TY  - JOUR
AU  - Hegedüs, Zsófia
AU  - Makra, Ildikó
AU  - Imre, Norbert
AU  - Hetényi, Anasztázia
AU  - Mándity, István
AU  - Monostori, Éva
AU  - Martinek, Tamás
TI  - Foldameric probes for membrane interactions by induced β-sheet folding
JF  - CHEMICAL COMMUNICATIONS
J2  - CHEM COMMUN
VL  - 52
PY  - 2016
IS  - 9
SP  - 1891
EP  - 1894
PG  - 4
SN  - 1359-7345
DO  - 10.1039/C5CC09257D
UR  - https://m2.mtmt.hu/api/publication/2993079
ID  - 2993079
N1  - Funding Agency and Grant Number: Hungarian Academy of Sciences; Lendulet program [LP-2011-009]; [TAMOP-4.2.6-14/1]\n Funding text: This work was supported by the Hungarian Academy of Sciences, Lendulet program (LP-2011-009) and TAMOP-4.2.6-14/1. Csaba Vizler is gratefully acknowledged for providing the bEND.3 cell line.\n
Funding Agency and Grant Number: Hungarian Academy of Sciences; Lendulet program [LP-2011-009];  [TAMOP-4.2.6-14/1]
            Funding text: This work was supported by the Hungarian Academy of Sciences, Lendulet program (LP-2011-009) and TAMOP-4.2.6-14/1. Csaba Vizler is gratefully acknowledged for providing the bEND.3 cell line.
Funding Agency and Grant Number: Hungarian Academy of SciencesHungarian Academy of Sciences; Lendulet program [LP-2011-009];  [TAMOP-4.2.6-14/1]
            Funding text: This work was supported by the Hungarian Academy of Sciences, Lendulet program (LP-2011-009) and TAMOP-4.2.6-14/1. Csaba Vizler is gratefully acknowledged for providing the bEND.3 cell line.
AB  - Design strategies were devised for alpha/beta-peptide foldameric analogues of the antiangiogenic anginex with the goal of mimicking the diverse structural features from the unordered conformation to a folded beta-sheet in response to membrane interactions. Structure-activity relationships were investigated in the light of different beta-sheet folding levels.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Cabrele, C
AU  - Martinek, Tamás
AU  - Reiser, O
AU  - Berlicki, Ł
TI  - Peptides containing β-amino acid patterns: Challenges and successes in medicinal chemistry
JF  - JOURNAL OF MEDICINAL CHEMISTRY
J2  - J MED CHEM
VL  - 57
PY  - 2014
IS  - 23
SP  - 9718
EP  - 9739
PG  - 22
SN  - 0022-2623
DO  - 10.1021/jm5010896
UR  - https://m2.mtmt.hu/api/publication/2817673
ID  - 2817673
AB  - The construction of bioactive peptides using β-amino acid-containing sequence patterns is a very promising strategy to obtain analogues that exhibit properties of high interest for medicinal chemistry applications. β-Amino acids have been shown to modulate the conformation, dynamics, and proteolytic susceptibility of native peptides. They can be either combined with α-amino acids by following specific patterns, which results in backbone architectures with well-defined orientations of the side chain functional groups, or assembled in de novo-designed bioactive β- or α,β-peptidic sequences. Such peptides display various biological functions, including antimicrobial activity, inhibition of protein-protein interactions, agonism/antagonism of GPCR ligands, and anti-angiogenic activity.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Berlicki, Ł
AU  - Pilsl, L
AU  - Wéber, Edit
AU  - Mándity, István
AU  - Cabrele, C
AU  - Martinek, Tamás
AU  - Fülöp, Ferenc
AU  - Reiser, O
TI  - Unique α,β- and α,α,β,β-peptide foldamers based on cis-β-aminocyclopentanecarboxylic acid
JF  - ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
J2  - ANGEW CHEM INT EDIT
VL  - 51
PY  - 2012
IS  - 9
SP  - 2208
EP  - 2212
PG  - 5
SN  - 1433-7851
DO  - 10.1002/anie.201107702
UR  - https://m2.mtmt.hu/api/publication/1926671
ID  - 1926671
N1  - Universität Regensburg, Institut für Organische Chemie, Universitätsstrasse 31, 93053 Regensburg, Germany            
            Department of Bioorganic Chemistry, Wrocław University of Technology, 50-370 Wrocław, Poland            
            Institute of Pharmaceutical Chemistry, University of Szeged, 6720 Szeged, Hungary            
            Faculty of Chemistry and Biochemistry, Ruhr University Bochum, 44801 Bochum, Germany            
            Paris Lodron University Salzburg, Department of Molecular Biology, Billrothstrasse 11, 5020 Salzburg, Austria            
            Cited By :69            
            Export Date: 1 October 2021            
            CODEN: ACIEF            
            Correspondence Address: Martinek, T.A.; Institute of Pharmaceutical Chemistry, , 6720 Szeged, Hungary; email: martinek@pharm.u-szeged.hu            
            Chemicals/CAS: cycloleucine, 52-52-8; Cycloleucine, 52-52-8; Peptides
AB  - Waterproof: cis-β-Aminocylopentanecarboxylic acid is a highly suitable building block for the synthesis of α,β- and α,α,β, β-peptides that have unique helical structures with high stability in methanol and aqueous media. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
LA  - English
DB  - MTMT
ER  -