@article{MTMT:3280066, title = {Blood-Based Protein Biomarkers for the Management of Traumatic Brain Injuries in Adults Presenting with Mild Head Injury to Emergency Departments : A Living Systematic Review and Meta-Analysis}, url = {https://m2.mtmt.hu/api/publication/3280066}, author = {Mondello, S and Sorinola, Abayomi Akinrinsola and Czeiter, Endre and Vámos, Zoltán and Amrein, Krisztina and Synnot, A and Donoghue, EL and Sándor, János and Wang, KKW and Diaz-Arrastia, R and Steyerberg, EW and Menon, D and Maas, A and Büki, András}, doi = {10.1089/neu.2017.5182}, journal-iso = {J NEUROTRAUM}, journal = {JOURNAL OF NEUROTRAUMA}, volume = {38}, unique-id = {3280066}, issn = {0897-7151}, abstract = {Accurate diagnosis of traumatic brain injury (TBI) is critical to effective management and intervention, but can be challenging in patients with mild TBI. A substantial number of studies have reported the use of circulating biomarkers as signatures for TBI, capable of improving diagnostic accuracy and clinical decision-making beyond current practice standards. We performed a systematic review and meta-analysis to comprehensively and critically evaluate the existing body of evidence for the use of blood protein biomarkers (S100B, GFAP, NSE, UCH-L1, Tau and Neurofilament proteins) for diagnosis of intracranial lesions on CT following mild TBI. Effects of potential confounding factors and differential diagnostic performance of the included markers were explored. Furthermore, appropriateness of study design, analysis, quality and demonstration of clinical utility were assessed. Studies published up to October 2016 were identified through a MEDLINE, EMBASE and CINHAL search. Following screening of the identified articles, 26 were selected as relevant. We found that measurement of S100B can help informed decision making in the emergency department possibly reducing resource use, but there is insufficient evidence that any of the other markers is ready for clinical application. Our work pointed out serious problems in the design, analysis and reporting of many of the studies and identi fi ed a substantial heterogeneity and research gaps. These findings emphasize the importance of methodologically rigorous studies focused on a biomarker's intended use and defining standardized, validated and reproducible approaches. The living nature of this systematic review, which will summarize key updated information as it becomes available, can inform and guide future implementation of biomarkers in the clinical arena.}, keywords = {Biomarkers; diagnosis; Meta-analysis; TBI; living systematic review}, year = {2021}, eissn = {1557-9042}, pages = {1086-1106}, orcid-numbers = {Czeiter, Endre/0000-0002-9578-6944} } @article{MTMT:30413739, title = {A new approach to evidence synthesis in traumatic brain injury : A Living Systematic Review}, url = {https://m2.mtmt.hu/api/publication/30413739}, author = {Synnot, A and Gruen, RL and Menon, D and Steyerberg, EW and Büki, András and Peul, W and Elliott, JH and Maas, A}, doi = {10.1089/neu.2015.4124}, journal-iso = {J NEUROTRAUM}, journal = {JOURNAL OF NEUROTRAUMA}, volume = {38}, unique-id = {30413739}, issn = {0897-7151}, abstract = {Living systematic reviews (LSRs) are online summaries of health care research that are updated as new research becomes available. This new development in evidence synthesis is being trialled as part of the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) project. We will develop and sustain an international TBI knowledge community that maintains up to date, high quality LSRs of the current state of knowledge in the most important questions in TBI. Automatic search updates will be run three-monthly, and newly identified studies incorporated into the review. Review teams will seek to publish journal updates at regular intervals with abridged updates available more frequently online. Future project stages include the integration of LSR and other study findings into 'living' clinical practice guidance. It is hoped these efforts will go some way to bridging current temporal disconnects between evidence, guidelines and practice in TBI.}, year = {2021}, eissn = {1557-9042}, pages = {1069-1071} } @article{MTMT:3297422, title = {Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research.}, url = {https://m2.mtmt.hu/api/publication/3297422}, author = {Maas, AIR and Menon, DK and Adelson, PD and Andelic, N and Bell, MJ and Belli, A and Bragge, P and Brazinova, A and Büki, András and Chesnut, RM and Citerio, G and Coburn, M and Cooper, DJ and Crowder, AT and Czeiter, Endre and Czosnyka, M and Diaz-Arrastia, R and Dreier, JP and Duhaime, AC and Ercole, A and van Essen, TA and Feigin, VL and Gao, G and Giacino, J and Gonzalez-Lara, LE and Gruen, RL and Gupta, D and Hartings, JA and Hill, S and Jiang, JY and Ketharanathan, N and Kompanje, EJO and Lanyon, L and Laureys, S and Lecky, F and Levin, H and Lingsma, HF and Maegele, M and Majdan, M and Manley, G and Marsteller, J and Mascia, L and McFadyen, C and Mondello, S and Newcombe, V and Palotie, A and Parizel, PM and Peul, W and Piercy, J and Polinder, S and Puybasset, L and Rasmussen, TE and Rossaint, R and Smielewski, P and Soderberg, J and Stanworth, SJ and Stein, MB and von Steinbuchel, N and Stewart, W and Steyerberg, EW and Stocchetti, N and Synnot, A and Te, Ao B and Tenovuo, O and Theadom, A and Tibboel, D and Videtta, W and Wang, KKW and Williams, WH and Wilson, L and Yaffe, K}, doi = {10.1016/S1474-4422(17)30371-X}, journal-iso = {LANCET