TY  - JOUR
AU  - Keller, CJ
AU  - Honey, CJ
AU  - Entz, László
AU  - Bickel, S
AU  - Groppe, DM
AU  - Tóth, Emília
AU  - Ulbert, István
AU  - Lado, FA
AU  - Mehta, AD
TI  - Corticocortical evoked potentials reveal projectors and integrators in human brain networks.
JF  - JOURNAL OF NEUROSCIENCE
J2  - J NEUROSCI
VL  - 34
PY  - 2014
IS  - 27
SP  - 9152
EP  - 9163
PG  - 12
SN  - 0270-6474
DO  - 10.1523/JNEUROSCI.4289-13.2014
UR  - https://m2.mtmt.hu/api/publication/2716516
ID  - 2716516
N1  - Megjegyzés-24082983
N1 Funding Details: F31NS080357-01, NINDS, National Institute of Neurological Disorders and Stroke
N1 Funding Details: T32-GM007288, NINDS, National Institute of Neurological Disorders and Stroke
AB  - The cerebral cortex is composed of subregions whose 
functional specialization is largely determined by their 
incoming and outgoing connections with each other. In the 
present study, we asked which cortical regions can exert the 
greatest influence over other regions and the cortical 
network as a whole. Previous research on this question has 
relied on coarse anatomy (mapping large fiber pathways) or 
functional connectivity (mapping inter-regional statistical 
dependencies in ongoing activity). Here we combined direct 
electrical stimulation with recordings from the cortical 
surface to provide a novel insight into directed, inter-
regional influence within the cerebral cortex of awake 
humans. These networks of directed interaction were 
reproducible across strength thresholds and across subjects. 
Directed network properties included (1) a decrease in the 
reciprocity of connections with distance; (2) major projector 
nodes (sources of influence) were found in peri-Rolandic 
cortex and posterior, basal and polar regions of the temporal 
lobe; and (3) major receiver nodes (receivers of influence) 
were found in anterolateral frontal, superior parietal, and 
superior temporal regions. Connectivity maps derived from 
electrical stimulation and from resting electrocorticography 
(ECoG) correlations showed similar spatial distributions for 
the same source node. However, higher-level network topology 
analysis revealed differences between electrical stimulation 
and ECoG that were partially related to the reciprocity of 
connections. Together, these findings inform our 
understanding of large-scale corticocortical influence as 
well as the interpretation of functional connectivity 
networks.
LA  - English
DB  - MTMT
ER  -