TY  - JOUR
AU  - Freytag, V
AU  - Probst, S
AU  - Hadziselimovic, N
AU  - Boglari, C
AU  - Hauser, Y
AU  - Peter, F
AU  - Fenyves, Bánk
AU  - Milnik, A
AU  - Demougin, P
AU  - Vukojevic, V
AU  - de Quervain, DJ-F
AU  - Papassotiropoulos, A
AU  - Stetak, A
TI  - Genome-wide temporal expression profiling in Caenorhabditis elegans identifies a core gene set related to long-term memory
JF  - JOURNAL OF NEUROSCIENCE
J2  - J NEUROSCI
VL  - 37
PY  - 2017
IS  - 28
SP  - 6661
EP  - 6672
PG  - 12
SN  - 0270-6474
DO  - 10.1523/JNEUROSCI.3298-16.2017
UR  - https://m2.mtmt.hu/api/publication/3278925
ID  - 3278925
AB  - The identification of genes related to encoding, storage, and retrieval of memories is a major interest in neuroscience. In the current study, we analyzed the temporal gene expression changes in a neuronal mRNA pool during an olfactory long-term associative memory (LTAM) in Caenorhabditis elegans hermaphrodites. Here, we identified a core set of 712 (538 upregulated and 174 downregulated) genes that follows three distinct temporal peaks demonstrating multiple gene regulation waves in LTAM. Compared with the previously published positive LTAM gene set (Lakhina et al., 2015), 50% of the identified upregulated genes here overlap with the previous dataset, possibly representing stimulus-independent memory-related genes. On the other hand, the remaining genes were not previously identified in positive associative memory and may specifically regulate aversive LTAM. Ourresults suggest a multistep gene activation process during the formation and retrieval of long-term memory and define general memory-implicated genes as well as conditioning-type-dependent gene sets. © 2017 the authors.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Hadziselimovic, N
AU  - Vukojevic, V
AU  - Peter, F
AU  - Milnik, A
AU  - Fastenrath, M
AU  - Fenyves, Bánk
AU  - Hieber, P
AU  - Demougin, P
AU  - Vogler, C
AU  - De Quervain, DJ-F
AU  - Papassotiropoulos, A
AU  - Stetak, A
TI  - Forgetting is regulated via musashi-mediated translational control of the Arp2/3 complex
JF  - CELL
J2  - CELL
VL  - 156
PY  - 2014
IS  - 6
SP  - 1153
EP  - 1166
PG  - 14
SN  - 0092-8674
DO  - 10.1016/j.cell.2014.01.054
UR  - https://m2.mtmt.hu/api/publication/3278926
ID  - 3278926
AB  - A plastic nervous system requires the ability not only to acquire and store but also to forget. Here, we report that musashi (msi-1) is necessary for time-dependent memory loss in C. elegans. Tissue-specific rescue demonstrates that MSI-1 function is necessary in the AVA interneuron. Using RNA-binding protein immunoprecipitation (IP), we found that MSI-1 binds to mRNAs of three subunits of the Arp2/3 actin branching regulator complex in vivo and downregulates ARX-1, ARX-2, and ARX-3 translation upon associative learning. The role of msi-1 in forgetting is also reflected by the persistence of learning-induced GLR-1 synaptic size increase in msi-1 mutants. We demonstrate that memory length is regulated cooperatively through the activation of adducin (add-1) and by the inhibitory effect of msi-1. Thus, a GLR-1/MSI-1/Arp2/3 pathway induces forgetting and represents a novel mechanism of memory decay by linking translational control to the structure of the actin cytoskeleton in neurons. © 2014 Elsevier Inc.
LA  - English
DB  - MTMT
ER  -