TY - JOUR AU - Végh, Tamás AU - Szatmári, Szilárd Attila AU - Véghné Juhász, Marianna Beáta AU - László, István AU - Vaskó, Attila AU - Takács, István AU - L, Szegedi AU - Fülesdi, Béla TI - One-lung ventilation does not result in cerebral desaturation during application of lung protective strategy if normocapnia is maintained JF - ACTA PHYSIOLOGICA HUNGARICA J2 - ACTA PHYSIOL HUNG VL - 100 PY - 2013 IS - 2 SP - 163 EP - 172 PG - 10 SN - 0231-424X DO - 10.1556/APhysiol.100.2013.003 UR - https://m2.mtmt.hu/api/publication/2271187 ID - 2271187 AB - Background: Previously a report has suggested that administration of lung protective strategy for one-lung ventilation (OLV) results in oxygen desaturation of the brain parenchyma. The aim of our work was to confirm that the maintenance of normocapnia during protective OLV strategy results in alteration of cerebral blood flow and cerebral oxygen saturation as compared to double-lung ventilation. Methods: Data were obtained from 24 patients undergoing thoracic surgery. Cerebral oxygen saturation (rSO(2)) was continuously monitored by INVOS 5100C Cerebral Oxymeter System along with measurement of cerebral blood flow velocity (MCAV) by transcranial Doppler sonography. Arterial blood samples were taken for blood gas analysis in the awake state, in the supine and lateral decubitus position during double-lung ventilation (DLV), and during OLV. Results: When ventilation was changed from DLV to OLV, no significant change was observed in rSO(2). A significant decrease of rSO(2) was found compared to the value observed during DLV in lateral decubitus at the time point 60 minutes after the start of OLV. No clinically significant changes in the MCAV was observed throughout the course of the thoracic surgical procedure. Conclusions: OLV does not result in clinically relevant decreases in cerebral blood flow and cerebral oxygen saturation during application of lung protective ventilation if normocapnia is maintained. LA - English DB - MTMT ER - TY - JOUR AU - Settakis, G AU - Páll, Dénes AU - Molnár, Csilla AU - Bereczki, Dániel AU - Csiba, László AU - Fülesdi, Béla TI - Cerebrovascular reactivity in hypertensive and healthy adolescents: TCD with vasodilatory challenge JF - JOURNAL OF NEUROIMAGING J2 - J NEUROIMAGING VL - 13 PY - 2003 IS - 2 SP - 106 EP - 112 PG - 7 SN - 1051-2284 DO - 10.1177/1051228403251265 UR - https://m2.mtmt.hu/api/publication/1052876 ID - 1052876 AB - BACKGROUND: Adolescent hypertension predicts hypertension and increased cardiovascular morbidity in adulthood. The aim of the present work was to test whether cerebrovascular reactivity to CO2 is altered among hypertensive adolescents. METHODS: From the population-based cohort of the Debrecen Hypertension Study, 113 hypertensive and 58 normotensive adolescents underwent transcranial Doppler measurements at rest and after 30 seconds of breath holding. RESULTS: Systolic, mean, and diastolic blood flow velocities were higher among hypertensive individuals at rest. Taking the absolute blood flow velocity parameters into account, after breath holding, only the pulsatility index was significantly higher in the hypertensive group. The percentage change of the different blood flow parameters showed less intensive change in hypertensive teenagers. CONCLUSION: Cerebral vasoreactivity is decreased among hypertensive individuals as compared to healthy controls. LA - English DB - MTMT ER - TY - JOUR AU - Fülesdi, Béla AU - Limburg, M AU - Bereczki, Dániel AU - Káplár, Miklós AU - Molnár, Csilla AU - Kappelmayer, János AU - Neuwirth, G AU - Csiba, László TI - Cerebrovascular reactivity and reserve capacity in type II diabetes mellitus JF - JOURNAL OF DIABETES AND ITS COMPLICATIONS J2 - J DIABETES COMPLICAT VL - 13 PY - 1999 IS - 4 SP - 191 EP - 199 PG - 9 SN - 1056-8727 DO - 10.1016/S1056-8727(99)00044-6 UR - https://m2.mtmt.hu/api/publication/1052918 ID - 1052918 AB - The aim of the study was to test the hypothesis that cerebrovascular reserve capacity and cerebrovascular reactivity are impaired in patients suffering from non insulin-dependent diabetes mellitus. We also intended to investigate factors which may influence resting cerebral blood flow velocity and cerebrovascular reserve capacity. A total of 28 patients suffering from type II diabetes mellitus and 20 healthy control subjects were studied. Based on diabetes duration patients were divided into two groups: subjects with > 10 years and those with < or = 10 years disease duration. Middle cerebral artery mean blood flow velocities were measured at rest and after intravenous administration of 1g acetazolamide. Cerebrovascular reactivity and reserve capacity were calculated. Blood glucose, insulin, glycosylated hemoglobin, hemostatic factors (fibrinogen, alpha-2 macroglobulin and von Willebrand factor antigen) were determined. Cerebrovascular reactivity and reserve capacity values were compared between the two diabetic subgroups and controls. Correlations between laboratory parameters and cerebrovascular reserve were investigated by linear regression analysis. Resting cerebral blood flow velocity was similar in controls and in the two diabetic subgroups. Cerebrovascular reactivity was elevated for a shorter time in patients with > 10 years disease duration than in controls and short-term diabetic patients. Cerebrovascular reserve capacity was lower in the long-term diabetes group (means +/- SD: 39.6 +/- 20.7%) than in patients with < or = 10 years disease duration (63.3 +/- 17.4%, p < 0.02 after Bonferroni correction). Cerebrovascular reserve capacity was inversely related to the duration of the disease (R = 0.53, p < 0.003). None of the determined laboratory factors had any relation with resting cerebral blood flow and cerebrovascular reserve capacity. The vasodilatory ability of cerebral arterioles is diminished in long-standing type II diabetes mellitus. LA - English DB - MTMT ER -