TY - JOUR AU - Zsarnovszky, Attila AU - Kiss, Dávid Sándor AU - Jócsák, Gergely AU - Németh, Gábor László AU - Tóth, István AU - Horváth, Tamás TI - Thyroid hormone- and estrogen receptor interactions with natural ligands and endocrine disruptors in the cerebellum JF - FRONTIERS IN NEUROENDOCRINOLOGY J2 - FRONT NEUROENDOCRIN VL - 48 PY - 2018 IS - SI SP - 23 EP - 36 PG - 14 SN - 0091-3022 DO - 10.1016/j.yfrne.2017.10.001 UR - https://m2.mtmt.hu/api/publication/3278620 ID - 3278620 AB - Although the effects of phytoestrogens on brain function is widely unknown, they are often regarded as "natural" and thus as harmless. However, the effects of phytoestrogens or environmental pollutants on brain function is underestimated. Estrogen (17beta-estradiol, E2) and thyroid hormones (THs) play pivoltal roles in brain development. In the mature brain, these hormones regulate metabolism on cellular and organismal levels. Thus, E2 and THs do not only regulate the energy metabolism of the entire organism, but simultaneously also regulate important homeostatic parameters of neurons and glia in the CNS. It is, therefore, obvious that the mechanisms through which these hormones exert their effects are pleiotropic and include both intra- and intercellular actions. These hormonal mechanisms are versatile, and the experimental investigation of simultaneous hormone-induced mechanisms is technically challanging. In addition, the normal physiological settings of metabolic parameters depend on a plethora of interactions of the steroid hormones. In this review, we discuss conceptual and experimental aspects of the gonadal and thyroid hormones as they relate to in vitro models of the cerebellum. LA - English DB - MTMT ER -