@article{MTMT:2940248,
	title = {Estrogen- and Satiety State-Dependent Metabolic Lateralization in the Hypothalamus of Female Rats.},
	url = {https://m2.mtmt.hu/api/publication/2940248},
	author = {Tóth, István and Kiss, Dávid Sándor and Jócsák, Gergely and Somogyi, Virág and Toronyi, Éva and Bartha, Tibor and Frenyó V., László and Horváth, Tamás and Zsarnovszky, Attila},
	doi = {10.1371/journal.pone.0137462},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {10},
	unique-id = {2940248},
	issn = {1932-6203},
	abstract = {Hypothalamus is the highest center and the main crossroad of numerous homeostatic regulatory pathways including reproduction and energy metabolism. Previous reports indicate that some of these functions may be driven by the synchronized but distinct functioning of the left and right hypothalamic sides. However, the nature of interplay between the hemispheres with regard to distinct hypothalamic functions is still unclear. Here we investigated the metabolic asymmetry between the left and right hypothalamic sides of ovariectomized female rats by measuring mitochondrial respiration rates, a parameter that reflects the intensity of cell and tissue metabolism. Ovariectomized (saline injected) and ovariectomized+estrogen injected animals were fed ad libitum or fasted to determine 1) the contribution of estrogen to metabolic asymmetry of hypothalamus; and 2) whether the hypothalamic asymmetry is modulated by the satiety state. Results show that estrogen-priming significantly increased both the proportion of animals with detected hypothalamic lateralization and the degree of metabolic difference between the hypothalamic sides causing a right-sided dominance during state 3 mitochondrial respiration (St3) in ad libitum fed animals. After 24 hours of fasting, lateralization in St3 values was clearly maintained; however, instead of the observed right-sided dominance that was detected in ad libitum fed animals here appeared in form of either right- or left-sidedness. In conclusion, our results revealed estrogen- and satiety state-dependent metabolic differences between the two hypothalamic hemispheres in female rats showing that the hypothalamic hemispheres drive the reproductive and satiety state related functions in an asymmetric manner.},
	year = {2015},
	eissn = {1932-6203},
	orcid-numbers = {Tóth, István/0000-0002-0168-4753; Toronyi, Éva/0000-0002-6284-6373}
}

@article{MTMT:3201614,
	title = {Ghrelin Promotes and Protects Nigrostriatal Dopamine Function via a UCP2-Dependent Mitochondrial Mechanism},
	url = {https://m2.mtmt.hu/api/publication/3201614},
	author = {Andrews, ZB and Erion, D and Beiler, R and Liu, ZW and Abizaid, A and Zigman, J and Elsworth, JD and Savitt, JM and DiMarchi, R and Tschoep, M and Roth, RH and Gao, XB and Horváth, Tamás},
	doi = {10.1523/JNEUROSCI.3890-09.2009},
	journal-iso = {J NEUROSCI},
	journal = {JOURNAL OF NEUROSCIENCE},
	volume = {29},
	unique-id = {3201614},
	issn = {0270-6474},
	year = {2009},
	eissn = {1529-2401},
	pages = {14057-14065}
}

@article{MTMT:1228647,
	title = {Ecto-nucleoside triphosphate diphosphohydrolase 3 in the ventral and lateral hypothalamic area of female rats: morphological characterization and functional implications},
	url = {https://m2.mtmt.hu/api/publication/1228647},
	author = {Kiss, Dávid Sándor and Zsarnovszky, Attila and Horvath, Krisztina and Győrffy, Andrea and Bartha, Tibor and Novák-Hazai, Diana and Sótonyi, Péter and Somogyi, Virág and Frenyó V., László and Diano, Sabrina},
	doi = {10.1186/1477-7827-7-31},
	journal-iso = {REPROD BIOL ENDOCRIN},
	journal = {REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY},
	volume = {7},
	unique-id = {1228647},
	issn = {1477-7827},
	abstract = {Abstract 
		 
		Background: Based on its distribution in the brain, ecto-nucleoside triphosphate 
		diphosphohydrolase 3 (NTPDase3) may play a role in the hypothalamic regulation of 
		homeostatic systems, including feeding, sleep-wake behavior and reproduction. To further 
		characterize the morphological attributes of NTPDase3-immunoreactive (IR) hypothalamic 
		structures in the rat brain, here we investigated: 1.) The cellular and subcellular localization of 
		NTPDase3; 2.) The effects of 17-estradiol on the expression level of hypothalamic 
		NTPDase3; and 3.) The effects of NTPDase inhibition in hypothalamic synaptosomal 
		preparations. 
		Methods: Combined light- and electron microscopic analyses were carried out to characterize 
		the cellular and subcellular localization of NTPDase3-immunoreactivity. The effects of 
		estrogen on hypothalamic NTPDase3 expression was studied by western blot technique. 
		Finally, the effects of NTPDase inhibition on mitochondrial respiration were investigated 
		using a Clark-type oxygen electrode. 
		Results: Combined light- and electron microscopic analysis of immunostained hypothalamic 
		slices revealed that NTPDase3-IR is linked to ribosomes and mitochondria, is predominantly 
		present in excitatory axon terminals and in distinct segments of the perikaryal plasma 
		membrane. Immunohistochemical labeling of NTPDase3 and glutamic acid decarboxylase 
		(GAD) indicated that -amino-butyric-acid- (GABA) ergic hypothalamic neurons do not 
		express NTPDase3, further suggesting that in the hypothalamus, NTPDase3 is predominantly 
		present in excitatory neurons. We also investigated whether estrogen influences the expression 
		level of NTPDase3 in the ventrobasal and lateral hypothalamus. A single subcutaneous 
		injection of estrogen differentially increased NTPDase3 expression in the medial and lateral 
		parts of the hypothalamus, indicating that this enzyme likely plays region-specific roles in 
		estrogen-dependent hypothalamic regulatory mechanisms. Determination of mitochondrial 
		respiration rates with and without the inhibition of NTPDases confirmed the presence of 
		NTPDases, including NTPDase3 in neuronal mitochondria and showed that blockade of 
		mitochondrial NTPDase functions decreases state 3 mitochondrial respiration rate and total 
		mitochondrial respiratory capacity. 
		Conclusions: Altogether, these results suggest the possibility that NTPDases, among them 
		NTPDase3, may play an estrogen-dependent modulatory role in the regulation of intracellular 
		availability of ATP needed for excitatory neuronal functions including neurotransmission.},
	year = {2009},
	eissn = {1477-7827},
	orcid-numbers = {Győrffy, Andrea/0000-0001-7110-1464}
}

@article{MTMT:3201232,
	title = {UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals},
	url = {https://m2.mtmt.hu/api/publication/3201232},
	author = {Andrews, ZB and Liu, ZW and Walllingford, N and Erion, DM and Borok, E and Friedman, JM and Tschop, MH and Shanabrough, M and Cline, G and Shulman, GI and Coppola, A and Gao, XB and Horváth, Tamás and Diano, S},
	doi = {10.1038/nature07181},
	journal-iso = {NATURE},
	journal = {NATURE},
	volume = {454},
	unique-id = {3201232},
	issn = {0028-0836},
	year = {2008},
	eissn = {1476-4687},
	pages = {846-851}
}