@article{MTMT:30643226,
	title = {Detection of cell-free, exosomal and whole blood mitochondrial DNA copy number in plasma or whole blood of patients with serous epithelial ovarian cancer.},
	url = {https://m2.mtmt.hu/api/publication/30643226},
	author = {Keserű, Judit Szilvia and Soltész, Beáta and Lukács, János and Márton, Éva and Szilágyi-Bónizs, Melinda and Penyige, András and Póka, Róbert and Nagy, Bálint},
	doi = {10.1016/j.jbiotec.2019.04.015},
	journal-iso = {J BIOTECHNOL},
	journal = {JOURNAL OF BIOTECHNOLOGY},
	volume = {298},
	unique-id = {30643226},
	issn = {0168-1656},
	abstract = {Ovarian tumor is one of the leading causes of cancer among women. Patients are diagnosed at an advanced stage, usually. There is a need for new specific and sensitive biomarkers. Mitochondrial DNA copy number change was observed in various cancers. Our aim was to detect mitochondrial DNA copy number in whole blood (wb-mtDNA) and in plasma (cell-free and exosome encapsulated mtDNA) in patients with serous epithelial ovarian tumor. DNA was isolated from EDTA blood and plasma obtained from 24 patients and 24 healthy controls. Exosomes were isolated from cell-free plasma, and exosome encapsulated DNA (exoDNA) was extracted. Quantitative-real-time PCR was performed with Human Mitochondrial DNA (mtDNA) Monitoring Primer Set. Kruskall‑Wallis and Mann‑Whitney U test were used for data analysis. Wb-mtDNA copy number was significantly different among healthy controls and patients in multiple comparison (p = 0.0090 considering FIGO stage independently, and p = 0.0048 considering early- and late-stage cancers). There was a significant decrease among early-stage, all advanced stage and all cancer patients (FIGO I: 32.5 ± 8.3, p = 0.0061; FIGO III + IV: 37.2 ± 13.7 p = 0.0139; FIGO I + III + IV: 35.6 ± 12.2, p = 0.0017) or FIGO III patients alone (32.8 ± 5.6, p = 0.00089) compared to healthy controls. We found significant increase in copy number in exosomal mtDNA in cancer patients (236.0 ± 499.0, p = 0.0155), advanced-stage cancer patients (333.0 ± 575.0, p = 0.0095), of FIGO III (362.0 ± 609.2, p = 0.0494), and FIGO IV (304.0 ± 585.0, p = 0.0393) patients alone but not in samples of FIGO I patients (10.0 ± 3.5, p = 0.3907). In multiple comparison the increase was significant considering early- and late-stage cancers (p = 0.0253). Cell-free mtDNA copy numbers were not increased significantly. We found the highest copy number of mtDNA in exosomes, followed by plasma and peripheral blood in late-stage cancer patients. We observed significant difference in wb-mtDNA copy number between healthy controls and both early- and late-stage cancer patients.},
	keywords = {mitochondrial DNA; cell-free mtDNA; exosomal mtDNA; serous ovarian cancer},
	year = {2019},
	eissn = {1873-4863},
	pages = {76-81},
	orcid-numbers = {Nagy, Bálint/0000-0002-0295-185X}
}

@article{MTMT:30338008,
	title = {Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines},
	url = {https://m2.mtmt.hu/api/publication/30338008},
