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Various levels of circulating exosomal total-miRNA and miR-210 hypoxamiR in different forms of pregnancy hypertension
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Introduction: Hypertension is a common complication during pregnancy, affecting 10% of pregnant women worldwide. Several microRNA (miRNA) were shown to be involved in hypertensive disorders of pregnancy. In preeclampsia (PE), placental dysfunction causes the enhanced release of extracellular vesicle-derived miRNAs. The hypoxia-sensitive hsa-mir-210 is the most common PE-associated miRNA, but its exosomal profile has not been investigated. Objectives: Our aims were to measure exosomal total-miRNA concentration and to perform expression analysis of circulating exosomal hsa-miR-210 in women affected by chronic hypertension (CHT) gestational hypertension (GHT) or PE. Materials and methods: We collected plasma samples from women with CHT, GHT, PE (moderate: mPE and severe: sPE) and from normotensive pregnancies. Exosomal miRNAs were extracted and miRNA concentration was measured. RT-PCR was carried out with hsa-miR-210-3p-specific primers and relative expression was calculated using the comparative Ct method. Results: The total-miRNA concentration was different in the disease subgroups, and was significantly higher in mPE and sPE compared to the other groups. We found a significant difference in the relative exosomal hsa-miR-210-3p expression between all hypertensive groups compared to the normotensive samples, but significant upregulation was only observed in case of mPE and sPE patients. Both the level of total-miRNA and hsa-miR-210 expression was higher in case of severe PE. Conclusions: The level of circulating exosomal total-miRNA and hsa-miR-210 was elevated in women with PE, and it was higher in the severe form. We showed that hsa-miR-210 is secreted via exosomes, which may have a role in the pathomechanism of the disease. © 2017 International Society for the Study of Hypertension in Pregnancy.
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(Molvarec Attila (Szülészet-nőgyógyászat...); 2017.10.01. 19:41:39)
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10051790"> <a href="/gui2/?type=authors&mode=browse&sel=10051790" target="_blank">Biró, O ✉</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10044797"> <a href="/gui2/?type=authors&mode=browse&sel=10044797" target="_blank">Alasztics, B</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10003519"> <a href="/gui2/?type=authors&mode=browse&sel=10003519" target="_blank">Molvarec, A</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10013560"> <a href="/gui2/?type=authors&mode=browse&sel=10013560" target="_blank">Joó, J</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10002497"> <a href="/gui2/?type=authors&mode=browse&sel=10002497" target="_blank">Nagy, B</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10003345"> <a href="/gui2/?type=authors&mode=browse&sel=10003345" target="_blank">Rigó, J</a> </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;3273020" mtid="3273020" target="_blank">Various levels of circulating exosomal total-miRNA and miR-210 hypoxamiR in different forms of pregnancy hypertension</a></div> <div class="pub-info"> <span class="journal-title">PREGNANCY HYPERTENSION</span> <span class="journal-volume">10</span> <span class="page"> pp. 207-212. , 6 p. </span> <span class="year">(2017)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.preghy.2017.09.002" target="_blank" href="https://doi.org/10.1016/j.preghy.2017.09.002"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000415611600038" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000415611600038"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="246006" target="_blank" href="http://hdl.handle.net/2437/246006"> DEA </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85029222570" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85029222570"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="29153681" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=29153681&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:3273020 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 70</span> | Független: 67 | Függő: 3 | Nem jelölt: 0 | WoS jelölt: 58 | Scopus jelölt: 58 | WoS/Scopus jelölt: 60 | DOI jelölt: 62 </div> </div> </div> </div><div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10051790"><a href="/gui2/?type=authors&mode=browse&sel=10051790" target="_blank">Biró O ✉ (<span class="authorship-author-name">Biró Orsolya</span> <span class="authorAux-mtmt"> Folyadékbiopszia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/I. Sz. Szülészeti és Nőgyógyászati Klinika</span> ; <span class="author-name" mtid="10044797"><a href="/gui2/?type=authors&mode=browse&sel=10044797" target="_blank">Alasztics B (<span class="authorship-author-name">Alasztics Bálint</span> <span class="authorAux-mtmt"> szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/I. Sz. Szülészeti és Nőgyógyászati Klinika</span> ; <span class="author-name" mtid="10003519"><a href="/gui2/?type=authors&mode=browse&sel=10003519" target="_blank">Molvarec A (<span class="authorship-author-name">Molvarec Attila</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/I. Sz. Szülészeti és Nőgyógyászati Klinika</span> ; <span class="author-name" mtid="10013560"><a href="/gui2/?type=authors&mode=browse&sel=10013560" target="_blank">Joó J (<span class="authorship-author-name">Joó József Gábor</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat, klinikai genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/I. Sz. Szülészeti és Nőgyógyászati Klinika</span> ; <span class="author-name" mtid="10002497"><a href="/gui2/?type=authors&mode=browse&sel=10002497" target="_blank">Nagy B (<span class="authorship-author-name">Nagy Bálint</span> <span class="authorAux-mtmt"> Molekuláris genetika</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Humángenetikai Tanszék</span> ; <span class="author-name" mtid="10003345"><a href="/gui2/?type=authors&mode=browse&sel=10003345" target="_blank">Rigó J (<span class="authorship-author-name">Rigó János</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/I. Sz. Szülészeti és Nőgyógyászati Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse¶ms=publication;3273020" target="_blank">Various levels of circulating exosomal total-miRNA and miR-210 hypoxamiR in different forms of pregnancy hypertension</a></div> <div> <span class="journal-title">PREGNANCY HYPERTENSION</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2210-7789">2210-7789</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2210-7797">2210-7797</a>)</span>: <span class="journal-volume">10</span> <span class="page"> pp 207-212 </span> <span class="year">(2017)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.preghy.2017.09.002" target="_blank" href="https://doi.org/10.1016/j.preghy.2017.09.002"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000415611600038" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000415611600038"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="246006" target="_blank" href="http://hdl.handle.net/2437/246006"> DEA </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85029222570" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85029222570"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="29153681" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=29153681&dopt=Abstract"> PubMed </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 70</span> | Független: 67 | Függő: 3 | Nem jelölt: 0 | WoS jelölt: 58 | Scopus jelölt: 58 | WoS/Scopus jelölt: 60 | DOI jelölt: 62 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3273020&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 3273020</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 3273020</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="lastModified">Utolsó módosítás: 2020.01.24. 12:19 DE API (DE_API_5, admin) </div> </div></div>