@article{MTMT:2755870,
	title = {Abeta(1-42) Enhances Neuronal Excitability in the CA1 via NR2B Subunit-Containing NMDA Receptors},
	url = {https://m2.mtmt.hu/api/publication/2755870},
	author = {Varga, Edina and Juhász, Gábor and Bozsó, Zsolt and Penke, Botond and Fülöp, Lívia and Szegedi, Viktor},
	doi = {10.1155/2014/584314},
	journal-iso = {NEURAL PLAST},
	journal = {NEURAL PLASTICITY},
	volume = {2014},
	unique-id = {2755870},
	issn = {2090-5904},
	abstract = {Neuronal hyperexcitability is a phenomenon associated with early Alzheimer's disease. The underlying mechanism is considered to involve excessive activation of glutamate receptors; however, the exact molecular pathway remains to be determined. Extracellular recording from the CA1 of hippocampal slices is a long-standing standard for a range of studies both in basic research and in neuropharmacology. Evoked field potentials (fEPSPs) are regarded as the input, while spiking rate is regarded as the output of the neuronal network; however, the relationship between these two phenomena is not fully clear. We investigated the relationship between spontaneous spiking and evoked fEPSPs using mouse hippocampal slices. Blocking AMPA receptors (AMPARs) with CNQX abolished fEPSPs, but left firing rate unchanged. NMDA receptor (NMDAR) blockade with MK801 decreased neuronal spiking dose dependently without altering fEPSPs. Activating NMDARs by small concentration of NMDA induced a trend of increased firing. These results suggest that fEPSPs are mediated by synaptic activation of AMPARs, while spontaneous firing is regulated by the activation of extrasynaptic NMDARs. Synaptotoxic Abeta(1-42) increased firing activity without modifying evoked fEPSPs. This hyperexcitation was prevented by ifenprodil, an antagonist of the NR2B NMDARs. Overall, these results suggest that Abeta(1-42) induced neuronal overactivity is not dependent on AMPARs but requires NR2B.},
	year = {2014},
	eissn = {1687-5443},
	orcid-numbers = {Bozsó, Zsolt/0000-0002-5713-3096; Penke, Botond/0000-0003-0938-0567; Fülöp, Lívia/0000-0002-8010-0129; Szegedi, Viktor/0000-0003-4191-379X}
}

@article{MTMT:2783420,
	title = {Age-dependent disruption in hippocampal theta oscillation in amyloid-beta overproducing transgenic mice},
	url = {https://m2.mtmt.hu/api/publication/2783420},
	author = {Scott, L and Feng, J and Kiss, Tamás and Needle, E and Atchison, K and Kawabe, TT and Milici, AJ and Hajos-Korcsok, E and Riddell, D and Hajos, M},
	doi = {10.1016/j.neurobiolaging.2011.12.010},
	journal-iso = {NEUROBIOL AGING},
	journal = {NEUROBIOLOGY OF AGING: AGE-RELATED PHENOMENA NEURODEGENERATION AND NEUROPATHOLOGY},
	volume = {33},
	unique-id = {2783420},
	issn = {0197-4580},
	year = {2012},
	eissn = {1558-1497},
	pages = {1481.e13-1481.e23}
}

@article{MTMT:207985,
	title = {Quantitative EEG in early Alzheimer's patients - power spectrum and complexity features},
	url = {https://m2.mtmt.hu/api/publication/207985},
	author = {Czigler, Balázs and Csikós, Dóra and Hidasi, Zoltán and Gaál, Zsófia Anna and Csibri, É and Kiss, É and Salacz, Pál and Molnár, Márk},
	doi = {10.1016/j.ijpsycho.2007.11.002},
	journal-iso = {INT J PSYCHOPHYSIOL},
	journal = {INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY},
	volume = {68},
	unique-id = {207985},
	issn = {0167-8760},
	year = {2008},
	eissn = {1872-7697},
	pages = {75-80},
	orcid-numbers = {Hidasi, Zoltán/0000-0002-7798-0145}
}

