TY  - JOUR
AU  - Hovens, IB
AU  - van Leeuwen, BL
AU  - Nyakas, Csaba
AU  - Heineman, E
AU  - van der Zee, EA
AU  - Schoemaker, RG
TI  - Prior infection exacerbates postoperative cognitive dysfunction in aged rats
JF  - AMERICAN JOURNAL OF PHYSIOLOGY: REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
J2  - AM J PHYSIOL REG I
VL  - 309
PY  - 2015
IS  - 2
SP  - R148
EP  - R159
SN  - 0363-6119
DO  - 10.1152/ajpregu.00002.2015
UR  - https://m2.mtmt.hu/api/publication/2966674
ID  - 2966674
N1  - Admin megjegyzés-27179084
#JournalID1#
Name: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
ISSN: 0363-6119
#JournalID2#
Admin megjegyzés-27179139
#JournalID1#
Name: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
ISSN: 0363-6119
#JournalID2#
AB  - Older patients may experience persisting postoperative cognitive dysfunction (POCD), which is considered to largely depend on surgery-induced (neuro)inflammation. We hypothesize that inflammatory events before surgery could predispose patients to POCD. When part of our aged rats developed Mycoplasma pulmonis, this presented the unique opportunity to investigate whether a pulmonary infection before surgery influences surgery-induced neuroinflammation and POCD. Male 18-mo-old Wistar rats that had recovered from an active mycoplasma infection (infection) and control rats (healthy) were subjected to abdominal surgery and jugular vein catheterization under general anesthesia (surgery) or remained naïve (control). In postoperative week 2, behavioral tests were performed to assess cognitive performance and exploratory behavior. The acute systemic inflammatory response was investigated by measuring plasma IL-6 and IL-12. In the hippocampus, prefrontal cortex and striatum, microglial activity, neurogenesis, and concentrations of IL-6, IL-12, IL1B, and brain-derived neurotropic factor on postoperative day 14 were determined. Rats still showed signs of increased neuroinflammatory activity, as well as cognitive and behavioral changes, 3 wk after the symptoms of infection had subsided. Rats that had experienced infection before surgery exhibited a more generalized and exacerbated postoperative cognitive impairment compared with healthy surgery rats, as well as a prolonged increase in systemic cytokine levels and increased microglial activation in the hippocampus and prefrontal cortex. These findings support the hypothesis that an infection before surgery under general anesthesia exacerbates POCD. Future studies are necessary to determine whether the found effects are aging specific and to investigate the magnitude and time course of this effect in a controlled manner. © 2015 the American Physiological Society.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Bretz, E
AU  - Kobor-Nyakas, DE
AU  - Bretz, Károly János
AU  - Hrehuss, N
AU  - Radák, Zsolt
AU  - Nyakas, Csaba
TI  - Correlations of psycho-physiological parameters influencing the physical fitness of aged women
JF  - ACTA PHYSIOLOGICA HUNGARICA
J2  - ACTA PHYSIOL HUNG
VL  - 101
PY  - 2014
IS  - 4
SP  - 471
EP  - 478
PG  - 8
SN  - 0231-424X
DO  - 10.1556/APhysiol.101.2014.005
UR  - https://m2.mtmt.hu/api/publication/2736490
ID  - 2736490
AB  - Regular assessment of psycho-physiological parameters in aged subjects helps to clarify physical and mental conditions which are important in the prevention of health-endangering events to assure a healthy aging. Thirty older care female residents consented voluntarily to participate in the study. The somatic and psycho-physiological parameters recorded were handgrip force, disjunctive reaction time, balance control and whole body movement coordination, the electrocardiogram and heart rate variability. Significant correlations were found between (a) reaction time and balance control efficiency (r = -0.567, p < 0.009), (b) reaction time and movement coordination accuracy (r = -0.453, p < 0.045), (c) cardiac state and movement coordination accuracy (r = 0.545, p < 0.016), (d) cardiac stress and cardiac state (r = -0.495, p < 0.031), and (e) cardiac stress and force (r = -0.822, p < 0.045). In conclusion, for the aim of establishing basic battery tests for assessing psycho-physiological condition of physical fitness our results emphasize the importance of systematic physical activity, endurance and strength training supporting muscle force, balance control and whole-body movement coordination, in addition to improving the cardiac stress index level. The strong interrelation among these parameters allows the drawing of a more complete view regarding the health condition of aged individuals.
LA  - English
DB  - MTMT
ER  - 

TY  - CHAP
AU  - Luiten, P
AU  - Nyakas, Csaba
AU  - Eisel, U
AU  - van der Zee, E
ED  - Donald, W Pfaff
TI  - Aging of the Brain
T2  - Neuroscience in the 21st Century
PB  - Springer New York
CY  - New York, New York
SN  - 9781461419969
PY  - 2013
SP  - 2239
EP  - 2272
PG  - 34
DO  - 10.1007/978-1-4614-1997-6_84
UR  - https://m2.mtmt.hu/api/publication/2334998
ID  - 2334998
LA  - English
DB  - MTMT
ER  -