@article{MTMT:31138432,
	title = {A management algorithm for adult patients with both brain oxygen and intracranial pressure monitoring : the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC)},
	url = {https://m2.mtmt.hu/api/publication/31138432},
	author = {Chesnut, Randall and Aguilera, Sergio and Büki, András and Bulger, Eileen and Citerio, Giuseppe and Cooper, D Jamie and Arrastia, Ramon Diaz and Diringer, Michael and Figaji, Anthony and Gao, Guoyi and Geocadin, Romer and Ghajar, Jamshid and Harris, Odette and Hoffer, Alan and Hutchinson, Peter and Joseph, Mathew and Kitagawa, Ryan and Manley, Geoffrey and Mayer, Stephan and Menon, David K and Meyfroidt, Geert and Michael, Daniel B and Oddo, Mauro and Okonkwo, David and Patel, Mayur and Robertson, Claudia and Rosenfeld, Jeffrey V and Rubiano, Andres M and Sahuquillo, Juan and Servadei, Franco and Shutter, Lori and Stein, Deborah and Stocchetti, Nino and Taccone, Fabio Silvio and Timmons, Shelly and Tsai, Eve and Ullman, Jamie S and Vespa, Paul and Videtta, Walter and Wright, David W and Zammit, Christopher and Hawryluk, Gregory W J},
	doi = {10.1007/s00134-019-05900-x},
	journal-iso = {INTENS CARE MED},
	journal = {INTENSIVE CARE MEDICINE},
	volume = {46},
	unique-id = {31138432},
	issn = {0342-4642},
	abstract = {Current guidelines for the treatment of adult severe traumatic brain injury (sTBI) consist of high-quality evidence reports, but they are no longer accompanied by management protocols, as these require expert opinion to bridge the gap between published evidence and patient care. We aimed to establish a modern sTBI protocol for adult patients with both intracranial pressure (ICP) and brain oxygen monitors in place.Our consensus working group consisted of 42 experienced and actively practicing sTBI opinion leaders from six continents. Having previously established a protocol for the treatment of patients with ICP monitoring alone, we addressed patients who have a brain oxygen monitor in addition to an ICP monitor. The management protocols were developed through a Delphi-method-based consensus approach and were finalized at an in-person meeting.We established three distinct treatment protocols, each with three tiers whereby higher tiers involve therapies with higher risk. One protocol addresses the management of ICP elevation when brain oxygenation is normal. A second addresses management of brain hypoxia with normal ICP. The third protocol addresses the situation when both intracranial hypertension and brain hypoxia are present. The panel considered issues pertaining to blood transfusion and ventilator management when designing the different algorithms.These protocols are intended to assist clinicians in the management of patients with both ICP and brain oxygen monitors but they do not reflect either a standard-of-care or a substitute for thoughtful individualized management. These protocols should be used in conjunction with recommendations for basic care, management of critical neuroworsening and weaning treatment recently published in conjunction with the Seattle International Brain Injury Consensus Conference.},
	keywords = {ALGORITHM; PROTOCOL; Consensus; Intracranial Pressure; brain injury; SEATTLE; Head trauma; PbtO2; SIBICC; Tiers; Brain oxygen},
	year = {2020},
	eissn = {1432-1238},
	pages = {919-929}
}

@article{MTMT:30808793,
	title = {Case-mix, care pathways, and outcomes in patients with traumatic brain injury in CENTER-TBI : a European prospective, multicentre, longitudinal, cohort study},
	url = {https://m2.mtmt.hu/api/publication/30808793},
	author = {Steyerberg, Ewout W and Wiegers, Eveline and Sewalt, Charlie and Büki, András and Citerio, Giuseppe and De Keyser, Véronique and Ercole, Ari and Kunzmann, Kevin and Lanyon, Linda and Lecky, Fiona and Lingsma, Hester and Manley, Geoffrey and Nelson, David and Peul, Wilco and Stocchetti, Nino and von Steinbüchel, Nicole and Vande Vyvere, Thijs and Verheyden, Jan and Wilson, Lindsay and Maas, Andrew I R and Menon, David K},
	doi = {10.1016/S1474-4422(19)30232-7},
	journal-iso = {LANCET NEUROL},
	journal = {LANCET NEUROLOGY},
	volume = {18},
	unique-id = {30808793},
	issn = {1474-4422},
	abstract = {The burden of traumatic brain injury (TBI) poses a large public health and societal problem, but the characteristics of patients and their care pathways in Europe are poorly understood. We aimed to characterise patient case-mix, care pathways, and outcomes of TBI.CENTER-TBI is a Europe-based, observational cohort study, consisting of a core study and a registry. Inclusion criteria for the core study were a clinical diagnosis of TBI, presentation fewer than 24 h after injury, and an indication for CT. Patients were differentiated by care pathway and assigned to the emergency room (ER) stratum (patients who were discharged from an emergency room), admission stratum (patients who were admitted to a hospital ward), or intensive care unit (ICU) stratum (patients who were admitted to the ICU). Neuroimages and biospecimens were stored in repositories and outcome was assessed at 6 months after injury. We used the IMPACT core model for estimating the expected mortality and proportion with unfavourable Glasgow Outcome Scale Extended (GOSE) outcomes in patients with moderate or severe TBI (Glasgow Coma Scale [GCS] score ≤12). The core study was registered with ClinicalTrials.gov, number NCT02210221, and with Resource Identification Portal (RRID: SCR_015582).Data from 4509 patients from 18 countries, collected between Dec 9, 2014, and Dec 17, 2017, were analysed in the core study and from 22 782 patients in the registry. In the core study, 848 (19%) patients were in the ER stratum, 1523 (34%) in the admission stratum, and 2138 (47%) in the ICU stratum. In the ICU stratum, 720 (36%) patients had mild TBI (GCS score 13-15). Compared with the core cohort, the registry had a higher proportion of patients in the ER (9839 [43%]) and admission (8571 [38%]) strata, with more than 95% of patients classified as having mild TBI. Patients in the core study were older than those in previous studies (median age 50 years [IQR 30-66], 1254 [28%] aged >65 years), 462 (11%) had serious comorbidities, 772 (18%) were taking anticoagulant or antiplatelet medication, and alcohol was contributory in 1054 (25%) TBIs. MRI and blood biomarker measurement enhanced characterisation of injury severity and type. Substantial inter-country differences existed in care pathways and practice. Incomplete recovery at 6 months (GOSE <8) was found in 207 (30%) patients in the ER stratum, 665 (53%) in the admission stratum, and 1547 (84%) in the ICU stratum. Among patients with moderate-to-severe TBI in the ICU stratum, 623 (55%) patients had unfavourable outcome at 6 months (GOSE <5), similar to the proportion predicted by the IMPACT prognostic model (observed to expected ratio 1·06 [95% CI 0·97-1·14]), but mortality was lower than expected (0·70 [0·62-0·76]).Patients with TBI who presented to European centres in the core study were older than were those in previous observational studies and often had comorbidities. Overall, most patients presented with mild TBI. The incomplete recovery of many patients should motivate precision medicine research and the identification of best practices to improve these outcomes.European Union 7th Framework Programme, the Hannelore Kohl Stiftung, OneMind, and Integra LifeSciences Corporation.},
	year = {2019},
	eissn = {1474-4465},
	pages = {923-934},
	orcid-numbers = {Barzó, Pál/0000-0001-8717-748X; Czeiter, Endre/0000-0002-9578-6944}
}