@article{MTMT:30804305, title = {2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD}, url = {https://m2.mtmt.hu/api/publication/30804305}, author = {Cosentino, Francesco and Grant, Peter J and Aboyans, Victor and Bailey, Clifford J and Ceriello, Antonio and Delgado, Victoria and Federici, Massimo and Filippatos, Gerasimos and Grobbee, Diederick E and Hansen, Tina Birgitte and Huikuri, Heikki V and Johansson, Isabelle and Jüni, Peter and Lettino, Maddalena and Marx, Nikolaus and Mellbin, Linda G and Östgren, Carl J and Rocca, Bianca and Roffi, Marco and Sattar, Naveed and Seferović, Petar M and Sousa-Uva, Miguel and Valensi, Paul and Wheeler, David C}, doi = {10.1093/eurheartj/ehz486}, journal-iso = {EUR HEART J}, journal = {EUROPEAN HEART JOURNAL}, volume = {41}, unique-id = {30804305}, issn = {0195-668X}, keywords = {diabetes mellitus; Risk Factors; PREVENTION; EPIDEMIOLOGY; cardiovascular diseases; GUIDELINES; impaired glucose tolerance; Revascularization; pharmacological treatment; patient-centred care; Patient management; Cardiovascular risk assessment}, year = {2020}, eissn = {1522-9645}, pages = {255-323}, orcid-numbers = {Lengyel, Csaba Attila/0000-0002-0434-0067} } @article{MTMT:31374214, title = {Bladder cancer-related microbiota. examining differences in urine and tissue samples}, url = {https://m2.mtmt.hu/api/publication/31374214}, author = {Mansour, Bassel and Monyók, Ádám and Makra, Nóra and Gajdács, Márió and Vadnay, István and Ligeti, Balázs and Juhász, János and Szabó, Dóra and Ostorházi, Eszter}, doi = {10.1038/s41598-020-67443-2}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {10}, unique-id = {31374214}, year = {2020}, eissn = {2045-2322}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Szabó, Dóra/0000-0002-8601-3923; Ostorházi, Eszter/0000-0002-9459-7316} } @article{MTMT:31122140, title = {The Hungarian Twin Registry Update: Turning From a Voluntary to a Population-Based Registry}, url = {https://m2.mtmt.hu/api/publication/31122140}, author = {Tárnoki, Ádám Domonkos and Tárnoki, Dávid László and Forgó, Bianka and Szabó, Helga and Melicher, Dóra and Metneki, Julia and Littvay, Levente}, doi = {10.1017/thg.2019.100}, journal-iso = {TWIN RES HUM GENET}, journal = {TWIN RESEARCH AND HUMAN GENETICS}, volume = {22}, unique-id = {31122140}, issn = {1832-4274}, year = {2019}, eissn = {1839-2628}, pages = {561-566}, orcid-numbers = {Tárnoki, Ádám Domonkos/0000-0001-5909-3780; Tárnoki, Dávid László/0000-0002-7001-7647; Melicher, Dóra/0000-0003-4848-1424; Littvay, Levente/0000-0003-2022-6886} } @article{MTMT:3404011, title = {Carotid Artery Atherosclerosis: A Review on Heritability and Genetics}, url = {https://m2.mtmt.hu/api/publication/3404011}, author = {Forgó, Bianka and Medda, E and Hernyes, Anita and Szalontai, László and Tárnoki, Dávid László and Tárnoki, Ádám Domonkos}, doi = {10.1017/thg.2018.45}, journal-iso = {TWIN RES HUM GENET}, journal = {TWIN RESEARCH AND HUMAN GENETICS}, volume = {21}, unique-id = {3404011}, issn = {1832-4274}, abstract = {Carotid atherosclerosis (CAS) is associated with increased cardiovascular risk, and therefore, assessing the genetic versus environmental background of CAS traits is of key importance. Carotid intima-media-thickness and plaque characteristics seem to be moderately heritable, with remarkable differences in both heritability and presence or severity of these traits among ethnicities. Although the considerable role of additive genetic effects is obvious, based on the results so far, there is an important emphasis on non-shared environmental factors as well. We aimed to collect and summarize the papers that investigate twin and family studies assessing the phenotypic variance attributable to genetic associations with CAS. Genes in relation to CAS markers were overviewed with a focus on genetic association studies and genome-wide association studies. Although the role of certain genes is confirmed by studies conducted on large populations and meta-analyses, many of them show conflicting results. A great focus should be on future studies elucidating the exact pathomechanism of these genes in CAS in order to imply them as novel therapeutic targets.