TY - JOUR AU - Mondello, S AU - Sorinola, Abayomi Akinrinsola AU - Czeiter, Endre AU - Vámos, Zoltán AU - Amrein, Krisztina AU - Synnot, A AU - Donoghue, EL AU - Sándor, János AU - Wang, KKW AU - Diaz-Arrastia, R AU - Steyerberg, EW AU - Menon, D AU - Maas, A AU - Büki, András TI - Blood-Based Protein Biomarkers for the Management of Traumatic Brain Injuries in Adults Presenting with Mild Head Injury to Emergency Departments : A Living Systematic Review and Meta-Analysis JF - JOURNAL OF NEUROTRAUMA J2 - J NEUROTRAUM VL - 38 PY - 2021 IS - 8 SP - 1086 EP - 1106 PG - 21 SN - 0897-7151 DO - 10.1089/neu.2017.5182 UR - https://m2.mtmt.hu/api/publication/3280066 ID - 3280066 N1 - Funding Agency and Grant Number: European Union FP 7th Framework program (CENTER-TBI) [602150]; Hungarian Brain Research Program [KTIA 13 NAP-A-II/8] Funding text: This work was supported by the European Union FP 7th Framework program (CENTER-TBI; Grant number: grant 602150) and the Hungarian Brain Research Program (Grant No. KTIA 13 NAP-A-II/8). We thank Dr. Ornella Clavisi for assistance with the search strategy. AB - Accurate diagnosis of traumatic brain injury (TBI) is critical to effective management and intervention, but can be challenging in patients with mild TBI. A substantial number of studies have reported the use of circulating biomarkers as signatures for TBI, capable of improving diagnostic accuracy and clinical decision-making beyond current practice standards. We performed a systematic review and meta-analysis to comprehensively and critically evaluate the existing body of evidence for the use of blood protein biomarkers (S100B, GFAP, NSE, UCH-L1, Tau and Neurofilament proteins) for diagnosis of intracranial lesions on CT following mild TBI. Effects of potential confounding factors and differential diagnostic performance of the included markers were explored. Furthermore, appropriateness of study design, analysis, quality and demonstration of clinical utility were assessed. Studies published up to October 2016 were identified through a MEDLINE, EMBASE and CINHAL search. Following screening of the identified articles, 26 were selected as relevant. We found that measurement of S100B can help informed decision making in the emergency department possibly reducing resource use, but there is insufficient evidence that any of the other markers is ready for clinical application. Our work pointed out serious problems in the design, analysis and reporting of many of the studies and identi fi ed a substantial heterogeneity and research gaps. These findings emphasize the importance of methodologically rigorous studies focused on a biomarker's intended use and defining standardized, validated and reproducible approaches. The living nature of this systematic review, which will summarize key updated information as it becomes available, can inform and guide future implementation of biomarkers in the clinical arena. LA - English DB - MTMT ER - TY - JOUR AU - Synnot, A AU - Gruen, RL AU - Menon, D AU - Steyerberg, EW AU - Büki, András AU - Peul, W AU - Elliott, JH AU - Maas, A TI - A new approach to evidence synthesis in traumatic brain injury : A Living Systematic Review JF - JOURNAL OF NEUROTRAUMA J2 - J NEUROTRAUM VL - 38 PY - 2021 IS - 8 SP - 1069 EP - 1071 PG - 3 SN - 0897-7151 DO - 10.1089/neu.2015.4124 UR - https://m2.mtmt.hu/api/publication/30413739 ID - 30413739 N1 - Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia Central Clinical School, Monash University, Melbourne, Australia Department of Infectious Diseases and Australasian Cochrane Centre, Monash University, Melbourne, Australia Cochrane Consumers and Communication Review Group, Centre for Health Communication and Participation, La Trobe University, Melbourne, Australia Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore University of Cambridge, Cambridge, United Kingdom Department of Public