TY - JOUR AU - Cosentino, Francesco AU - Grant, Peter J AU - Aboyans, Victor AU - Bailey, Clifford J AU - Ceriello, Antonio AU - Delgado, Victoria AU - Federici, Massimo AU - Filippatos, Gerasimos AU - Grobbee, Diederick E AU - Hansen, Tina Birgitte AU - Huikuri, Heikki V AU - Johansson, Isabelle AU - Jüni, Peter AU - Lettino, Maddalena AU - Marx, Nikolaus AU - Mellbin, Linda G AU - Östgren, Carl J AU - Rocca, Bianca AU - Roffi, Marco AU - Sattar, Naveed AU - Seferović, Petar M AU - Sousa-Uva, Miguel AU - Valensi, Paul AU - Wheeler, David C ED - European, Association for the Study of Diabetes (EASD) / Collaborative Organization ED - Piepoli, Massimo Francesco / Collaborator ED - Birkeland, Kåre I / Collaborator ED - Adamopoulos, Stamatis / Collaborator ED - Ajjan, Ramzi / Collaborator ED - Avogaro, Angelo / Collaborator ED - Baigent, Colin / Collaborator ED - Brodmann, Marianne / Collaborator ED - Bueno, Héctor / Collaborator ED - Ceconi, Claudio / Collaborator ED - Chioncel, Ovidiu / Collaborator ED - Coats, Andrew / Collaborator ED - Collet, Jean-Philippe / Collaborator ED - Collins, Peter / Collaborator ED - Cosyns, Bernard / Collaborator ED - Di Mario, Carlo / Collaborator ED - Fisher, Miles / Collaborator ED - Fitzsimons, Donna / Collaborator ED - Halvorsen, Sigrun / Collaborator ED - Hansen, Dominique / Collaborator ED - Hoes, Arno / Collaborator ED - Holt, Richard I G / Collaborator ED - Home, Philip / Collaborator ED - Katus, Hugo A / Collaborator ED - Khunti, Kamlesh / Collaborator ED - Komajda, Michel / Collaborator ED - Lambrinou, Ekaterini / Collaborator ED - Landmesser, Ulf / Collaborator ED - Lewis, Basil S / Collaborator ED - Linde, Cecilia / Collaborator ED - Lorusso, Roberto / Collaborator ED - Mach, François / Collaborator ED - Mueller, Christian / Collaborator ED - Neumann, Franz-Josef / Collaborator ED - Persson, Frederik / Collaborator ED - Petersen, Steffen E / Collaborator ED - Petronio, Anna Sonia / Collaborator ED - Richter, Dimitrios J / Collaborator ED - Rosano, Giuseppe M C / Collaborator ED - Rossing, Peter / Collaborator ED - Rydén, Lars / Collaborator ED - Shlyakhto, Evgeny / Collaborator ED - Simpson, Iain A / Collaborator ED - Touyz, Rhian M / Collaborator ED - Wijns, William / Collaborator ED - Wilhelm, Matthias / Collaborator ED - Williams, Bryan / Collaborator ED - Aboyans, Victor / Collaborator ED - Bailey, Clifford J / Collaborator ED - Ceriello, Antonio / Collaborator ED - Delgado, Victoria / Collaborator ED - Federici, Massimo / Collaborator ED - Filippatos, Gerasimos / Collaborator ED - Grobbee, Diederick E / Collaborator ED - Hansen, Tina Birgitte / Collaborator ED - Huikuri, Heikki V / Collaborator ED - Johansson, Isabelle / Collaborator ED - Jüni, Peter / Collaborator ED - Lettino, Maddalena / Collaborator ED - Marx, Nikolaus / Collaborator ED - Mellbin, Linda G / Collaborator ED - Östgren, Carl J / Collaborator ED - Rocca, Bianca / Collaborator ED - Roffi, Marco / Collaborator ED - Sattar, Naveed / Collaborator ED - Seferović, Petar M / Collaborator ED - Sousa-Uva, Miguel / Collaborator ED - Valensi, Paul / Collaborator ED - Wheeler, David C / Collaborator ED - Windecker, Stephan / Collaborator ED - Aboyans, Victor / Collaborator ED - Baigent, Colin / Collaborator ED - Collet, Jean-Philippe / Collaborator ED - Dean, Veronica / Collaborator ED - Delgado, Victoria / Collaborator ED - Fitzsimons, Donna / Collaborator ED - Gale, Chris P / Collaborator ED - Grobbee, Diederick E / Collaborator ED - Halvorsen, Sigrun / Collaborator ED - Hindricks, Gerhard / Collaborator ED - Iung, Bernard / Collaborator ED - Jüni, Peter / Collaborator ED - Katus, Hugo A / Collaborator ED - Landmesser, Ulf / Collaborator ED - Leclercq, Christophe / Collaborator ED - Lettino, Maddalena / Collaborator ED - Lewis, Basil S / Collaborator ED - Merkely, Bela / Collaborator ED - Mueller, Christian / Collaborator ED - Petersen, Steffen E / Collaborator ED - Petronio, Anna Sonia / Collaborator ED - Richter, Dimitrios J / Collaborator ED - Roffi, Marco / Collaborator ED - Shlyakhto, Evgeny / Collaborator ED - Simpson, Iain A / Collaborator ED - Sousa-Uva, Miguel / Collaborator ED - Touyz, Rhian M / Collaborator ED - Zelveian, Parounak H / Collaborator ED - Scherr, Daniel / Collaborator ED - Jahangirov, Tofig / Collaborator ED - Lazareva, Irina / Collaborator ED - Shivalkar, Bharati / Collaborator ED - Naser, Nabil / Collaborator ED - Gruev, Ivan / Collaborator ED - Milicic, Davor / Collaborator ED - Petrou, Petros M / Collaborator ED - Linhart, Aleš / Collaborator ED - Hildebrandt, Per / Collaborator ED - Hasan-Ali, Hosam / Collaborator ED - Marandi, Toomas / Collaborator ED - Lehto, Seppo / Collaborator ED - Mansourati, Jacques / Collaborator ED - Kurashvili, Ramaz / Collaborator ED - Siasos, Gerasimos / Collaborator ED - Lengyel, Csaba Attila / Collaborator ED - Thrainsdottir, Inga S / Collaborator ED - Aronson, Doron / Collaborator ED - Di Lenarda, Andrea / Collaborator ED - Raissova, Aigul / Collaborator ED - Ibrahimi, Pranvera / Collaborator ED - Abilova, Saamai / Collaborator ED - Trusinskis, Karlis / Collaborator ED - Saade, Georges / Collaborator ED - Benlamin, Hisham / Collaborator ED - Petrulioniene, Zaneta / Collaborator ED - Banu, Cristiana / Collaborator ED - Magri, Caroline Jane / Collaborator ED - David, Lilia / Collaborator ED - Boskovic, Aneta / Collaborator ED - Alami, Mohamed / Collaborator ED - Liem, An Ho / Collaborator ED - Bosevski, Marijan / Collaborator ED - Svingen, Gard Frodahl Tveitevaag / Collaborator ED - Janion, Marianna / Collaborator ED - Gavina, Cristina / Collaborator ED - Vinereanu, Dragos / Collaborator ED - Nedogoda, Sergey / Collaborator ED - Mancini, Tatiana / Collaborator ED - Ilic, Marina Deljanin / Collaborator ED - Fabryova, Lubomira / Collaborator ED - Fras, Zlatko / Collaborator ED - Jiménez-Navarro, Manuel F / Collaborator ED - Norhammar, Anna / Collaborator ED - Lehmann, Roger / Collaborator ED - Mourali, Mohamed Sami / Collaborator ED - Ural, Dilek / Collaborator ED - Nesukay, Elena / Collaborator ED - Chowdhury, Tahseen Ahmad / Collaborator ED - Lengyel, Csaba / Collaborator TI - 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD JF - EUROPEAN HEART JOURNAL J2 - EUR HEART J VL - 41 PY - 2020 IS - 2 SP - 255 EP - 323 PG - 69 SN - 0195-668X DO - 10.1093/eurheartj/ehz486 UR - https://m2.mtmt.hu/api/publication/30804305 ID - 30804305 LA - English DB - MTMT ER - TY - JOUR AU - Mansour, Bassel AU - Monyók, Ádám AU - Makra, Nóra AU - Gajdács, Márió AU - Vadnay, István AU - Ligeti, Balázs AU - Juhász, János AU - Szabó, Dóra AU - Ostorházi, Eszter TI - Bladder cancer-related microbiota. examining differences in urine and tissue samples TS - examining differences in urine and tissue samples JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 10 PY - 2020 IS - 1 PG - 10 SN - 2045-2322 DO - 10.1038/s41598-020-67443-2 UR - https://m2.mtmt.hu/api/publication/31374214 ID - 31374214 LA - English DB - MTMT ER - TY - JOUR AU - Tárnoki, Ádám Domonkos AU - Tárnoki, Dávid László AU - Forgó, Bianka AU - Szabó, Helga AU - Melicher, Dóra AU - Metneki, Julia AU - Littvay, Levente TI - The Hungarian Twin Registry Update: Turning From a Voluntary to a Population-Based Registry JF - TWIN RESEARCH AND HUMAN GENETICS J2 - TWIN RES HUM GENET VL - 22 PY - 2019 IS - 6 SP - 561 EP - 566 PG - 6 SN - 1832-4274 DO - 10.1017/thg.2019.100 UR - https://m2.mtmt.hu/api/publication/31122140 ID - 31122140 LA - English DB - MTMT ER - TY - JOUR AU - Forgó, Bianka AU - Medda, E AU - Hernyes, Anita AU - Szalontai, László AU - Tárnoki, Dávid László AU - Tárnoki, Ádám Domonkos TI - Carotid Artery Atherosclerosis: A Review on Heritability and Genetics JF - TWIN RESEARCH AND HUMAN GENETICS J2 - TWIN RES HUM GENET VL - 21 PY - 2018 IS - 5 SP - 333 EP - 346 PG - 14 SN - 1832-4274 DO - 10.1017/thg.2018.45 UR - https://m2.mtmt.hu/api/publication/3404011 ID - 3404011 N1 - Export Date: 11 October 2023 Correspondence Address: Tarnoki, A.D.; Department of Radiology, Ülloi Street 78/A, Hungary; email: tarnoki2@gmail.com AB - Carotid atherosclerosis (CAS) is associated with increased cardiovascular