	author = {Théry, C. and Witwer, K.W. and Aikawa, E. and Alcaraz, M.J. and Anderson, J.D. and Andriantsitohaina, R. and Antoniou, A. and Arab, T. and Archer, F. and Atkin-Smith, G.K. and Ayre, D.C. and Bach, J.-M. and Bachurski, D. and Baharvand, H. and Balaj, L. and Baldacchino, S. and Bauer, N.N. and Baxter, A.A. and Bebawy, M. and Beckham, C. and Bedina, Zavec A. and Benmoussa, A. and Berardi, A.C. and Bergese, P. and Bielska, E. and Blenkiron, C. and Bobis-Wozowicz, S. and Boilard, E. and Boireau, W. and Bongiovanni, A. and Borràs, F.E. and Bosch, S. and Boulanger, C.M. and Breakefield, X. and Breglio, A.M. and Brennan, M.Á. and Brigstock, D.R. and Brisson, A. and Broekman, M.L.D. and Bromberg, J.F. and Bryl-Górecka, P. and Buch, S. and Buck, A.H. and Burger, D. and Busatto, S. and Buschmann, D. and Bussolati, B. and Buzás, Edit Irén and Byrd, J.B. and Camussi, G. and Carter, D.R.F. and Caruso, S. and Chamley, L.W. and Chang, Y.-T. and Chaudhuri, A.D. and Chen, C. and Chen, S. and Cheng, L. and Chin, A.R. and Clayton, A. and Clerici, S.P. and Cocks, A. and Cocucci, E. and Coffey, R.J. and Cordeiro-da-Silva, A. and Couch, Y. and Coumans, F.A.W. and Coyle, B. and Crescitelli, R. and Criado, M.F. and D’Souza-Schorey, C. and Das, S. and de, Candia P. and De, Santana E.F. Jr. and De, Wever O. and del, Portillo H.A. and Demaret, T. and Deville, S. and Devitt, A. and Dhondt, B. and Di, Vizio D. and Dieterich, L.C. and Dolo, V. and Dominguez, Rubio A.P. and Dominici, M. and Dourado, M.R. and Driedonks, T.A.P. and Duarte, F.V. and Duncan, H.M. and Eichenberger, R.M. and Ekström, K. and EL, Andaloussi S. and Elie-Caille, C. and Erdbrügger, U. and Falcón-Pérez, J.M. and Fatima, F. and Fish, J.E. and Flores-Bellver, M. and Försönits, András and Frelet-Barrand, A. and Fricke, F. and Fuhrmann, G. and Gabrielsson, S. and Gámez-Valero, A. and Gardiner, C. and Gärtner, K. and Gaudin, R. and Gho, Y.S. and Giebel, B. and Gilbert, C. and Gimona, M. and Giusti, I. and Goberdhan, D.C.I. and Görgens, A. and Gorski, S.M. and Greening, D.W. and Gross, J.C. and Gualerzi, A. and Gupta, G.N. and Gustafson, D. and Handberg, A. and Haraszti, R.A. and Harrison, P. and Hegyesi, Hargita and Hendrix, A. and Hill, A.F. and Hochberg, F.H. and Hoffmann, K.F. and Holder, B. and Holthofer, H. and Hosseinkhani, B. and Hu, G. and Huang, Y. and Huber, V. and Hunt, S. and Ibrahim, A.G.-E. and Ikezu, T. and Inal, J.M. and Isin, M. and Ivanova, A. and Jackson, H.K. and Jacobsen, S. and Jay, S.M. and Jayachandran, M. and Jenster, G. and Jiang, L. and Johnson, S.M. and Jones, J.C. and Jong, A. and Jovanovic-Talisman, T. and Jung, S. and Kalluri, R. and Kano, S.-I. and Kaur, S. and Kawamura, Y. and Keller, E.T. and Khamari, Delaram and Khomyakova, E. and Khvorova, A. and Kierulf, P. and Kim, K.P. and Kislinger, T. and Klingeborn, M. and Klinke, D.J. II and Kornek, M. and Kosanović, M.M. and Kovács, Árpád Ferenc and Krämer-Albers, E.-M. and Krasemann, S. and Krause, M. and Kurochkin, I.V. and Kusuma, G.D. and Kuypers, S. and Laitinen, S. and Langevin, S.M. and Languino, L.R. and Lannigan, J. and Lässer, C. and Laurent, L.C. and Lavieu, G. and Lázaro-Ibáñez, E. and Le, Lay S. and Lee, M.