@article{MTMT:30864881, title = {Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)}, url = {https://m2.mtmt.hu/api/publication/30864881}, author = {Cossarizza, A. and Chang, H.-D. and Radbruch, A. and Acs, A. and Adam, D. and Adam-Klages, S. and Agace, W.W. and Aghaeepour, N. and Akdis, M. and Allez, M. and Almeida, L.N. and Alvisi, G. and Anderson, G. and Andrä, I. and Annunziato, F. and Anselmo, A. and Bacher, P. and Baldari, C.T. and Bari, S. and Barnaba, V. and Barros-Martins, J. and Battistini, L. and Bauer, W. and Baumgart, S. and Baumgarth, N. and Baumjohann, D. and Baying, B. and Bebawy, M. and Becher, B. and Beisker, W. and Benes, V. and Beyaert, R. and Blanco, A. and Boardman, D.A. and Bogdan, C. and Borger, J.G. and Borsellino, G. and Boulais, P.E. and Bradford, J.A. and Brenner, D. and Brinkman, R.R. and Brooks, A.E.S. and Busch, D.H. and Büscher, M. and Bushnell, T.P. and Calzetti, F. and Cameron, G. and Cammarata, I. and Cao, X. and Cardell, S.L. and Casola, S. and Cassatella, M.A. and Cavani, A. and Celada, A. and Chatenoud, L. and Chattopadhyay, P.K. and Chow, S. and Christakou, E. and Čičin-Šain, L. and Clerici, M. and Colombo, F.S. and Cook, L. and Cooke, A. and Cooper, A.M. and Corbett, A.J. and Cosma, A. and Cosmi, L. and Coulie, P.G. and Cumano, A. and Cvetkovic, L. and Dang, V.D. and Dang-Heine, C. and Davey, M.S. and Davies, D. and De, Biasi S. and Del, Zotto G. and Dela, Cruz G.V. and Delacher, M. and Della, Bella S. and Dellabona, P. and Deniz, G. and Dessing, M. and Di, Santo J.P. and Diefenbach, A. and Dieli, F. and Dolf, A. and Dörner, T. and Dress, R.J. and Dudziak, D. and Dustin, M. and Dutertre, C.-A. and Ebner, F. and Eckle, S.B.G. and Edinger, M. and Eede, P. and Ehrhardt, G.R.A. and Eich, M. and Engel, P. and Engelhardt, B. and Erdei, Anna and Esser, C. and Everts, B. and Evrard, M. and Falk, C.S. and Fehniger, T.A. and Felipo-Benavent, M. and Ferry, H. and Feuerer, M. and Filby, A. and Filkor, K. and Fillatreau, S. and Follo, M. and Förster, I. and Foster, J. and Foulds, G.A. and Frehse, B. and Frenette, P.S. and Frischbutter, S. and Fritzsche, W. and Galbraith, D.W. and Gangaev, A. and Garbi, N. and Gaudilliere, B. and Gazzinelli, R.T. and Geginat, J. and Gerner, W. and Gherardin, N.A. and Ghoreschi, K. and Gibellini, L. and Ginhoux, F. and Goda, K. and Godfrey, D.I. and Goettlinger, C. and González-Navajas, J.M. and Goodyear, C.S. and Gori, A. and Grogan, J.L. and Grummitt, D. and Grützkau, A. and Haftmann, C. and Hahn, J. and Hammad, H. and Hämmerling, G. and Hansmann, L. and Hansson, G. and Harpur, C.M. and Hartmann, S. and Hauser, A. and Hauser, A.E. and Haviland, D.L. and Hedley, D. and Hernández, D.C. and Herrera, G. and Herrmann, M. and Hess, C. and Höfer, T. and Hoffmann, P. and Hogquist, K. and Holland, T. and Höllt, T. and Holmdahl, R. and Hombrink, P. and Houston, J.P. and Hoyer, B.F. and Huang, B. and Huang, F.-P. and Huber, J.E. and Huehn, J. and Hundemer, M. and Hunter, C.A. and Hwang, W.Y.K. and Iannone, A. and Ingelfinger, F. and Ivison, S.M. and Jäck, H.-M. and Jani, P.K. and Jávega, B. and Jonjic, S. and Kaiser, T. and Kalina, T. and Kamradt, T. and Kaufmann, S.H.E. and Keller, B. and Ketelaars, S.L.C. and Khalilnezhad, A. and Khan, S. and Kisielow, J. and Klenerman, P. and Knopf, J. and Koay, H.