@article{MTMT:112923,
	title = {Epileptogenesis and chronic seizures in a mouse model of temporal lobe epilepsy are associated with distinct EEG patterns and selective neurochemical alterations in the contralateral hippocampus},
	url = {https://m2.mtmt.hu/api/publication/112923},
	author = {Arabadzisz, D and Antal, Károly and Parpan, F and Emri, Zsuzsa and Fritschy, JM},
	doi = {10.1016/j.expneurol.2005.01.029},
	journal-iso = {EXP NEUROL},
	journal = {EXPERIMENTAL NEUROLOGY},
	volume = {194},
	unique-id = {112923},
	issn = {0014-4886},
	keywords = {Animals; MICE; Calcium-Binding Protein, Vitamin D-Dependent/metabolism; Chronic Disease; Disease Models, Animal; *Electroencephalography; Action Potentials/drug effects/*physiology; Theta Rhythm/drug effects; Kainic Acid/pharmacology; Neuropeptide Y/metabolism; Up-Regulation/drug effects/physiology; Neurotoxins/pharmacology; Down-Regulation/drug effects/physiology; Functional Laterality/drug effects/physiology; Galanin/metabolism; Pyramidal Cells/drug effects/metabolism; Brain Chemistry/drug effects/*physiology; Status Epilepticus/chemically induced/metabolism/physiopathology; Sincalide/metabolism; Neural Pathways/drug effects/metabolism/physiopathology; Nerve Degeneration/chemically induced/metabolism/physiopathology; Mossy Fibers, Hippocampal/drug effects/metabolism; Hippocampus/drug effects/metabolism/*physiopathology; Epilepsy, Temporal Lobe/chemically induced/metabolism/*physiopathology; Epilepsy/chemically induced/metabolism/*physiopathology},
	year = {2005},
	eissn = {1090-2430},
	pages = {76-90},
	orcid-numbers = {Antal, Károly/0000-0001-8993-3314}
}

@article{MTMT:1428428,
	title = {GAMMA (40-100-HZ) OSCILLATION IN THE HIPPOCAMPUS OF THE BEHAVING RAT},
	url = {https://m2.mtmt.hu/api/publication/1428428},
	author = {BRAGIN, A and Jandó, Gábor and Nádasdy, Zoltán and HETKE, J and WISE, K and Buzsáki, György},
	doi = {10.1523/jneurosci.15-01-00047.1995},
	journal-iso = {J NEUROSCI},
	journal = {JOURNAL OF NEUROSCIENCE},
	volume = {15},
	unique-id = {1428428},
	issn = {0270-6474},
	abstract = {The cellular generation and spatial distribution of gamma frequency (40-100 Hz) activity was examined in the hippocampus of the awake rat. Field potentials and unit activity were recorded by multiple site silicon probes (5- and 16-site shanks) and wire electrode arrays. Gamma waves were highly coherent along the long axis of the dentate hilus, but average coherence decreased rapidly in the CA3 and CA1 directions. Analysis of short epochs revealed large fluctuations in coherence values between the dentate and CA1 gamma waves, Current source density analysis revealed large sinks and sources in the dentate gyrus with spatial distribution similar to the dipoles evoked by stimulation of the perforant path, The frequency changes of gamma and theta waves positively correlated (40-100 Hz and 5-10 Hz, respectively), Putative interneurons in the dentate gyrus discharged at gamma frequency and were phase-locked to the ascending part of the gamma waves recorded from the hilus, Following bilateral lesion of the entorhinal cortex the power and frequency of hilar gamma activity significantly decreased or disappeared. Instead, a large amplitude but slower gamma pattern (25-50 Hz) emerged in the CA3-CA1 network, We suggest that gamma oscillation emerges from an interaction between intrinsic oscillatory properties of interneurons and the network properties of the dentate gyrus. We also hypothesize that under physiological conditions the hilar gamma oscillation may be entrained by the entorhinal rhythm and that gamma oscillation in the CA3-CA1 circuitry is suppressed by either the hilar region or the entorhinal cortex.},
	keywords = {BEHAVIOR; CELLS; NEURONS; hippocampus; EEG; FIELD POTENTIALS; Theta; THETA-RHYTHM; FREELY-MOVING RATS; dentate gyrus; SYNCHRONIZATION; CAT VISUAL-CORTEX; SOURCE DENSITY ANALYSIS; HILAR REGION; 40 HZ; GAMMA OSCILLATION; UNIT ACTIVITY},
	year = {1995},
	eissn = {1529-2401},
	pages = {47-60},
	orcid-numbers = {Nádasdy, Zoltán/0000-0002-6515-9683}
}