-S. and Lee, Y.X.F. and Lemos, D.S. and Lenassi, M. and Leszczynska, A. and Li, I.T.S. and Liao, K. and Libregts, S.F. and Ligeti, Erzsébet and Lim, R. and Lim, S.K. and Linē, A. and Linnemannstöns, K. and Llorente, A. and Lombard, C.A. and Lorenowicz, M.J. and Lőrincz, Márton Ákos and Lötvall, J. and Lovett, J. and Lowry, M.C. and Loyer, X. and Lu, Q. and Lukomska, B. and Lunavat, T.R. and Maas, S.L.N. and Malhi, H. and Marcilla, A. and Mariani, J. and Mariscal, J. and Martens-Uzunova, E.S. and Martin-Jaular, L. and Martinez, M.C. and Martins, V.R. and Mathieu, M. and Mathivanan, S. and Maugeri, M. and McGinnis, L.K. and McVey, M.J. and Meckes, D.G. Jr and Meehan, K.L. and Mertens, I. and Minciacchi, V.R. and Möller, A. and Møller, Jørgensen M. and Morales-Kastresana, A. and Morhayim, J. and Mullier, F. and Muraca, M. and Musante, L. and Mussack, V. and Muth, D.C. and Myburgh, K.H. and Najrana, T. and Nawaz, M. and Nazarenko, I. and Nejsum, P. and Neri, C. and Neri, T. and Nieuwland, R. and Nimrichter, L. and Nolan, J.P. and Nolte-’t, Hoen E.N.M. and Hooten, N.N. and O’Driscoll, L. and O’Grady, T. and O’Loghlen, A. and Ochiya, T. and Olivier, M. and Ortiz, A. and Ortiz, L.A. and Osteikoetxea, Xabier and Ostegaard, O. and Ostrowski, M. and Park, J. and Pegtel, D.M. and Peinado, H. and Perut, F. and Pfaffl, M.W. and Phinney, D.G. and Pieters, B.C.H. and Pink, R.C. and Pisetsky, D.S. and Pogge, von Strandmann E. and Polakovicova, I. and Poon, I.K.H. and Powell, B.H. and Prada, I. and Pulliam, L. and Quesenberry, P. and Radeghieri, A. and Raffai, R.L. and Raimondo, S. and Rak, J. and Ramirez, M.I. and Raposo, G. and Rayyan, M.S. and Regev-Rudzki, N. and Ricklefs, F.L. and Robbins, P.D. and Roberts, D.D. and Rodrigues, S.C. and Rohde, E. and Rome, S. and Rouschop, K.M.A. and Rughetti, A. and Russell, A.E. and Saá, P. and Sahoo, S. and Salas-Huenuleo, E. and Sánchez, C. and Saugstad, J.A. and Saul, M.J. and Schiffelers, R.M. and Schneider, R. and Schøyen, T.H. and Scott, A. and Shahaj, E. and Sharma, S. and Shatnyeva, O. and Shekari, F. and Shelke, G.V. and Shetty, A.K. and Shiba, K. and Siljander, P.R.-M. and Silva, A.M. and Skowronek, A. and Snyder, O.L. II and Soares, R.P. and Sódar, Barbara and Soekmadji, C. and Sotillo, J. and Stahl, P.D. and Stoorvogel, W. and Stott, S.L. and Strasser, E.F. and Swift, S. and Tahara, H. and Tewari, M. and Timms, K. and Tiwari, S. and Tixeira, R. and Tkach, M. and Toh, W.S. and Tomasini, R. and Torrecilhas, A.C. and Tosar, J.P. and Toxavidis, V. and Urbanelli, L. and Vader, P. and van, Balkom B.W.M. and van, der Grein S.G. and Van, Deun J. and van, Herwijnen M.J.C. and Van, Keuren-Jensen K. and van, Niel G. and van, Royen M.E. and van, Wijnen A.J. and Vasconcelos, M.H. and Vechetti, I.J. Jr and Veit, T.D. and Vella, L.J. and Velot, É. and Verweij, F.J. and Vestad, B. and Viñas, J.L. and Visnovitz, Tamás and Visnovitzné Dr Vukman, Krisztina and Wahlgren, J. and Watson, D.C. and Wauben, M.H.M. and Weaver, A. and Webber, J.P. and Weber, V. and Wehman, A.M. and Weiss, D.J. and Welsh, J.A. and Wendt, S. and Wheelock, A.M. and Wiener, Zoltán and Witte, L. and Wolfram, J. and Xagorari, A. and Xander, P. and Xu, J. and Yan, X. and Yáñez-Mó, M. and Yin, H. and Yuana, Y. and Zappulli, V. and Zarubova, J. and Žėkas, V. and Zhang, J.-Y. and Zhao, Z. and Zheng, L. and Zheutlin, A.R. and Zickler, A.M. and Zimmermann, P. and Zivkovic, A.M. and Zocco, D. and Zuba-Surma, E.K.},
	doi = {10.1080/20013078.2018.1535750},
	journal-iso = {J EXTRACELLULAR VESICL},
	journal = {JOURNAL OF EXTRACELLULAR VESICLES},
	volume = {7},
	unique-id = {30338008},
	year = {2018},
	eissn = {2001-3078},