-F. and Kobow, K. and Kolls, J.K. and Kong, W.T. and Kopf, M. and Korn, T. and Kriegsmann, K. and Kristyanto, H. and Kroneis, T. and Krueger, A. and Kühne, J. and Kukat, C. and Kunkel, D. and Kunze-Schumacher, H. and Kurosaki, T. and Kurts, C. and Kvistborg, P. and Kwok, I. and Landry, J. and Lantz, O. and Lanuti, P. and LaRosa, F. and Lehuen, A. and LeibundGut-Landmann, S. and Leipold, M.D. and Leung, L.Y.T. and Levings, M.K. and Lino, A.C. and Liotta, F. and Litwin, V. and Liu, Y. and Ljunggren, H.-G. and Lohoff, M. and Lombardi, G. and Lopez, L. and López-Botet, M. and Lovett-Racke, A.E. and Lubberts, E. and Luche, H. and Ludewig, B. and Lugli, E. and Lunemann, S. and Maecker, H.T. and Maggi, L. and Maguire, O. and Mair, F. and Mair, K.H. and Mantovani, A. and Manz, R.A. and Marshall, A.J. and Martínez-Romero, A. and Martrus, G. and Marventano, I. and Maslinski, W. and Matarese, G. and Mattioli, A.V. and Maueröder, C. and Mazzoni, A. and McCluskey, J. and McGrath, M. and McGuire, H.M. and McInnes, I.B. and Mei, H.E. and Melchers, F. and Melzer, S. and Mielenz, D. and Miller, S.D. and Mills, K.H.G. and Minderman, H. and Mjösberg, J. and Moore, J. and Moran, B. and Moretta, L. and Mosmann, T.R. and Müller, S. and Multhoff, G. and Muñoz, L.E. and Münz, C. and Nakayama, T. and Nasi, M. and Neumann, K. and Ng, L.G. and Niedobitek, A. and Nourshargh, S. and Núñez, G. and O'Connor, J.-E. and Ochel, A. and Oja, A. and Ordonez, D. and Orfao, A. and Orlowski-Oliver, E. and Ouyang, W. and Oxenius, A. and Palankar, R. and Panse, I. and Pattanapanyasat, K. and Paulsen, M. and Pavlinic, D. and Penter, L. and Peterson, P. and Peth, C. and Petriz, J. and Piancone, F. and Pickl, W.F. and Piconese, S. and Pinti, M. and Pockley, A.G. and Podolska, M.J. and Poon, Z. and Pracht, K. and Prinz, I. and Pucillo, C.E.M. and Quataert, S.A. and Quatrini, L. and Quinn, K.M. and Radbruch, H. and Radstake, T.R.D.J. and Rahmig, S. and Rahn, H.-P. and Rajwa, B. and Ravichandran, G. and Raz, Y. and Rebhahn, J.A. and Recktenwald, D. and Reimer, D. and Reis, e Sousa C. and Remmerswaal, E.B.M. and Richter, L. and Rico, L.G. and Riddell, A. and Rieger, A.M. and Robinson, J.P. and Romagnani, C. and Rubartelli, A. and Ruland, J. and Saalmüller, A. and Saeys, Y. and Saito, T. and Sakaguchi, S. and Sala-de-Oyanguren, F. and Samstag, Y. and Sanderson, S. and Sandrock, I. and Santoni, A. and Sanz, R.B. and Saresella, M. and Sautes-Fridman, C. and Sawitzki, B. and Schadt, L. and Scheffold, A. and Scherer, H.U. and Schiemann, M. and Schildberg, F.A. and Schimisky, E. and Schlitzer, A. and Schlosser, J. and Schmid, S. and Schmitt, S. and Schober, K. and Schraivogel, D. and Schuh, W. and Schüler, T. and Schulte, R. and Schulz, A.R. and Schulz, S.R. and Scottá, C. and Scott-Algara, D. and Sester, D.P. and Shankey, T.V. and Silva-Santos, B. and Simon, A.K. and Sitnik, K.M. and Sozzani, S. and Speiser, D.E. and Spidlen, J. and Stahlberg, A. and Stall, A.M. and Stanley, N. and Stark, R. and Stehle, C. and Steinmetz, T. and Stockinger, H. and Takahama, Y. and Takeda, K. and Tan, L. and Tárnok, A. and Tiegs, G. and Toldi, Gergely and Tornack, J. and Traggiai, E. and Trebak, M. and Tree, T.I.M. and Trotter, J. and Trowsdale, J. and Tsoumakidou, M. and Ulrich, H. and Urbanczyk, S. and van, de Veen W. and van, den Broek M. and van, der Pol E. and Van, Gassen S. and Van, Isterdael G. and van, Lier R.A.W. and Veldhoen, M. and Vento-Asturias, S. and Vieira, P. and Voehringer, D. and Volk, H.