@article{MTMT:2941583,
	title = {LOW-FREQUENCY AND HIGH-FREQUENCY MEMBRANE-POTENTIAL OSCILLATIONS DURING THETA ACTIVITY IN CA1 AND CA3 PYRAMIDAL NEURONS OF THE RAT HIPPOCAMPUS UNDER KETAMINE-XYLAZINE ANESTHESIA},
	url = {https://m2.mtmt.hu/api/publication/2941583},
	author = {Soltesz, Ivan and DESCHENES, M},
	doi = {10.1152/jn.1993.70.1.97},
	journal-iso = {J NEUROPHYSIOL},
	journal = {JOURNAL OF NEUROPHYSIOLOGY},
	volume = {70},
	unique-id = {2941583},
	issn = {0022-3077},
	abstract = {1. Intracellularly recorded low- and high-frequency (4-6 and 25-50 Hz, respectively), rhythmic, spontaneous membrane potential oscillations were investigated in pyramidal neurons of the rat hippocampus in vivo, during theta(THETA, 4-6 Hz)electroencephalographic (EEG) activity, under ketamine-xylazine anesthesia. 2. The EEG activity showed two spectral peaks, one in the THETA range. the other at higher frequencies (25-50 Hz). On the basis of their electrophysiological and pharmacological properties, it was concluded that the EEG THETA-waves, and the fast EEG rhythm, recorded during ketamine-xylazine anesthesia, share the basic properties of those THETA and fast rhythms that are recorded under the effects of other types of anesthetics. 3. When intracellular recordings (n = 32) were made with electrodes filled with potassium-acetate (K-acetate), the only CA1 and CA3 pyramidal cells (PCs) considered for further analysis were those that did not fire rhythmically at most or each cycle of the THETA rhythm at the resting membrane potential. During EEG-THETA, the membrane potential (V(m)) of these cells showed a prominent oscillation (3-15 mV) with frequencies similar to those of the EEG-THETA (the intracellular THETA rhythm, intra-THETA). 4. The frequency of the intra-THETA was independent of the V(m). However, the phase difference between the intra-THETA and the EEG-THETA was voltage dependent in both types of cells. CA1 PCs showed a large ( 120-180-degrees, where 360-degrees is the full cycle), gradual shift in the phase difference between the intra-THETA and the EEG-THETA, when the membrane was hyperpolarized to -85 from -65 mV. Although CA3 PCs displayed a larger variability in their phase-voltage relations. a voltage-dependent phase shift (90-180-degrees) could be observed in CA3 PCs as well. 5. Although the amplitude of the intra-THETA in both CA1 and CA3 PCs could display large, sudden, spontaneous changes at a given V(m), the amplitude-V(m) plots tended to show a minimum between -70 and -80 mV. Spontaneous changes in the amplitude of the intra-THETA did not affect the phase difference between the intra- and the EEG-THETA rhythms. 6. Intracellular injection of QX-314 (50-100 mM) did not change the phase-V(m) or the amplitude-V(m) relationships of CA1 PCs. 7. Intracellular injection of chloride (Cl-) ions greatly reduced the voltage dependency of the phase difference and revealed fast (duration: 20-25 ms), depolarizing potentials (5-20 mV), which appeared at high frequencies (25-50 Hz), amplitude modulated at THETA-frequencies. 8. These findings are consistent with the hypothesis that rhythmic, high-frequency, gamma-aminobutyric acid-A (GABA(A))-receptor-mediated inhibitory postsynaptic potentials have an important role in the generation of both the THETA and the fast hippocampal rhythms.},
	keywords = {CELLS; SLICES; ENTORHINAL CORTEX; INHIBITORY INTERNEURONS; BEHAVING RAT; Urethane; GENERATORS; RHYTHMICAL SLOW ACTIVITY; SYNAPTIC RESPONSES; QX-314},
	year = {1993},
	eissn = {1522-1598},
	pages = {97-116}
}