@article{MTMT:3315427, title = {Gene-sex interaction in Hypercompetitive Attitude suggests beneficial effect of the DRD4 7-repeat allele in adaptation}, url = {https://m2.mtmt.hu/api/publication/3315427}, author = {Bircher, Julianna and Kótyuk, Eszter and Fülöp, Márta and Vereczkei, Andrea and Rónai, Zsolt and Varga, Katalin and Székely, Anna}, journal-iso = {NEUROPSYCHOPHARM HUNG}, journal = {NEUROPSYCHOPHARMACOLOGIA HUNGARICA}, volume = {21}, unique-id = {3315427}, issn = {1419-8711}, year = {2019}, pages = {47-58}, orcid-numbers = {Bircher, Julianna/0000-0002-0173-7616; Kótyuk, Eszter/0000-0002-6630-087X; Fülöp, Márta/0000-0002-5020-041X; Vereczkei, Andrea/0000-0001-6477-9306; Rónai, Zsolt/0000-0002-0909-7932; Varga, Katalin/0000-0003-0141-6596; Székely, Anna/0000-0002-7590-7681} } @article{MTMT:3004248, title = {Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores.}, url = {https://m2.mtmt.hu/api/publication/3004248}, author = {Bjarni, J Vilhjálmsson and Jian, Yang and Hilary, K Finucane and Alexander, Gusev and Sara, Lindström and Stephan, Ripke and Giulio, Genovese and Po-Ru, Loh and Gaurav, Bhatia and Ron, Do and Tristan, Hayeck and Hong-Hee, Won and Sekar, Kathiresan and Michele, Pato and Carlos, Pato and Rulla, Tamimi and Eli, Stahl and Noah, Zaitlen and Bogdan, Pasaniuc and Gillian, Belbin and Eimear, E Kenny and Mikkel, H Schierup and Philip, De Jager and Nikolaos, A Patsopoulos and Steve, McCarroll and Mark, Daly and Shaun, Purcell and Daniel, Chasman and Benjamin, Neale and Michael, Goddard and Peter, M Visscher and Peter, Kraft and Nick, Patterson and Alkes, L Price}, doi = {10.1016/j.ajhg.2015.09.001}, journal-iso = {AM J HUM GENET}, journal = {AMERICAN JOURNAL OF HUMAN GENETICS}, volume = {97}, unique-id = {3004248}, issn = {0002-9297}, keywords = {Humans; PHENOTYPE; QUANTITATIVE TRAIT LOCI; Prognosis; Genotype; Polymorphism, Single Nucleotide/*genetics; *Models, Theoretical; Multiple Sclerosis/*genetics; Genome-Wide Association Study; Multifactorial Inheritance/*genetics; Schizophrenia/*genetics; Linkage Disequilibrium/*genetics}, year = {2015}, eissn = {1537-6605}, pages = {576-592} } @article{MTMT:3004249, title = {LD Score regression distinguishes confounding from polygenicity in genome-wide association studies}, url = {https://m2.mtmt.hu/api/publication/3004249}, author = {Bulik-Sullivan, BK and Loh, PR and Finucane, HK and Ripke, S and Yang, J and Patterson, N and Daly, MJ and Price, AL and Neale, BM}, doi = {10.1038/ng.3211}, journal-iso = {NAT GENET}, journal = {NATURE GENETICS}, volume = {47}, unique-id = {3004249}, issn = {1061-4036}, abstract = {Both polygenicity (many small genetic effects) and confounding biases, such as cryptic relatedness and population stratification, can yield an inflated distribution of test statistics in genome-wide association studies (GWAS). However, current methods cannot distinguish between inflation from a true polygenic signal and bias. We have developed an approach, LD Score regression, that quantifies the contribution of each by examining the relationship between test statistics and linkage disequilibrium (LD). The LD Score regression intercept can be used to estimate a more powerful and accurate correction factor than genomic control. We find strong evidence that polygenicity accounts for the majority of the inflation in test statistics in many GWAS of large sample size.}, keywords = {Humans; Polymorphism, Single Nucleotide; computer simulation; Regression Analysis; Genome, Human; Sample Size; *Linkage Disequilibrium; Genome-Wide Association Study/*methods}, year = {2015}, eissn = {1546-1718}, pages = {291-295} } @article{MTMT:2719006, title = {Biological insights from 108 schizophrenia-associated genetic loci}, url = {https://m2.mtmt.hu/api/publication/2719006}, doi = {10.1038/nature13595}, journal-iso = {NATURE}, journal = {NATURE}, volume = {511}, unique-id = {2719006}, issn = {0028-0836}, year = {2014}, eissn = {1476-4687}, pages = {421-427} }