-D. and von, Borstel A. and von, Volkmann K. and Waisman, A. and Walker, R.V. and Wallace, P.K. and Wang, S.A. and Wang, X.M. and Ward, M.D. and Ward-Hartstonge, K.A. and Warnatz, K. and Warnes, G. and Warth, S. and Waskow, C. and Watson, J.V. and Watzl, C. and Wegener, L. and Weisenburger, T. and Wiedemann, A. and Wienands, J. and Wilharm, A. and Wilkinson, R.J. and Willimsky, G. and Wing, J.B. and Winkelmann, R. and Winkler, T.H. and Wirz, O.F. and Wong, A. and Wurst, P. and Yang, J.H.M. and Yang, J. and Yazdanbakhsh, M. and Yu, L. and Yue, A. and Zhang, H. and Zhao, Y. and Ziegler, S.M. and Zielinski, C. and Zimmermann, J. and Zychlinsky, A.}, doi = {10.1002/eji.201970107}, journal-iso = {EUR J IMMUNOL}, journal = {EUROPEAN JOURNAL OF IMMUNOLOGY}, volume = {49}, unique-id = {30864881}, issn = {0014-2980}, year = {2019}, eissn = {1521-4141}, pages = {1457-1973}, orcid-numbers = {Erdei, Anna/0000-0002-3622-6680; Toldi, Gergely/0000-0003-0178-1243} } @article{MTMT:30338008, title = {Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines}, url = {https://m2.mtmt.hu/api/publication/30338008}, author = {Théry, C. and Witwer, K.W. and Aikawa, E. and Alcaraz, M.J. and Anderson, J.D. and Andriantsitohaina, R. and Antoniou, A. and Arab, T. and Archer, F. and Atkin-Smith, G.K. and Ayre, D.C. and Bach, J.-M. and Bachurski, D. and Baharvand, H. and Balaj, L. and Baldacchino, S. and Bauer, N.N. and Baxter, A.A. and Bebawy, M. and Beckham, C. and Bedina, Zavec A. and Benmoussa, A. and Berardi, A.C. and Bergese, P. and Bielska, E. and Blenkiron, C. and Bobis-Wozowicz, S. and Boilard, E. and Boireau, W. and Bongiovanni, A. and Borràs, F.E. and Bosch, S. and Boulanger, C.M. and Breakefield, X. and Breglio, A.M. and Brennan, M.Á. and Brigstock, D.R. and Brisson, A. and Broekman, M.L.D. and Bromberg, J.F. and Bryl-Górecka, P. and Buch, S. and Buck, A.H. and Burger, D. and Busatto, S. and Buschmann, D. and Bussolati, B. and Buzás, Edit Irén and Byrd, J.B. and Camussi, G. and Carter, D.R.F. and Caruso, S. and Chamley, L.W. and Chang, Y.-T. and Chaudhuri, A.D. and Chen, C. and Chen, S. and Cheng, L. and Chin, A.R. and Clayton, A. and Clerici, S.P. and Cocks, A. and Cocucci, E. and Coffey, R.J. and Cordeiro-da-Silva, A. and Couch, Y. and Coumans, F.A.W. and Coyle, B. and Crescitelli, R. and Criado, M.F. and D’Souza-Schorey, C. and Das, S. and de, Candia P. and De, Santana E.F. Jr. and De, Wever O. and del, Portillo H.A. and Demaret, T. and Deville, S. and Devitt, A. and Dhondt, B. and Di, Vizio D. and Dieterich, L.C. and Dolo, V. and Dominguez, Rubio A.P. and Dominici, M. and Dourado, M.R. and Driedonks, T.A.P. and Duarte, F.V. and Duncan, H.M. and Eichenberger, R.M. and Ekström, K. and EL, Andaloussi S. and Elie-Caille, C. and Erdbrügger, U. and Falcón-Pérez, J.M. and Fatima, F. and Fish, J.E. and Flores-Bellver, M. and Försönits, András and Frelet-Barrand, A. and Fricke, F. and Fuhrmann, G. and Gabrielsson, S. and Gámez-Valero, A. and Gardiner, C. and Gärtner, K. and Gaudin, R. and Gho, Y.S. and Giebel, B. and Gilbert, C. and Gimona, M. and Giusti, I. and Goberdhan, D.C.I. and Görgens, A. and Gorski, S.M. and Greening, D.W. and Gross, J.C. and Gualerzi, A. and Gupta, G.N. and Gustafson, D. and Handberg, A. and Haraszti, R.A. and Harrison, P. and Hegyesi, Hargita and Hendrix, A. and Hill, A.F. and Hochberg, F.H. and Hoffmann, K.F. and Holder, B. and Holthofer, H. and Hosseinkhani, B. and Hu, G. and Huang, Y. and Huber, V. and Hunt, S. and Ibrahim, A.G.-E. and Ikezu, T. and Inal, J.M. and Isin, M. and Ivanova, A. and Jackson, H.K. and Jacobsen, S. and Jay, S.M. and Jayachandran, M. and Jenster, G. and Jiang, L. and Johnson, S.M. and Jones, J.C. and Jong, A. and Jovanovic-Talisman, T. and Jung, S. and Kalluri, R. and Kano, S.