TY  - JOUR
AU  - Tóth, Emília
AU  - Fabó, Dániel
AU  - Entz, László
AU  - Ulbert, István
AU  - Erőss, Loránd
TI  - Intracranial neuronal ensemble recordings and analysis in epilepsy.
JF  - JOURNAL OF NEUROSCIENCE METHODS
J2  - J NEUROSCI METH
VL  - 260
PY  - 2016
IS  - SI
SP  - 261
EP  - 269
PG  - 9
SN  - 0165-0270
DO  - 10.1016/j.jneumeth.2015.09.028
UR  - https://m2.mtmt.hu/api/publication/3015678
ID  - 3015678
N1  - Funding Agency and Grant Number: Hungarian Government - National Research Development and Innovation Office [OTKA PD101754, KTIA NAP 13-1-2013-0001]
            Funding text: This work was supported by Hungarian Government - National Research Development and Innovation Office (OTKA PD101754, KTIA NAP 13-1-2013-0001).
AB  - Pathological neuronal firing was demonstrated 50 years ago as the hallmark of epileptically transformed cortex with the use of implanted microelectrodes. Since then, microelectrodes remained only experimental tools in humans to detect unitary neuronal activity to reveal physiological and pathological brain functions. This recording technique has evolved substantially in the past few decades; however, based on recent human data implying their usefulness as diagnostic tools, we expect a substantial increase in the development of microelectrodes in the near future. Here, we review the technological background and history of microelectrode array development for human examinations in epilepsy, including discussions on of wire-based and microelectrode arrays fabricated using micro-electro-mechanical system (MEMS) techniques and novel future techniques to record neuronal ensemble. We give an overview of clinical and surgical considerations, and try to provide a list of probes on the market with their availability for human recording. Then finally, we briefly review the literature on modulation of single neuron for the treatment of epilepsy, and highlight the current topics under examination that can be background for the future development.
LA  - English
DB  - MTMT
ER  -