	orcid-numbers = {Buzás, Edit Irén/0000-0002-3744-206X; Försönits, András/0000-0002-9298-8890; Hegyesi, Hargita/0000-0002-8800-5169; Kovács, Árpád Ferenc/0000-0002-7742-160X; Ligeti, Erzsébet/0000-0001-6374-729X; Lőrincz, Márton Ákos/0000-0002-2819-5116; Osteikoetxea, Xabier/0000-0003-3628-0174; Sódar, Barbara/0000-0002-8803-7304; Visnovitz, Tamás/0000-0002-7962-5083; Wiener, Zoltán/0000-0001-7056-4926}
}

@article{MTMT:3273020,
	title = {Various levels of circulating exosomal total-miRNA and miR-210 hypoxamiR in different forms of pregnancy hypertension},
	url = {https://m2.mtmt.hu/api/publication/3273020},
	author = {Biró, Orsolya and Alasztics, Bálint and Molvarec, Attila and Joó, József Gábor and Nagy, Bálint and Rigó, János},
	doi = {10.1016/j.preghy.2017.09.002},
	journal-iso = {PREGNANCY HYPERTENS},
	journal = {PREGNANCY HYPERTENSION},
	volume = {10},
	unique-id = {3273020},
	issn = {2210-7789},
	abstract = {Introduction: Hypertension is a common complication during pregnancy, affecting 10% of pregnant women worldwide. Several microRNA (miRNA) were shown to be involved in hypertensive disorders of pregnancy. In preeclampsia (PE), placental dysfunction causes the enhanced release of extracellular vesicle-derived miRNAs. The hypoxia-sensitive hsa-mir-210 is the most common PE-associated miRNA, but its exosomal profile has not been investigated. Objectives: Our aims were to measure exosomal total-miRNA concentration and to perform expression analysis of circulating exosomal hsa-miR-210 in women affected by chronic hypertension (CHT) gestational hypertension (GHT) or PE. Materials and methods: We collected plasma samples from women with CHT, GHT, PE (moderate: mPE and severe: sPE) and from normotensive pregnancies. Exosomal miRNAs were extracted and miRNA concentration was measured. RT-PCR was carried out with hsa-miR-210-3p-specific primers and relative expression was calculated using the comparative Ct method. Results: The total-miRNA concentration was different in the disease subgroups, and was significantly higher in mPE and sPE compared to the other groups. We found a significant difference in the relative exosomal hsa-miR-210-3p expression between all hypertensive groups compared to the normotensive samples, but significant upregulation was only observed in case of mPE and sPE patients. Both the level of total-miRNA and hsa-miR-210 expression was higher in case of severe PE. Conclusions: The level of circulating exosomal total-miRNA and hsa-miR-210 was elevated in women with PE, and it was higher in the severe form. We showed that hsa-miR-210 is secreted via exosomes, which may have a role in the pathomechanism of the disease. © 2017 International Society for the Study of Hypertension in Pregnancy.},
	keywords = {PREECLAMPSIA; microRNA; exosome; Maternal circulation},
	year = {2017},
	eissn = {2210-7797},
	pages = {207-212},
	orcid-numbers = {Biró, Orsolya/0000-0002-4300-3602; Alasztics, Bálint/0000-0002-4011-8439; Molvarec, Attila/0000-0002-3229-3034; Joó, József Gábor/0000-0001-9820-6514; Nagy, Bálint/0000-0002-0295-185X; Rigó, János/0000-0003-2762-6516}
}

@article{MTMT:3214053,
	title = {Obstacles and opportunities in the functional analysis of extracellular vesicle RNA - an ISEV position paper.},
	url = {https://m2.mtmt.hu/api/publication/3214053},