}, year = {2018}, eissn = {1839-2628}, pages = {333-346}, orcid-numbers = {Hernyes, Anita/0000-0001-5875-4006; Tárnoki, Dávid László/0000-0002-7001-7647; Tárnoki, Ádám Domonkos/0000-0001-5909-3780} } @article{MTMT:2101783, title = {The Hungarian Twin Registry}, url = {https://m2.mtmt.hu/api/publication/2101783}, author = {Littvay, Levente and Metneki, J and Tárnoki, Ádám Domonkos and Tárnoki, Dávid László}, doi = {10.1017/thg.2012.76}, journal-iso = {TWIN RES HUM GENET}, journal = {TWIN RESEARCH AND HUMAN GENETICS}, volume = {16}, unique-id = {2101783}, issn = {1832-4274}, abstract = {The first Hungarian Twin Registry was established in Budapest in 1970 through the mandatory reporting of multiple-births. In the 1980s a second, volunteer adult registry was also founded. Unfortunately, both registries ceased to exist in the 1990s. Efforts started in 2006 to revive a Hungarian twin registry. The team spearheading this effort reports here on this progress. Currently, the voluntary Hungarian Twin Registry consists of 310 adult twin pairs and multiplets. Current research focuses on cardiovascular and respiratory health and yielded multiple awards and publications. Efforts are on the way to expand into social, psychological, and obesity studies.}, year = {2013}, eissn = {1839-2628}, pages = {185-189}, orcid-numbers = {Littvay, Levente/0000-0003-2022-6886; Tárnoki, Ádám Domonkos/0000-0001-5909-3780; Tárnoki, Dávid László/0000-0002-7001-7647} } @article{MTMT:2941365, title = {The gut microbiota as an environmental factor that regulates fat storage}, url = {https://m2.mtmt.hu/api/publication/2941365}, author = {Backhed, F and Ding, H and Wang, T and Hooper, LV and Koh, GY and Nagy, András and Semenkovich, CF and Gordon, JI}, doi = {10.1073/pnas.0407076101}, journal-iso = {P NATL ACAD SCI USA}, journal = {PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA}, volume = {101}, unique-id = {2941365}, issn = {0027-8424}, abstract = {New therapeutic targets for noncognitive reductions in energy intake, absorption, or storage are crucial given the worldwide epidemic of obesity. The gut microbial community (microbiota) is essential for processing dietary polysaccharides. We found that conventionalization of adult germ-free (GF) C57BL/6 mice with a normal microbiota harvested from the distal intestine (cecum) of conventionally raised animals produces a 60% increase in body fat content and insulin resistance within 14 days despite reduced food intake. Studies of GF and conventionalized mice revealed that the microbiota promotes absorption of monosaccharides from the gut lumen, with resulting induction of de novo hepatic lipogenesis. Fasting-induced adipocyte factor (Fiaf), a member of the angiopoietin-like family of proteins, is selectively suppressed in the intestinal epithelium of normal mice by conventionalization. Analysis of GF and conventionalized, normal and Fiaf knockout mice established that Fiaf is a circulating lipoprotein lipase inhibitor and that its suppression is essential for the microbiota-induced deposition of triglycerides in adipocytes. Studies of Rag1(-/-) animals indicate that these host responses do not require mature lymphocytes. Our findings suggest that the gut microbiota is an important environmental factor that affects energy harvest from the diet and energy storage in the host.}, keywords = {metabolism; PROTEIN; MICE; GENE-EXPRESSION; STATES; INTESTINE; GLUCOSE; ADIPOSE-TISSUE; Energy storage; Adiposity; symbiosis; LIPOPROTEIN-LIPASE; fasting-induced adipose factor; TARGET GENE; nutrient processing}, year = {2004}, eissn = {1091-6490}, pages = {15718-15723} }