@article{MTMT:30375043,
	title = {Postconditioning-like effect of exercis: new paradigm in experimental menopause},
	url = {https://m2.mtmt.hu/api/publication/30375043},
	author = {Szabó, Renáta and Börzsei, Denise and Karácsonyi, Zoltán and Gesztelyi, Rudolf and Nemes, Kolos and Magyariné, Berkó Anikó and Veszelka, Médea and Török, Szilvia and Kupai, Krisztina and Varga, Csaba and Juhász, Béla and Pósa, Anikó},
	doi = {10.1152/ajpheart.00485.2018},
	journal-iso = {AM J PHYSIOL HEART C},
	journal = {AMERICAN JOURNAL OF PHYSIOLOGY: HEART AND CIRCULATORY PHYSIOLOGY},
	volume = {316},
	unique-id = {30375043},
	issn = {0363-6135},
	abstract = {The progression of coronary artery diseases in premenopausal women is lower than in age-matched men; however, its probability increases rapidly after menopause. The aim of our study was to investigate the postconditioning-like effects of voluntary physical exercise on postmenopausal cardiovascular outcomes after myocardial infarction. We used fertile Wistar females [control (CTRL)] and pharmacologically induced estrogen-deficient (POVX; 750 mu g/kg triptorelin im. every 4th week) rats. CTRL and POVX animals were randomly assigned to receive an injection of 0.1 mg isoproterenol (ISO)/kg. At the 20th hour after ISO injection, serum markers of myocardial injury, such as lactate dehydrogenase (LDH) and myoglobin, were measured. After a 3-wk resting period, ISO-treated and untreated animals were further divided into subgroups on the basis of 6 wk of physical exercise. At the end of the experiment, cardiac activity and content of the antioxidative heme oxygenase (HO) enzyme, levels of GSM and GSH + GSSG, activity of myeloperoxidase, as well as the concentration of TNF-alpha were determined. At the end of the experimental period, we observed a significant decrease in the activity and content of HO enzymes in POVX and POVX/ISO rats, whereas physical exercise significantly improved 110 and GSH values in both CTRL and POVX rats. Furthermore, our training protocol significantly reduced the pathological levels of myeloperoxidase and TNF-alpha. Our findings clearly demonstrate that modulation of the HO system by voluntary physical exercise is a key process to decrease inflammatory parameters and ameliorate the antioxidative status in estrogen-deficient conditions postmyocardial injury.},
	keywords = {Inflammation; PHYSICAL EXERCISE; myocardial infarction; HEME OXYGENASE; ESTROGEN DEFICIENCY},
	year = {2019},
	eissn = {1522-1539},
	pages = {H400-H407},
	orcid-numbers = {Gesztelyi, Rudolf/0000-0001-7911-055X; Magyariné, Berkó Anikó/0000-0002-1237-5745; Kupai, Krisztina/0000-0002-0644-1718; Varga, Csaba/0000-0002-2678-665X; Pósa, Anikó/0000-0003-2167-2888}
}

@article{MTMT:3258158,
	title = {Cardioprotective Effect of Selective Estrogen Receptor Modulator Raloxifene Are Mediated by Heme Oxygenase in Estrogen-Deficient Rat},
	url = {https://m2.mtmt.hu/api/publication/3258158},
	author = {Pósa, Anikó and Szabó, Renáta and Kupai, Krisztina and Magyariné, Berkó Anikó and Veszelka, Médea and Szűcs, Gergő and Börzsei, Denise and Gyongyosi, M and Pavo, I and Deim, Zoltán and Szilvássy, Zoltán and Juhász, Béla and Varga, Csaba},
	doi = {10.1155/2017/2176749},
	journal-iso = {OXID MED CELL LONGEV},
	journal = {OXIDATIVE MEDICINE AND CELLULAR LONGEVITY},
	volume = {2017},
	unique-id = {3258158},
	issn = {1942-0900},
	abstract = {Estrogens and raloxifene (RAL) have beneficial effects on certain cardiovascular indices in postmenopausal women characterized by estrogen deficiency. Heme oxygenase (HO) activity is increased by 17 beta-estradiol (E-2) and RAL in estrogen-deficient rat resulting in vasorelaxation mediated by carbon monoxide. We determined the expressions of HO in cardiac and aortic tissues after ovariectomy (OVX) and subsequent RAL or E-2 treatment. We investigated the effects of pharmacological inhibition of HO enzyme on the arginine vasopressin-(AVP-) induced blood pressure in vivo, the epinephrine- and phentolamine-induced electrocardiogram ST segment changes in vivo, and the myeloperoxidase (MPO) enzyme activity. When compared with intact females, OVX decreased the HO-1 and HO-2 expression, aggravated the electrocardiogram signs of heart ischemia and the blood pressure response to AVP, and increased the cardiac MPO. E-2 and RAL are largely protected against these negative impacts induced by OVX. The pharmacological inhibition of HO in E-2- or RAL-treated OVX animals, however, restored the cardiovascular status close to that observed in nontreated OVX animals. The decreased expression of HO enzymes and the changes in blood pressure ischemia susceptibility and inflammatory state in OVX rat can be reverted by the administration of E-2 or RAL partly through its antioxidant and anti-inflammatory roles.},
	year = {2017},
	eissn = {1942-0994},
	orcid-numbers = {Pósa, Anikó/0000-0003-2167-2888; Kupai, Krisztina/0000-0002-0644-1718; Magyariné, Berkó Anikó/0000-0002-1237-5745; Szűcs, Gergő/0000-0003-1874-2718; Deim, Zoltán/0000-0003-3925-5564; Varga, Csaba/0000-0002-2678-665X}
}

