TY  - JOUR
AU  - Rónavári, Andrea
AU  - Igaz, Nóra
AU  - Gopisetty, Mohana Krishna
AU  - Szerencsés, Bettina
AU  - Kovács, Dávid
AU  - Papp, Csaba Gergő
AU  - Vágvölgyi, Csaba
AU  - Boros, Imre Miklós
AU  - Kónya, Zoltán
AU  - Csontné Kiricsi, Mónika
AU  - Pfeiffer, Ilona
TI  - Biosynthesized silver and gold nanoparticles are potent antimycotics against opportunistic pathogenic yeasts and dermatophytes
JF  - INTERNATIONAL JOURNAL OF NANOMEDICINE
J2  - INT J NANOMED
VL  - 13
PY  - 2018
SP  - 695
EP  - 703
PG  - 9
SN  - 1176-9114
DO  - 10.2147/IJN.S152010
UR  - https://m2.mtmt.hu/api/publication/3335848
ID  - 3335848
N1  - Department of Applied and Environmental Chemistry, University of Szeged, Szeged, Hungary            
            Department of Biochemistry and Molecular Biology, University of Szeged, Szeged, Hungary            
            Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary            
            Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, Hungary            
            MTA-SZTE Reaction Kinetics and Surface Chemistry Research Group, Szeged, Hungary            
            Cited By :27            
            Export Date: 31 May 2021            
            Correspondence Address: Pfeiffer, I.; Department of Microbiology, Közép fasor 52, Hungary; email: pfeiffer@bio.u-szeged.hu
AB  - Background: Epidemiologic observations indicate that the number of systemic fungal infections has increased significantly during the past decades, however in human mycosis, mainly cutaneous infections predominate, generating major public health concerns and providing much of the impetus for current attempts to develop novel and efficient agents against cutaneous mycosis causing species. Innovative, environmentally benign and economic nanotechnology-based approaches have recently emerged utilizing principally biological sources to produce nano-sized structures with unique antimicrobial properties. In line with this, our aim was to generate silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) by biological synthesis and to study the effect of the obtained nanoparticles on cutaneous mycosis causing fungi and on human keratinocytes. Methods: Cell-free extract of the red yeast Phaffia rhodozyma proved to be suitable for nanoparticle preparation and the generated AgNPs and AuNPs were characterized by transmission electron microscopy, dynamic light scattering and X-ray powder diffraction. Results: Antifungal studies demonstrated that the biosynthesized silver particles were able to inhibit the growth of several opportunistic Candida or Cryptococcus species and were highly potent against filamentous Microsporum and Trichophyton dermatophytes. Among the tested species only Cryptococcus neoformans was susceptible to both AgNPs and AuNPs. Neither AgNPs nor AuNPs exerted toxicity on human keratinocytes. Conclusion: Our results emphasize the therapeutic potential of such biosynthesized nanoparticles, since their biocompatibility to skin cells and their outstanding antifungal performance can be exploited for topical treatment and prophylaxis of superficial cutaneous mycosis. © 2018 Rónavári et al.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Rónavári, Andrea
AU  - Kovács, Dávid
AU  - Igaz, Nóra
AU  - Vágvölgyi, Csaba
AU  - Boros, Imre Miklós
AU  - Kónya, Zoltán
AU  - Pfeiffer, Ilona
AU  - Csontné Kiricsi, Mónika
TI  - Biological activity of green-synthesized silver nanoparticles depends on the applied natural extracts: a comprehensive study
JF  - INTERNATIONAL JOURNAL OF NANOMEDICINE
J2  - INT J NANOMED
VL  - 12
PY  - 2017
SP  - 871
EP  - 883
PG  - 13
SN  - 1176-9114
DO  - 10.2147/IJN.S122842
UR  - https://m2.mtmt.hu/api/publication/3176690
ID  - 3176690
N1  - Department of Applied and Environmental Chemistry, University of Szeged, Szeged, Hungary            
            Department of Biochemistry and Molecular Biology, University of Szeged, Szeged, Hungary            
            Department of Microbiology, University of Szeged, Szeged, Hungary            
            Institute of Biochemistry, Biological Research Center, Hungarian Academy of Sciences, Hungary            
            MTA-SZTE Reaction Kinetics and Surface Chemistry Research Group, Szeged, Hungary            
            Cited By :63            
            Export Date: 31 May 2021            
            Correspondence Address: Kiricsi, M.; Department of Biochemistry and Molecular Biology, Középfasor 52, Hungary; email: kiricsim@bio.u-szeged.hu
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Kovács, Dávid
AU  - Igaz, Nóra
AU  - Csilla, Keskeny
AU  - Bélteky, Péter
AU  - Tímea, Tóth
AU  - Molnár-Gáspár, Renáta
AU  - Madarász, Dániel
AU  - Rázga, Zsolt
AU  - Kónya, Zoltán
AU  - Boros, Imre Miklós
AU  - Csontné Kiricsi, Mónika
TI  - Silver nanoparticles defeat p53-positive and p53-negative osteosarcoma cells by triggering mitochondrial stress and apoptosis
JF  - SCIENTIFIC REPORTS
J2  - SCI REP
VL  - 6
PY  - 2016
PG  - 13
SN  - 2045-2322
DO  - 10.1038/srep27902
UR  - https://m2.mtmt.hu/api/publication/3079142
ID  - 3079142
LA  - English
DB  - MTMT
ER  -