Health, Erasmus University Medical Center, Rotterdam, Netherlands Department of Neurosurgery, University of Pécs and Clinical Neuroscience Image Center of Hungarian Academy of Sciences, Pécs, Hungary Department of Neurosurgery, Leiden University Medical Centre and Medical Centre the Hague, Hague and Leiden, Netherlands Department of Neurosurgery, University Hospital Antwerp and University of Antwerp, Antwerp, Belgium National Trauma Research Institute, Alfred Hospital, Melbourne, Australia Cited By :6 Export Date: 1 February 2024 CODEN: JNEUE Correspondence Address: Synnot, A.; Department of Epidemiology and Preventive Medicine, Australia; email: Anneliese.synnot@monash.edu AB - Living systematic reviews (LSRs) are online summaries of health care research that are updated as new research becomes available. This new development in evidence synthesis is being trialled as part of the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) project. We will develop and sustain an international TBI knowledge community that maintains up to date, high quality LSRs of the current state of knowledge in the most important questions in TBI. Automatic search updates will be run three-monthly, and newly identified studies incorporated into the review. Review teams will seek to publish journal updates at regular intervals with abridged updates available more frequently online. Future project stages include the integration of LSR and other study findings into 'living' clinical practice guidance. It is hoped these efforts will go some way to bridging current temporal disconnects between evidence, guidelines and practice in TBI. LA - English DB - MTMT ER - TY - JOUR AU - Maas, AIR AU - Menon, DK AU - Adelson, PD AU - Andelic, N AU - Bell, MJ AU - Belli, A AU - Bragge, P AU - Brazinova, A AU - Büki, András AU - Chesnut, RM AU - Citerio, G AU - Coburn, M AU - Cooper, DJ AU - Crowder, AT AU - Czeiter, Endre AU - Czosnyka, M AU - Diaz-Arrastia, R AU - Dreier, JP AU - Duhaime, AC AU - Ercole, A AU - van Essen, TA AU - Feigin, VL AU - Gao, G AU - Giacino, J AU - Gonzalez-Lara, LE AU - Gruen, RL AU - Gupta, D AU - Hartings, JA AU - Hill, S AU - Jiang, JY AU - Ketharanathan, N AU - Kompanje, EJO AU - Lanyon, L AU - Laureys, S AU - Lecky, F AU - Levin, H AU - Lingsma, HF AU - Maegele, M AU - Majdan, M AU - Manley, G AU - Marsteller, J AU - Mascia, L AU - McFadyen, C AU - Mondello, S AU - Newcombe, V AU - Palotie, A AU - Parizel, PM AU - Peul, W AU - Piercy, J AU - Polinder, S AU - Puybasset, L AU - Rasmussen, TE AU - Rossaint, R AU - Smielewski, P AU - Soderberg, J AU - Stanworth, SJ AU - Stein, MB AU - von Steinbuchel, N AU - Stewart, W AU - Steyerberg, EW AU - Stocchetti, N AU - Synnot, A AU - Te, Ao B AU - Tenovuo, O AU - Theadom, A AU - Tibboel, D AU - Videtta, W AU - Wang, KKW AU - Williams, WH AU - Wilson, L AU - Yaffe, K ED - Adams, H / Collaborator ED - Agnoletti, V / Collaborator ED - Allanson, J / Collaborator ED - Amrein, K / Collaborator ED - Andaluz, N / Collaborator ED - Anke, A / Collaborator ED - Antoni, A / Collaborator ED - van As, AB / Collaborator ED - Audibert, G / Collaborator ED - Azaševac, A / Collaborator ED - Azouvi, P / Collaborator ED - Azzolini, ML / Collaborator ED - Baciu, C / Collaborator ED - Badenes, R / Collaborator ED - Barlow, KM / Collaborator ED - Bartels, R / Collaborator ED - Bauerfeind, U / Collaborator ED - Beauchamp, M / Collaborator ED - Beer, D / Collaborator ED - Beer, R / Collaborator ED - Belda, FJ / Collaborator ED - Bellander, BM / Collaborator ED - Bellier, R / Collaborator ED - Benali, H / Collaborator ED - Benard, T / Collaborator ED - Beqiri, V / Collaborator ED - Beretta, L / Collaborator ED - Bernard, F / Collaborator ED - Bertolini, G / Collaborator ED - Bilotta, F / Collaborator ED - Blaabjerg, M / Collaborator ED - den Boogert, H / Collaborator ED - Boutis, K / Collaborator ED - Bouzat, P / Collaborator ED - Brooks, B / Collaborator ED - Brorsson, C / Collaborator ED - Bullinger, M / Collaborator ED - Burns, E / Collaborator ED - Calappi, E / Collaborator ED - Cameron, P / Collaborator ED - Carise, E / Collaborator ED - Castaño-León, AM / Collaborator ED - Causin, F / Collaborator ED - Chevallard, G / Collaborator ED - Chieregato, A / Collaborator ED - Christie, B / Collaborator ED - Cnossen, M / Collaborator ED - Coles, J / Collaborator ED - Collett, J / Collaborator ED - Della Corte, F / Collaborator ED - Craig, W / Collaborator ED - Csato, G / Collaborator ED - Csomós, Ákos / Collaborator ED - Curry, N / Collaborator ED - Dahyot-Fizelier, C / Collaborator ED - Dawes, H / Collaborator ED - DeMatteo, C / Collaborator ED - Depreitere, B / Collaborator ED - Dewey, D / Collaborator ED - van Dijck, J / Collaborator ED - Đilvesi, Đ / Collaborator ED - Dippel, D / Collaborator ED - Dizdarevic, K / Collaborator ED - Donoghue, E / Collaborator ED - Duek, O / Collaborator ED - Dulière, GL / Collaborator ED - Dzeko, A / Collaborator ED - Eapen, G / Collaborator ED - Emery, CA / Collaborator ED - English, S / Collaborator ED - Esser, P / Collaborator ED - Ezer, E / Collaborator ED - Fabricius, M / Collaborator ED - Feng, J / Collaborator ED - Fergusson, D / Collaborator ED - Figaji, A / Collaborator ED - Fleming, J / Collaborator ED - Foks, K / Collaborator ED - Francony, G / Collaborator ED - Freedman, S / Collaborator ED - Freo, U / Collaborator ED - Frisvold, SK / Collaborator ED - Gagnon, I / Collaborator ED - Galanaud, D / Collaborator ED - Gantner, D / Collaborator ED - Giraud, B / Collaborator ED - Glocker, B / Collaborator ED - Golubovic, J / Collaborator ED - Gómez, López PA / Collaborator ED - Gordon, WA / Collaborator ED - Gradisek, P / Collaborator ED - Gravel, J / Collaborator ED - Griesdale, D / Collaborator ED - Grossi, F / Collaborator ED - Haagsma, JA / Collaborator ED - Håberg, AK / Collaborator ED - Haitsma, I / Collaborator ED - Van, Hecke W / Collaborator ED - Helbok, R / Collaborator ED - Helseth, E / Collaborator ED - van Heugten, C / Collaborator ED - Hoedemaekers, C / Collaborator ED - Höfer, S / Collaborator ED - Horton, L / Collaborator ED - Hui, J / Collaborator ED - Huijben, JA / Collaborator ED - Hutchinson, PJ / Collaborator ED - Jacobs, B / Collaborator ED - van der Jagt, M / Collaborator ED - Jankowski, S / Collaborator ED - Janssens, K / Collaborator ED - Jelaca, B / Collaborator ED - Jones, KM / Collaborator ED - Kamnitsas, K / Collaborator ED - Kaps, R / Collaborator ED - Karan, M / Collaborator ED - Katila, A / Collaborator ED - Kaukonen, KM / Collaborator ED - De Keyser, V / Collaborator ED - Kivisaari, R / Collaborator ED - Kolias, AG / Collaborator ED - Kolumbán, B / Collaborator ED - Kolundžija, K / Collaborator ED - Kondziella, D / Collaborator ED - Koskinen, LO / Collaborator ED - Kovács, N / Collaborator ED - Kramer, A / Collaborator ED - Kutsogiannis, D / Collaborator ED - Kyprianou, T / Collaborator ED - Lagares, A / Collaborator ED - Lamontagne, F / Collaborator ED - Latini, R / Collaborator ED - Lauzier, F / Collaborator ED - Lazar, I / Collaborator ED - Ledig, C / Collaborator ED - Lefering, R / Collaborator ED - Legrand, V / Collaborator ED - Levi, L / Collaborator ED - Lightfoot, R / Collaborator ED - Lozano, A / Collaborator ED - MacDonald, S / Collaborator ED - Major, S / Collaborator ED - Manara, A / Collaborator ED - Manhes, P / Collaborator ED - Maréchal, H / Collaborator ED - Martino, C / Collaborator ED - Masala, A / Collaborator ED - Masson, S / Collaborator ED - Mattern, J / Collaborator ED - McFadyen, B / Collaborator ED - McMahon, C / Collaborator ED - Meade, M / Collaborator ED - Melegh, Béla / Collaborator ED - Menovsky, T / Collaborator ED - Moore, L / Collaborator ED - Morgado, Correia M / Collaborator ED - Morganti-Kossmann, MC / Collaborator ED - Muehlan, H / Collaborator ED - Mukherjee, P / Collaborator ED - Murray, L / Collaborator ED - van der Naalt, J / Collaborator ED - Negru, A / Collaborator ED - Nelson, D / Collaborator ED - Nieboer, D / Collaborator ED - Noirhomme, Q / Collaborator ED - Nyirádi, J / Collaborator ED - Oddo, M / Collaborator ED - Okonkwo, DO / Collaborator ED - Oldenbeuving, AW / Collaborator ED - Ortolano, F / Collaborator ED - Osmond, M / Collaborator ED - Payen, JF / Collaborator ED - Perlbarg, V / Collaborator ED - Persona, P / Collaborator ED - Pichon, N / Collaborator ED - Piippo-Karjalainen, A / Collaborator ED - Pili-Floury, S / Collaborator ED - Pirinen, M / Collaborator ED - Ple, H / Collaborator ED - Poca, MA / Collaborator ED - Posti, J / Collaborator ED - Van, Praag D / Collaborator ED - Ptito, A / Collaborator ED - Radoi, A / Collaborator ED - Ragauskas, A / Collaborator ED - Raj, R / Collaborator ED - Real, RGL / Collaborator ED - Reed, N / Collaborator ED - Rhodes, J / Collaborator ED - Robertson, C / Collaborator ED - Rocka, S / Collaborator ED - Røe, C / Collaborator ED - Røise, O / Collaborator ED - Roks, G / Collaborator ED - Rosand, J / Collaborator ED - Rosenfeld, JV / Collaborator ED - Rosenlund, C / Collaborator ED - Rosenthal, G / Collaborator ED - Rossi, S / Collaborator ED - Rueckert, D / Collaborator ED - de Ruiter, GCW / Collaborator ED - Sacchi, M / Collaborator ED - Sahakian, BJ / Collaborator ED - Sahuquillo, J / Collaborator ED - Sakowitz, O / Collaborator ED - Salvato, G / Collaborator ED - Sánchez-Porras, R / Collaborator ED - Sándor, János / Collaborator ED - Sangha, G / Collaborator ED - Schäfer, N / Collaborator ED - Schmidt, S / Collaborator ED - Schneider, KJ / Collaborator ED - Schnyer, D / Collaborator ED - Schöhl, H / Collaborator ED - Schoonman, GG / Collaborator ED - Schou, RF / Collaborator ED - Sir, Ö / Collaborator ED - Skandsen, T / Collaborator ED - Smeets, D / Collaborator ED - Sorinola, A / Collaborator ED - Stamatakis, E / Collaborator ED - Stevanovic, A / Collaborator ED - Stevens, RD / Collaborator ED - Sundström, N / Collaborator ED - Taccone, FS / Collaborator ED - Takala, R / Collaborator ED - Tanskanen, P / Collaborator ED - Taylor, MS / Collaborator ED - Telgmann, R / Collaborator ED - Temkin, N / Collaborator ED - Teodorani, G / Collaborator ED - Thomas, M / Collaborator ED - Tolias, CM / Collaborator ED - Trapani, T / Collaborator ED - Turgeon, A / Collaborator ED - Vajkoczy, P / Collaborator ED - Valadka, AB / Collaborator ED - Valeinis, E / Collaborator ED - Vallance, S / Collaborator ED - Vámos, Z / Collaborator ED - Vargiolu, A / Collaborator ED - Vega, E / Collaborator ED - Verheyden, J / Collaborator ED - Vik, A / Collaborator ED - Vilcinis, R / Collaborator ED - Vleggeert-Lankamp, C / Collaborator ED - Vogt, L / Collaborator ED - Volovici, V / Collaborator ED - Voormolen, DC / Collaborator ED - Vulekovic, P / Collaborator ED - Vande, Vyvere T / Collaborator ED - Van, Waesberghe J / Collaborator ED - Wessels, L / Collaborator ED - Wildschut, E / Collaborator ED - Williams, G / Collaborator ED - Winkler, MKL / Collaborator ED - Wolf, S / Collaborator ED - Wood, G / Collaborator ED - Xirouchaki, N / Collaborator ED - Younsi, A / Collaborator ED - Zaaroor, M / Collaborator ED - Zelinkova, V / Collaborator ED - Zemek, R / Collaborator ED - Zumbo, F / Collaborator TI - Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research. JF - LANCET NEUROLOGY J2 - LANCET NEUROL VL - 16 PY - 2017 IS - 12 SP - 987 EP - 1048 PG - 62 SN - 1474-4422 DO - 10.1016/S1474-4422(17)30371-X UR - https://m2.mtmt.hu/api/publication/3297422 ID - 3297422 N1 - CN: InTBIR Participants and Investigators AB - Executive summary A concerted effort to tackle the global health problem posed by traumatic brain injury (TBI) is long overdue. TBI is a public health challenge of vast, but insufficiently recognised, proportions. Worldwide, more than 50 million people have