@article{MTMT:3126895,
	title = {From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on "New frontiers in cardiovascular research"},
	url = {https://m2.mtmt.hu/api/publication/3126895},
	author = {Cabrera-Fuentes, HA and Aragones, J and Bernhagen, J and Boening, A and Boisvert, WA and Botker, HE and Bulluck, H and Cook, S and Di Lisa, F and Engel, FB and Engelmann, B and Ferrazzi, F and Ferdinandy, Péter and Fong, A and Fleming, I and Gnaiger, E and Hernandez-Resendiz, S and Kalkhoran, SB and Kim, MH and Lecour, S and Liehn, EA and Marber, MS and Mayr, M and Miura, T and Ong, SB and Peter, K and Sedding, D and Singh, MK and Suleiman, MS and Schnittler, HJ and Schulz, R and Shim, W and Tello, D and Vogel, CW and Walker, M and Li, QO and Yellon, DM and Hausenloy, DJ and Preissner, KT},
	doi = {10.1007/s00395-016-0586-x},
	journal-iso = {BASIC RES CARDIOL},
	journal = {BASIC RESEARCH IN CARDIOLOGY},
	volume = {111},
	unique-id = {3126895},
	issn = {0300-8428},
	abstract = {In this meeting report, particularly addressing the topic of protection of the cardiovascular system from ischemia/reperfusion injury, highlights are presented that relate to conditioning strategies of the heart with respect to molecular mechanisms and outcome in patients' cohorts, the influence of co-morbidities and medications, as well as the contribution of innate immune reactions in cardioprotection. Moreover, developmental or systems biology approaches bear great potential in systematically uncovering unexpected components involved in ischemia-reperfusion injury or heart regeneration. Based on the characterization of particular platelet integrins, mitochondrial redox-linked proteins, or lipid-diol compounds in cardiovascular diseases, their targeting by newly developed theranostics and technologies opens new avenues for diagnosis and therapy of myocardial infarction to improve the patients' outcome.},
	year = {2016},
	eissn = {1435-1803},
	orcid-numbers = {Ferdinandy, Péter/0000-0002-6424-6806}
}

@article{MTMT:2885084,
	title = {Heme oxygenase contributes to estradiol and raloxifene-induced vasorelaxation in estrogen deficiency},
	url = {https://m2.mtmt.hu/api/publication/2885084},
	author = {Pósa, Anikó and Pavo, I and Varga, Csaba},
	doi = {10.1016/j.ijcard.2015.04.112},
	journal-iso = {INT J CARDIOL},
	journal = {INTERNATIONAL JOURNAL OF CARDIOLOGY},
	volume = {189},
	unique-id = {2885084},
	issn = {0167-5273},
	year = {2015},
	eissn = {1874-1754},
	pages = {252-254},
	orcid-numbers = {Pósa, Anikó/0000-0003-2167-2888; Varga, Csaba/0000-0002-2678-665X}
}

