TY  - JOUR
AU  - Henn, László
AU  - Szabó, Anikó
AU  - Imre, László
AU  - Román, Ádám
AU  - Ábrahám, Andrea
AU  - Vedelek, Balázs
AU  - Nánási, Péter Pál
AU  - Boros, Imre Miklós
TI  - Alternative linker histone permits fast paced nuclear divisions in early Drosophila embryo
JF  - NUCLEIC ACIDS RESEARCH
J2  - NUCLEIC ACIDS RES
VL  - 48
PY  - 2020
IS  - 16
SP  - 9007
EP  - 9018
PG  - 12
SN  - 0305-1048
DO  - 10.1093/nar/gkaa624
UR  - https://m2.mtmt.hu/api/publication/31397830
ID  - 31397830
AB  - In most animals, the start of embryogenesis requires specific histones. In Drosophila linker histone variant BigH1 is present in early embryos. To uncover the specific role of this alternative linker histone at early embryogenesis, we established fly lines in which domains of BigH1 have been replaced partially or completely with that of H1. Analysis of the resulting Drosophila lines revealed that at normal temperature somatic H1 can substitute the alternative linker histone, but at low temperature the globular and C-terminal domains of BigH1 are essential for embryogenesis. In the presence of BigH1 nucleosome stability increases and core histone incorporation into nucleosomes is more rapid, while nucleosome spacing is unchanged. Chromatin formation in the presence of BigH1 permits the fast-paced nuclear divisions of the early embryo. We propose a model which explains how this specific linker histone ensures the rapid nucleosome reassembly required during quick replication cycles at the start of embryogenesis.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Kirilly, Dániel
AU  - Xie, T
TI  - The Drosophila Ovary: an Active Stem Cell Community
JF  - CELL RESEARCH
J2  - CELL RES
VL  - 17
PY  - 2007
IS  - 1
SP  - 15
EP  - 25
PG  - 11
SN  - 1001-0602
DO  - 10.1038/sj.cr.7310123
UR  - https://m2.mtmt.hu/api/publication/1915067
ID  - 1915067
LA  - English
DB  - MTMT
ER  -