TY  - JOUR
AU  - Bircher, Julianna
AU  - Kótyuk, Eszter
AU  - Fülöp, Márta
AU  - Vereczkei, Andrea
AU  - Rónai, Zsolt
AU  - Varga, Katalin
AU  - Székely, Anna
TI  - Gene-sex interaction in Hypercompetitive Attitude suggests beneficial effect of the DRD4 7-repeat allele in adaptation
JF  - NEUROPSYCHOPHARMACOLOGIA HUNGARICA
J2  - NEUROPSYCHOPHARM HUNG
VL  - 21
PY  - 2019
IS  - 2
SP  - 47
EP  - 58
PG  - 12
SN  - 1419-8711
UR  - https://m2.mtmt.hu/api/publication/3315427
ID  - 3315427
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Bjarni, J Vilhjálmsson
AU  - Jian, Yang
AU  - Hilary, K Finucane
AU  - Alexander, Gusev
AU  - Sara, Lindström
AU  - Stephan, Ripke
AU  - Giulio, Genovese
AU  - Po-Ru, Loh
AU  - Gaurav, Bhatia
AU  - Ron, Do
AU  - Tristan, Hayeck
AU  - Hong-Hee, Won
AU  - Sekar, Kathiresan
AU  - Michele, Pato
AU  - Carlos, Pato
AU  - Rulla, Tamimi
AU  - Eli, Stahl
AU  - Noah, Zaitlen
AU  - Bogdan, Pasaniuc
AU  - Gillian, Belbin
AU  - Eimear, E Kenny
AU  - Mikkel, H Schierup
AU  - Philip, De Jager
AU  - Nikolaos, A Patsopoulos
AU  - Steve, McCarroll
AU  - Mark, Daly
AU  - Shaun, Purcell
AU  - Daniel, Chasman
AU  - Benjamin, Neale
AU  - Michael, Goddard
AU  - Peter, M Visscher
AU  - Peter, Kraft
AU  - Nick, Patterson
AU  - Alkes, L Price
ED  - Bene, Judit / Collaborator
ED  - Melegh, Béla / Collaborator
TI  - Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores.
JF  - AMERICAN JOURNAL OF HUMAN GENETICS
J2  - AM J HUM GENET
VL  - 97
PY  - 2015
IS  - 4
SP  - 576
EP  - 592
PG  - 17
SN  - 0002-9297
DO  - 10.1016/j.ajhg.2015.09.001
UR  - https://m2.mtmt.hu/api/publication/3004248
ID  - 3004248
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Bulik-Sullivan, BK
AU  - Loh, PR
AU  - Finucane, HK
AU  - Ripke, S
AU  - Yang, J
AU  - Patterson, N
AU  - Daly, MJ
AU  - Price, AL
AU  - Neale, BM
ED  - Bene, Judit / Collaborator
ED  - Melegh, Béla / Collaborator
TI  - LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
JF  - NATURE GENETICS
J2  - NAT GENET
VL  - 47
PY  - 2015
IS  - 3
SP  - 291
EP  - 295
PG  - 5
SN  - 1061-4036
DO  - 10.1038/ng.3211
UR  - https://m2.mtmt.hu/api/publication/3004249
ID  - 3004249
AB  - Both polygenicity (many small genetic effects) and confounding biases, such as cryptic relatedness and population stratification, can yield an inflated distribution of test statistics in genome-wide association studies (GWAS). However, current methods cannot distinguish between inflation from a true polygenic signal and bias. We have developed an approach, LD Score regression, that quantifies the contribution of each by examining the relationship between test statistics and linkage disequilibrium (LD). The LD Score regression intercept can be used to estimate a more powerful and accurate correction factor than genomic control. We find strong evidence that polygenicity accounts for the majority of the inflation in test statistics in many GWAS of large sample size.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
ED  - Bene, Judit / Collaborator
ED  - Melegh, Béla / Collaborator
TI  - Biological insights from 108 schizophrenia-associated genetic loci
JF  - NATURE
J2  - NATURE
VL  - 511
PY  - 2014
IS  - 7510
SP  - 421
EP  - 427
PG  - 7
SN  - 0028-0836
DO  - 10.1038/nature13595
UR  - https://m2.mtmt.hu/api/publication/2719006
ID  - 2719006
LA  - English
DB  - MTMT
ER  -