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10006074, "snippet" : true }, "volume" : "27", "issue" : "4", "firstPage" : "951", "lastPage" : "956", "firstPageOrInternalIdForSort" : "951", "pageLength" : 6, "publishedYear" : 2018, "abstractText" : "BACKGROUND: In patients with acute ischemic stroke (AIS) without cardiovascular complications, we investigated the association of serum concentration of cardiac troponin (high-sensitivity cardiac troponin T [hs-cTnT]) with thrombo-inflammatory markers. METHODS: Thirty-five patients with first-ever AIS were prospectively examined. Serum hs-cTnT was measured 6 and 24 hours after stroke, whereas S100B, high-sensitivity C-reactive protein (hsCRP), soluble CD40 ligand, tissue plasminogen activator (tPA), monocyte chemoattractant protein-1 (MCP-1), and P-selectin were measured 6 and 72 hours after stroke. Severity of stroke was assessed by the National Institutes of Health Stroke Scale (NIHSS) on admission, 24 hours later, and at discharge. RESULTS: Concentration of MCP-1 at 6 hours was higher in the serum of patients with worsened NIHSS by 24 hours (P = .009). Concentration of hs-cTnT at both 6 and 24 hours was higher, if NIHSS worsened by discharge (P = .026 and P = .001). A cutoff value for hs-cTnT measured at T24 greater than or equal to 9.4 predicted worsened NIHSS on discharge with a sensitivity of 81% and a specificity of 74% (area: .808, P = .002). Concentration of hs-cTnT at both 6 and 24 hours was also higher in nonsurvivors compared with survivors (P = .03, respectively), and correlated with (1) tPA levels at 6 hours (P = .001 and P = .002, respectively); (2) MCP-1 concentration at 6 hours (P = .01 and P = .015, respectively); and increased hsCRP levels at 72 hours (P = .01, respectively). Concentration of hs-cTnT at 24 hours was an independent predictor of worsened NIHSS at discharge (odds ratio: 1.58, 95% confidence interval: 1.063-2.370, P = .024). CONCLUSIONS: Elevated concentration of hs-cTnT measured 24 hours after AIS is an independent predictor of progressing neurologic deficit in patients without apparent myocardial damage, and also correlates with acute elevation of tPA and MCP-1.", "subjects" : [ { "otype" : "Classification", "mtid" : 12125, "link" : "/api/classification/12125", "label" : "Általános orvostudomány", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12347, "link" : "/api/classification/12347", "label" : "Egészségtudományok", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12215, "link" : "/api/classification/12215", "label" : "Klinikai orvostan", "published" : true, "snippet" : true } ], "keywords" : [ { "otype" : "Keyword", "mtid" : 137, "link" : "/api/keyword/137", "label" : "DISEASE", "published" : true, "oldId" : 137, "snippet" : true }, { "otype" : "Keyword", "mtid" : 307, "link" : "/api/keyword/307", "label" : "RISK", "published" : true, "oldId" : 307, "snippet" : true }, { "otype" : "Keyword", "mtid" : 315, "link" : "/api/keyword/315", "label" : "C-REACTIVE PROTEIN", "published" : true, "oldId" : 315, "snippet" : true }, { "otype" : "Keyword", "mtid" : 568, "link" : "/api/keyword/568", "label" : "MARKER", "published" : true, "oldId" : 568, "snippet" : true }, { "otype" : "Keyword", "mtid" : 623, "link" : "/api/keyword/623", "label" : "ASSOCIATION", "published" : true, "oldId" : 623, "snippet" : true }, { "otype" : "Keyword", "mtid" : 627, "link" : "/api/keyword/627", "label" : "ACUTE MYOCARDIAL-INFARCTION", "published" : true, "oldId" : 627, "snippet" : true }, { "otype" : "Keyword", "mtid" : 2591, "link" : "/api/keyword/2591", "label" : "MORTALITY", "published" : true, "oldId" : 2591, "snippet" : true }, { "otype" : "Keyword", "mtid" : 4396, "link" : "/api/keyword/4396", "label" : "Biomarkers", "published" : true, "oldId" : 4396, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1005593, "link" : "/api/keyword/1005593", "label" : "ARTERY", "published" : true, "oldId" : 1005593, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1020507, "link" : "/api/keyword/1020507", "label" : "outcome", "published" : true, "oldId" : 1020507, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1044366, "link" : "/api/keyword/1044366", "label" : "Acute ischemic stroke", "published" : true, "oldId" : 1044366, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1084077, "link" : "/api/keyword/1084077", "label" : "Neurosciences", "published" : true, "oldId" : 1084077, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1497369, "link" : "/api/keyword/1497369", "label" : "MONOCYTE CHEMOATTRACTANT PROTEIN-1", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2017, "packet" : "175019", "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : true, "missingAuthor" : false, "oaType" : "PAY", "oaCheckDate" : "2024-02-19", "oaFree" : false, "citationCount" : 22, "citationCountUnpublished" : 0, "citationCountWoOther" : 20, "independentCitCountWoOther" : 9, "nationalOriginCitationCount" : 11, "foreignEditionCitationCount" : 16, "doiCitationCount" : 15, "wosCitationCount" : 11, "scopusCitationCount" : 12, "wosScopusCitationCount" : 13, "wosScopusCitationCountWoOther" : 13, "wosScopusIndependentCitationCount" : 7, "wosScopusIndependentCitationCountWoOther" : 7, "independentCitationCount" : 10, "selfCitationCount" : 12, "unhandledCitationCount" : 0, "citingPubCount" : 22, "independentCitingPubCount" : 10, "citingPubCountWoOther" : 20, "independentCitingPubCountWoOther" : 9, "unhandledCitingPubCount" : 0, "citedPubCount" : 3, "citedCount" : 3, "ratings" : [ { "otype" : "SjrRating", "mtid" : 10889522, "link" : "/api/sjrrating/10889522", "label" : "sjr:Q1 (2018) Scopus - Rehabilitation JOURNAL OF STROKE AND CEREBROVASCULAR DISEASES 1052-3057 1532-8511", "listPos" : 24, "rankValue" : 0.24, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 2742, "link" : "/api/classificationexternal/2742", "label" : "Scopus - Rehabilitation", "published" : true, "oldId" : 2742, "snippet" : true }, "ranking" : "Q1", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "Q1", "hasCitationDuplums" : false, "inSelectedPubs" : "10012988,10025852", "userChangeableUntil" : "2018-04-05T05:43:25.000+0000", "publishDate" : "2017-12-28T09:47:27.000+0000", "directInstitutesForSort" : "Aneszteziológiai és Intenzív Terápiás Intézet (PTE / ÁOK); 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