a TBI each year, and it is estimated that about half the world’s population will have one or more TBIs over their lifetime. TBI is the leading cause of mortality in young adults and a major cause of death and disability across all ages in all countries, with a disproportionate burden of disability and death occurring in low-income and middle-income countries (LMICs). It has been estimated that TBI costs the global economy approximately $US400 billion annually. Deficiencies in prevention, care, and research urgently need to be addressed to reduce the huge burden and societal costs of TBI. This Commission highlights priorities and provides expert recommendations for all stakeholders—policy makers, funders, health-care professionals, researchers, and patient representatives—on clinical and research strategies to reduce this growing public health problem and improve the lives of people with TBI. LA - English DB - MTMT ER - TY - JOUR AU - Thelin, EP AU - Zeiler, FA AU - Ercole, A AU - Mondello, S AU - Büki, András AU - Bellander, BM AU - Helmy, A AU - Menon, DK AU - Nelson, DW TI - Serial Sampling of Serum Protein Biomarkers for Monitoring Human Traumatic Brain injury Dynamics: A Systematic Review JF - FRONTIERS IN NEUROLOGY J2 - FRONT NEUR VL - 8 PY - 2017 PG - 23 SN - 1664-2295 DO - 10.3389/fneur.2017.00300 UR - https://m2.mtmt.hu/api/publication/3248575 ID - 3248575 N1 - Funding Agency and Grant Number: Swedish Society of Medicine [SLS-587221]; Cambridge Commonwealth Trust Scholarship; Royal College of Surgeons of Canada-Harry S. Morton Travelling Fellowship in Surgery; University of Manitoba Clinician Investigator Program, R. Samuel McLaughlin Research and Education Award; Manitoba Medical Service Foundation; University of Manitoba Faculty of Medicine Dean's Fellowship Fund; Hungarian Brain Research Program [KTIA_13_NAP-A-II/8]; National Institute for Healthcare Research (NIHR, UK) through the Acute Brain Injury and Repair theme of the Cambridge NIHR Biomedical Research Centre, an NIHR Senior Investigator Award; European Union Framework Program 7 grant [602150]; Medical Research Council; Cambridge Biomedical Research Centre; Royal College of Surgeons of England; National Institute for Health Research [NF-SI-0512-10090] Funding Source: researchfish Funding text: The following funding should be acknowledged: ET: Swedish Society of Medicine (Grant no. SLS-587221). FZ: Cambridge Commonwealth Trust Scholarship, the Royal College of Surgeons of Canada-Harry S. Morton Travelling Fellowship in Surgery, the University of Manitoba Clinician Investigator Program, R. Samuel McLaughlin Research and Education Award, the Manitoba Medical Service Foundation, and the University of Manitoba Faculty of Medicine Dean's Fellowship Fund. AB: Hungarian Brain Research Program-Grant No. KTIA_13_NAP-A-II/8. DM: National Institute for Healthcare Research (NIHR, UK) through the Acute Brain Injury and Repair theme of the Cambridge NIHR Biomedical Research Centre, an NIHR Senior Investigator Award to DM. The authors were also supported by a European Union Framework Program 7 grant (CENTER-TBI; Grant Agreement No. 602150). AH: Medical Research Council, Cambridge Biomedical Research Centre, Royal College of Surgeons of England. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. LA - English DB - MTMT ER - TY - JOUR AU - Tosetti, P AU - Hicks, RR AU - Theriault, E AU - Phillips, A AU - Koroshetz, W AU - Draghia-Akli, R ED - Büki, András / Collaborator TI - Toward an international initiative for traumatic brain injury research. JF - JOURNAL OF NEUROTRAUMA J2 - J NEUROTRAUM VL - 30 PY - 2013 IS - 14 SP - 1211 EP - 1222 PG - 12 SN - 0897-7151 DO - 10.1089/neu.2013.2896 UR - https://m2.mtmt.hu/api/publication/2424624 ID - 2424624 N1 - Funding Agency and Grant Number: National Institute for Health Research [NF-SI-0512-10090] Funding Source: researchfish AB - The European