NEUROL}, journal = {LANCET NEUROLOGY}, volume = {16}, unique-id = {3297422}, issn = {1474-4422}, abstract = {Executive summary A concerted effort to tackle the global health problem posed by traumatic brain injury (TBI) is long overdue. TBI is a public health challenge of vast, but insufficiently recognised, proportions. Worldwide, more than 50 million people have a TBI each year, and it is estimated that about half the world’s population will have one or more TBIs over their lifetime. TBI is the leading cause of mortality in young adults and a major cause of death and disability across all ages in all countries, with a disproportionate burden of disability and death occurring in low-income and middle-income countries (LMICs). It has been estimated that TBI costs the global economy approximately $US400 billion annually. Deficiencies in prevention, care, and research urgently need to be addressed to reduce the huge burden and societal costs of TBI. This Commission highlights priorities and provides expert recommendations for all stakeholders—policy makers, funders, health-care professionals, researchers, and patient representatives—on clinical and research strategies to reduce this growing public health problem and improve the lives of people with TBI.}, year = {2017}, eissn = {1474-4465}, pages = {987-1048}, orcid-numbers = {Czeiter, Endre/0000-0002-9578-6944} } @article{MTMT:3248575, title = {Serial Sampling of Serum Protein Biomarkers for Monitoring Human Traumatic Brain injury Dynamics: A Systematic Review}, url = {https://m2.mtmt.hu/api/publication/3248575}, author = {Thelin, EP and Zeiler, FA and Ercole, A and Mondello, S and Büki, András and Bellander, BM and Helmy, A and Menon, DK and Nelson, DW}, doi = {10.3389/fneur.2017.00300}, journal-iso = {FRONT NEUR}, journal = {FRONTIERS IN NEUROLOGY}, volume = {8}, unique-id = {3248575}, issn = {1664-2295}, year = {2017}, eissn = {1664-2295} } @article{MTMT:2424624, title = {Toward an international initiative for traumatic brain injury research.}, url = {https://m2.mtmt.hu/api/publication/2424624}, author = {Tosetti, P and Hicks, RR and Theriault, E and Phillips, A and Koroshetz, W and Draghia-Akli, R}, doi = {10.1089/neu.2013.2896}, journal-iso = {J NEUROTRAUM}, journal = {JOURNAL OF NEUROTRAUMA}, volume = {30}, unique-id = {2424624}, issn = {0897-7151}, abstract = {The European Commission (EC) and the National Institutes of Health (NIH) jointly sponsored a workshop on October 18-20, 2011 in Brussels to discuss the feasibility and benefits of an international collaboration in the field of traumatic brain injury (TBI) research. The workshop brought together scientists, clinicians, patients, and industry representatives from around the globe as well as funding agencies from the EU, Spain, the United States, and Canada. Sessions tackled both the possible goals and governance of a future initiative and the scientific questions that would most benefit from an integrated international effort: how to optimize data collection and sharing; injury classification; outcome measures; clinical study design; and statistical analysis. There was a clear consensus that increased dialogue and coordination of research at an international level would be beneficial for advancing TBI research, treatment, and care. To this end, the EC, the NIH, and the Canadian Institutes of Health Research expressed interest in developing a framework for an international initiative for TBI Research (InTBIR). The workshop participants recommended that InTBIR initially focus on collecting, standardizing, and sharing clinical TBI data for comparative effectiveness research, which will ultimately result in better management and treatments for TBI.}, year = {2013}, eissn = {1557-9042}, pages = {1211-1222} } @article{MTMT:1875152, title = {Glial Neuronal Ratio (GNR): a Novel Index for Differentiating Injury Type in Patients with Severe Traumatic Brain Injury}, url = {https://m2.mtmt.hu/api/publication/1875152}, author = {Mondello, S and Jeromin, A and Büki, András and Bullock, R and Czeiter, Endre and Kovács, Noémi and Barzó, Pál and Schmid, K and Tortella, FC and Wang, KK and Hayes, RL}, doi = {10.1089/neu.2011.2092}, journal-iso = {J NEUROTRAUM}, journal = {JOURNAL OF NEUROTRAUMA}, volume = {29}, unique-id = {1875152}, issn = {0897-7151}, abstract = {Neurobiochemical marker levels in blood after traumatic brain injury (TBI) may reflect structural changes detected by neuroimaging. This study evaluates whether correlations between neuronal (Ubiquitin carboxy-terminal hydrolase L1 [UCH-L1]) and glial (glial fibrillary acidic protein [GFAP]) biomarkers may be used as an indicator of differing intracranial pathologies after brain trauma. In 59 patients with severe TBI (Glasgow Coma Scale score [GCS]}, year = {2012}, eissn = {1557-9042}, pages = {1096-1104}, orcid-numbers = {Czeiter, Endre/0000-0002-9578-6944; Barzó, Pál/0000-0001-8717-748X} } @article{MTMT:1729332, title = {Neuronal and glial markers are differently associated with computed tomography findings and outcome in patients with severe traumatic brain injury: a case control study.}, url = {https://m2.mtmt.hu/api/publication/1729332}, author = {Mondello, S and Papa, L and Büki, András and Bullock, MR and Czeiter, Endre and Tortella, FC and Wang, KK and Hayes, RL}, doi = {10.1186/cc10286}, journal-iso = {CRIT CARE}, journal = {CRITICAL CARE}, volume = {15}, unique-id = {1729332}, issn = {1364-8535}, year = {2011}, eissn = {1466-609X}, orcid-numbers = {Czeiter, Endre/0000-0002-9578-6944} }