	author = {Mateescu, B and Kowal, EJ and van Balkom, BW and Bartel, S and Bhattacharyya, SN and Buzás, Edit Irén and Buck, AH and de Candia, P and Chow, FW and Das, S and Driedonks, TA and Fernandez-Messina, L and Haderk, F and Hill, AF and Jones, JC and Van, Keuren-Jensen KR and Lai, CP and Lasser, C and Liegro, ID and Lunavat, TR and Lorenowicz, MJ and Maas, SL and Mager, I and Mittelbrunn, M and Momma, S and Mukherjee, K and Nawaz, M and Pegtel, DM and Pfaffl, MW and Schiffelers, RM and Tahara, H and Thery, C and Tosar, JP and Wauben, MH and Witwer, KW and Nolte-'t, Hoen EN},
	doi = {10.1080/20013078.2017.1286095},
	journal-iso = {J EXTRACELLULAR VESICL},
	journal = {JOURNAL OF EXTRACELLULAR VESICLES},
	volume = {6},
	unique-id = {3214053},
	abstract = {The release of RNA-containing extracellular vesicles (EV) into the extracellular milieu has been demonstrated in a multitude of different in vitro cell systems and in a variety of body fluids. RNA-containing EV are in the limelight for their capacity to communicate genetically encoded messages to other cells, their suitability as candidate biomarkers for diseases, and their use as therapeutic agents. Although EV-RNA has attracted enormous interest from basic researchers, clinicians, and industry, we currently have limited knowledge on which mechanisms drive and regulate RNA incorporation into EV and on how RNA-encoded messages affect signalling processes in EV-targeted cells. Moreover, EV-RNA research faces various technical challenges, such as standardisation of EV isolation methods, optimisation of methodologies to isolate and characterise minute quantities of RNA found in EV, and development of approaches to demonstrate functional transfer of EV-RNA in vivo. These topics were discussed at the 2015 EV-RNA workshop of the International Society for Extracellular Vesicles. This position paper was written by the participants of the workshop not only to give an overview of the current state of knowledge in the field, but also to clarify that our incomplete knowledge - of the nature of EV(-RNA)s and of how to effectively and reliably study them - currently prohibits the implementation of gold standards in EV-RNA research. In addition, this paper creates awareness of possibilities and limitations of currently used strategies to investigate EV-RNA and calls for caution in interpretation of the obtained data.},
	year = {2017},
	eissn = {2001-3078},
	orcid-numbers = {Buzás, Edit Irén/0000-0002-3744-206X}
}

@article{MTMT:3246966,
	title = {EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research},
	url = {https://m2.mtmt.hu/api/publication/3246966},
	author = {Van, Deun J and Mestdagh, P and Agostinis, P and Akay, O and Anand, S and Anckaert, J and Martinez, ZA and Baetens, T and Beghein, E and Bertier, L and Berx, G and Boere, J and Boukouris, S and Bremer, M and Buschmann, D and Byrd, JB and Casert, C and Cheng, L and Cmoch, A and Daveloose, D and De Smedt, E and Demirsoy, S and Depoorter, V and Dhondt, B and Driedonks, TA and Dudek, A and Elsharawy, A and Floris, I and Foers, AD and Gartner, K and Garg, AD and Geeurickx, E and Gettemans, J and Ghazavi, F and Giebel, B and Kormelink, TG and Hancock, G and Helsmoortel, H and Hill, AF and Hyenne, V and Kalra, H and Kim, D and Kowal, J and Kraemer, S and Leidinger, P and Leonelli, C and Liang, Y and Lippens, L and Liu, S and Lo, Cicero A and Martin, S and Mathivanan, S and Mathiyalagan, P and Matusek, T and Milani, G and Monguio-Tortajada, M and