-I. and Kaur, S. and Kawamura, Y. and Keller, E.T. and Khamari, Delaram and Khomyakova, E. and Khvorova, A. and Kierulf, P. and Kim, K.P. and Kislinger, T. and Klingeborn, M. and Klinke, D.J. II and Kornek, M. and Kosanović, M.M. and Kovács, Árpád Ferenc and Krämer-Albers, E.-M. and Krasemann, S. and Krause, M. and Kurochkin, I.V. and Kusuma, G.D. and Kuypers, S. and Laitinen, S. and Langevin, S.M. and Languino, L.R. and Lannigan, J. and Lässer, C. and Laurent, L.C. and Lavieu, G. and Lázaro-Ibáñez, E. and Le, Lay S. and Lee, M.-S. and Lee, Y.X.F. and Lemos, D.S. and Lenassi, M. and Leszczynska, A. and Li, I.T.S. and Liao, K. and Libregts, S.F. and Ligeti, Erzsébet and Lim, R. and Lim, S.K. and Linē, A. and Linnemannstöns, K. and Llorente, A. and Lombard, C.A. and Lorenowicz, M.J. and Lőrincz, Márton Ákos and Lötvall, J. and Lovett, J. and Lowry, M.C. and Loyer, X. and Lu, Q. and Lukomska, B. and Lunavat, T.R. and Maas, S.L.N. and Malhi, H. and Marcilla, A. and Mariani, J. and Mariscal, J. and Martens-Uzunova, E.S. and Martin-Jaular, L. and Martinez, M.C. and Martins, V.R. and Mathieu, M. and Mathivanan, S. and Maugeri, M. and McGinnis, L.K. and McVey, M.J. and Meckes, D.G. Jr and Meehan, K.L. and Mertens, I. and Minciacchi, V.R. and Möller, A. and Møller, Jørgensen M. and Morales-Kastresana, A. and Morhayim, J. and Mullier, F. and Muraca, M. and Musante, L. and Mussack, V. and Muth, D.C. and Myburgh, K.H. and Najrana, T. and Nawaz, M. and Nazarenko, I. and Nejsum, P. and Neri, C. and Neri, T. and Nieuwland, R. and Nimrichter, L. and Nolan, J.P. and Nolte-’t, Hoen E.N.M. and Hooten, N.N. and O’Driscoll, L. and O’Grady, T. and O’Loghlen, A. and Ochiya, T. and Olivier, M. and Ortiz, A. and Ortiz, L.A. and Osteikoetxea, Xabier and Ostegaard, O. and Ostrowski, M. and Park, J. and Pegtel, D.M. and Peinado, H. and Perut, F. and Pfaffl, M.W. and Phinney, D.G. and Pieters, B.C.H. and Pink, R.C. and Pisetsky, D.S. and Pogge, von Strandmann E. and Polakovicova, I. and Poon, I.K.H. and Powell, B.H. and Prada, I. and Pulliam, L. and Quesenberry, P. and Radeghieri, A. and Raffai, R.L. and Raimondo, S. and Rak, J. and Ramirez, M.I. and Raposo, G. and Rayyan, M.S. and Regev-Rudzki, N. and Ricklefs, F.L. and Robbins, P.D. and Roberts, D.D. and Rodrigues, S.C. and Rohde, E. and Rome, S. and Rouschop, K.M.A. and Rughetti, A. and Russell, A.E. and Saá, P. and Sahoo, S. and Salas-Huenuleo, E. and Sánchez, C. and Saugstad, J.A. and Saul, M.J. and Schiffelers, R.M. and Schneider, R. and Schøyen, T.H. and Scott, A. and Shahaj, E. and Sharma, S. and Shatnyeva, O. and Shekari, F. and Shelke, G.V. and Shetty, A.K. and Shiba, K. and Siljander, P.R.-M. and Silva, A.M. and Skowronek, A. and Snyder, O.L. II and Soares, R.P. and Sódar, Barbara and Soekmadji, C. and Sotillo, J. and Stahl, P.D. and Stoorvogel, W. and Stott, S.L. and Strasser, E.F. and Swift, S. and Tahara, H. and Tewari, M. and Timms, K. and Tiwari, S. and Tixeira, R. and Tkach, M. and Toh, W.S. and Tomasini, R. and Torrecilhas, A.C. and Tosar, J.P. and Toxavidis, V. and Urbanelli, L. and Vader, P. and van, Balkom B.W.M. and van, der Grein S.G. and Van, Deun J. and van, Herwijnen M.J.C. and Van, Keuren-Jensen K. and van, Niel G. and van, Royen M.E. and van, Wijnen A.J. and Vasconcelos, M.H. and Vechetti, I.J. Jr and Veit, T.D. and Vella, L.J. and Velot, É. and Verweij, F.J. and Vestad, B. and Viñas, J.L. and Visnovitz, Tamás and Visnovitzné Dr Vukman, Krisztina and Wahlgren, J. and Watson, D.C. and Wauben, M.H.M. and Weaver, A. and Webber, J.P. and Weber, V. and Wehman, A.M. and Weiss, D.J. and Welsh, J.A. and Wendt, S. and Wheelock, A.M. and Wiener, Zoltán and Witte, L. and Wolfram, J. and Xagorari, A. and Xander, P. and Xu, J. and Yan, X. and Yáñez-Mó, M. and Yin, H. and Yuana, Y. and Zappulli, V. and Zarubova, J. and Žėkas, V. and Zhang, J.