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The aim of the current study was to detect potential myocardial inflammation present in asymptomatic SSc patients by 18F-FDG-PET/CT and to investigate its relationship with early signs of myocardial dysfunction as detected by 2D speckle tracking echocardiography (2DSTE).Sixteen consecutive patients with SSc and 9 control patients without clinical evidence of cardiac involvement were enrolled in the study. On 18F-FDG-PET acquired images blood-pool normalised SUV ratio and heterogenity index (HI: standard deviation of SUV divided with mean SUV) were calculated. Within 24 hours all SSc patients underwent 2DSTE strain analysis.Eight of 16 SSc patients were found to be visually PET-positive and showed significantly higher myocardial 18F-FDG SUV ratio (1.78±0.74 vs. 0.98±0.03; p<0.05) and heterogenity index (0.13±0.02 vs. 0.05±0.02; p<0.001) as compared to the control group. FDG-PET/CT derived values did not differ significantly between visually PET-negative (8/16) and control patients (SUV ratio: 0.98±0.05 vs. 0.98±0.03; HI: 0.05±0.01 vs. 0.05±0.02). Global left ventricular longitudinal strain values did not differ significantly between PET-positive and negative patients (17.18±3.49% vs. 17.59±3.65%).Myocardial inflammation, as a potential sign of early cardiac involvement can be detected by 18-FDG-PET/CT in a considerable percentage of systemic sclerosis patients presenting without cardiac symptoms.", "subjects" : [ { "otype" : "Classification", "mtid" : 12125, "link" : "/api/classification/12125", "label" : "Basic medicine", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12215, "link" : "/api/classification/12215", "label" : "Clinical medicine", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12124, "link" : "/api/classification/12124", "label" : "MEDICAL AND HEALTH SCIENCES", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12282, "link" : "/api/classification/12282", "label" : "Rheumatology", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12221, "link" : "/api/classification/12221", "label" : "Cardiac and Cardiovascular systems", "published" : true, "snippet" : true } ], "keywords" : [ { "otype" : "Keyword", "mtid" : 20166, "link" : "/api/keyword/20166", "label" : "systemic sclerosis", "published" : true, "oldId" : 20166, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1508970, "link" : "/api/keyword/1508970", "label" : "HEART INVOLVEMENT", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1653803, "link" : "/api/keyword/1653803", "label" : "FDG-PET/CT", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1655212, "link" : "/api/keyword/1655212", "label" : "strain echocardiography", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1671014, "link" : "/api/keyword/1671014", "label" : "myocardial inflammation", "published" : true, "snippet" : true } ], "digital" : true, "printed" : null, "sourceYear" : 2019, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : true, "missingAuthor" : false, "oaType" : "GOLD", "oaCheckDate" : "2024-02-19", "oaFree" : true, "oaLink" : "https://www.clinexprheumatol.org/abstract.asp?a=13308", "citationCount" : 14, "citationCountUnpublished" : 0, "citationCountWoOther" : 13, "independentCitCountWoOther" : 12, "nationalOriginCitationCount" : 2, "foreignEditionCitationCount" : 11, "doiCitationCount" : 13, "wosCitationCount" : 12, "scopusCitationCount" : 11, "wosScopusCitationCount" : 13, "wosScopusCitationCountWoOther" : 13, "wosScopusIndependentCitationCount" : 12, "wosScopusIndependentCitationCountWoOther" : 12, "independentCitationCount" : 12, "selfCitationCount" : 2, "unhandledCitationCount" : 0, "citingPubCount" : 14, "independentCitingPubCount" : 12, "citingPubCountWoOther" : 13, "independentCitingPubCountWoOther" : 12, "unhandledCitingPubCount" : 0, "citedPubCount" : 2, "citedCount" : 2, "ratings" : [ { "otype" : "SjrRating", "mtid" : 10820766, "link" : "/api/sjrrating/10820766", "label" : "sjr:Q2 (2019) Scopus - Immunology CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 0392-856X 1593-098X", "listPos" : 85, "rankValue" : 0.49, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 2403, "link" : "/api/classificationexternal/2403", "label" : "Scopus - Immunology", "published" : true, "oldId" : 2403, "snippet" : true }, "ranking" : "Q2", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "Q2", "hasCitationDuplums" : false, "inSelectedPubs" : "10005990,10045117,10043855", "userChangeableUntil" : "2019-04-18T13:21:33.071+0000", "publishDate" : "2019-01-18T14:21:33.176+0000", "directInstitutesForSort" : "Családorvosi Intézet és Rendelő (SZTE / SZAOK); II. sz. 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