@article{MTMT:2966674, title = {Prior infection exacerbates postoperative cognitive dysfunction in aged rats}, url = {https://m2.mtmt.hu/api/publication/2966674}, author = {Hovens, IB and van Leeuwen, BL and Nyakas, Csaba and Heineman, E and van der Zee, EA and Schoemaker, RG}, doi = {10.1152/ajpregu.00002.2015}, journal-iso = {AM J PHYSIOL REG I}, journal = {AMERICAN JOURNAL OF PHYSIOLOGY: REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY}, volume = {309}, unique-id = {2966674}, issn = {0363-6119}, abstract = {Older patients may experience persisting postoperative cognitive dysfunction (POCD), which is considered to largely depend on surgery-induced (neuro)inflammation. We hypothesize that inflammatory events before surgery could predispose patients to POCD. When part of our aged rats developed Mycoplasma pulmonis, this presented the unique opportunity to investigate whether a pulmonary infection before surgery influences surgery-induced neuroinflammation and POCD. Male 18-mo-old Wistar rats that had recovered from an active mycoplasma infection (infection) and control rats (healthy) were subjected to abdominal surgery and jugular vein catheterization under general anesthesia (surgery) or remained naïve (control). In postoperative week 2, behavioral tests were performed to assess cognitive performance and exploratory behavior. The acute systemic inflammatory response was investigated by measuring plasma IL-6 and IL-12. In the hippocampus, prefrontal cortex and striatum, microglial activity, neurogenesis, and concentrations of IL-6, IL-12, IL1B, and brain-derived neurotropic factor on postoperative day 14 were determined. Rats still showed signs of increased neuroinflammatory activity, as well as cognitive and behavioral changes, 3 wk after the symptoms of infection had subsided. Rats that had experienced infection before surgery exhibited a more generalized and exacerbated postoperative cognitive impairment compared with healthy surgery rats, as well as a prolonged increase in systemic cytokine levels and increased microglial activation in the hippocampus and prefrontal cortex. These findings support the hypothesis that an infection before surgery under general anesthesia exacerbates POCD. Future studies are necessary to determine whether the found effects are aging specific and to investigate the magnitude and time course of this effect in a controlled manner. © 2015 the American Physiological Society.}, keywords = {Animals; Body Weight; Aged; Age Factors; Male; metabolism; NEUROPEPTIDE; MEMORY; immunohistochemistry; neuropeptides; prefrontal cortex; INFECTION; hippocampus; ARTICLE; PATHOPHYSIOLOGY; AGE; immunology; animal; TIME; Postoperative complications; Risk Factors; risk factor; priority journal; controlled study; Time Factors; nonhuman; animal tissue; animal model; animal experiment; microbiology; disease severity; pathogenicity; exploratory behavior; learning; Psychology; cognition; Aging; Wistar rat; Behavior, Animal; animal behavior; Spatial learning; Rats, Wistar; Western blotting; Disease Models, Animal; surgery; abdomen; disease exacerbation; interleukin 6; disease model; immune response; symptom; ENCEPHALITIS; Grooming; neuroinflammation; abdominal surgery; Brain-Derived Neurotrophic Factor; brain derived neurotrophic factor; Learning and memory; general anesthesia; interleukin 1beta; Cognition Disorders; Anesthesia, General; systemic inflammatory response syndrome; Inflammation Mediators; autacoid; Complication; interleukin 12; maze test; Microtubule-Associated Proteins; microtubule associated protein; Mycoplasma Infections; nervous system inflammation; mycoplasmosis; Mycoplasma pulmonis; doublecortin protein; Brain-derived neurotropic factor; Postoperative cognitive dysfunction; rat}, year = {2015}, eissn = {1522-1490}, pages = {R148-R159}, orcid-numbers = {Nyakas, Csaba/0000-0003-3756-0186} } @article{MTMT:2736490, title = {Correlations of psycho-physiological parameters influencing the physical fitness of aged women}, url = {https://m2.mtmt.hu/api/publication/2736490}, author = {Bretz, E and Kobor-Nyakas, DE and Bretz, Károly János and Hrehuss, N and Radák, Zsolt and Nyakas, Csaba}, doi = {10.1556/APhysiol.101.2014.005}, journal-iso = {ACTA PHYSIOL HUNG}, journal = {ACTA PHYSIOLOGICA HUNGARICA}, volume = {101}, unique-id = {2736490}, issn = {0231-424X}, abstract = {Regular assessment of psycho-physiological parameters in aged subjects helps to clarify physical and mental conditions which are important in the prevention of health-endangering events to assure a healthy aging. Thirty older care female residents consented voluntarily to participate in the study. The somatic and psycho-physiological parameters recorded were handgrip force, disjunctive reaction time, balance control and whole body movement coordination, the electrocardiogram and heart rate variability. Significant correlations were found between (a) reaction time and balance control efficiency (r = -0.567, p < 0.009), (b) reaction time and movement coordination accuracy (r = -0.453, p < 0.045), (c) cardiac state and movement coordination accuracy (r = 0.545, p < 0.016), (d) cardiac stress and cardiac state (r = -0.495, p < 0.031), and (e) cardiac stress and force (r = -0.822, p < 0.045). In conclusion, for the aim of establishing basic battery tests for assessing psycho-physiological condition of physical fitness our results emphasize the importance of systematic physical activity, endurance and strength training supporting muscle force, balance control and whole-body movement coordination, in addition to improving the cardiac stress index level. The strong interrelation among these parameters allows the drawing of a more complete view regarding the health condition of aged individuals.}, year = {2014}, eissn = {1588-2683}, pages = {471-478}, orcid-numbers = {Radák, Zsolt/0000-0003-1297-6804; Nyakas, Csaba/0000-0003-3756-0186} } @inbook{MTMT:2334998, title = {Aging of the Brain}, url = {https://m2.mtmt.hu/api/publication/2334998}, author = {Luiten, P and Nyakas, Csaba and Eisel, U and van der Zee, E}, booktitle = {Neuroscience in the 21st Century}, doi = {10.1007/978-1-4614-1997-6_84}, unique-id = {2334998}, year = {2013}, pages = {2239-2272}, orcid-numbers = {Nyakas, Csaba/0000-0003-3756-0186} }