-Y. and Zhao, Z. and Zheng, L. and Zheutlin, A.R. and Zickler, A.M. and Zimmermann, P. and Zivkovic, A.M. and Zocco, D. and Zuba-Surma, E.K.}, doi = {10.1080/20013078.2018.1535750}, journal-iso = {J EXTRACELLULAR VESICL}, journal = {JOURNAL OF EXTRACELLULAR VESICLES}, volume = {7}, unique-id = {30338008}, year = {2018}, eissn = {2001-3078}, orcid-numbers = {Buzás, Edit Irén/0000-0002-3744-206X; Försönits, András/0000-0002-9298-8890; Hegyesi, Hargita/0000-0002-8800-5169; Kovács, Árpád Ferenc/0000-0002-7742-160X; Ligeti, Erzsébet/0000-0001-6374-729X; Lőrincz, Márton Ákos/0000-0002-2819-5116; Osteikoetxea, Xabier/0000-0003-3628-0174; Sódar, Barbara/0000-0002-8803-7304; Visnovitz, Tamás/0000-0002-7962-5083; Wiener, Zoltán/0000-0001-7056-4926} } @article{MTMT:3273020, title = {Various levels of circulating exosomal total-miRNA and miR-210 hypoxamiR in different forms of pregnancy hypertension}, url = {https://m2.mtmt.hu/api/publication/3273020}, author = {Biró, Orsolya and Alasztics, Bálint and Molvarec, Attila and Joó, József Gábor and Nagy, Bálint and Rigó, János}, doi = {10.1016/j.preghy.2017.09.002}, journal-iso = {PREGNANCY HYPERTENS}, journal = {PREGNANCY HYPERTENSION}, volume = {10}, unique-id = {3273020}, issn = {2210-7789}, abstract = {Introduction: Hypertension is a common complication during pregnancy, affecting 10% of pregnant women worldwide. Several microRNA (miRNA) were shown to be involved in hypertensive disorders of pregnancy. In preeclampsia (PE), placental dysfunction causes the enhanced release of extracellular vesicle-derived miRNAs. The hypoxia-sensitive hsa-mir-210 is the most common PE-associated miRNA, but its exosomal profile has not been investigated. Objectives: Our aims were to measure exosomal total-miRNA concentration and to perform expression analysis of circulating exosomal hsa-miR-210 in women affected by chronic hypertension (CHT) gestational hypertension (GHT) or PE. Materials and methods: We collected plasma samples from women with CHT, GHT, PE (moderate: mPE and severe: sPE) and from normotensive pregnancies. Exosomal miRNAs were extracted and miRNA concentration was measured. RT-PCR was carried out with hsa-miR-210-3p-specific primers and relative expression was calculated using the comparative Ct method. Results: The total-miRNA concentration was different in the disease subgroups, and was significantly higher in mPE and sPE compared to the other groups. We found a significant difference in the relative exosomal hsa-miR-210-3p expression between all hypertensive groups compared to the normotensive samples, but significant upregulation was only observed in case of mPE and sPE patients. Both the level of total-miRNA and hsa-miR-210 expression was higher in case of severe PE. Conclusions: The level of circulating exosomal total-miRNA and hsa-miR-210 was elevated in women with PE, and it was higher in the severe form. We showed that hsa-miR-210 is secreted via exosomes, which may have a role in the pathomechanism of the disease. © 2017 International Society for the Study of Hypertension in Pregnancy.