risk, and therefore, assessing the genetic versus environmental background of CAS traits is of key importance. Carotid intima-media-thickness and plaque characteristics seem to be moderately heritable, with remarkable differences in both heritability and presence or severity of these traits among ethnicities. Although the considerable role of additive genetic effects is obvious, based on the results so far, there is an important emphasis on non-shared environmental factors as well. We aimed to collect and summarize the papers that investigate twin and family studies assessing the phenotypic variance attributable to genetic associations with CAS. Genes in relation to CAS markers were overviewed with a focus on genetic association studies and genome-wide association studies. Although the role of certain genes is confirmed by studies conducted on large populations and meta-analyses, many of them show conflicting results. A great focus should be on future studies elucidating the exact pathomechanism of these genes in CAS in order to imply them as novel therapeutic targets. LA - English DB - MTMT ER - TY - JOUR AU - Littvay, Levente AU - Metneki, J AU - Tárnoki, Ádám Domonkos AU - Tárnoki, Dávid László TI - The Hungarian Twin Registry JF - TWIN RESEARCH AND HUMAN GENETICS J2 - TWIN RES HUM GENET VL - 16 PY - 2013 IS - 1 SP - 185 EP - 189 PG - 5 SN - 1832-4274 DO - 10.1017/thg.2012.76 UR - https://m2.mtmt.hu/api/publication/2101783 ID - 2101783 N1 - Epub: 2012 Oct 19:1-5. AB - The first Hungarian Twin Registry was established in Budapest in 1970 through the mandatory reporting of multiple-births. In the 1980s a second, volunteer adult registry was also founded. Unfortunately, both registries ceased to exist in the 1990s. Efforts started in 2006 to revive a Hungarian twin registry. The team spearheading this effort reports here on this progress. Currently, the voluntary Hungarian Twin Registry consists of 310 adult twin pairs and multiplets. Current research focuses on cardiovascular and respiratory health and yielded multiple awards and publications. Efforts are on the way to expand into social, psychological, and obesity studies. LA - English DB - MTMT ER - TY - JOUR AU - Backhed, F AU - Ding, H AU - Wang, T AU - Hooper, LV AU - Koh, GY AU - Nagy, András AU - Semenkovich, CF AU - Gordon, JI TI - The gut microbiota as an environmental factor that regulates fat storage JF - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA J2 - P NATL ACAD SCI USA VL - 101 PY - 2004 IS - 44 SP - 15718 EP - 15723 PG - 6 SN - 0027-8424 DO - 10.1073/pnas.0407076101 UR - https://m2.mtmt.hu/api/publication/2941365 ID - 2941365 AB - New therapeutic targets for noncognitive reductions in energy intake, absorption, or storage are crucial given the worldwide epidemic of obesity. The gut microbial community (microbiota) is essential for processing dietary polysaccharides. We found that conventionalization of adult germ-free (GF) C57BL/6 mice with a normal microbiota harvested from the distal intestine (cecum) of conventionally raised animals produces a 60% increase in body fat content and insulin resistance within 14 days despite reduced food intake. Studies of GF and conventionalized mice revealed that the microbiota promotes absorption of monosaccharides from the gut lumen, with resulting induction of de novo hepatic lipogenesis. Fasting-induced adipocyte factor (Fiaf), a member of the angiopoietin-like family of proteins, is selectively suppressed in the intestinal epithelium of normal mice by conventionalization. Analysis of GF and conventionalized, normal and Fiaf knockout mice established that Fiaf is a circulating lipoprotein lipase inhibitor and that its suppression is essential for the microbiota-induced deposition of triglycerides in adipocytes. Studies of Rag1(-/-) animals indicate that these host responses do not require mature lymphocytes. Our findings suggest that the gut microbiota is an important environmental factor that affects energy harvest from the diet and energy storage in the host. LA - English DB - MTMT ER -