@article{MTMT:3097004,
	title = {Modulating chromatin structure and DNA accessibility by deacetylase inhibition enhances the anti-cancer activity of silver nanoparticles},
	url = {https://m2.mtmt.hu/api/publication/3097004},
	author = {Igaz, Nóra and Kovács, Dávid and Rázga, Zsolt and Kónya, Zoltán and Boros, Imre Miklós and Csontné Kiricsi, Mónika},
	doi = {10.1016/j.colsurfb.2016.07.004},
	journal-iso = {COLLOID SURFACE B},
	journal = {COLLOIDS AND SURFACES B: BIOINTERFACES},
	volume = {146},
	unique-id = {3097004},
	issn = {0927-7765},
	abstract = {Abstract Histone deacetylase (HDAC) inhibitors are considered as novel therapeutic agents inducing cell cycle arrest and apoptotic cell death in various cancer cells. Inhibition of deacetylase activity results in a relaxed chromatin structure thereby rendering the genetic material more vulnerable to DNA targeting agents that could be exploited by combinational cancer therapy. The unique potential of silver nanoparticles (AgNPs) in tumor therapy relies on the generation of reactive radicals which trigger oxidative stress, DNA damage and apoptosis in cancer cells. The revolutionary application of AgNPs as chemotherapeutical drugs seems very promising, nevertheless the exact molecular mechanisms of AgNP action in combination with other anti-cancer agents have yet to be elucidated in details before clinical administrations. As a step towards this we investigated the combinational effect of HDAC inhibition and AgNP administration in HeLa cervical cancer cells. We identified synergistic inhibition of cancer cell growth and migration upon combinational treatments. Here we report that the HDAC inhibitor Trichostatin A enhances the DNA targeting capacity and apoptosis inducing efficacy of AgNPs most probably due to its effect on chromatin condensation. These results point to the potential benefits of combinational application of HDAC inhibitors and AgNPs in novel cancer medication protocols.},
	keywords = {Trichostatin A; Histone acetylation; Silver nanoparticles; combinational therapy},
	year = {2016},
	eissn = {1873-4367},
	pages = {670-677},
	orcid-numbers = {Igaz, Nóra/0000-0003-1580-4397; Kovács, Dávid/0000-0002-5706-5126; Rázga, Zsolt/0000-0003-4717-8482; Kónya, Zoltán/0000-0002-9406-8596; Boros, Imre Miklós/0000-0001-8504-9687; Csontné Kiricsi, Mónika/0000-0002-8416-2052}
}

@article{MTMT:3079142,
	title = {Silver nanoparticles defeat p53-positive and p53-negative osteosarcoma cells by triggering mitochondrial stress and apoptosis},
	url = {https://m2.mtmt.hu/api/publication/3079142},
	author = {Kovács, Dávid and Igaz, Nóra and Keskeny, Csilla and Bélteky, Péter and Tóth, Tímea and Molnár-Gáspár, Renáta and Madarász, Dániel and Rázga, Zsolt and Kónya, Zoltán and Boros, Imre Miklós and Csontné Kiricsi, Mónika},
	doi = {10.1038/srep27902},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {6},
	unique-id = {3079142},
	abstract = {Loss of function of the tumour suppressor p53 observed frequently in human cancers challenges the drug-induced apoptotic elimination of cancer cells from the body. This phenomenon is a major concern and provides much of the impetus for current attempts to develop a new generation of anticancer drugs capable of provoking apoptosis in a p53-independent manner. Since silver nanoparticles (AgNPs) possess unique cytotoxic features, we examined, whether their activity could be exploited to kill tumour suppressor-deficient cancer cells. Therefore, we investigated the effects of AgNPs on osteosarcoma cells of different p53 genetic backgrounds. As particle diameters might influence the molecular mechanisms leading to AgNP-induced cell death we applied 5 nm and 35 nm sized citrate-coated AgNPs. We found that both sized AgNPs targeted mitochondria and induced apoptosis in wild-type p53-containing U2Os and p53-deficient Saos-2 cells. According to our findings AgNPs are able to kill osteosarcoma cells independently from their actual p53 status and induce p53-independent cancer cell apoptosis. This feature renders AgNPs attractive candidates for novel chemotherapeutic approaches.},
	year = {2016},
	eissn = {2045-2322},
	orcid-numbers = {Kovács, Dávid/0000-0002-5706-5126; Igaz, Nóra/0000-0003-1580-4397; Molnár-Gáspár, Renáta/0000-0001-9673-4532; Rázga, Zsolt/0000-0003-4717-8482; Kónya, Zoltán/0000-0002-9406-8596; Boros, Imre Miklós/0000-0001-8504-9687; Csontné Kiricsi, Mónika/0000-0002-8416-2052}
}