}, keywords = {PREECLAMPSIA; microRNA; exosome; Maternal circulation}, year = {2017}, eissn = {2210-7797}, pages = {207-212}, orcid-numbers = {Biró, Orsolya/0000-0002-4300-3602; Alasztics, Bálint/0000-0002-4011-8439; Molvarec, Attila/0000-0002-3229-3034; Joó, József Gábor/0000-0001-9820-6514; Nagy, Bálint/0000-0002-0295-185X; Rigó, János/0000-0003-2762-6516} } @article{MTMT:3255872, title = {Methodological Guidelines to Study Extracellular Vesicles}, url = {https://m2.mtmt.hu/api/publication/3255872}, author = {Coumans, FAW and Brisson, AR and Buzás, Edit Irén and Dignat-George, F and Drees, EEE and El-Andaloussi, S and Emanueli, C and Gasecka, A and Hendrix, A and Hill, AF and Lacroix, R and Lee, Y and van Leeuwen, TG and Mackman, N and Mager, I and Nolan, JP and van der Pol, E and Pegtel, DM and Sahoo, S and Siljander, PRM and Sturk, G and de Wever, O and Nieuwland, R}, doi = {10.1161/CIRCRESAHA.117.309417}, journal-iso = {CIRC RES}, journal = {CIRCULATION RESEARCH}, volume = {120}, unique-id = {3255872}, issn = {0009-7330}, abstract = {Owing to the relationship between extracellular vesicles (EVs) and physiological and pathological conditions, the interest in EVs is exponentially growing. EVs hold high hopes for novel diagnostic and translational discoveries. This review provides an expert-based update of recent advances in the methods to study EVs and summarizes currently accepted considerations and recommendations from sample collection to isolation, detection, and characterization of EVs. Common misconceptions and methodological pitfalls are highlighted. Although EVs are found in all body fluids, in this review, we will focus on EVs from human blood, not only our most complex but also the most interesting body fluid for cardiovascular research.}, year = {2017}, eissn = {1524-4571}, pages = {1632-1648}, orcid-numbers = {Buzás, Edit Irén/0000-0002-3744-206X} } @article{MTMT:2502232, title = {Innovation in detection of microparticles and exosomes}, url = {https://m2.mtmt.hu/api/publication/2502232}, author = {van der Pol, E and Coumans, F and Varga, Zoltán and Krumrey, M and Nieuwland, R}, doi = {10.1111/jth.12254}, journal-iso = {J THROMB HAEMOST}, journal = {JOURNAL OF THROMBOSIS AND HAEMOSTASIS}, volume = {11}, unique-id = {2502232}, issn = {1538-7933}, year = {2013}, eissn = {1538-7836}, pages = {36-45}, orcid-numbers = {Varga, Zoltán/0000-0002-5741-2669} } @article{MTMT:2471567, title = {Standardization of sample collection, isolation and analysis methods in extracellular vesicle research}, url = {https://m2.mtmt.hu/api/publication/2471567}, author = {Witwer, KW and Buzás, Edit Irén and Bemis, LT and Bora, A and Lasser, C and Lotvall, J and Nolte-'t, Hoen EN and Piper, MG and Sivaraman, S and Skog, J and Thery, C and Wauben, MH and Hochberg, F}, doi = {10.3402/jev.v2i0.20360}, journal-iso = {J EXTRACELLULAR VESICL}, journal = {JOURNAL OF EXTRACELLULAR VESICLES}, volume = {2}, unique-id = {2471567}, abstract = {The emergence of publications on extracellular RNA (exRNA) and extracellular vesicles (EV) has highlighted the potential of these molecules and vehicles as biomarkers of disease and therapeutic targets. These findings have created a paradigm shift, most prominently in the field of oncology, prompting expanded interest in the field and dedication of funds for EV research. At the same time, understanding of EV subtypes, biogenesis, cargo and mechanisms of shuttling remains incomplete. The