@article{MTMT:3278925,
	title = {Genome-wide temporal expression profiling in Caenorhabditis elegans identifies a core gene set related to long-term memory},
	url = {https://m2.mtmt.hu/api/publication/3278925},
	author = {Freytag, V and Probst, S and Hadziselimovic, N and Boglari, C and Hauser, Y and Peter, F and Fenyves, Bánk and Milnik, A and Demougin, P and Vukojevic, V and de Quervain, DJ-F and Papassotiropoulos, A and Stetak, A},
	doi = {10.1523/JNEUROSCI.3298-16.2017},
	journal-iso = {J NEUROSCI},
	journal = {JOURNAL OF NEUROSCIENCE},
	volume = {37},
	unique-id = {3278925},
	issn = {0270-6474},
	abstract = {The identification of genes related to encoding, storage, and retrieval of memories is a major interest in neuroscience. In the current study, we analyzed the temporal gene expression changes in a neuronal mRNA pool during an olfactory long-term associative memory (LTAM) in Caenorhabditis elegans hermaphrodites. Here, we identified a core set of 712 (538 upregulated and 174 downregulated) genes that follows three distinct temporal peaks demonstrating multiple gene regulation waves in LTAM. Compared with the previously published positive LTAM gene set (Lakhina et al., 2015), 50% of the identified upregulated genes here overlap with the previous dataset, possibly representing stimulus-independent memory-related genes. On the other hand, the remaining genes were not previously identified in positive associative memory and may specifically regulate aversive LTAM. Ourresults suggest a multistep gene activation process during the formation and retrieval of long-term memory and define general memory-implicated genes as well as conditioning-type-dependent gene sets. © 2017 the authors.},
	keywords = {Animals; EXPRESSION; metabolism; GENES; GENETICS; ARTICLE; animal; GENOME; gene expression regulation; Chromosome Mapping; physiology; priority journal; controlled study; nonhuman; animal tissue; learning; Temporal Lobe; long term memory; Western blotting; Gene Expression; Gene Expression Profiling; gene activation; GENE ONTOLOGY; microarray analysis; microarray; Caenorhabditis elegans; Nerve Tissue Proteins; nerve protein; real time polymerase chain reaction; proteome; CREB; Association Learning; C. ELEGANS; Caenorhabditis elegans Proteins; Long-term memory; Caenorhabditis elegans protein; Memory, Long-Term; chromosomal mapping},
	year = {2017},
	eissn = {1529-2401},
	pages = {6661-6672},
	orcid-numbers = {Fenyves, Bánk/0000-0003-2374-7513}
}

@article{MTMT:3278926,
	title = {Forgetting is regulated via musashi-mediated translational control of the Arp2/3 complex},
	url = {https://m2.mtmt.hu/api/publication/3278926},
	author = {Hadziselimovic, N and Vukojevic, V and Peter, F and Milnik, A and Fastenrath, M and Fenyves, Bánk and Hieber, P and Demougin, P and Vogler, C and De Quervain, DJ-F and Papassotiropoulos, A and Stetak, A},
	doi = {10.1016/j.cell.2014.01.054},
	journal-iso = {CELL},
	journal = {CELL},
	volume = {156},
	unique-id = {3278926},
	issn = {0092-8674},
	abstract = {A plastic nervous system requires the ability not only to acquire and store but also to forget. Here, we report that musashi (msi-1) is necessary for time-dependent memory loss in C. elegans. Tissue-specific rescue demonstrates that MSI-1 function is necessary in the AVA interneuron. Using RNA-binding protein immunoprecipitation (IP), we found that MSI-1 binds to mRNAs of three subunits of the Arp2/3 actin branching regulator complex in vivo and downregulates ARX-1, ARX-2, and ARX-3 translation upon associative learning. The role of msi-1 in forgetting is also reflected by the persistence of learning-induced GLR-1 synaptic size increase in msi-1 mutants. We demonstrate that memory length is regulated cooperatively through the activation of adducin (add-1) and by the inhibitory effect of msi-1. Thus, a GLR-1/MSI-1/Arp2/3 pathway induces forgetting and represents a novel mechanism of memory decay by linking translational control to the structure of the actin cytoskeleton in neurons. © 2014 Elsevier Inc.},
	keywords = {Animals; GENE; MUTATION; PROTEIN; PHENOTYPE; MEMORY; ARTICLE; Genotype; Molecular Sequence Data; amino acid sequence; priority journal; controlled study; nonhuman; animal tissue; animal experiment; Sequence Alignment; regulatory mechanism; sensory stimulation; memory consolidation; SYNAPSES; synapse; Protein Biosynthesis; Gene Expression; Immunoprecipitation; Gene Deletion; unclassified drug; RNA, Messenger; messenger rna; Chemotaxis; Actins; RNA binding; nerve cell plasticity; Caenorhabditis elegans; Locomotion; promoter region; down regulation; interneuron; laser surgery; Nerve Tissue Proteins; gene interaction; actin filament; confocal microscopy; protein processing; nerve cell differentiation; AMNESIA; 4 aminobutyric acid receptor; MUTANT; state dependent learning; conditioning; 3' untranslated region; associative memory; Caenorhabditis elegans Proteins; smelling; RNA-Binding Proteins; RNA binding protein; short term memory; F actin; translation regulation; adducin; RNA, Helminth; Actin-Related Protein 2-3 Complex; genomic fragment; actin capping; musashi gene; ARX 3 gene; ARX 2 gene; ARX 1 gene; protein ARX 3; protein ARX 2; protein ARX 1; musashi protein; actin related protein 2-3 complex; interneurons},
	year = {2014},
	eissn = {1097-4172},
	pages = {1153-1166},
	orcid-numbers = {Fenyves, Bánk/0000-0003-2374-7513}
}