@article{MTMT:2980124,
	title = {Environmentally benign synthesis methods of zero valent iron nanoparticles},
	url = {https://m2.mtmt.hu/api/publication/2980124},
	author = {Kozma, Gábor and Rónavári, Andrea and Kónya, Zoltán and Kukovecz, Ákos},
	doi = {10.1021/acssuschemeng.5b01185},
	journal-iso = {ACS SUSTAIN CHEM ENG},
	journal = {ACS SUSTAINABLE CHEMISTRY & ENGINEERING},
	volume = {4},
	unique-id = {2980124},
	issn = {2168-0485},
	year = {2016},
	eissn = {2168-0485},
	pages = {291-297},
	orcid-numbers = {Kozma, Gábor/0000-0003-2033-0720; Rónavári, Andrea/0000-0001-7054-0975; Kónya, Zoltán/0000-0002-9406-8596; Kukovecz, Ákos/0000-0003-0716-9557}
}

@article{MTMT:3045389,
	title = {Ion exchange defines the biological activity of titanate nanotubes},
	url = {https://m2.mtmt.hu/api/publication/3045389},
	author = {Rónavári, Andrea and Kovács, Dávid and Vágvölgyi, Csaba and Kónya, Zoltán and Csontné Kiricsi, Mónika and Pfeiffer, Ilona},
	doi = {10.1002/jobm.201500742},
	journal-iso = {J BASIC MICROB},
	journal = {JOURNAL OF BASIC MICROBIOLOGY},
	volume = {56},
	unique-id = {3045389},
	issn = {0233-111X},
	abstract = {One-dimensional titanate nanotubes (TiONTs) were subjected to systematic ion exchange to determine the impact of these modifications on biological activities. Ion exchanged TiONTs (with Ag, Mg, Bi, Sb, Ca, K, Sr, Fe, and Cu ions) were successfully synthesized and the presence of the substituted ions was verified by energy dispersive X-ray spectroscopy (EDS). A complex screening was carried out to reveal differences in toxicity to human cells, as well as in antibacterial, antifungal, and antiviral activities between the various modified nanotubes. Our results demonstrated that Ag ion exchanged TiONTs exerted potent antibacterial and antifungal effects against all examined microbial species but were ineffective on viruses. Surprisingly, the antibacterial activity of Cu/TiONTs was restricted to Micrococcus luteus. Most ion exchanged TiONTs did not show antimicrobial activity against the tested bacterial and fungal species. Incorporation of various ions into nanotube architectures lead to mild, moderate, or even to a massive loss of human cell viability; therefore, this type of biological effect exerted by TiONTs can be greatly modulated by ion exchange. These findings further emphasize the contribution of ion exchange in determining not only the physical and chemical characteristics but also the bioactivity of TiONT against different types of living cells.},
	year = {2016},
	eissn = {1521-4028},
	pages = {557-565},
	orcid-numbers = {Rónavári, Andrea/0000-0001-7054-0975; Kovács, Dávid/0000-0002-5706-5126; Vágvölgyi, Csaba/0000-0003-0009-7773; Kónya, Zoltán/0000-0002-9406-8596; Csontné Kiricsi, Mónika/0000-0002-8416-2052; Pfeiffer, Ilona/0000-0003-0680-7596}
}