TY - JOUR AU - Entz, László AU - Tóth, Emília AU - Keller, CJ AU - Bickel, S AU - Groppe, DM AU - Fabó, Dániel AU - Kozák, Lajos Rudolf AU - Erőss, Loránd AU - Ulbert, István AU - Mehta, AD TI - Evoked effective connectivity of the human neocortex JF - HUMAN BRAIN MAPPING J2 - HUM BRAIN MAPP VL - 35 PY - 2014 IS - 12 SP - 5736 EP - 5753 PG - 18 SN - 1065-9471 DO - 10.1002/hbm.22581 UR - https://m2.mtmt.hu/api/publication/2717967 ID - 2717967 N1 - Department of Neurosurgery, Hofstra North Shore LIJ School of Medicine, Feinstein Institute of Medical Research, Manhasset, NY, United States Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, 1132, Hungary Department of Functional Neurosurgery and Department of Epilepsy, National Institute of Clinical Neuroscience, Budapest, 1145, Hungary Péter Pázmány Catholic University, Faculty of Information Technology and Bionics, Budapest, 1083, Hungary Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, United States Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, United States MR Research Center, Semmelweis University Budapest1083, Hungary Cited By :47 Export Date: 8 April 2021 CODEN: HBMAE Correspondence Address: Mehta, A.D.Mail: 611 Northern Boulevard, Suite 150, United States Funding details: National Institutes of Health, NIH Funding details: National Institute of General Medical Sciences, NIGMS, T32GM007288 Funding details: National Institute of Neurological Disorders and Stroke, NINDS, F31NS080357 Department of Neurosurgery, Hofstra North Shore LIJ School of Medicine, Feinstein Institute of Medical Research, Manhasset, NY, United States Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, 1132, Hungary Department of Functional Neurosurgery and Department of Epilepsy, National Institute of Clinical Neuroscience, Budapest, 1145, Hungary Péter Pázmány Catholic University, Faculty of Information Technology and Bionics, Budapest, 1083, Hungary Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, United States Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, United States MR Research Center, Semmelweis University Budapest1083, Hungary Cited By :47 Export Date: 26 April 2021 CODEN: HBMAE Correspondence Address: Mehta, A.D.Mail: 611 Northern Boulevard, Suite 150, United States Funding details: National Institutes of Health, NIH Funding details: National Institute of General Medical Sciences, NIGMS, T32GM007288 Funding details: National Institute of Neurological Disorders and Stroke, NINDS, F31NS080357 AB - The role of cortical connectivity in brain function and pathology is increasingly being recognized. While in vivo magnetic resonance imaging studies have provided important insights into anatomical and functional connectivity, these methodologies are limited in their ability to detect electrophysiological activity and the causal relationships that underlie effective connectivity. Here, we describe results of cortico-cortical evoked potential (CCEP) mapping using single pulse electrical stimulation in 25 patients undergoing seizure monitoring with subdural electrode arrays. Mapping was performed by stimulating adjacent electrode pairs and recording CCEPs from the remainder of the electrode array. CCEPs reliably revealed functional networks and showed an inverse relationship to distance between sites. Coregistration to Brodmann areas (BA) permitted group analysis. Connections were frequently directional with 43% of early responses and 50% of late responses of connections reflecting relative dominance of incoming or outgoing connections. The most consistent connections were seen as outgoing from motor cortex, BA6-BA9, somatosensory (SS) cortex, anterior cingulate cortex, and Broca's area. Network topology revealed motor, SS, and premotor cortices along with BA9 and BA10 and language areas to serve as hubs for cortical connections. BA20 and BA39 demonstrated the most consistent dominance of outdegree connections, while BA5, BA7, auditory cortex, and anterior cingulum demonstrated relatively greater indegree. This multicenter, large-scale, directional study of local and long-range cortical connectivity using direct recordings from awake, humans will aid the interpretation of noninvasive functional connectome studies. Hum Brain Mapp, 2014. (c) 2014 Wiley Periodicals, Inc. LA - English DB - MTMT ER - TY - JOUR AU - Devor, A AU - Tian, P AU - Nishimura, N AU - Teng, IC AU - Hillman, EM AU - Narayanan, SN AU - Ulbert, István AU - Boas, DA AU - Kleinfeld, D AU - Dale, AM TI - Suppressed neuronal activity and concurrent arteriolar vasoconstriction may explain negative blood oxygenation level-dependent signal. JF - JOURNAL OF NEUROSCIENCE J2 - J NEUROSCI VL - 27 PY - 2007 IS - 16 SP - 4452 EP - 4459 PG - 8 SN - 0270-6474 DO - 10.1523/JNEUROSCI.0134-07.2007 UR - https://m2.mtmt.hu/api/publication/1121164 ID - 1121164 N1 - Funding Agency and Grant Number: NATIONAL CENTER FOR RESEARCH RESOURCES [R21RR021907] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB000790, R01EB003832] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R21NS053684, R01NS051188] Funding Source: NIH RePORTER; NCRR NIH HHS [R21 RR021907, R21 RR021907-03, RR021907] Funding Source: Medline; NIBIB NIH HHS [R01 EB003832, R01 EB000790, R01 EB003832-03, EB003832, R01 EB000790-05, EB00790] Funding Source: Medline; NINDS NIH HHS [NS-051188, NS053684, R01 NS051188, R21 NS053684-03, R01 NS051188-05, R21 NS053684] Funding Source: Medline AB - Synaptic transmission initiates a cascade of signal transduction events that couple neuronal activity to local changes in blood flow and oxygenation. Although a number of vasoactive molecules and specific cell types have been implicated, the transformation of stimulus-induced activation of neuronal circuits to hemodynamic changes is still unclear. We use somatosensory stimulation and a suite of in vivo imaging tools to study neurovascular coupling in rat primary somatosensory cortex. Our stimulus evoked a central region of net neuronal depolarization surrounded by net hyperpolarization. Hemodynamic measurements revealed that predominant depolarization corresponded to an increase in oxygenation, whereas predominant hyperpolarization corresponded to a decrease in oxygenation. On the microscopic level of single surface arterioles, the response was composed of a combination of dilatory and constrictive phases. Critically, the relative strength of vasoconstriction covaried with the relative strength of oxygenation decrease and neuronal hyperpolarization. These results suggest that a neuronal inhibition and concurrent arteriolar vasoconstriction correspond to a decrease in blood oxygenation, which would be consistent with a negative blood oxygenation level-dependent functional magnetic resonance imaging signal. LA - English DB - MTMT ER -