@article{MTMT:2964742,
	title = {Timing of CFTR Pore Opening and Structure of Its Transition State.},
	url = {https://m2.mtmt.hu/api/publication/2964742},
	author = {Sorum, Ben and Czégé, Dávid and Csanády, László},
	doi = {10.1016/j.cell.2015.09.052},
	journal-iso = {CELL},
	journal = {CELL},
	volume = {163},
	unique-id = {2964742},
	issn = {0092-8674},
	abstract = {In CFTR, the chloride ion channel mutated in cystic fibrosis (CF) patients, pore opening is coupled to ATP-binding-induced dimerization of two cytosolic nucleotide binding domains (NBDs) and closure to dimer disruption following ATP hydrolysis. CFTR opening rate, unusually slow because of its high-energy transition state, is further slowed by CF mutation DeltaF508. Here, we exploit equilibrium gating of hydrolysis-deficient CFTR mutant D1370N and apply rate-equilibrium free-energy relationship analysis to estimate relative timing of opening movements in distinct protein regions. We find clear directionality of motion along the longitudinal protein axis and identify an opening transition-state structure with the NBD dimer formed but the pore still closed. Thus, strain at the NBD/pore-domain interface, the DeltaF508 mutation locus, underlies the energetic barrier for opening. Our findings suggest a therapeutic opportunity to stabilize this transition-state structure pharmacologically in DeltaF508-CFTR to correct its opening defect, an essential step toward restoring CFTR function.},
	year = {2015},
	eissn = {1097-4172},
	pages = {724-733},
	orcid-numbers = {Sorum, Ben/0000-0001-6742-1094; Czégé, Dávid/0000-0001-7746-5816; Csanády, László/0000-0002-6547-5889}
}

@article{MTMT:1493081,
	title = {Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations},
	url = {https://m2.mtmt.hu/api/publication/1493081},
	author = {Csanády, László and Vergani, P and Gadsby, DC},
	doi = {10.1073/pnas.0911061107},
	journal-iso = {P NATL ACAD SCI USA},
	journal = {PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA},
	volume = {107},
	unique-id = {1493081},
	issn = {0027-8424},
	year = {2010},
	eissn = {1091-6490},
	pages = {1241-1246},
	orcid-numbers = {Csanády, László/0000-0002-6547-5889}
}

@article{MTMT:1493077,
	title = {Involvement of F1296 and N1303 of CFTR in induced-fit conformational change in response to ATP binding at NBD2},
	url = {https://m2.mtmt.hu/api/publication/1493077},
	author = {Szöllősi, András and Vergani, P and Csanády, László},
	doi = {10.1085/jgp.201010434},
	journal-iso = {J GEN PHYSIOL},
	journal = {JOURNAL OF GENERAL PHYSIOLOGY},
	volume = {136},
	unique-id = {1493077},
	issn = {0022-1295},
	year = {2010},
	eissn = {1540-7748},
	pages = {407-423},
	orcid-numbers = {Szöllősi, András/0000-0002-5570-4609; Csanády, László/0000-0002-6547-5889}
}

@article{MTMT:1493092,
	title = {Rapid kinetic analysis of multichannel records by a simultaneous fit to all dwell-time histograms},
	url = {https://m2.mtmt.hu/api/publication/1493092},
	author = {Csanády, László},
	doi = {10.1016/S0006-3495(00)76636-7},
	journal-iso = {BIOPHYS J},
	journal = {BIOPHYSICAL JOURNAL},
	volume = {78},
	unique-id = {1493092},
	issn = {0006-3495},
	year = {2000},
	eissn = {1542-0086},
	pages = {785-799},
	orcid-numbers = {Csanády, László/0000-0002-6547-5889}
}