Commission (EC) and the National Institutes of Health (NIH) jointly sponsored a workshop on October 18-20, 2011 in Brussels to discuss the feasibility and benefits of an international collaboration in the field of traumatic brain injury (TBI) research. The workshop brought together scientists, clinicians, patients, and industry representatives from around the globe as well as funding agencies from the EU, Spain, the United States, and Canada. Sessions tackled both the possible goals and governance of a future initiative and the scientific questions that would most benefit from an integrated international effort: how to optimize data collection and sharing; injury classification; outcome measures; clinical study design; and statistical analysis. There was a clear consensus that increased dialogue and coordination of research at an international level would be beneficial for advancing TBI research, treatment, and care. To this end, the EC, the NIH, and the Canadian Institutes of Health Research expressed interest in developing a framework for an international initiative for TBI Research (InTBIR). The workshop participants recommended that InTBIR initially focus on collecting, standardizing, and sharing clinical TBI data for comparative effectiveness research, which will ultimately result in better management and treatments for TBI. LA - English DB - MTMT ER - TY - JOUR AU - Mondello, S AU - Jeromin, A AU - Büki, András AU - Bullock, R AU - Czeiter, Endre AU - Kovács, Noémi AU - Barzó, Pál AU - Schmid, K AU - Tortella, FC AU - Wang, KK AU - Hayes, RL TI - Glial Neuronal Ratio (GNR): a Novel Index for Differentiating Injury Type in Patients with Severe Traumatic Brain Injury JF - JOURNAL OF NEUROTRAUMA J2 - J NEUROTRAUM VL - 29 PY - 2012 IS - 6 SP - 1096 EP - 1104 PG - 9 SN - 0897-7151 DO - 10.1089/neu.2011.2092 UR - https://m2.mtmt.hu/api/publication/1875152 ID - 1875152 N1 - Department of Anesthesiology, University of Florida, Center of Innovative Research, 12085 Research Drive, Alachua, FL 32615, United States Banyan Biomarkers, Inc., Alachua, FL, United States Department of Neurosurgery, University of Pecs, Pecs, Hungary Department of Neurosurgery, University of Miami, Miami, FL, United States Department of Neurosurgery, University of Szeged, Szeged, Hungary Department of Applied Neurobiology, Division of Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD, United States Center of Innovative Research, Diagnostic Research and Development Department, Banyan Biomarkers, Inc., Alachua, FL, United States Department of Clinical Programs, Center of Innovative Research, Banyan Biomarkers, Inc., Alachua, FL, United States Cited By :107 Export Date: 1 February 2024 CODEN: JNEUE Correspondence Address: Mondello, S.; Department of Anesthesiology, 12085 Research Drive, Alachua, FL 32615, United States; email: smondello@banyanbio.com AB - Neurobiochemical marker levels in blood after traumatic brain injury (TBI) may reflect structural changes detected by neuroimaging. This study evaluates whether correlations between neuronal (Ubiquitin carboxy-terminal hydrolase L1 [UCH-L1]) and glial (glial fibrillary acidic protein [GFAP]) biomarkers may be used as an indicator of differing intracranial pathologies after brain trauma. In 59 patients with severe TBI (Glasgow Coma Scale score [GCS] LA - English DB - MTMT ER - TY - JOUR AU - Mondello, S AU - Papa, L AU - Büki, András AU - Bullock, MR AU - Czeiter, Endre AU - Tortella, FC AU - Wang, KK AU - Hayes, RL TI - Neuronal and glial markers are differently associated with computed tomography findings and outcome in patients with severe traumatic brain injury: a case control study. JF - CRITICAL CARE J2 - CRIT CARE VL - 15 PY - 2011 IS - 3 SN - 1364-8535 DO - 10.1186/cc10286 UR - https://m2.mtmt.hu/api/publication/1729332 ID - 1729332 N1 - Export Date: 27 January 2024; CODEN: CRCAF LA - English DB - MTMT ER -