TY - JOUR AU - Zsarnovszky, Attila AU - Foldvari, EG AU - Rónai, Zsuzsanna AU - Bartha, Tibor AU - Frenyó V., László TI - Oestrogens in the mammalian brain: From conception to adulthood - A review JF - ACTA VETERINARIA HUNGARICA J2 - ACTA VET HUNG VL - 55 PY - 2007 IS - 3 SP - 333 EP - 347 PG - 15 SN - 0236-6290 DO - 10.1556/AVet.55.2007.3.8 UR - https://m2.mtmt.hu/api/publication/1637677 ID - 1637677 N1 - INSSHR: 1 Megjegyzés-22225996 DI: 10.1556/AVet.55.2007.3.8 AB - Environmental and plant oestrogens have been identified as compounds that when ingested, disrupt the physiological pathways of endogenous oestrogen actions and thus, act as agonists or antagonists of oestrogen. Although the risks of exposure to exogenous oestrogens (ExEs) are subject to scientific debate, the question of how ExE exposure affects the central nervous system remains to be answered. We attempt to summarise the mechanisms of oestrogenic effects in the central nervous tissue with the purpose to highlight the avenues potentially used by ExEs. The genomic and rapid, non-genomic cellular pathways activated by oestrogen are listed and discussed together with the best known interneuronal mechanisms of oestrogenic effects. Because the effects of oestrogen on the brain seem to be age dependent, we also found it necessary to put the age-dependent oestrogenic effects in parallel to their intra- and intercellular mechanisms of action. Finally, considering the practical risks of human ExE exposure, we briefly discuss the human significance of this matter. We believe this short review of the topic became necessary because recent data suggest new fields and pathways for endogenous oestrogen actions and have generated the concern that the hidden exposure of humans and domestic animal species to ExEs may also exert its beneficial and/or adverse effects through these avenues. LA - English DB - MTMT ER - TY - JOUR AU - Belcher, SM AU - Zsarnovszky, Attila TI - Estrogenic actions in the brain: Estrogen, phytoestrogens, and rapid intracellular signaling mechanisms JF - JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS J2 - J PHARMACOL EXP THER VL - 299 PY - 2001 IS - 2 SP - 408 EP - 414 PG - 7 SN - 0022-3565 UR - https://m2.mtmt.hu/api/publication/1637679 ID - 1637679 AB - The endogenous gonadal steroid 17 beta -estradiol (E-2) plays an important role in the development, maturation, and function of a wide variety of reproductive and nonreproductive tissues, including those of the nervous system. The actions of E-2 at target tissues can be divided into 1) long-term "genomic" actions that are mediated by intracellular estrogen receptor-induced changes in gene expression and 2) rapid actions that modulate a diverse array of intracellular signal transduction cascades. Environmental estrogens are compounds present in the environment that can mimic, and in some cases antagonize, the effects of endogenous estrogens. As a result of these actions, there is currently much interest within the scientific community regarding the relative benefits or threats associated with exposure to different environmental estrogens. Within the general public there is considerable acceptance of the benefits associated with increased use of "natural" estrogens as a component of a healthy diet and in postmenopausal women as an alternative to estrogen replacement therapies. First, this review will focus attention on the role of estrogens in the central nervous system by briefly discussing some of the known mechanisms through which estrogen's effects are mediated, focusing on rapid intracellular signaling mechanisms during neurodevelopment. Second, with the hope of bringing attention to an area of study that until recently has received little consideration, we will briefly discuss phytoestrogens and suggest that these compounds have the potential to influence rapid E-2-induced mechanisms in the nervous system in ways that may result in modified brain functions. LA - English DB - MTMT ER -