  - 1513
EP  - 1530
PG  - 18
SN  - 0140-6736
DO  - 10.1016/S0140-6736(16)00618-8
UR  - https://m2.mtmt.hu/api/publication/32552932
ID  - 32552932
AB  - One of the global targets for non-communicable diseases is to halt, by 2025, the rise in the age-standardised adult prevalence of diabetes at its 2010 levels. We aimed to estimate worldwide trends in diabetes, how likely it is for countries to achieve the global target, and how changes in prevalence, together with population growth and ageing, are affecting the number of adults with diabetes.We pooled data from population-based studies that had collected data on diabetes through measurement of its biomarkers. We used a Bayesian hierarchical model to estimate trends in diabetes prevalence-defined as fasting plasma glucose of 7.0 mmol/L or higher, or history of diagnosis with diabetes, or use of insulin or oral hypoglycaemic drugs-in 200 countries and territories in 21 regions, by sex and from 1980 to 2014. We also calculated the posterior probability of meeting the global diabetes target if post-2000 trends continue.We used data from 751 studies including 4,372,000 adults from 146 of the 200 countries we make estimates for. Global age-standardised diabetes prevalence increased from 4.3% (95% credible interval 2.4-7.0) in 1980 to 9.0% (7.2-11.1) in 2014 in men, and from 5.0% (2.9-7.9) to 7.9% (6.4-9.7) in women. The number of adults with diabetes in the world increased from 108 million in 1980 to 422 million in 2014 (28.5% due to the rise in prevalence, 39.7% due to population growth and ageing, and 31.8% due to interaction of these two factors). Age-standardised adult diabetes prevalence in 2014 was lowest in northwestern Europe, and highest in Polynesia and Micronesia, at nearly 25%, followed by Melanesia and the Middle East and north Africa. Between 1980 and 2014 there was little change in age-standardised diabetes prevalence in adult women in continental western Europe, although crude prevalence rose because of ageing of the population. By contrast, age-standardised adult prevalence rose by 15 percentage points in men and women in Polynesia and Micronesia. In 2014, American Samoa had the highest national prevalence of diabetes (>30% in both sexes), with age-standardised adult prevalence also higher than 25% in some other islands in Polynesia and Micronesia. If post-2000 trends continue, the probability of meeting the global target of halting the rise in the prevalence of diabetes by 2025 at the 2010 level worldwide is lower than 1% for men and is 1% for women. Only nine countries for men and 29 countries for women, mostly in western Europe, have a 50% or higher probability of meeting the global target.Since 1980, age-standardised diabetes prevalence in adults has increased, or at best remained unchanged, in every country. Together with population growth and ageing, this rise has led to a near quadrupling of the number of adults with diabetes worldwide. The burden of diabetes, both in terms of prevalence and number of adults affected, has increased faster in low-income and middle-income countries than in high-income countries.Wellcome Trust.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Varga, Zoltán
AU  - Giricz, Zoltán
AU  - Liaudet, L
AU  - Haskó, György
AU  - Ferdinandy, Péter
AU  - Pacher, Pál
TI  - Interplay of oxidative, nitrosative/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy
JF  - BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
J2  - BBA-MOL BASIS DIS
VL  - 1852
PY  - 2015
IS  - 2
SP  - 232
EP  - 242
PG  - 11
SN  - 0925-4439
DO  - 10.1016/j.bbadis.2014.06.030
UR  - https://m2.mtmt.hu/api/publication/2706302
ID  - 2706302
N1  - Funding Agency and Grant Number: Intramural Research Program of NIH/NIAAA; New Horizons Grant of the European Foundation for the Study of Diabetes; Hungarian Scientific Research Fund [OTKA K109737]; Hungarian Academy of Sciences; National Program of Excellence [TAMOP 4.2.4.A/2-11-1-2012-0001]
            Funding text: This study was supported by Intramural Research Program of NIH/NIAAA (to PP), the New Horizons Grant of the European Foundation for the Study of Diabetes, and Hungarian Scientific Research Fund (OTKA K109737) (to PF, ZG, and ZVV). ZG holds a "Janos Bolyai Fellowship" from the Hungarian Academy of Sciences. PF is a Szentagothai Fellow of the National Program of Excellence (TAMOP 4.2.4.A/2-11-1-2012-0001). Authors are indebted to Dr. George Kunos, the Scientific Director of NIAAA for continuous support
AB  - Diabetes is a recognized risk factor for cardiovascular diseases and heart failure. Diabetic cardiovascular dysfunction also underscores the development of diabetic retinopathy, nephropathy and neuropathy. Despite the broad availability of antidiabetic therapy, glycaemic control still remains a major challenge in the management of diabetic patients. Hyperglycaemia triggers formation of advanced glycosylation end products(AGEs), activates protein kinase C, enhances polyol pathway, glucose autoxidation, which coupled with elevated levels of free fatty acids, and leptin have been implicated in increased generation of superoxide anion by mitochondria, NADPH oxidases and xanthine oxidoreductase in diabetic vasculature and myocardium. Superoxide anion interacts with nitric oxide forming the potent toxin peroxynitrite via diffusion limited reaction, which in concert with other oxidants triggers activation of stress kinases, endoplasmic reticulum stress, mitochondrial and poly(ADP-ribose) polymerase 1-dependent cell death, dysregulates autophagy/mitophagy, inactivates key proteins involved in myocardial calcium handling/contractility and antioxidant defense, activates matrix metalloproteinases and redox-dependent pro-inflammatory transcription factors (e.g. nuclear factor kappaB) promoting inflammation, AGEs formation, eventually culminating in myocardial dysfunction, remodeling and heart failure. Understanding the complex interplay of oxidative/nitrosative stress with pro-inflammatory, metabolic and cell death pathways is critical to devise novel targeted therapies for diabetic cardiomyopathy, which will be overviewed in this brief synopsis. This article is part of a Special Issue entitled: Autophagy and protein quality control in cardiometabolic diseases.
LA  - English
DB  - MTMT
ER  -