@article{MTMT:2473505,
	title = {Sexual dimorphism of cardiovascular ischemia susceptibility is mediated by heme oxygenase},
	url = {https://m2.mtmt.hu/api/publication/2473505},
	author = {Pósa, Anikó and Kupai, Krisztina and Ménesi, Rudolf and Szalai, Zita and Szabó, Renáta and Pintér, Zoltán and Pálfi, György and Gyöngyösi, M and Magyariné, Berkó Anikó and Pávó, I and Varga, Csaba},
	doi = {10.1155/2013/521563},
	journal-iso = {OXID MED CELL LONGEV},
	journal = {OXIDATIVE MEDICINE AND CELLULAR LONGEVITY},
	volume = {2013},
	unique-id = {2473505},
	issn = {1942-0900},
	abstract = {We investigated the gender differences in heme-oxygenase (HO) enzyme, which produces endogenous vascular protective carbon monoxide (CO). We studied (1) the activity and expression of HO enzymes in the left ventricle (LV) and aorta, (2) basal increase in basal blood pressure provoked by arginine vasopressine (AVP) in vivo, (3) the heart perfusion induced by AVP, (4) the ST segment depression provoked by adrenaline and 30 seconds later phentolamine, and (5) the aorta ring contraction induced by AVP in female and male Wistar rats. We found that HO activity and the expression of HO-1 and HO-2 were increased in female rat aorta and LV. We demonstrated that the basal blood pressure and administration of AVP provoked blood pressure response are increased in the males; the female myocardium was less sensitive towards angina. Both differences could be aggravated by the inhibition of HO. The aorta rings were more susceptible towards vasoconstriction by AVP in males; isolated heart perfusion decrease was higher in males. The HO inhibition aggravated the heart perfusion in both sexes. In conclusion, the increased HO activity and expression in females might play a role in the sexual dimorphism of cardiovascular ischemia susceptibility during the reproductive age. © 2013 Anikó Pósa et al.},
	keywords = {Blood Pressure; Female; Male; ENZYMES; ARTICLE; VASOCONSTRICTION; controlled study; nonhuman; animal model; animal experiment; Aorta; sex difference; phentolamine; argipressin; enzyme activity; protein expression; carbon monoxide; adrenalin; in vivo study; heart muscle ischemia; amino acids; isolated heart; heart perfusion; Porphyrins; HEME OXYGENASE; Blood Vessels; heme oxygenase 1; vascular ring; gender differences; heart left ventricle; ST segment depression; sexual dimorphism; heme oxygenase 2; aorta constriction; Left ventricles; Ring contraction; Pressure response; Heme oxygenases; Cardiovascular ischemia; rat},
	year = {2013},
	eissn = {1942-0994},
	orcid-numbers = {Pósa, Anikó/0000-0003-2167-2888; Kupai, Krisztina/0000-0002-0644-1718; Szalai, Zita/0000-0002-8722-0211; Magyariné, Berkó Anikó/0000-0002-1237-5745; Varga, Csaba/0000-0002-2678-665X}
}

@article{MTMT:1195223,
	title = {Bromelain induces cardioprotection against ischemia-reperfusion injury through Akt/FOXO pathway in rat myocardium},
	url = {https://m2.mtmt.hu/api/publication/1195223},
	author = {Juhász, Béla and Thirunavukkarasu, M and Pant, R and Zhan, L and Penumathsa, SV and Secor, ER and Srivastava, S and Raychaudhuri, U and Menon, VP and Otani, H and Thrall, RS and Maulik, N},
	doi = {10.1152/ajpheart.01005.2007},
	journal-iso = {AM J PHYSIOL HEART C},
	journal = {AMERICAN JOURNAL OF PHYSIOLOGY: HEART AND CIRCULATORY PHYSIOLOGY},
	volume = {294},
	unique-id = {1195223},
	issn = {0363-6135},
	year = {2008},
	eissn = {1522-1539},
	pages = {H1365-H1370}
}

@article{MTMT:2204594,
	title = {Modulation of the endocannabinoid system in cardiovascular disease: therapeutic potential and limitations},
	url = {https://m2.mtmt.hu/api/publication/2204594},
	author = {Pacher, Pál and Mukhopadhyay, P and Mohanraj, R and Godlewski, G and Batkai, S and Kunos, G},
	doi = {10.1161/HYPERTENSIONAHA.105.063651},
	journal-iso = {HYPERTENSION},
	journal = {HYPERTENSION},
	volume = {52},
	unique-id = {2204594},
	issn = {0194-911X},
	keywords = {Humans; Treatment Outcome; *Endocannabinoids; Central Nervous System Agents/*therapeutic use; Cardiovascular Diseases/*drug therapy/*metabolism; Cannabinoids/therapeutic use; Cannabinoid Receptor Modulators/*metabolism},
	year = {2008},
	eissn = {1524-4563},
	pages = {601-607},
	orcid-numbers = {Pacher, Pál/0000-0001-7036-8108}
}