@article{MTMT:3335848, title = {Biosynthesized silver and gold nanoparticles are potent antimycotics against opportunistic pathogenic yeasts and dermatophytes}, url = {https://m2.mtmt.hu/api/publication/3335848}, author = {Rónavári, Andrea and Igaz, Nóra and Gopisetty, Mohana Krishna and Szerencsés, Bettina and Kovács, Dávid and Papp, Csaba Gergő and Vágvölgyi, Csaba and Boros, Imre Miklós and Kónya, Zoltán and Csontné Kiricsi, Mónika and Pfeiffer, Ilona}, doi = {10.2147/IJN.S152010}, journal-iso = {INT J NANOMED}, journal = {INTERNATIONAL JOURNAL OF NANOMEDICINE}, volume = {13}, unique-id = {3335848}, issn = {1176-9114}, abstract = {Background: Epidemiologic observations indicate that the number of systemic fungal infections has increased significantly during the past decades, however in human mycosis, mainly cutaneous infections predominate, generating major public health concerns and providing much of the impetus for current attempts to develop novel and efficient agents against cutaneous mycosis causing species. Innovative, environmentally benign and economic nanotechnology-based approaches have recently emerged utilizing principally biological sources to produce nano-sized structures with unique antimicrobial properties. In line with this, our aim was to generate silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) by biological synthesis and to study the effect of the obtained nanoparticles on cutaneous mycosis causing fungi and on human keratinocytes. Methods: Cell-free extract of the red yeast Phaffia rhodozyma proved to be suitable for nanoparticle preparation and the generated AgNPs and AuNPs were characterized by transmission electron microscopy, dynamic light scattering and X-ray powder diffraction. Results: Antifungal studies demonstrated that the biosynthesized silver particles were able to inhibit the growth of several opportunistic Candida or Cryptococcus species and were highly potent against filamentous Microsporum and Trichophyton dermatophytes. Among the tested species only Cryptococcus neoformans was susceptible to both AgNPs and AuNPs. Neither AgNPs nor AuNPs exerted toxicity on human keratinocytes. Conclusion: Our results emphasize the therapeutic potential of such biosynthesized nanoparticles, since their biocompatibility to skin cells and their outstanding antifungal performance can be exploited for topical treatment and prophylaxis of superficial cutaneous mycosis. © 2018 Rónavári et al.}, keywords = {TOXICITY; Antifungal activity; Silver nanoparticles; Dermatophytes; BIOLOGICAL SYNTHESIS; Opportunistic pathogenic yeasts}, year = {2018}, eissn = {1178-2013}, pages = {695-703}, orcid-numbers = {Rónavári, Andrea/0000-0001-7054-0975; Igaz, Nóra/0000-0003-1580-4397; Gopisetty, Mohana Krishna/0000-0002-4310-3478; Papp, Csaba Gergő/0000-0003-4450-0667; Vágvölgyi, Csaba/0000-0003-0009-7773; Boros, Imre Miklós/0000-0001-8504-9687; Kónya, Zoltán/0000-0002-9406-8596; Csontné Kiricsi, Mónika/0000-0002-8416-2052; Pfeiffer, Ilona/0000-0003-0680-7596} } @article{MTMT:3176690, title = {Biological activity of green-synthesized silver nanoparticles depends on the applied natural extracts: a comprehensive study}, url = {https://m2.mtmt.hu/api/publication/3176690}, author = {Rónavári, Andrea and Kovács, Dávid and Igaz, Nóra and Vágvölgyi, Csaba and Boros, Imre Miklós and Kónya, Zoltán and Pfeiffer, Ilona and Csontné Kiricsi, Mónika}, doi = {10.2147/IJN.S122842}, journal-iso = {INT J NANOMED}, journal = {INTERNATIONAL JOURNAL OF NANOMEDICINE}, volume = {12}, unique-id = {3176690}, issn = {1176-9114}, year = {2017}, eissn = {1178-2013}, pages = {871-883}, orcid-numbers = {Rónavári, Andrea/0000-0001-7054-0975; Igaz, Nóra/0000-0003-1580-4397; Vágvölgyi, Csaba/0000-0003-0009-7773; Boros, Imre Miklós/0000-0001-8504-9687; Kónya, Zoltán/0000-0002-9406-8596; Pfeiffer, Ilona/0000-0003-0680-7596; Csontné Kiricsi, Mónika/0000-0002-8416-2052} } @article{MTMT:3079142, title = {Silver nanoparticles defeat p53-positive and p53-negative osteosarcoma cells by triggering mitochondrial stress and apoptosis}, url = {https://m2.mtmt.hu/api/publication/3079142}, author = {Kovács, Dávid and Igaz, Nóra and Csilla, Keskeny and Bélteky, Péter and Tímea, Tóth and Molnár-Gáspár, Renáta and Madarász, Dániel and Rázga, Zsolt and Kónya, Zoltán and Boros, Imre Miklós and Csontné Kiricsi, Mónika}, doi = {10.1038/srep27902}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {6}, unique-id = {3079142}, issn = {2045-2322}, year = {2016}, eissn = {2045-2322}, orcid-numbers = {Igaz, Nóra/0000-0003-1580-4397; Molnár-Gáspár, Renáta/0000-0001-9673-4532; Rázga, Zsolt/0000-0003-4717-8482; Kónya, Zoltán/0000-0002-9406-8596; Boros, Imre Miklós/0000-0001-8504-9687; Csontné Kiricsi, Mónika/0000-0002-8416-2052} }