techniques that can be harnessed to address the many gaps in our current knowledge were the subject of a special workshop of the International Society for Extracellular Vesicles (ISEV) in New York City in October 2012. As part of the "ISEV Research Seminar: Analysis and Function of RNA in Extracellular Vesicles (evRNA)", 6 round-table discussions were held to provide an evidence-based framework for isolation and analysis of EV, purification and analysis of associated RNA molecules, and molecular engineering of EV for therapeutic intervention. This article arises from the discussion of EV isolation and analysis at that meeting. The conclusions of the round table are supplemented with a review of published materials and our experience. Controversies and outstanding questions are identified that may inform future research and funding priorities. While we emphasize the need for standardization of specimen handling, appropriate normative controls, and isolation and analysis techniques to facilitate comparison of results, we also recognize that continual development and evaluation of techniques will be necessary as new knowledge is amassed. On many points, consensus has not yet been achieved and must be built through the reporting of well-controlled experiments.}, year = {2013}, eissn = {2001-3078}, orcid-numbers = {Buzás, Edit Irén/0000-0002-3744-206X} } @article{MTMT:1577931, title = {Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles}, url = {https://m2.mtmt.hu/api/publication/1577931}, author = {György, Bence and Szabó, Géza Tamás and Szente-Pásztói, Mária and Pál, Zsuzsanna and Misják, Petra and Aradi, B and László, Valéria and Pállinger, Éva and Nyitrayné Pap, Erna and Kittel, Ágnes and Nagy, György and Falus, András and Buzás, Edit Irén}, doi = {10.1007/s00018-011-0689-3}, journal-iso = {CELL MOL LIFE SCI}, journal = {CELLULAR AND MOLECULAR LIFE SCIENCES}, volume = {68}, unique-id = {1577931}, issn = {1420-682X}, abstract = {Release of membrane vesicles, a process conserved in both prokaryotes and eukaryotes, represents an evolutionary link, and suggests essential functions of a dynamic extracellular vesicular compartment (including exosomes, microparticles or microvesicles and apoptotic bodies). Compelling evidence supports the significance of this compartment in a broad range of physiological and pathological processes. However, classification of membrane vesicles, protocols of their isolation and detection, molecular details of vesicular release, clearance and biological functions are still under intense investigation. Here, we give a comprehensive overview of extracellular vesicles. After discussing the technical pitfalls and potential artifacts of the rapidly emerging field, we compare results from meta-analyses of published proteomic studies on membrane vesicles. We also summarize clinical implications of membrane vesicles. Lessons from this compartment challenge current paradigms concerning the mechanisms of intercellular communication and immune regulation. Furthermore, its clinical implementation may open new perspectives in translational medicine both in diagnostics and therapy.}, year = {2011}, eissn = {1420-9071}, pages = {2667-2688}, orcid-numbers = {Szabó, Géza Tamás/0000-0001-9745-6255; Pál, Zsuzsanna/0000-0001-6478-9969; Pállinger, Éva/0000-0002-5789-0951; Nyitrayné Pap, Erna/0000-0003-0333-9934; Nagy, György/0000-0003-1198-3228; Falus, András/0000-0002-6843-6789; Buzás, Edit Irén/0000-0002-3744-206X} }