Mus, LM and Muth, DC and Németh, Andrea and Nolte-'t, Hoen EN and O'Driscoll, L and Palmulli, R and Pfaffl, MW and Primdal-Bengtson, B and Romano, E and Rousseau, Q and Sahoo, S and Sampaio, N and Samuel, M and Scicluna, B and Soen, B and Steels, A and Swinnen, JV and Takatalo, M and Thaminy, S and Thery, C and Tulkens, J and Van, Audenhove I and van der Grein, S and Van, Goethem A and van Herwijnen, MJ and Van, Niel G and Van, Roy N and Van, Vliet AR and Vandamme, N and Vanhauwaert, S and Vergauwen, G and Verweij, F and Wallaert, A and Wauben, M and Witwer, KW and Zonneveld, MI and De Wever, O and Vandesompele, J and Hendrix, A},
	doi = {10.1038/nmeth.4185},
	journal-iso = {NAT METHODS},
	journal = {NATURE METHODS},
	volume = {14},
	unique-id = {3246966},
	issn = {1548-7091},
	abstract = {We argue that the field of extracellular vesicle (EV) biology needs more transparent reporting to facilitate interpretation and replication of experiments. To achieve this, we describe EV-TRACK, a crowdsourcing knowledgebase (http://evtrack.org) that centralizes EV biology and methodology with the goal of stimulating authors, reviewers, editors and funders to put experimental guidelines into practice.},
	keywords = {*Internationality; *Biomedical Research; *Databases, Bibliographic; Extracellular Vesicles/*physiology},
	year = {2017},
	eissn = {1548-7105},
	pages = {228-232},
	orcid-numbers = {Németh, Andrea/0000-0002-0015-8436}
}

@article{MTMT:3054080,
	title = {Low-density lipoprotein mimics blood plasma-derived exosomes and microvesicles during isolation and detection},
	url = {https://m2.mtmt.hu/api/publication/3054080},
	author = {Sódar, Barbara and Kittel, Ágnes and Pálóczi, Krisztina and Visnovitzné Dr Vukman, Krisztina and Osteikoetxea, Xabier and Szabó-Taylor, Katalin and Németh, Andrea and Sperlágh, Beáta and Baranyai, Tamás and Giricz, Zoltán and Wiener, Zoltán and Turiák, Lilla and Drahos, László and Pállinger, Éva and Vékey, Károly and Ferdinandy, Péter and Falus, András and Buzás, Edit Irén},
	doi = {10.1038/srep24316},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {6},
	unique-id = {3054080},
	issn = {2045-2322},
	abstract = {Circulating extracellular vesicles have emerged as potential new biomarkers in a wide variety of diseases. Despite the increasing interest, their isolation and purification from body fluids remains challenging. Here we studied human pre-prandial and 4 hours postprandial platelet-free blood plasma samples as well as human platelet concentrates. Using flow cytometry, we found that the majority of circulating particles within the size range of extracellular vesicles lacked common vesicular markers. We identified most of these particles as lipoproteins (predominantly low-density lipoprotein, LDL) which mimicked the characteristics of extracellular vesicles and also co-purified with them. Based on biophysical properties of LDL this finding was highly unexpected. Current state-of-the-art extracellular vesicle isolation and purification methods did not result in lipoprotein-free vesicle preparations from blood plasma or from platelet concentrates. Furthermore, transmission electron microscopy showed an association of LDL with isolated vesicles upon in vitro mixing. This is the first study to show co-purification and in vitro association of LDL with extracellular vesicles and its interference with vesicle analysis. Our data point to the importance of careful study design and data interpretation in studies using blood-derived extracellular vesicles with special focus on potentially co-purified LDL.},
	year = {2016},
	eissn = {2045-2322},
	orcid-numbers = {Sódar, Barbara/0000-0002-8803-7304; Pálóczi, Krisztina/0000-0001-7065-3582; Osteikoetxea, Xabier/0000-0003-3628-0174; Szabó-Taylor, Katalin/0000-0002-4763-3521; Németh, Andrea/0000-0002-0015-8436; Baranyai, Tamás/0000-0002-9378-8938; Giricz, Zoltán/0000-0003-2036-8665; Wiener, Zoltán/0000-0001-7056-4926; Drahos, László/0000-0001-9589-6652; Pállinger, Éva/0000-0002-5789-0951; Ferdinandy, Péter/0000-0002-6424-6806; Falus, András/0000-0002-6843-6789; Buzás, Edit Irén/0000-0002-3744-206X}
}

@article{MTMT:2930099,
	title = {Biological properties of extracellular vesicles and their physiological functions},
	url = {https://m2.mtmt.hu/api/publication/2930099},
	author = {Yanez-Mo, M and Siljander, PR and Andreu, Z and Zavec, AB and Borras, FE and Buzás, Edit Irén and Buzás, Krisztina and Casal, E and Cappello, F and Carvalho, J and Colas, E and Cordeiro-da Silva, A and Fais, S and Falcon-Perez, JM and Ghobrial, IM and Giebel, B and Gimona, M and Graner, M and Gursel, I and Gursel, M and Heegaard, NH and Hendrix, A and Kierulf, P and Kokubun, K and Kosanovic, M and Kralj-Iglic, V and Kramer-Albers, EM and Laitinen, S and Lasser, C and Lener, T and Ligeti, Erzsébet and Line, A and Lipps, G and Llorente, A and Lotvall, J and Mancek-Keber, M and Marcilla, A and Mittelbrunn, M and Nazarenko, I and Nolte-'t, Hoen EN and Nyman, TA and O'Driscoll, L and Olivan, M and Oliveira, C and Pállinger, Éva and Del Portillo, HA and Reventos, J and Rigau, M and Rohde, E and Sammar, M and Sanchez-Madrid, F and Santarem, N and Schallmoser, K and Ostenfeld, MS and Stoorvogel, W and Stukelj, R and Van, der Grein SG and Vasconcelos, MH and Wauben, MH and De Wever, O},
	doi = {10.3402/jev.v4.27066},
	journal-iso = {J EXTRACELLULAR VESICL},
	journal = {JOURNAL OF EXTRACELLULAR VESICLES},
	volume = {4},
	unique-id = {2930099},
	abstract = {In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells. While intensive investigation has targeted the role of EVs in different pathological processes, for example, in cancer and autoimmune diseases, the EV-mediated maintenance of homeostasis and the regulation of physiological functions have remained less explored. Here, we provide a comprehensive overview of the current understanding of the physiological roles of EVs, which has been written by crowd-sourcing, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia. This review is intended to be of relevance to both researchers already working on EV biology and to newcomers who will encounter this universal cell biological system. Therefore, here we address the molecular contents and functions of EVs in various tissues and body fluids from cell systems to organs. We also review the physiological mechanisms of EVs in bacteria, lower eukaryotes and plants to highlight the functional uniformity of this emerging communication system.},
	year = {2015},
	eissn = {2001-3078},
	orcid-numbers = {Buzás, Edit Irén/0000-0002-3744-206X; Buzás, Krisztina/0000-0001-8933-2033; Ligeti, Erzsébet/0000-0001-6374-729X; Pállinger, Éva/0000-0002-5789-0951}
}